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1. 'I'm 27, and my disability admin feels like a full-time job'

   Thu, 26 Dec 2024 21:47:42 -0000

   Sofia Brizio, who lives in Cardiff, said she can spend four hours a day on "disability admin".

2. Bird flu kills 20 big cats at US animal sanctuary

   Wed, 25 Dec 2024 21:36:59 -0000

   The animals - including a Bengal tiger, cougars and bobcats - have died of the virus over the past several weeks.

3. £90,000-a-year patient safety role remains unfilled

   Tue, 24 Dec 2024 22:57:53 -0000

   A law creating a Patient Safety Commissioner post was passed last year - but no-one has yet been found to take it on.

4. Hospitals trial AI to spot type 2 diabetes risk

   Tue, 24 Dec 2024 11:09:30 -0000

   The system checks patients' ECG heart traces for subtle early warning signs.

5. People seek NHS advice on drinking and breastfeeding at Christmas

   Tue, 24 Dec 2024 03:38:12 -0000

   Any alcohol that the mother drinks can pass into her breastmilk, the NHS advises.

6. Doctors warn over water bead gifts for children

   Mon, 23 Dec 2024 02:27:13 -0000

   The Royal College of Emergency Medicine issues a "safety flash" about the dangers to children.

7. 'Lungs in a box' could increase vital transplants

   Mon, 23 Dec 2024 05:37:35 -0000

   The number of lung of transplants could rise as a new machine keeps organs alive outside the body.

8. Hospitals write off £112m in foreign patient bills

   Thu, 19 Dec 2024 01:44:43 -0000

   Hospitals say they often struggle to recover costs, particularly when patients return overseas.

9. 'My former work colleague gave me her kidney'

   Sun, 15 Dec 2024 07:17:20 -0000

   Jamie Lonsdale made a donor plea on Facebook and was delighted when Lauren Lane answered the call.

10. Flu cases make NHS busier than ever with 95% of beds full

    Thu, 05 Dec 2024 16:23:15 -0000

    NHS England medical director warns hospitals under strain after sharp rise in flu cases.

11. Fix palliative care before assisted dying is introduced, doctors urge

    Sat, 30 Nov 2024 20:17:03 -0000

    Leading end-of-life doctors warn system is struggling, and changing law could make situation worse.

12. Terminally ill people on both sides of assisted dying debate react to vote

    Sat, 30 Nov 2024 04:32:33 -0000

    BBC News speaks to two terminally ill people with opposing views on the impact of assisted dying.

13. What happens next to the bill on assisted dying?

    Fri, 29 Nov 2024 15:28:31 -0000

    MPs have backed a change in the law, but the measure still faces many hurdles before coming into force.

14. What is assisted dying and how could the law change?

    Fri, 29 Nov 2024 17:06:52 -0000

    A proposed law would let terminally ill people in England and Wales choose to end their life.

15. Hope, fear, faith and love: Four people on why assisted dying vote matters

    Thu, 28 Nov 2024 17:41:10 -0000

    For the first time in nearly a decade, MPs will debate and vote on the issue of assisted suicide.

16. How assisted dying has spread across the world and how laws differ

    Fri, 29 Nov 2024 09:48:06 -0000

    About 300 million people have access to some form of assisted dying - what are the policies of other countries?

17. 'I might be dead before a decision is made': Terminally ill people on assisted dying

    Tue, 12 Nov 2024 17:50:20 -0000

    Nik is worried assisted dying could lead to coercion - but Elise, who has cancer, wants the choice.

18. 'Focus on palliative care not assisted dying'

    Fri, 29 Nov 2024 11:12:05 -0000

    Doctor Mike Blabin tells the BBC the sector is desperately underfunded despite facing huge demand.

19. Rantzen did not expect to see assisted dying bill

    Fri, 29 Nov 2024 06:07:57 -0000

    Dame Esther says she thought she would be "long gone" by the time MPs debated assisted dying.

20. Assisted dying bill about right to choose - minister

    Sun, 24 Nov 2024 14:46:25 -0000

    Labour’s cabinet remains divided on how to vote on Friday’s bill to legalise assisted dying.

21. Assisted dying bill: What is in proposed law?

    Fri, 29 Nov 2024 15:30:26 -0000

    The proposed law would allow some terminally ill adults to end their own lives. But there are requirements.

22. Assisted dying bill dangerous, says Archbishop

    Wed, 16 Oct 2024 12:11:15 -0000

    His comments came ahead of an assisted dying bill being introduced to Parliament.

23. Dartitis: The condition where you try to throw a dart - but can't

    Mon, 16 Dec 2024 16:27:17 -0000

    The psychological condition stops players from releasing a dart.

24. Puberty blockers: Can a drug trial solve one of medicine's most controversial debates?

    Mon, 09 Dec 2024 00:43:50 -0000

    The government has pledged to determine the evidence - and establish whether the benefits outweigh any potential harms of prescribing puberty blockers to children questioning their gender

25. Why are doctors wary of wearables?

    Mon, 02 Dec 2024 01:36:30 -0000

    Wearable tech claims to help monitor our health, but many doctors remain sceptical.

26. What is methanol and how does it affect the body?

    Fri, 22 Nov 2024 17:22:11 -0000

    Travellers are being warned of the dangers after six tourists in Laos died from methanol poisoning.

27. Contraceptive pills recalled in South Africa after mix-up

    Thu, 21 Nov 2024 18:35:06 -0000

    A faulty batch of Yaz Plus means some packs contain only four active pills rendering them ineffective.

28. Can RFK Jr make America's diet healthy again?

    Sun, 24 Nov 2024 05:12:18 -0000

    Kennedy's plans to ban dyes in cereals and fluoride in water could get major pushback from the food industry.

29. Women plan UK legal action over talc cancer claims

    Wed, 20 Nov 2024 06:16:47 -0000

    Hundreds of women in the UK are taking legal action against Johnson and Johnson.

30. What does an unheated room do to your body?

    Sat, 19 Nov 2022 01:11:29 -0000

    The BBC's health and science correspondent undergoes an experiment to find out how a cold home affects him.

31. Trump picks vaccine sceptic RFK Jr for health secretary

    Fri, 15 Nov 2024 11:38:38 -0000

    Robert F Kennedy Jr has a history of spreading health information scientists say is false.

32. NHS to review prostate cancer testing after Chris Hoy call for change

    Tue, 05 Nov 2024 14:03:26 -0000

    The Olympic cycling champion, who has terminal cancer, wants more younger men to get checked.

33. How many people still smoke in the UK?

    Wed, 27 Nov 2024 12:48:37 -0000

    The government wants to create a smoke-free generation, and restrict the sale and marketing of vapes.

34. What are the symptoms of prostate cancer?

    Mon, 21 Oct 2024 10:15:07 -0000

    One in eight men will be diagnosed with prostate cancer in their lifetime.

35. 'I can't afford a child on £53,000 salary' - why fertility rate is falling

    Sun, 03 Nov 2024 00:09:01 -0000

    From 'fruitless' dating to financial pressures, people share their views on falling fertility rates.

36. NHS will not fund new drug to slow Alzheimer’s

    Wed, 23 Oct 2024 09:02:04 -0000

    A new drug that slows the pace of Alzheimer's disease is too expensive for too little benefit to be used on the NHS, the watchdog says.

37. How do weight loss drugs like Mounjaro and Wegovy work?

    Thu, 05 Dec 2024 10:02:47 -0000

    NHS experts report unprecedented demand for the new generation of obesity treatments.

38. NHS hours from PPE running out in Covid - Hancock

    Thu, 21 Nov 2024 16:58:34 -0000

    Former health secretary tells inquiry some healthcare settings did run out - "and it was awful".

39. Covid inquiry told Treasury blocked NHS bed request

    Mon, 11 Nov 2024 18:06:48 -0000

    NHS England chief executive Amanda Pritchard says the decision, in July 2020, was very disappointing.

40. Covid inquiry told top NHS doctor was terrified

    Thu, 07 Nov 2024 17:34:34 -0000

    Sir Stephen Powis says points-based tool was drawn up should need to prioritise patients have arisen.

41. How close were hospitals to collapse in Covid?

    Mon, 28 Oct 2024 00:06:04 -0000

    The Covid inquiry restarts its live hearings this week, after senior staff in the NHS revealed just how close some hospitals were to collapse

42. Covid inquiry told of trust do-not-resuscitate rule

    Thu, 10 Oct 2024 16:54:11 -0000

    Patients' families were “horrified but not surprised” when told the blanket policy had been in place.

43. We were not treated as parents, Covid inquiry told

    Mon, 07 Oct 2024 14:11:38 -0000

    Mum of premature twins says rigid restrictions on birthing wards during Covid were traumatic.

44. Covid ambulance crews faced 'crucial PPE delays'

    Tue, 01 Oct 2024 14:39:04 -0000

    Crews say they faced crucial delays trying to save dying patients because of the time it took to put on equipment.

45. Covid was like a daily terror attack, doctor tells inquiry

    Thu, 26 Sep 2024 14:06:37 -0000

    Covid inquiry hears harrowing testimony from ex-adviser in emergency preparedness at NHS England.

46. Covid inquiry rejects clinicians’ anonymity plea

    Thu, 26 Sep 2024 00:11:07 -0000

    The UK Health Security Agency argued naming the junior officials could put them at risk of abuse.

47. Warning tax rises could force care homes to close

    Thu, 31 Oct 2024 13:50:35 -0000

    Social care providers say the sector is in "unprecedented danger" without more funding.

48. High-grade masks evidence weak, Covid inquiry told

    Thu, 19 Sep 2024 11:39:28 -0000

    UKHSA's Prof Susan Hopkins said respirator masks may have worked no better than thin surgical masks.

49. Nurses bore the brunt of Covid, ex-chief nurse says

    Tue, 17 Sep 2024 15:58:13 -0000

    Dame Ruth May tells the Covid inquiry nurses struggled with low staffing levels and difficulties accessing protective equipment.

50. ‘I grieve for the person I was before' - Covid inquiry to begin new phase

    Mon, 09 Sep 2024 01:13:17 -0000

    The Covid inquiry opens its next set of hearings on Monday, looking at the impact on healthcare and the NHS.

51. Corruption review finds 'red flags' in more than 130 Covid contracts

    Mon, 09 Sep 2024 00:04:10 -0000

    An anti-corruption charity finds significant concerns in £15.3bn worth of contracts awarded during the pandemic.

52. How the UK planned for the wrong pandemic

    Thu, 18 Jul 2024 17:28:01 -0000

    Over-confidence, wasted opportunities and muddled-thinking left UK sleep-walking into Covid.

53. What is the UK Covid inquiry and how does it work?

    Wed, 04 Sep 2024 09:23:46 -0000

    The next public hearings will consider how the pandemic affected healthcare systems across the UK.

54. Covid inquiry: The UK pandemic in numbers

    Wed, 05 Jul 2023 12:18:18 -0000

    Explore the data on how the coronavirus pandemic unfolded in the UK.

55. Assisted dying bill: What is in proposed law?

    Fri, 29 Nov 2024 15:30:26 -0000

    The proposed law would allow some terminally ill adults to end their own lives. But there are requirements.

56. How are the vaping rules changing?

    Tue, 05 Nov 2024 17:06:32 -0000

    Marketing rules will be stricter, nicotine vapes will be taxed and disposable vapes will be banned.

57. Is the system letting down people who were harmed by Covid vaccines?

    Wed, 23 Oct 2024 05:48:59 -0000

    People affected by rare blood clots say they feel they have been airbrushed out of the pandemic.

58. How will weight-loss drugs change our relationship with food?

    Sat, 19 Oct 2024 03:10:13 -0000

    The rise of these treatments has major implications for how we think about obesity, says James Gallagher.

59. NHS needs better plan around weight loss jabs, warn experts

    Wed, 16 Oct 2024 07:27:18 -0000

    Experts call for an urgent review of obesity treatment services amid booming demand for weight loss jabs.

60. How many of us will end up being diagnosed with ADHD?

    Sun, 15 Sep 2024 00:36:40 -0000

    Experts suggest that the number of people with ADHD is actually going to remain steady.

61. The junior doctors' strikes may be over. But is trouble ahead?

    Fri, 02 Aug 2024 00:43:02 -0000

    The end of the pay dispute sounded too good to be true. And now some are wondering if it might be.

62. Why we might never know the truth about ultra-processed foods

    Sat, 27 Jul 2024 23:33:23 -0000

    Experts can’t agree how exactly they affect us and it’s not clear that science will give us an answer.

63. Are weight-loss injections the answer to obesity?

    Sun, 19 Mar 2023 00:52:45 -0000

    The appeal is clear - but should we be turning to appetite-suppressing injections?

64. What is assisted dying and how could the law change?

    Fri, 29 Nov 2024 17:06:52 -0000

    A proposed law would let terminally ill people in England and Wales choose to end their life.

65. Chris Hoy says men should talk about health issues more

    Fri, 13 Dec 2024 09:51:18 -0000

    Six-time Olympic cycling champion Chris Hoy calls for more openness on health matters

66. Paris: Grassroots to Glory

    Mon, 08 Jul 2024 09:43:25 -0000

    The Rugby 7s player has struggled with body image in the past, but says sport has helped

67. Paris: Grassroots to Glory

    Thu, 18 Jul 2024 05:01:00 -0000

    The Paralympic Rowing Cox will compete a year after getting the all clear from cancer.

68. How Dame Deborah James helped save a mum's life

    Mon, 24 Jun 2024 09:06:52 -0000

    A mother-of-three shared her story with Dame Deborah's mother Heather on BBC Breakfast.

69. Can health secretary name NHS trusts performing well?

    Thu, 11 Apr 2024 09:09:11 -0000

    Victoria Atkins is challenged to name some health trusts meeting their targets to cut waiting lists.

70. 'I embrace my alopecia, but I’d love my old hair back’

    Sun, 03 Mar 2024 23:36:30 -0000

    People living with alopecia could have access to treatment on the NHS in Scotland for the first time.

71. ‘I have a blood test coming up — how should I prepare?’: Ask a doctor

    Thu, 26 Dec 2024 22:01:21 -0000

    Blood tests are common, but can cause fear or anxiety for some. Fox News Digital spoke with a doctor about what you can do to be prepared and comfortable before your next blood draw.

72. Dance eases depression symptoms in Parkinson's patients, new study suggests

    Thu, 26 Dec 2024 14:44:30 -0000

    A new study found that Parkinson's disease patients who took dance classes experienced fewer symptoms of depression, with dance having "a positive effect on the mood circuits in the brain."

73. What is sunset anxiety? Here's how to know if you have late-day distress

    Thu, 26 Dec 2024 09:30:16 -0000

    Nearly 20% of American adults reported having an anxiety disorder in the past year — and many are more likely to feel uneasy and anxious as the sun sets. Experts reveal the common triggers.

74. 'Miracle therapy' could correct heart failure in kids

    Thu, 26 Dec 2024 00:31:27 -0000

    The Fox News Health Newsletter brings you trending and important stories about health care, drug developments, mental health issues, real people's triumphs over medical struggles, and more.

75. Pregnant woman and baby saved after doctors find grapefruit-sized tumor: 'Extremely rare'

    Wed, 25 Dec 2024 09:30:27 -0000

    A Chicago woman was just weeks away from giving birth when a nagging cough led to a shocking medical discovery. MaKenna Lauterbach shared her harrowing story with Fox News Digital.

76. FDA approves first medication for obstructive sleep apnea, which also promotes weight loss

    Tue, 24 Dec 2024 15:55:47 -0000

    The FDA approved a new drug treatment for obstructive sleep apnea that improves the condition through weight loss. Sleep expert Dr. Wendy Troxel discusses the impact of the new development.

77. Stem cell therapy to correct heart failure in children could 'transform lives'

    Tue, 24 Dec 2024 13:30:28 -0000

    Doctors and specialists at the Murdoch Children's Research Institute in Melbourne, Australia, are studying and reprogramming the potential of the blood to treat heart failure in children.

78. 5 sleep tips to get better rest during the busy holiday season

    Tue, 24 Dec 2024 09:30:35 -0000

    Dr. Brian Licuanan, board-certified clinical psychologist, offers expert advice to ensuring good quality sleep over the holidays, which can pose challenges.

79. First rare human case of bird flu reported in Los Angeles County

    Tue, 24 Dec 2024 02:42:52 -0000

    The LA County Department of Public Health confirmed the first human case of bird flu in the county, just days after Gov. Gavin Newsom issued a state of emergency over the disease.

80. Boy, 8, saves choking friend with Heimlich maneuver: See the video

    Mon, 23 Dec 2024 23:11:17 -0000

    An 8-year-old boy is being hailed as a hero after saving the life of his choking friend in the elementary school cafeteria. See the video of Thomas Conley's brave act of heroism.

81. The year in cancer: Advances made in 2024, predictions for 2025

    Mon, 23 Dec 2024 11:31:35 -0000

    Four oncologists from the Sarah Cannon Research Institute in Tennessee shared with Fox News Digital what they see as the most notable accomplishments from 2024 and what's on the horizon for 2025.

82. Traveling for Christmas? Stay healthy with these 7 tips

    Sun, 22 Dec 2024 19:10:13 -0000

    Dr. Marc Siegel, clinical professor of medicine at NYU Langone Health and Fox News senior medical analyst, shares his top tips for preventing illness during holiday travel.

83. New skincare trend has people rubbing beef fat on their faces: Dermatologists react

    Sun, 22 Dec 2024 09:30:11 -0000

    Tallow balm maker and natural cosmetics brand Hearth and Homestead has seen a major rise in demand for beef tallow products. Experts weigh the potential benefits and risks.

84. 'Pendulum lifestyle' could be key to juggling daily challenges

    Sat, 21 Dec 2024 09:30:37 -0000

    For those who are feeling “stuck" or overwhelmed while striving for work-life balance, some experts recommend adopting a “pendulum lifestyle." Psychologists weigh in on the potential benefits.

85. Eggs now qualify as ‘healthy’ food, FDA says: Here’s why

    Fri, 20 Dec 2024 20:28:18 -0000

    The U.S. Food and Drug Administration (FDA) now classifies eggs as a “healthy, nutrient-dense" food, according to a new proposed rule. Registered dietitians react to the change.

86. Vitamin D not recommended for preventing fractures in older individuals, panel finds

    Fri, 20 Dec 2024 16:10:30 -0000

    The U.S. Preventive Services Task Force released a draft recommendation advising against using vitamin D to prevent falls and fractures in people over 60. Pharmacist Katy Dubinsky weighs in.

87. 10 tips for dementia caregivers to make the holidays less stressful and more enjoyable

    Fri, 20 Dec 2024 09:30:56 -0000

    The holiday season can be particularly stressful for those living with dementia. Experts share tips to help dementia patients, family members and caregivers enjoy a smooth, low-stress season.

88. Woman receives pig kidney transplant, walks out of hospital days later: ‘Second chance'

    Thu, 19 Dec 2024 22:45:13 -0000

    Towana Looney of Alabama received a successful pig kidney transplant. NYU Langone Drs. Robert Montgomery and Marc Siegel comment on what this means for the future of transplant accessibility.

89. Bird flu leads to severe human illness and state of emergency; experts discuss risk

    Thu, 19 Dec 2024 21:26:42 -0000

    The CDC has confirmed the country’s first severe case of bird flu in a human, and California Gov. Gavin Newsom has declared a state of emergency. Doctors react to the latest viral developments.

90. Trump's daylight saving time plan and sleep: What you must know

    Thu, 19 Dec 2024 09:30:18 -0000

    President-elect Donald Trump has a plan for daylight saving time, a move that some experts say could improve health and wellness. Experts react to the potential effects on sleep and more.

91. Manmohan Singh dies: His illustrious family

    Thu, 26 Dec 2024 19:01:26 -0000

    Manmohan Singh, India's former Prime Minister, passed away at age 92. He held the office for a decade and was known for his economic expertise. Survived by his wife and three daughters, Singh's career spanned academia, bureaucracy, and politics, earning him global respect. His contributions will be remembered.

92. How do some people lose weight by just walking?

    Thu, 26 Dec 2024 08:30:00 -0000

    Walking can be an effective weight loss tool when combined with consistent habits and lifestyle changes. Incorporate daily walking, mindful eating, and increased intensity. Simple adjustments like parking farther away and taking the stairs add steps. Walking uphill engages more muscles and burns more calories. These combined efforts lead to sustainable weight loss.

93. 7 suitable dog breeds for first-time pet parents

    Fri, 27 Dec 2024 04:31:21 -0000

    From Shih Tzu to Labrador Retriever, here we list some pet dog breeds that are more suitable for first-time dog parents.

94. 6 most famous and iconic seascapes in art

    Thu, 26 Dec 2024 10:45:27 -0000

    Seascapes have a certain beauty to them. The oceans, the endless waters, the calm waves, and the turbulent high tides, they are loved and admired by people. Here we mention 6 iconic seascapes that deserve all the love and recognition.

95. 6 ways to have a healthy and happy relationship in 2025

    Thu, 26 Dec 2024 16:40:36 -0000

    A happy and healthy relationship positively impacts mental and emotional well-being. Key ways to maintain such a relationship include effective communication, supporting each other's growth, spending quality time together, sharing gratitude, ensuring physical and emotional intimacy, and practicing self-care to encourage mutual health and happiness.

96. Pheran styling ideas to pick for your trip to Kashmir

    Thu, 26 Dec 2024 14:30:00 -0000

    Let's take a look at some stunning ways in which you can style a pheran.

97. 10 completely life-changing books recommended by top billionaires

    Wed, 25 Dec 2024 12:30:00 -0000

    Everyone looks up to millionaires and billionaires and wants to reach their ranks. The money, luxury, and fame all look so glamorous! And so, if you wish to excel in 2025, here we mention 10 life-changing books recommended by top billionaires.

98. How to spot fake Nike Air Force 1 sneakers

    Fri, 27 Dec 2024 00:30:00 -0000

    With these tips in mind, you can enjoy your authentic pair of Nike Air Force 1s and avoid falling victim to counterfeit products.

99. Hidden meaning of Kate Middleton's Christmas earrings

    Thu, 26 Dec 2024 17:30:00 -0000

    Princess Kate attended Sandringham's Christmas Morning Service in 2024, exuding elegance in an emerald-green outfit. She wore meaningful accessories, including Blue Topaz earrings symbolizing healing and her battle with cancer. The Black Watch tartan scarf added historical significance. The event marked her gradual return to royal duties post-chemotherapy.

100. 'Living Nostradamus' predicts out-of-control AI

     Thu, 26 Dec 2024 16:48:29 -0000

     Brazilian 'prophet' Athos Salomé predicts groundbreaking changes for 2025, including genetically modified humans, AI becoming uncontrollable, proof of extraterrestrial life on Mars, a significant energy crisis, and increased government surveillance through implanted chips. Salomé's predictions also include shocking climate disasters and secret military operations.

101. Are you confident or have self-doubt?

     Thu, 26 Dec 2024 10:58:09 -0000

     Optical illusion personality tests reveal hidden traits based on what is seen first in an image. A specific test, shared on TikTok by Mia Yilin, uses a bird and a vintage record player to determine if a person is creative but self-doubting or resilient and confident respectively.

102. Nita Ambani's fitness trainer shares doable weight loss tips

     Thu, 26 Dec 2024 07:00:52 -0000

     Nita Ambani's fitness trainer, Vinod Channa, shares tips on effective weight loss, emphasizing the importance of personalized nutrition plans and regular eating intervals. He advises performing abs workouts after working on large muscles for faster results. A combination of targeted exercises, a balanced diet, and overall body fat reduction is crucial for toning abs effectively.

103. Aishwarya's iconic outfit at Academy Museum

     Thu, 26 Dec 2024 12:30:00 -0000

     Aishwarya Rai Bachchan, celebrated for her role in 'Jodhaa Akbar' as Jodhaa Bai, has her iconic red lehenga featured in the Academy Museum's 'Color in Motion' exhibition. The extravagant jewelry in the film, made from real gold and precious stones, showcased unmatched craftsmanship, emphasizing her lasting global legacy.

104. 10 relationship resolutions to take in the New Year

     Thu, 26 Dec 2024 09:10:36 -0000

     From practising gratitude to saying no when required, here we list 10 relationship resolutions one should take to strengthen their bonds and have healthier connections in the New Year.

105. How to use Coconut Milk to increase hair growth

     Thu, 26 Dec 2024 07:56:47 -0000

     Coconut milk is rich in essential nutrients like vitamins C and E, which promote healthy hair growth.

106. Prince Harry replaced by THIS Prince?

     Thu, 26 Dec 2024 07:51:17 -0000

     This year, the UK royals celebrated Christmas at Sandringham without Prince Harry and Meghan. Prince Harry was replaced by Prince George in the traditional pre-Christmas football match, signifying the strained relationship between Harry and his family. Prince George participated alongside Prince William, highlighting healthy father-son bonding moments.

107. "36-size jeans to fitting in 30, this is how I made it happen"

     Thu, 26 Dec 2024 06:30:00 -0000

     ​I was wearing size 36 jeans a few years back. One day I realised my physical growth is progressing at a faster pace and that's when I decided to bring it to a halt.​

108. Pune DCP's timely action saves the life of accident-hit man

     Thu, 26 Dec 2024 05:04:17 -0000

     Pune DCP Sandeep Bhajibhakre saved a critically injured boy by swiftly administering first aid after a car accident at Jagtap Chowk. His prompt response and medical expertise prevented a tragic outcome, earning widespread praise. Bhajibhakre's actions highlight the importance of timely intervention and calmness during emergencies to ensure victims' safety.

109. 5 highlights K-pop fans can't afford to miss

     Thu, 26 Dec 2024 06:17:41 -0000

     2024 SBS Gayo Daejeon is one starry affair with K-pop idols lighting up the stage with their charming presence. From G-Dragon returning with a big bang to Hyunjin debuting a new buzz cut and leaving fans swooning, it was one unmissable night of iconic moments.

110. 10 must do things to transform your body in 45 days

     Thu, 26 Dec 2024 05:30:00 -0000

     Transforming your body in 45 days isn’t about impossible expectations; it’s about small, meaningful changes that add up. Whether it’s hydrating like a champ, embracing new workout styles, or walking with purpose, every step counts. Start today and watch yourself grow stronger, fitter, and more confident.

111. 700-bed Civil hospital coming up in Gurugram, Health Minister reviews progress

     Fri, 27 Dec 2024 04:00:00 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/26/266530-nayab-singh-saini-2.webp' /><div class="pasted-from-word-wrapper"><p><span style="text-align: justify;">Chandigarh: Haryana Chief Minister, Sh. <a href="https://medicaldialogues.in/topics/nayab-singh-saini" target="_blank">Nayab Singh Saini</a> on Tuesday chaired a review meeting regarding the construction process of the 700-bed civil hospital to be built in Gurugram.&nbsp;</span></p><p style="text-align: justify;">The hospital will be constructed as part of efforts to improve healthcare services in the region.</p><p style="text-align: justify; ">During the meeting, the Additional Chief Secretary, Health Department, Sh. Sudhir Rajpal while providing an update on the construction progress of the civil hospital in Civil Lines shared that the hospital will be built on 7.73 acres of land at a cost of around Rs. 990 crore.</p><p style="text-align: justify;">The hospital will consist of a 13-story building, including a basement, ground floor, and 11 floors. The hospital will include 60 ICU beds, 12 operation theaters, and an emergency helipad, among other important facilities.</p><p style="text-align: justify; "><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/hospital-diagnostics/gurugram-to-get-700-bed-govt-hospital-named-after-guru-nanak-dev-138123"><b><i>Also Read:Gurugram to get 700-bed Govt Hospital named after Guru Nanak Dev</i></b></a></p><p style="text-align: justify;">He further shared that at present there is a nearby government school built on approximately 1.5 acres of land to provide more space for the hospital's future needs and improve public access to the facility. The state government can think of shifting the school building on the opposite side of the road to a 2.5-acre plot of land owned by the Education Department.</p><p style="text-align: justify;">Meanwhile, after receiving a detailed report on the progress of the hospital’s construction, the Chief Minister directed that arrangements should be made according to the project’s timeline. He further directed the officers to ensure that the hospital meets the future medical needs of the city. He also directed that the new building for the school, proposed by the Education Department, be constructed in a multi-story design. He said that the school should continue to operate in its current building until the new one is ready.</p><p style="text-align: justify;">Union Minister of State Rao Inderjit Singh, Health Minister, Kumari Arti Singh Rao, Industries &amp; Commerce, Environment, Forest &amp; Wildlife Minister, Rao Narbir Singh, Pataudi MLA, Bimla Chaudhary, Sohna MLA Tejpal Tanwar, Gurugram MLA Mukesh Sharma and other officers also remained present during this.</p><p style="text-align: justify;"><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/state-news/haryana/haryana-govt-to-enhance-health-facilities-for-soldiers-ex-servicemen-131758"><b><i>Also Read:Haryana Govt to enhance health facilities for Soldiers, Ex-Servicemen</i></b></a></p><div class="hocal-draggable" draggable="true"><div class="read-this-also-wrap"><div></div></div></div></div>

112. NT-proBNP levels useful tool to predict increased risk of Atrial Fibrillation, reveals research

     Fri, 27 Dec 2024 03:30:56 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/11/08/259837-heart-inflammation-50.webp' /><p style="text-align: justify; ">A recent groundbreaking study found that NT-proBNP levels are associated with an increased risk of atrial fibrillation in older adults, as per results that were published in the journal Heart.</p><div class="pasted-from-word-wrapper"> <p style="text-align: justify; ">N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a widely recognized and established biomarker for cardiac conditions like heart failure. However, there is ambiguity in establishing its role or predicting atrial fibrillation. Hence, researchers from China conducted a study to evaluate the association between NT-proBNP levels and the incidence of AF and explore the potential of NT-proBNP in enhancing AF risk prediction models.</p></div><div class="hocal-draggable" draggable="true"><div class="read-this-also-wrap" style="text-align: justify; "><a class="also-read-media-wrap" href="https://medicaldialogues.in/cardiology-ctvs/news/drinking-multiple-cups-of-coffee-may-help-prevent-mental-decline-in-people-with-atrial-fibrillation-study-140148"><img class="also-read-media" data-src="https://medicaldialogues.in/h-upload/2024/12/20/265702-coffee-50.webp"></a><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/cardiology-ctvs/news/drinking-multiple-cups-of-coffee-may-help-prevent-mental-decline-in-people-with-atrial-fibrillation-study-140148"><span class="read-this-also">Also Read:&nbsp;</span>Drinking multiple cups of coffee may help prevent mental decline in people with atrial fibrillation: Study</a></div></div><div class="pasted-from-word-wrapper"> <p style="text-align: justify;">A systematic review and meta-analysis were conducted by searching databases like PubMed, Embase, Cochrane Library, Web of Science, and Scopus from inception to August 2024. All the prospective studies that reported the association between baseline NT-proBNP levels and incident AF were included. Random effects models were used to pool the Hazard ratios and relative risks with 95% confidence intervals. </p> <p style="text-align: justify;">Findings:</p> <ul><li style="text-align: justify;">About 136 089 participants from 16 cohorts were included in the meta-analysis. </li><li style="text-align: justify; ">Among them, there were 8017 incident AF cases. </li><li style="text-align: justify;">Higher NT-proBNP levels were significantly associated with an increased risk of developing AF, with a relative risk of 3.84 when comparing the top and bottom quartiles.</li><li style="text-align: justify;">It also showed a 1.70 relative risk per standard deviation increment.</li><li style="text-align: justify;">A significant non-linear dose-response relationship was seen (P_{non-linearity}&lt;0.05). </li><li style="text-align: justify;">The association was stronger in older populations and when serum samples were used. </li><li style="text-align: justify;">Incorporating NT-proBNP levels into traditional AF risk models increased the predictive accuracy. </li></ul> <p style="text-align: justify; ">Thus, the study highlighted the potential value of adding NT-proBNP levels in the risk stratification of atrial fibrillation. The study underscores the importance of using NT=proBNP as a valuable biomarker for identifying individuals at potential risk of developing AF. Due to its predictive accuracy, the researchers suggested adding this to the AF risk assessment tools.</p></div><div class="hocal-draggable" draggable="true"><div class="read-this-also-wrap" style="text-align: justify; "><a class="also-read-media-wrap" href="https://medicaldialogues.in/cardiology-ctvs/news/partial-cardiac-denervation-reduces-postoperative-atrial-fibrillation-risk-after-cabg-pcad-poaf-trial-138677"><img class="also-read-media" data-src="https://medicaldialogues.in/h-upload/2024/11/18/261186-cardiac-denervation.webp"></a><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/cardiology-ctvs/news/partial-cardiac-denervation-reduces-postoperative-atrial-fibrillation-risk-after-cabg-pcad-poaf-trial-138677"><span class="read-this-also">Also Read:&nbsp;</span>Partial Cardiac Denervation Reduces Postoperative Atrial Fibrillation Risk After CABG: pCAD-POAF trial</a></div></div><div class="pasted-from-word-wrapper"> <p style="text-align: justify;">The study also highlights the potential of using NT-proBNP levels for more intensive screening and early identification of Atrial fibrillation. Personalized treatment approaches can be used due to early identification by using NT-proBNP levels for AF and also developing a preventive strategy for at-risk individuals. </p> <p style="text-align: justify; ">Further reading: Wang W, Zhou T, Li J<i>, et al</i>. Association between NT-proBNP levels and risk of atrial fibrillation: a systematic review and meta-analysis of cohort studies. <i>Heart </i>Published Online First: 06 December 2024. doi:&nbsp;<a href="https://heart.bmj.com/content/early/2024/12/06/heartjnl-2024-324685" rel="nofollow">10.1136/heartjnl-2024-324685</a></p></div>

113. High-protein diet may enhance glycemic control by boosting peripheral insulin levels, finds study

     Fri, 27 Dec 2024 03:30:15 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/23/266206-images-2024-12-23t114251351.webp' /><p style="text-align: justify; ">A study published in Diabetes, Obesity, and Metabolism found that a high-protein diet may enhance glycemic control by boosting peripheral insulin levels.</p><div class="pasted-from-word-wrapper"><p dir="ltr" style="text-align: justify; ">High-protein diets have been recognized as a potential strategy in the nutritional management of type 2 diabetes (T2D). Mycoprotein is a high-fibre, high-protein food ingredient previously shown to improve acute glycaemic control. We determined whether incorporating mycoprotein into a high-protein vegan diet would improve glycaemic control to a greater extent than an isonitrogenous omnivorous diet in people with T2D. Seventeen adults (f = 5, age = 58.3 ± 8.3 years, BMI = 32.9 ± 4.7 kg∙m−2, HbA1c = 60 ± 15 mmol∙mol−1) with T2D were randomly allocated to a 5-week eucaloric high-protein (30% energy from protein) diet, either an omnivorous diet (OMNI; 70% protein from omnivorous sources) or an isonitrogenous, mycoprotein-rich, vegan diet (VEG; 50% protein from mycoprotein). Glycaemic control was assessed using a two-step hyperinsulinaemic-euglycaemic clamp (HEC) with D-[6,6-2H2] glucose infusion, a mixed-meal tolerance test (MMTT) and continuous glucose monitoring. Results: The rate of glucose disappearance (RdT), glucose disposal rate and endogenous glucose production, as well as postprandial time-course of blood glucose, serum insulin and C-peptide were assessed during the HEC and MMTT, respectively. Both groups had improved peripheral insulin sensitivity (intervention effect, p = 0.006; increased RdT/Insulin of 1.0 ± 0.6 and 1.0 ± 0.3 mg kg−1 min−1 in OMNI and VEG, respectively), HbA1c (intervention; p = 0.001) and glycaemic variability (intervention; p = 0.040; increased time in-range of 11.8 ± 9.3% and 23.3 ± 12.9% in OMNI and VEG). There were no improvements in hepatic insulin sensitivity or in postprandial blood glucose and serum C-peptide (p &gt; 0.05) during the MMTT.</p><div style="text-align: justify;"><br></div><p dir="ltr" style="text-align: justify; ">Conclusions</p><p dir="ltr" style="text-align: justify; ">High-protein diets, whether predicated on vegan or omnivorous proteins, can improve glycaemic control by increasing peripheral insulin sensitivity in people with T2D.</p><div style="text-align: justify;"><br></div><div style="text-align: justify;"><br></div><p dir="ltr" style="text-align: justify; ">Reference:</p><p dir="ltr" style="text-align: justify; ">Whelehan G, Dirks ML, West S, et al. High-protein vegan and omnivorous diets improve peripheral insulin sensitivity to a similar extent in people with type 2 diabetes. Diabetes Obes Metab. 2024; 1-10. doi:10.1111/dom.16100</p><div style="text-align: justify;"><br></div><p dir="ltr" style="text-align: justify; ">Keywords:</p><p dir="ltr" style="text-align: justify; ">High-protein, diet, enhance, glycemic control, boosting, peripheral, insulin, levels, finds, study, Whelehan G, Dirks ML, West S, Diabetes, Obesity and Metabolism</p><div style="text-align: justify;"><br></div><div style="text-align: justify;"><br></div></div><p style="text-align: justify; "><br></p>

114. Higher dosage of anticoagulation linked to lower mortality risk among COVID-19 patients: Study

     Fri, 27 Dec 2024 03:15:29 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/01/30/231201-covid-19-50-3.webp' /><p style="text-align: justify; ">A prospective metanalysis of clinical trials examined the effects of high and low doses of<a href="https://medicaldialogues.in/topics/anticoagulation"> anticoagulation</a> for hospitalized patients with COVID-19. The study found that administering therapeutic dose anticoagulation with heparins reduced mortality, need for invasive mechanical ventilation (IMV) and thromboembolic events compared with prophylactic dose heparins. The findings are published in<i> Annals of Internal Medicine. </i></p><p style="text-align: justify; ">Researchers funded by the World Health Organization studied data from 18 randomized clinical trials which randomly assigned patients hospitalized for COVID-19 to higher versus lower doses of anticoagulants. The intensity of anticoagulant used was classified as prophylactic, intermediate, or therapeutic dosing. </p><p style="text-align: justify; ">The objective of the study was to estimate intention-to-treat effects of therapeutic vs prophylactic; therapeutic vs intermediate; and intermediate vs prophylactic dose anticoagulation in hospitalized patients with suspected or confirmed COVID-19. The primary outcome was all-cause mortality by 28 days after randomization, and secondary outcomes were progression to IMV or death, thromboembolic events and major bleeding.</p><p style="text-align: justify; "> The majority of trials studied evaluated heparins, including <a href="https://medicaldialogues.in/topics/enoxaparin">enoxaparin</a>, tinzaparin or <a href="https://medicaldialogues.in/topics/dalteparin">dalteparin</a>, so the researchers focused their findings on anticoagulation using heparins. The researchers found that administering therapeutic vs prophylactic-dose anticoagulation to patients hospitalized for COVID-19 was associated with 23% lower 28-day mortality. Mortality was higher for therapeutic vs intermediate dose anticoagulation; however, the researchers note that this comparison was not estimated precisely. Mortality risk was similar for similar for intermediate vs prophylactic dose anticoagulation. Risk of progression to IMV or death was similar to mortality risk. Across all dosage comparisons, the risk for major bleeding was higher, but the risk for thromboembolic events was lower. </p><p style="text-align: justify; ">The findings suggest a high certainty that therapeutic dose anticoagulation of heparin reduces 28-day mortality in hospitalized patients with COVID-19.</p><p style="text-align: justify; ">Reference:</p><p style="text-align: justify; ">The WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group, The WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group, et al. Anticoagulation Among Patients Hospitalized for COVID-19: A Systematic Review and Prospective Meta-analysis. Ann Intern Med. [Epub 24 December 2024]. doi:10.7326/ANNALS-24-00800</p>

115. Potassium nitrate fails to improve aerobic capacity or QoL in participants with HFpEF, unravels JAMA study

     Fri, 27 Dec 2024 03:00:25 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/11/08/259837-heart-inflammation-50.webp' /><p style="text-align: justify; ">A new study published in the <i>Journal of American Medical Association</i> showed that individuals with heart failure with preserved ejection fraction (HFpEF) did not see improvements in aerobic capacity, total work, or quality of life after taking potassium nitrate.</p><p style="text-align: justify; ">The patients with HFpEF have been reported to have impaired nitric oxide (NO) signaling. However, there has been no improvement in exercise capacity in this state despite attempts to restore NO bioavailability by organic nitrate supplementation, phosphodiesterase type 5 inhibition, or activation of the soluble guanylate-cyclase receptor. As an alternative, supplementing with inorganic nitrate can enhance NO signaling. In this supplementary route, oral commensal bacteria absorb inorganic nitrate and then use an enterosalivary circuit to convert it to nitrite.</p><p style="text-align: justify; ">The patients with heart failure with maintained ejection fraction may have exercise intolerance as a result of nitric oxide insufficiency. Previous pilot investigations have demonstrated that short-term and single-dose inorganic nitrate treatment improves exercise tolerance. To evaluate the effect of long-term inorganic nitrate administration on exercise tolerance in a bigger trial of people with HFpEF, Payman Zamani and his team carried out this investigation.</p><p style="text-align: justify; ">From October 2016 to July 2022, participants with Northwestern University, the University of Pennsylvania, and the Philadelphia Veterans Affairs Medical Center were included in this multicenter randomized double-blind crossover study. The patients with symptomatic (NYHA class II/III) HFpEF who had objective evidence of higher left ventricular filling pressures were among the participants. </p><p style="text-align: justify; ">In 2024, image quantification, statistical analysis, unblinding, physiological data modeling, and biochemical tests were finished. Peak oxygen uptake and total work completed during a maximum effort incremental cardiopulmonary exercise test were the coprimary end goals. activity systemic vasodilatory reserve (i.e., the decrease in systemic vascular resistance with activity) and quality of life as measured by the Kansas City Cardiomyopathy Questionnaire were secondary endpoints.</p><p style="text-align: justify; ">There were a total of 84 contestants, where 58 participants (69.0%) were female, and the median age was 68 years. With a mean 6-minute walk distance of 335.5 (SD, 97.3) m, the majority of individuals (69%) had NYHA class II illness.</p><p style="text-align: justify; ">The KNO3 and KCl interventions were administered to 77 and 74 subjects, respectively. After 6 weeks, KNO3 raised the trough levels of metabolites of serum nitric oxide. KNO3 had no effect on total work completed or peak oxygen consumption.</p><p style="text-align: justify; ">Although KNO3 nitrate was well tolerated, it had no effect on quality of life or vasodilatory reserve. Overall, when compared to KCl, chronic KNO3 treatment did not enhance exercise capacity or quality of life in persons with HFpEF in this randomized crossover experiment.</p><p style="text-align: justify; ">Source:</p><p style="text-align: justify; ">Zamani, P., Shah, S. J., Cohen, J. B., Zhao, M., Yang, W., Afable, J. L., Caturla, M., Maynard, H., Pourmussa, B., Demastus, C., Mohanty, I., Miyake, M. M., Adusumalli, S., Margulies, K. B., Prenner, S. B., Poole, D. C., Wilson, N., Reddy, R., Townsend, R. R., … Chirinos, J. A. (2024). Potassium Nitrate in Heart Failure With Preserved Ejection Fraction. In JAMA Cardiology. American Medical Association (AMA). <a href="https://jamanetwork.com/journals/jamacardiology/fullarticle/2827840?guestAccessKey=5a7a1028-5f40-448b-a0e6-9623921929cc&amp;utm_source=silverchair&amp;utm_medium=email&amp;utm_campaign=article_alert-jamacardiology&amp;utm_content=olf&amp;utm_term=121824&amp;adv=000002993726" rel="nofollow">https://doi.org/10.1001/jamacardio.2024.4417</a></p>

116. Intratracheal budesonide improves survival in preterm infants with bronchopulmonary dysplasia: Study 📖

     Thu, 26 Dec 2024 16:30:17 -0000

     <img src='https://medicaldialogues.in/h-upload/2020/01/15/123006-bronchopulmonary.jpg' /><p style="text-align: justify; ">A recent clinical trial published in the <i>Journal of American Medical Association</i> found the potential of early intratracheal budesonide administration to improve outcomes in extremely preterm infants at risk of bronchopulmonary dysplasia (BPD). The study spanned across neonatal units in Australia, New Zealand, Canada, and Singapore on infants born before 28 weeks of gestation to evaluate whether adding budesonide to surfactant treatment could enhance survival without BPD.</p><p style="text-align: justify; ">This study was conducted between January 2018 and March 2023, and involved a total of 1059 infants under 48 hours old. The participants, who were on mechanical ventilation or receiving noninvasive respiratory support requiring surfactant, were randomly assigned to one of two groups. The intervention group received a mixture of budesonide (0.25 mg/kg) and surfactant (poractant alfa) via an endotracheal tube or thin catheter. The control group received surfactant alone.</p><p style="text-align: justify; ">Survival without BPD at 36 weeks’ postmenstrual age was the primary outcome and this showed modest results. Among the budesonide group, 25.6% of infants survived without BPD compared to 22.6% in the surfactant-only group. This yielded an adjusted risk difference of 2.7%, with a confidence interval indicating no statistically significant difference (-2.1% to 7.4%).</p><p style="text-align: justify; ">Survival rates at 36 weeks were slightly higher in the budesonide group (83.2%) versus the surfactant-only group (80.6%). However, rates of BPD among survivors were similar, with 69.3% of the budesonide group and 71.9% of the control group diagnosed with the condition.</p><p style="text-align: justify; ">Secondary safety analyses reviewed adverse events but did not show significant differences between groups. The findings suggest that while the intratracheal administration of budesonide is safe and offers limited improvement in clinical outcomes regarding BPD prevention.</p><p style="text-align: justify; ">While the addition of budesonide to surfactant therapy demonstrated safety, its marginal effect on reducing BPD suggests that alternative strategies may be necessary to improve outcomes in this vulnerable population. Overall, the study illuminates the complexities of treating respiratory distress syndrome in preterm infants and the need for further exploration of effective therapies.</p><p style="text-align: justify; ">Reference:</p><p style="text-align: justify; ">Manley, B. J., Kamlin, C. O. F., Donath, S. M., Francis, K. L., Cheong, J. L. Y., Dargaville, P. A., Dawson, J. A., Jacobs, S. E., Birch, P., Resnick, S. M., Schmölzer, G. M., Law, B., Bhatia, R., Bach, K. P., de Waal, K., Travadi, J. N., Koorts, P. J., Berry, M. J., Lui, K., … Jeong, W. (2024). Intratracheal Budesonide Mixed With Surfactant for Extremely Preterm Infants. In JAMA (Vol. 332, Issue 22, p. 1889). American Medical Association (AMA). <a href="https://jamanetwork.com/journals/jama/fullarticle/2826118?guestAccessKey=38484c63-177c-4b68-af38-f0006fd340c7&amp;utm_source=silverchair&amp;utm_medium=email&amp;utm_campaign=article_alert-jama&amp;utm_content=etoc&amp;utm_term=121024&amp;utm_adv=000002993726" rel="nofollow">https://doi.org/10.1001/jama.2024.17380</a></p>

117. Higher Daily Step Counts Linked to Lower Depression Risk in Adults: Study

     Thu, 26 Dec 2024 16:00:18 -0000

     <img src='https://medicaldialogues.in/h-upload/2023/10/27/223863-walking.webp' /><p style="text-align: justify;">According to the findings from a recent research, higher daily step counts are linked with fewer depressive symptoms. The new systematic review with meta-analysis of 33 studies that involved more than 96,000 adults found that people who took higher steps per day also experienced lower levels of depression compared with those who had minimal physical activities. This study was conducted by Bruno B.P. and colleagues which was published in the journal <i>JAMA Network Open</i>.</p><div class="pasted-from-word-wrapper"><p dir="ltr" style="text-align: justify;">The systematic review and meta-analysis were conducted to examine the relationship between objectively measured daily step counts and depression in adults. Data were drawn from five major databases: PubMed, PsycINFO, Scopus, SPORTDiscus, and Web of Science up to May 18, 2024. There were thirty-three observational studies included, consisting of 27 cross-sectional and 6 longitudinal studies (3 panel and 3 prospective cohorts).</p><p dir="ltr" style="text-align: justify;">Of all the analyzed adults 96,173, aged 18 years or more, were from diverse age ranges of mean: 18.6 and 91.2. The effect sizes like the standardized mean difference SMD and the risk ratio, RR pooled were applied to evaluate association for step counts and depression symptomatology. The analysis also used Sidik Jonkman's random effect so as not to make the outcomes loose.</p><p dir="ltr" style="text-align: justify;">The study showed clear evidence that higher daily steps were inversely related to depression symptoms:</p><ul><li dir="ltr" aria-level="1"><p dir="ltr" role="presentation" style="text-align: justify;">Participants with steps/day of 10,000 or more had considerable reductions in depressive symptoms. SMD: −0.26; 95% CI: −0.38 to −0.14.</p></li><li dir="ltr" aria-level="1"><p dir="ltr" role="presentation" style="text-align: justify;">Participants with 7500 to 9999 steps/day gained similar benefits. SMD: −0.27; 95% CI: −0.43 to −0.11.</p></li><li dir="ltr" aria-level="1"><p dir="ltr" role="presentation" style="text-align: justify;">Walking 5000 to 7499 steps/day also decreased depressive symptoms, although to a lesser degree (SMD: −0.17; 95% CI: −0.30 to −0.04).</p></li><li dir="ltr" aria-level="1"><p dir="ltr" role="presentation" style="text-align: justify;">Risk reduction: Prospective cohort studies showed that people walking 7000 or more steps/day had a 31% lower risk of depression than those walking less than 7000 steps/day (RR: 0.69; 95% CI: 0.62-0.77).</p></li><li dir="ltr" aria-level="1"><p dir="ltr" role="presentation" style="text-align: justify;">Incremental benefits: With each extra 1000 steps taken a day, the incidence of depression was reduced by 9% (RR: 0.91; 95% CI: 0.87-0.94).</p></li></ul><p dir="ltr" style="text-align: justify;">Higher daily steps had a correlation with lower symptom level of depression among adults. Walking 7000 to 10,000 steps daily was linked to a significant reduction in depression risk, with incremental benefits observed for every 1000 additional steps. These findings highlight the importance of daily physical activity as a straightforward approach to improving mental health.</p><p dir="ltr" style="text-align: justify;">Reference:</p><div style="text-align: justify;">Bizzozero-Peroni B, Díaz-Goñi V, Jiménez-López E, et al. Daily Step Count and Depression in Adults: A Systematic Review and Meta-Analysis. JAMA Netw Open. 2024;7(12):e2451208. doi:10.1001/jamanetworkopen.2024.51208</div></div>

118. Preterm Birth may have devastating Impact on Neonatal Mortality Worldwide, finds study

     Thu, 26 Dec 2024 15:45:50 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/01/27/231017-preterm-birth-50.webp' /><p style="text-align: justify; ">Preterm birth, which occurs when a baby is born before 37 weeks of gestation, is a prevalent adverse outcome during childbirth, impacting around 10% of all births globally. It is the primary contributor to neonatal deaths and ranks second among the leading causes of mortality for children under five years old worldwide.Recent population-based matched cohort study examined the associations between preterm birth (PTB) and all-cause and cause-specific mortality from birth to adulthood (up to 36 years of age) in Canada. The study used vital statistics data on live births in Canada from 1983 to 1996 and followed individuals until 2019.</p><p style="text-align: justify;">Key Findings on All-Cause Mortality</p><p style="text-align: justify;">Overall, the study found that individuals born preterm were at an increased risk of mortality compared to those born at term. In the unmatched cohort, the unadjusted incidence rate of all-cause mortality was higher among those born preterm, with the risk increasing as gestational age (GA) decreased. In the matched cohort, PTB was associated with an increased risk of all-cause mortality between ages 1-36 years (risk difference \[RD\]: 0.54%, risk ratio \[RR\]: 1.49). The highest RDs and RRs were observed in the first year of life (RD: 2.29%, RR: 11.61) and early childhood (ages 1-5 years, RD: 0.34%, RR: 2.79), with the lowest in ages 18-28 years (RD: 0.07%, RR: 1.13). The associations were stronger for lower GA categories.</p><p style="text-align: justify;">Key Findings on Cause-Specific Mortality</p><p style="text-align: justify;">For cause-specific mortality, PTB was associated with increased risks of mortality related to respiratory, circulatory, and digestive system disorders; nervous system, endocrine, and infectious diseases; cancers; congenital malformations; and conditions originating in the perinatal period. No associations were found for external causes of mortality.</p><p style="text-align: justify;">Implications and Recommendations</p><p style="text-align: justify;">The findings suggest that individuals born preterm, especially at lower GAs, are at increased risk of mortality from birth through their third and fourth decades of life. These associations may be partly due to underlying health determinants that affected both PTB and mortality. The results highlight the need to recognize PTB as a risk factor for mortality and to develop preventive strategies. Further follow-up studies are needed to assess potential adverse consequences of PTB into adulthood.</p><p style="text-align: justify;">Concluding Remarks</p><p style="text-align: justify;">In summary, this large population-based study provides comprehensive evidence on the increased risks of both short-term and long-term mortality associated with PTB, especially at lower GAs, in a North American setting. The findings emphasize the importance of addressing PTB as a major public health concern.</p><p style="text-align: justify;">Key Points</p><p style="text-align: justify;">1. The study examined the associations between preterm birth (PTB) and all-cause and cause-specific mortality from birth to adulthood (up to 36 years of age) in Canada, using vital statistics data on live births from 1983 to 1996.</p><p style="text-align: justify;">2. The study found that individuals born preterm were at an increased risk of all-cause mortality compared to those born at term, with the risk increasing as gestational age decreased. The highest risk differences and risk ratios were observed in the first year of life and early childhood.</p><p style="text-align: justify;">3. For cause-specific mortality, PTB was associated with increased risks of mortality related to respiratory, circulatory, and digestive system disorders; nervous system, endocrine, and infectious diseases; cancers; congenital malformations; and conditions originating in the perinatal period. No associations were found for external causes of mortality.</p><p style="text-align: justify;">4. The findings suggest that individuals born preterm, especially at lower gestational ages, are at increased risk of mortality from birth through their third and fourth decades of life, which may be partly due to underlying health determinants that affected both PTB and mortality.</p><p style="text-align: justify;">5. The results highlight the need to recognize PTB as a risk factor for mortality and to develop preventive strategies to address this public health concern.</p><p style="text-align: justify;">6. Further follow-up studies are needed to assess potential adverse consequences of PTB into adulthood.</p><p style="text-align: justify;">Reference –</p><p style="text-align: justify;">Asma M Ahmed et al. (2024). Short-Term And Long-Term Mortality Risk After Preterm Birth. *JAMA Network Open*, 7. https://doi.org/10.1001/jamanetworkopen.2024.45871.</p>

119. Study reveals cause of Postprandial hypoglycemia- one of main complications of bariatric surgery

     Thu, 26 Dec 2024 15:45:19 -0000

     <img src='https://medicaldialogues.in/h-upload/2023/01/16/198409-bariatric-surgery.webp' /><p style="text-align: justify; ">Postprandial hypoglycemia is one of the main complications of<a href="https://medicaldialogues.in/topics/bariatric-surgery"> bariatric surgery</a> and can affect up to 30% of patients. Unlike ordinary <a href="https://medicaldialogues.in/topics/hypoglycemia">hypoglycemia</a>, in which low blood sugar is usually associated with little food, postprandial hypoglycemia occurs after meals and causes symptoms such as sweating, tremors, weakness and even mental confusion. </p><p style="text-align: justify; ">A study conducted at Harvard University in the United States has identified the central role of serotonin (a hormone involved in mood regulation) in the development of post-bariatric hypoglycemia. The results were published in the <i>Journal of Clinical Investigation </i>and, according to the authors, point the way to possible treatments. </p><p style="text-align: justify;">“We identified that this type of hypoglycemia is associated with the dysregulation of serotonin levels in the blood, a hormone that, in addition to controlling mood, is also capable of stimulating the secretion of the hormones<a href="https://medicaldialogues.in/topics/insulin"> insulin </a>[in the pancreas] and GLP-1 [an acronym for glucagon-like peptide-1, produced in the small intestine in response to food intake] in the body,” says Rafael Ferraz-Bannitz, who conducted the research during an internship abroad supported by FAPESP. The group also received funding from the U.S. National Institutes of Health (NIH). </p><p style="text-align: justify;">“We observed that in individuals with post-bariatric hypoglycemia, serotonin levels are low when they’re fasting. However, after a meal, they increase significantly, unlike patients without symptoms or people who’ve not had bariatric surgery, whose serotonin levels decrease after a meal,” adds Ferraz-Bannitz, who is currently a postdoctoral fellow at Joslin Diabetes Center and Harvard Medical School. </p><p style="text-align: justify;">According to the researcher, although the problem is common – in the United States, the country with the highest number of bariatric surgeries in the world, it is estimated to affect up to 30% of those who undergo surgery – little was known about the mechanisms that trigger postprandial hypoglycemia. “It’s extremely debilitating. Patients even concentrate their food in just one meal a day because they know they’re going to be very sick. Many are unable to work, drive or have even the slightest quality of life. And it’s a problem that can affect up to 83,000 people every year in the United States alone. In Brazil, the number is likely to be high as well, since it’s the country that performs the second most bariatric surgeries in the world,” the researcher emphasizes. </p><h3 style="text-align: justify; ">How it was done </h3><p style="text-align: justify;">The researchers analyzed 189 metabolites (compounds produced by the enzymatic reactions of the metabolism) in the blood of three groups of individuals: 13 patients with post-bariatric hypoglycemia; ten who had undergone surgery but had no symptoms; and eight individuals who had neither undergone surgery nor had hypoglycemia. </p><p style="text-align: justify;">Blood was taken while the participants were fasting, 30 minutes after taking a shake (made up of proteins, carbohydrates, and lipids), and two hours after drinking the drink (the time when patients with postprandial hypoglycemia usually show signs). </p><p style="text-align: justify;">The analysis showed changes mainly in the serotonin pattern. “For many metabolites, we noticed significant differences between the group that developed hypoglycemia and those who were asymptomatic. However, the difference in the serotonin pattern was what most caught our attention. Individuals with post-bariatric hypoglycemia had very low fasting serotonin levels. Curiously, in response to the meal, there was a fivefold increase in the levels of this hormone in these individuals,” Ferraz-Bannitz told Agência FAPESP. </p><p style="text-align: justify;">The researchers also found other important metabolic alterations. “In the fasting state, these individuals showed a decrease in the levels of ten amino acids, including tryptophan [a precursor of serotonin], as well as biomarkers related to diabetes. On the other hand, we noticed an increase in the levels of ketones, bile acids, and some metabolites from the Krebs cycle [which is part of the energy production process in cells],” he reports. </p><p style="text-align: justify;">There is a relationship between serotonin and the secretion of insulin and GLP-1. According to Ferraz-Bannitz, previous in vitro studies had already shown that serotonin is able to stimulate the secretion of insulin in pancreatic beta cells and GLP-1 in intestinal neuroendocrine cells. </p><p style="text-align: justify;">It is worth noting that insulin is responsible for transporting sugar from the blood to the body’s cells, where it is used as a source of energy. GLP-1, on the other hand, is a hormone that is released in the presence of glucose and provides a sense of satiety by signaling to the brain that the individual is full. </p><p style="text-align: justify;">“In this study, we’ve demonstrated in vivo that serotonin administration in mice was able to induce hypoglycemia by increasing the endogenous secretion of insulin and GLP-1,” comments the researcher. </p><p style="text-align: justify;">Thus, the results suggest that the post-meal increase in serotonin observed in individuals with post-bariatric hypoglycemia may contribute to the increase in insulin secretion and, consequently, the development of hypoglycemia and symptoms such as dizziness, tremors, and mental confusion. </p><h3 style="text-align: justify; ">Serotonin blocker </h3><p style="text-align: justify;">To better understand the role of serotonin in the development of post-bariatric hypoglycemia, tests were conducted on mice. “When serotonin was injected into the animals, they suffered a dizzying drop in blood glucose, inducing hypoglycemia – a condition very similar to that of patients. When we evaluated the plasma of the mice, we observed that the injection of serotonin increased the secretion of insulin and GLP-1, the same hormones that are elevated in individuals who’ve developed postprandial hypoglycemia,” he says. </p><p style="text-align: justify;">The researchers then decided to test the use of serotonin antagonists as a treatment strategy in mice. “The use of ketanserin, a well-known serotonin receptor 2 blocking drug, proved to be very effective in the experiments. It was able to block serotonin-induced hypoglycemia in the animals and promote a reduction in insulin and GLP-1 secretion. This is a promising result that suggests a potential therapeutic target for individuals with post-bariatric hypoglycemia,” he concludes. </p><p style="text-align: justify;">With the results, the group, coordinated by Mary-Elizabeth Patti, professor at Harvard Medical School and senior investigator at the Joslin Diabetes Center, plans to conduct new clinical trials to prove the effectiveness of this potential treatment for people suffering from postprandial hypoglycemia. </p><p style="text-align: justify;">Although they have shown that serotonin may be responsible for triggering the entire hypoglycemia process in people who have had bariatric surgery, the researchers still do not know what causes this difference in the pattern of the hormone. </p><p style="text-align: justify; ">“This is one of the acknowledged limitations of the study, as we didn’t have access to biopsies of the intestines of these individuals to assess the amount and activity of serotonin-producing cells. However, one of the hypotheses we raised is that hypoglycemia may be associated with some alteration in the microbiota, bile acids, or other factors in the intestine – the organ that produces 90% of the body’s serotonin. Future studies in Professor Patti’s laboratory could answer this question,” says Ferraz-Bannitz.</p><p style="text-align: justify; ">Reference:</p><p style="text-align: justify; ">Rafael Ferraz-Bannitz, Cameron Cummings, Vissarion Efthymiou, Pilar Casanova Querol, Postprandial metabolomics analysis reveals disordered serotonin metabolism in post-bariatric hypoglycemia, Journal of Clinical Investigation, DOI:10.1172/JCI180157&nbsp;</p>

120. Study highlights association of IBD with left ventricular, atrial dysfunction, arrhythmias & heart failure

     Thu, 26 Dec 2024 15:30:53 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/22/266075-1-s20-s2352906724001222-gr2.webp' /><p style="text-align: justify; ">The study highlights association of IBD with left ventricular and atrial dysfunction, arrhythmias &amp; heart failure.</p><div class="pasted-from-word-wrapper"><p dir="ltr" style="text-align: justify; ">Morphological and functional cardiac involvement is rarely described in patients with inflammatory bowel disease (IBD) but there is evidence that they have an increased risk of cardiovascular (CV) events despite the lower prevalence of traditional CV risk factors. The systematic review and meta-analysis examined the relationship between IBD and cardiac function, namely the incidence of heart failure (HF) and subclinical echocardiographic changes. Results: The qualitative analysis comprised a total of 18 studies (14 retrospective and 4 prospective studies) involving 59,838 patients. IBD was associated with subtle systolic and diastolic alterations, vascular dysfunction, increased risk for HF hospitalizations, and globally worse CV outcomes. Nine studies were included in the meta-analysis. In the IBD population, we found statistically significant reduced early to late diastolic transmitral flow (E/A), higher E to early diastolic mitral annular tissue velocity (E/e'), and decreased global longitudinal strain. Increased left atrial diameter and area were also present in IBD patients but no statistical significance was reached. Inter-atrial and right intra-atrial conduction delays were observed. The IBD population has an increased risk for left ventricular and atrial dysfunction, vascular changes, arrhythmias, and HF hospitalization. Screening with sensitive imaging like speckle tracking echocardiography could identify early subclinical changes. IBD is in fact a CV risk factor and tight inflammation control may reduce CV risk.</p><p dir="ltr" style="text-align: justify; ">Reference:</p><p dir="ltr" style="text-align: justify; ">Soares CA, Fiuza JG, Rodrigues CAM, Craveiro N, Gil Pereira J, Sousa PCRF, Martins DCP, Cancela EM, Ministro Dos Santos MP. Inflammatory bowel disease and cardiac function: a systematic review of literature with meta-analysis. Therap Adv Gastroenterol. 2024 Dec 16;17:17562848241299534. doi: 10.1177/17562848241299534. PMID: 39691207; PMCID: PMC11650564.</p><p dir="ltr" style="text-align: justify; ">Keywords:</p><p dir="ltr" style="text-align: justify; ">Soares CA, Fiuza JG, Rodrigues CAM, Craveiro N, Gil Pereira J, Sousa PCRF, Martins DCP, Cancela EM, Ministro Dos Santos MP, Therapeutic Advances in Gastroenterology, cardiovascular risk; inflammation; inflammatory bowel disease.</p></div>

121. Brexpiprazole with sertraline may improve posttraumatic stress disorder symptoms, finds JAMA study

     Thu, 26 Dec 2024 15:30:43 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/02/15/232331-ptsd-50.webp' /><p style="text-align: justify; ">A new study published in the <i>Journal of American Medical Association</i> showed that the majority of individuals tolerated the brexpiprazole + sertraline therapy, which reduced posttraumatic stress disorder (PTSD) symptoms.</p><p style="text-align: justify; ">4 clusters of symptoms are indicative of posttraumatic stress disorder (PTSD) which are, intrusive reliving of the event, avoidance of internal and external connections with the trauma, unfavorable changes in mood and thought patterns, and increased arousal and reactivity. In the US and across the world, PTSD is quite common (estimates vary between research). </p><p style="text-align: justify; ">The only medications for PTSD that have been authorized by the US Food and Drug Administration are sertraline and paroxetine, both of which are selective serotonin reuptake inhibitors (SSRIs). Yet, 42% of PTSD patients in a large meta-analysis did not improve with SSRI therapy. Atypical antipsychotics like brexpiprazole have a wide range of pharmacological effects on the dopaminergic, serotonergic, and noradrenergic neurotransmitter systems, which are linked to mental disorders like PTSD. This trial looked at the effectiveness, safety, and tolerability of treating PTSD with a combination of brexpiprazole and sertraline (brexpiprazole + sertraline) against sertraline + placebo.</p><p style="text-align: justify; ">From October 2019 to August 2023, a double-blind, randomized clinical study using a parallel design was carried out. The investigation was conducted at 86 clinical trial locations in the United States and included a 1-week placebo run-in period followed by an 11-week randomized, parallel-arm period (with a 21-day follow-up). Adult PTSD outpatients (volunteer sample) were recruited. From randomization (week 1) to week 10, the main outcome was the difference in the Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) total score, which gauges the intensity of 20 PTSD symptoms, between brexpiprazole + sertraline and sertraline + placebo. Adverse incidents were included in safety evaluations.</p><p style="text-align: justify; ">A total of 1327 people had their eligibility evaluated. 416 individuals were randomly assigned following 878 screen failures. Brexpiprazole + sertraline had a completion rate of 137 out of 214 individuals (64.0%), whereas sertraline + placebo had a completion rate of 113 out of 202 participants (55.9%). In comparison to sertraline + placebo, brexpiprazole + sertraline showed a statistically significant improvement in the CAPS-5 total score at week 10 (LS mean difference: −5.59).</p><p style="text-align: justify; ">Also, all important secondary and additional effectiveness endpoints were satisfied. For brexpiprazole + sertraline, treatment-emergent adverse effects included nausea, exhaustion, weight gain, and somnolence, with an incidence of 5% or higher. Adverse event-related discontinuation rates were 20 of 196 individuals (10.2%) for sertraline + placebo and 8 of 205 participants (3.9%) for brexpiprazole + sertraline. Overall, this study found the effectiveness of brexpiprazole + sertraline as a novel, effective therapy for PTSD.</p><p style="text-align: justify; ">Source:</p><p style="text-align: justify; ">Davis, L. L., Behl, S., Lee, D., Zeng, H., Skubiak, T., Weaver, S., Hefting, N., Larsen, K. G., &amp; Hobart, M. (2024). Brexpiprazole and Sertraline Combination Treatment in Posttraumatic Stress Disorder. In JAMA Psychiatry. American Medical Association (AMA). <a href="https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2827796" rel="nofollow">https://doi.org/10.1001/jamapsychiatry.2024.3996</a></p>

122. Late-onset RA Patients Face Greater Decline in Physical Function and higher incidence of adverse events, finds research

     Thu, 26 Dec 2024 15:15:49 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/03/06/233773-rheumatoid-arthritis.webp' /><p style="text-align: justify;">Researchers have discovered that, although patients with late-onset rheumatoid arthritis (LORA) and younger-onset rheumatoid arthritis (YORA) show comparable improvement in disease activity, the patients with LORA exhibit a greater decline in physical function over time. A recent study was conducted by Naohiro S. and colleagues which was published in the journal <i>Rheumatology</i>.</p><div class="pasted-from-word-wrapper"><p dir="ltr" style="text-align: justify;">This chronic autoimmune disease is characterized by progressive disability and joint inflammation. Patients whose disease starts at ≥65 years are termed as LORA, while YORA is defined in the setting where onset happens when less than 65 years. The objective of the study was to compare the treatment outcomes and long-term physical function in both these groups.</p><p dir="ltr" style="text-align: justify;">The study assessed data from the IORRA cohort. This comprises patients who were diagnosed early with rheumatoid arthritis and whose disease duration was less than 2 years. The patients are classified into LORA and YORA depending on age at onset of disease. Outcome measures of this study consisted of change in Clinical Disease Activity Index (CDAI) and Japanese version of the Health Assessment Questionnaire (J-HAQ). The adverse event rates assessed the secondary outcome of the five-year follow-up.</p><p dir="ltr" style="text-align: justify;">Main Results</p><p dir="ltr" style="text-align: justify;">A total of 813 LORA patients and 2,457 YORA patients with a median age of 71 years and 51 years, respectively, were enrolled in the study. Main results are presented below:</p><p dir="ltr" style="text-align: justify;">Medication Use</p><ul><li dir="ltr" aria-level="1"><p dir="ltr" role="presentation" style="text-align: justify;">The use of methotrexate was 70.6% in LORA patients and 81.6% in YORA patients.</p></li><li dir="ltr" aria-level="1"><p dir="ltr" role="presentation" style="text-align: justify;">Biological DMARDs were prescribed in 8.4% of LORA patients versus 19.4% of YORA patients.</p></li><li dir="ltr" aria-level="1"><p dir="ltr" role="presentation" style="text-align: justify;">Glucocorticoids were used in 38.0% of LORA patients and 32.0% of YORA patients.</p></li></ul><p dir="ltr" style="text-align: justify;">Disease Activity (CDAI):</p><ul><li dir="ltr" aria-level="1"><p dir="ltr" role="presentation" style="text-align: justify;">Both arms achieved significant early gains in CDAI scores.</p></li><li dir="ltr" aria-level="1"><p dir="ltr" role="presentation" style="text-align: justify;">By Year 5, mean CDAI scores were similar for both treatments: LORA at 4.39 and YORA at 4.03, showing equal disease activity control.</p></li></ul><p dir="ltr" style="text-align: justify;">Physical Function (J-HAQ): </p><ul><li dir="ltr" aria-level="1"><p dir="ltr" role="presentation" style="text-align: justify;">J-HAQ score of YORA settled below 0.5 after Year 2.</p></li><li dir="ltr" aria-level="1"><p dir="ltr" role="presentation" style="text-align: justify;">The J-HAQ score for LORA gradually increased through the study to a mean of 0.56 at Year 5 vs. 0.33 for YORA.</p></li></ul><p dir="ltr" style="text-align: justify;">Adverse Events: </p><ul><li dir="ltr" aria-level="1"><p dir="ltr" role="presentation" style="text-align: justify;">The frequency of adverse events was significantly higher with LORA.</p></li><li dir="ltr" aria-level="1"><p dir="ltr" role="presentation" style="text-align: justify;">Adjusted hazard ratios for death and malignancy were 4.70 and 2.58, respectively, for LORA compared to YORA.</p></li></ul><p dir="ltr" style="text-align: justify;">In conclusion, patients with late-onset rheumatoid arthritis demonstrated similar disease activity improvements as younger-onset patients over five years. However, LORA patients experienced a greater decline in physical function and faced a higher incidence of adverse events, emphasizing the need for tailored treatment strategies to improve long-term outcomes in this population.</p><p dir="ltr" style="text-align: justify;">Reference:</p><p dir="ltr" style="text-align: justify;">Sugitani N, Tanaka E, Inoue E, Abe M, Sugano E, Saka K, Ochiai M, Yamaguchi R, Ikari K, Yamanaka H, Harigai M. Higher risk of poor functional outcome and unfavorable clinical events for late-onset rheumatoid arthritis: results from the IORRA cohort. Rheumatology (Oxford). 2024 Dec 16:keae673. doi: 10.1093/rheumatology/keae673. Epub ahead of print. PMID: 39680892. </p><div style="text-align: justify;"><br></div></div><p style="text-align: justify;"><br></p>

123. Diarrheal diseases remain leading killer for children under 5 years and adults over 70 years, claims research

     Thu, 26 Dec 2024 15:00:37 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/19/265589-untitled-design-2024-12-19t110321004.webp' /><p style="text-align: justify; ">New global study reports a 60% drop in global mortality from <a href="https://medicaldialogues.in/topics/diarrheal-disease">diarrheal diseases</a>, but children and the elderly still have the highest death rates, particularly in sub-Saharan Africa and South Asia. That’s according to the latest and most comprehensive study from the Global Burden of Disease (GBD) conducted by the Institute for Health Metrics and Evaluation (IHME) and published today in <i>The Lancet Infectious Diseases </i>journal. </p><p style="text-align: justify;">In 2021, diarrheal diseases caused 1.2 million deaths worldwide, which is a substantial drop from 2.9 million deaths recorded in 1990. The largest decrease was among children under 5 years with a 79% decline, but that age group still had the highest mortality rate among all ages, followed by those 70 years and older, making it a leading cause of death across all ages. </p><p style="text-align: justify; ">Regional disparities in diarrheal disease deaths remain stark. Regions with high-income countries see less than one death per 100,000 population in children under 5. In sub-Saharan Africa, more than 150 deaths per 100,000 population were in children under 5, which is the highest mortality rate for children in that age group when compared to all other global regions. South Asia had the highest mortality rates among those aged 70 years and older with 476 deaths per 100,000. Diarrheal mortality rates declined substantially across age groups in most super-regions. </p><p style="text-align: justify;">Researchers analyzed the overall burden of diarrheal diseases by measuring disability-adjusted life years, or DALYs. That’s the sum of the number of years of life lost and the number of years lived with disability. DALYs declined from 186 million in 1990 to 59 million in 2021, but 31 million of those 2021 DALYs were in children younger than 5 years. Major risk factors for diarrheal DALYs include poor neonatal conditions such as low birthweight and<a href="https://medicaldialogues.in/topics/preterm-birth"> preterm birth</a>, child growth failure, unsafe water, and poor sanitation. </p><p style="text-align: justify;">The decline in diarrheal mortality and morbidity suggests health interventions are working. They include oral rehydration therapy, enhanced water, sanitation, and hygiene infrastructure, and global immunization efforts against rotavirus. Preventive measures against key risk factors and pathogens could further reduce the global burden; according to researchers’ estimates, if leading risk factors were eliminated around the world, DALYs could be reduced to less than 5 million in 2021. </p><p style="text-align: justify;">“The new granular-level analysis by our study can further help decision-makers better target and prioritize the evidence-based strategies to fight diarrheal diseases,” said Dr. Hmwe Hmwe Kyu, study author and associate professor at IHME. “In spite of the encouraging progress made combating diarrheal mortality, a multipronged approach is required to simultaneously tackle live-saving solutions while also prioritizing preventive interventions to alleviate burdens on health systems.” </p><p style="text-align: justify;">WHO-recommended rotavirus vaccines, now administered in over 100 countries, have led to substantial reductions in hospitalizations and deaths from diarrhea. With more vaccines being added to WHO’s Expanded Programme on Immunization, combining them could reduce manufacturing costs and make scheduling easier. </p><p style="text-align: justify;">“In addition to increasing immunizations globally, we need to expand vaccine development to target specific pathogens that cause diarrheal diseases and consider combining vaccines to create a broader protection. This approach would be efficient and cost-effective for regions that are hit hardest by this global health crisis,” said Dr. Heidi Soeters, epidemiologist with WHO’s Department of Immunization, Vaccines and Biologicals. </p><p style="text-align: justify;">For the first time, this research incorporates pathogen-specific data from WHO’s Global Pediatric Diarrhea Surveillance network from many high-burden countries. </p><p style="text-align: justify; ">The GBD is the most comprehensive assessment of health, which includes granular estimates of burden across all age groups, sexes, and locations, as well as risk factors for 204 countries and territories from 1990 to 2021. More data on the burden of diarrheal diseases are available via IHME’s visualization tools.</p><p style="text-align: justify; ">Reference:</p><p style="text-align: justify; ">Kyu, Hmwe Hmwe et al., Global, regional, and national age-sex-specific burden of diarrhoeal diseases, their risk factors, and aetiologies, 1990–2021, for 204 countries and territories: a systematic analysis for the Global Burden of Disease Study 2021, The Lancet Infectious Diseases,DOI:10.1016/S1473-3099(24)00691-1&nbsp;</p>

124. Anatomical classification system can standardize parametrectomy procedures and outcomes in deep endometriosis: Study

     Thu, 26 Dec 2024 15:00:30 -0000

     <img src='https://medicaldialogues.in/h-upload/2020/03/11/125373-endometriosis.webp' /><p style="text-align: justify; ">Deep endometriosis, characterized by the presence of endometrial tissue infiltrating at least 5mm into the peritoneum, is considered the most severe type of endometriosis. This condition commonly affects the dorsolateral parametrium, leading to severe pain, diminished quality of life, and dysfunction of pelvic organs or somatic innervation, especially as it progresses laterally and deeper in the pelvis. Recent prospective single-center study examined the complication rate and functional outcomes of nerve-sparing parametrectomy for deep endometriosis, based on the anatomical extent of the surgical procedure. The researchers divided dorsolateral parametrectomies into three groups - superficial parametrectomy (SP), deep parametrectomy type 1 (DP1), and deep parametrectomy types 2 and 3 (DP2, DP3) - determined by whether the procedure extended beyond established anatomical landmarks like the presacral fascia and medial rectal artery.</p><p style="text-align: justify;">The study included 185 patients who underwent parametrectomy for deep endometriosis between 2020-2023. Intraoperative complications were low overall (3.2%), but bladder voiding deficit occurred in 9.7% of cases, with higher rates in the DP2 (20.8%) and DP3 (30%) groups. Urinary tract infections also differed, appearing in 7.6% of patients, with 11.8% in DP1 and 20.8% in DP2. Self-catheterization was required long-term in 1.6% of patients, more common in the deeper parametrectomy groups. Mean operative time and blood loss were longest in the DP3 group.</p><p style="text-align: justify;">Functional Outcomes</p><p style="text-align: justify;">Functional outcomes were evaluated using validated questionnaires. A significant improvement over time in bowel function (KESS score) was seen in the SP, DP1 and DP3 groups, but not DP2. Urinary function (BFLUTS) only improved in DP3. Sexual function (FSFI) did not concurrently improve with parametrectomy in any group.</p><p style="text-align: justify;">Conclusions</p><p style="text-align: justify;">The researchers conclude that their anatomical classification system can standardize the reporting of parametrectomy procedures and associated outcomes. Even with nerve-sparing techniques, a non-negligible rate of bladder voiding deficit was observed, particularly in cases requiring deeper, more lateral dissection (DP2, DP3). Parametrectomy alone did not reliably improve functional outcomes related to bowel, bladder or sexual function. The authors suggest the concept of a "dominant hemipelvis" from a neurofunctional standpoint may explain the variable impact on pelvic organ function.</p><p style="text-align: justify;">Key Points</p><p style="text-align: justify;">1. The study examined the complication rate and functional outcomes of nerve-sparing parametrectomy for deep endometriosis, based on the anatomical extent of the surgical procedure.</p><p style="text-align: justify;">2. The researchers divided dorsolateral parametrectomies into three groups - superficial parametrectomy (SP), deep parametrectomy type 1 (DP1), and deep parametrectomy types 2 and 3 (DP2, DP3) - determined by whether the procedure extended beyond anatomical landmarks.</p><p style="text-align: justify;">3. Intraoperative complications were low overall (3.2%), but bladder voiding deficit occurred in 9.7% of cases, with higher rates in the DP2 (20.8%) and DP3 (30%) groups. Urinary tract infections also differed, appearing in 7.6% of patients, with 11.8% in DP1 and 20.8% in DP2. Self-catheterization was required long-term in 1.6% of patients, more common in the deeper parametrectomy groups.</p><p style="text-align: justify;">4. A significant improvement over time in bowel function (KESS score) was seen in the SP, DP1 and DP3 groups, but not DP2. Urinary function (BFLUTS) only improved in DP3. Sexual function (FSFI) did not concurrently improve with parametrectomy in any group.</p><p style="text-align: justify;">5. The researchers conclude that their anatomical classification system can standardize the reporting of parametrectomy procedures and associated outcomes.</p><p style="text-align: justify;">6. Even with nerve-sparing techniques, a non-negligible rate of bladder voiding deficit was observed, particularly in cases requiring deeper, more lateral dissection (DP2, DP3). Parametrectomy alone did not reliably improve functional outcomes related to bowel, bladder or sexual function.</p><p style="text-align: justify;">Reference –</p><p style="text-align: justify;">M. Ianieri et al. (2024). Anatomical-Based Classification Of Dorsolateral Parametrectomy For Deep Endometriosis. Correlation With Surgical Complications And Functional Outcomes: A Single- Center Prospective Study.. *International Journal Of Gynaecology And Obstetrics: The Official Organ Of The International Federation Of Gynaecology And Obstetrics*. <a href="https://doi.org/10.1002/ijgo.15781">https://doi.org/10.1002/ijgo.15781</a></p><p style="text-align: justify;"><br></p>

125. Low-Dose Prednisone Exposure During Pregnancy Increases Risk of GDM and Impaired Glucose Tolerance: Study Finds

     Thu, 26 Dec 2024 15:00:27 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/11/26/262331-spontaneous-abortion.webp' /><p style="text-align: justify; ">China: A recent single-center, prospective cohort study has revealed potential risks associated with the use of low-dose <a href="https://speciality.medicaldialogues.in/topics/prednisone">prednisone </a>during pregnancy, particularly concerning <a href="https://speciality.medicaldialogues.in/topics/glucose-metabolism/">glucose metabolism.</a> The study, published in<em> the Journal of Reproductive Immunology</em>, found that prolonged use of low-dose prednisone during pregnancy may disrupt postprandial blood glucose levels and elevate the risk of developing<a href="https://speciality.medicaldialogues.in/topics/gestational-diabetes-mellitus"> gestational diabetes mellitus</a> (GDM).</p><div class="pasted-from-word-wrapper"><p style="text-align: justify;">"Regular monitoring of blood glucose and C-peptide levels is advised for patients undergoing prednisone treatment during pregnancy," the researchers wrote. </p><p style="text-align: justify;">In this single-center prospective cohort study, Qiaohong Wang, Department of Obstetrics and Gynecology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, and colleagues investigated the impact of low-dose prednisone treatment during pregnancy on blood glucose levels in patients who had experienced spontaneous abortion. </p><p style="text-align: justify;">For this purpose, the researchers enrolled patients with a history of spontaneous abortion. They divided them into two groups based on whether they were exposed to low-dose prednisone during pregnancy. All participants underwent an oral glucose tolerance test (OGTT) in both early and late pregnancy, and fasting serum C-peptide and HbA1c levels were measured at the same time. The study then analyzed the incidence of diabetes mellitus (DM), impaired fasting glucose, impaired glucose tolerance, and gestational diabetes mellitus. A total of 355 patients were included in the study. </p><p style="text-align: justify;"><strong>Based on the study, the researchers reported the following findings:</strong></p><ul><li style="text-align: justify;">No significant difference in OGTT between the two groups were observed in the first trimester.</li><li style="text-align: justify;">Patients in the prednisone group showed a significant increase in fasting serum C-peptide.</li><li style="text-align: justify;">Regarding late pregnancy, patients in the prednisone group showed a significant increase in 2-h plasma glucose.</li><li style="text-align: justify;">Patients in the prednisone group also had a higher incidence of GDM.</li><li style="text-align: justify;">Family history of DM and receiving low-dose prednisone were significantly associated with a higher risk of gestational glycometabolism abnormality in patients with spontaneous abortion.</li></ul><p style="text-align: justify;">The study found that prolonged use of low-dose prednisone during pregnancy can impair glucose tolerance in late pregnancy and increase the risk of gestational diabetes mellitus. A family history of diabetes mellitus and exposure to low-dose prednisone were identified as independent risk factors for gestational glycometabolic abnormalities.</p><p style="text-align: justify;">"Based on these findings, we recommend routine monitoring of blood glucose and C-peptide levels in patients receiving prednisone during pregnancy," the researchers concluded. </p><p style="text-align: justify;">Reference:</p><p style="text-align: justify; ">Wang, Q., Bai, W., Li, C., Zhang, X., &amp; Zhao, A. (2024). Effect of low dose prednisone on glucose metabolism levels in patients with spontaneous abortion: A single-center, prospective cohort study. Journal of Reproductive Immunology, 166, 104395. https://doi.org/10.1016/j.jri.2024.104395</p></div><p style="text-align: justify; "><br></p>

126. Oral Roflumilast Shows Promise in Treating Recurrent Aphthous Stomatitis: Multicenter Study Highlights Efficacy and Safety

     Thu, 26 Dec 2024 14:45:16 -0000

     <img src='https://medicaldialogues.in/h-upload/2023/03/20/205518-aphthous-stomatitis.webp' /><p style="text-align: justify; ">Spain: A multicenter observational study has highlighted the potential of oral <a href="https://medicaldialogues.in/topics/roflumilast-cream">roflumilast</a>, a phosphodiesterase-4 (PDE4) inhibitor, as an effective treatment for recurrent <a href="https://medicaldialogues.in/topics/aphthous-stomatitis">aphthous stomatitis</a> (RAS).</p><div class="pasted-from-word-wrapper"><p style="text-align: justify; ">The study, published in the<em> International Journal of Dermatology, </em>indicates that roflumilast may be an effective treatment for RAS, helping to reduce the frequency and duration of flare-ups and ulcers, and alleviating associated symptoms.</p><p style="text-align: justify; ">"Additionally, roflumilast is well tolerated at low doses, has a favorable safety profile, and does not necessitate frequent monitoring. Combined with its cost-effectiveness, these benefits position roflumilast as a promising therapeutic option for managing RAS," the researchers wrote. </p><p style="text-align: justify; ">Recurrent aphthous stomatitis is a condition characterized by painful ulcers in the oral cavity, that often disrupts patients' quality of life due to frequent flare-ups, prolonged healing times, and significant discomfort. RAS poses a therapeutic challenge due to its significant impact on a patient's quality of life. Moreover, there are currently no approved systemic treatments for the condition. Roflumilast, a phosphodiesterase-4 inhibitor, has demonstrated potential in treating other inflammatory dermatological disorders, showing promise for use in RAS.</p><p style="text-align: justify; ">Against the above background, Rodrigo Peñuelas Leal, Dermatology Department, Consorci Hospital General Universitari de Valencia, Valencia, Spain, and colleagues aimed to evaluate the characteristics, effectiveness, and safety of roflumilast in the treatment of RAS within routine clinical practice. </p><p style="text-align: justify; ">For this purpose, the researchers conducted a single-cohort ambispective observational study across five Spanish centers involving 22 RAS patients with RAS who were treated with roflumilast. The study collected data on demographic, clinical, and outcome variables. Statistical analysis was performed to compare the outcomes of 12 weeks of roflumilast treatment with a comparable 12-week period before treatment. </p><p style="text-align: justify; "><strong>The study revealed the following findings:</strong></p><ul><li style="text-align: justify; ">During roflumilast treatment, flare-ups (88%) and <a href="https://medicaldialogues.in/topics/oral-ulcers/">oral ulcers</a> (94%) significantly reduced compared to the untreated period.</li><li style="text-align: justify; ">Pain decreased by 66%, and ulcer duration was shortened by 63%.</li><li style="text-align: justify; ">Adverse effects (AEs) were reported in 13 patients, including headache and gastrointestinal disturbances.</li><li style="text-align: justify; ">Most AEs were self-limiting or could be managed with dose adjustments.</li><li style="text-align: justify; ">Treatment was discontinued in three cases, mainly due to AEs.</li></ul><p style="text-align: justify; ">The researchers note that the study's small sample size, unblinded design, lack of a placebo, and potential recall bias may affect the results.</p><p style="text-align: justify; ">"While further research, including long-term and randomized trials with larger patient groups and varying dosages, is needed, these factors suggest that roflumilast could become a safe, effective, and cost-efficient treatment for RAS, benefiting a broader patient population," the researchers concluded.</p><p style="text-align: justify; ">Reference:</p><p style="text-align: justify; ">Leal, R. P., Bagan, L., Echevarría, A. G., Peñuelas Ruiz, J. A., Ninet, V. Z., Sánchez Carazo, J. L., Pastor, G. P., Hoyos, C. L., Finello, M., Fernández, S. M., Imbernon, D. B., García, Á. G., Zafrilla, E. P., Cabrera, M. M., &amp; Bagan, J. Treatment of recurrent aphthous stomatitis with oral roflumilast, a multicenter observational study. International Journal of Dermatology. https://doi.org/10.1111/ijd.17478</p><p style="text-align: justify; "> </p></div><p style="text-align: justify; "><br></p>

127. New targets for diabetic kidney disease could prevent end stage kidney failure, suggests study

     Thu, 26 Dec 2024 14:45:01 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/11/264365-diabetic-kidney-disease-50.webp' /><p style="text-align: justify; ">New potential therapeutic targets have been identified for <a href="https://medicaldialogues.in/topics/diabetic-kidney-disease-dkd">diabetic kidney disease</a> (DKD) - the leading cause of kidney failure in the world - that could see patients treated with new gene and drug therapies preventing the disease’s progression into end stage<a href="https://medicaldialogues.in/topics/kidney-failure"> kidney failure</a>. The study is published in <i>Nature Communications</i>. </p><p style="text-align: justify;">The University of Bristol-led breakthrough, involving scientists from the UK, Europe and USA, discovered specific cell changes in the kidney caused by <a href="https://medicaldialogues.in/topics/insulin">insulin</a> resistance – a major driver of diabetic kidney disease. </p><p style="text-align: justify;">Despite its prevalence, the molecular mechanisms underlying DKD development remain poorly understood. Researchers sought to understand the cellular and molecular changes occurring in the kidney (specifically the glomerulus and proximal tubule) which is key to understanding the mechanisms underlying the disease, identifying therapeutic targets and biomarker candidates. </p><p style="text-align: justify;"> Building on the team’s previous work in this area, the team examined the changes caused by insulin-resistance in four types of kidney cells, and then compared these changes with kidney biopsies from patients with early and late diabetic kidney disease. </p><p style="text-align: justify;">The study revealed multiple ‘common’ and ‘cell specific’ changes caused by insulin-resistance representing new targets for pharmacological or targeted gene therapy approaches. </p><p style="text-align: justify;">Richard Coward, Professor of Renal Medicine at the University of Bristol and Consultant Paediatric Nephrologist at Bristol Royal Hospital for Children, and one of the study's lead authors said: “Diabetic kidney disease is the leading cause of end-stage kidney failure in the world, occurring in up to 50 per cent of individuals with diabetes. Patients with end stage kidney disease require daily dialysis or a kidney transplant to survive. If we can find a way to prevent this, it would save and improve countless lives. </p><p style="text-align: justify;">“Our aim now is to take several of these therapeutic targets forward in a pre-clinical setting, and hopefully through clinical trials.” </p><p style="text-align: justify; ">Dr Aisling McMahon, Executive Director of Research at Kidney Research UK, added: “We are determined to find ways to tackle diabetic kidney disease. By providing detailed information on genes and pathways involved in diabetic kidney disease, Professor Coward's work takes us one step closer to a more complete understanding of this condition, but also towards discovering new targeted agents to prevent it.”&nbsp;</p><p style="text-align: justify; ">Reference:</p><p style="text-align: justify; ">Abigail C. Lay et al, Profiling of insulin-resistant kidney models and human biopsies reveals common and cell-type-specific mechanisms underpinning Diabetic Kidney Disease, Nature Communications (2024). DOI: 10.1038/s41467-024-54089-1</p>

128. Third molars with completely formed roots suitable donors for replacing missing teeth: Study

     Thu, 26 Dec 2024 14:30:07 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/05/263701-images-87.webp' /><p style="text-align: justify; ">A study published in the Journal of the American Dental Association suggests that third molars with completely formed roots are suitable donors for replacing missing teeth.</p><div class="pasted-from-word-wrapper"><p dir="ltr" style="text-align: justify; ">The autotransplant of third molars to replace missing teeth is gaining attention. This study aimed to analyze factors influencing the success, survival, and inflammatory root resorption (IRR) of autotransplanted third molars with completely formed roots. A total of 160 patients who underwent autotransplant of third molars with completely formed roots were evaluated retrospectively, involving 168 teeth. Preoperative, intraoperative, and postoperative variables were assessed to identify prognostic factors for success, survival, and IRR. Results: The average (SD) follow-up was 5.21 (1.99) years. The success, survival, and IRR rates were 75.0%, 91.1%, and 17.3%, respectively. Cox proportional hazards regression analysis revealed that both apical resection and retro filling (ARR) (P &lt; .001) and donor tooth replicas (P &lt; .001 for success and IRR; P = .013 for survival) were associated significantly with success, survival, and IRR. Furthermore, root canal treatment timing and patient age significantly affected success and survival, respectively (P = .006 and P = .036). The use of donor tooth replicas significantly reduced both the surgical time (P &lt; .001) and extraoral time of the donor tooth (P &lt; .001), whereas ARR increased the extraoral time of the donor tooth (P = .002). The use of a single root donor tooth was associated with a reduced surgical time (P = .003). Using donor tooth replicas and avoiding ARR contributed to increased success and survival rates and prevented IRR. Third molars with completely formed roots are suitable donors for replacing missing teeth, provided that appropriate preoperative, intraoperative, and postoperative indications are considered.</p><div style="text-align: justify;"><br></div><p dir="ltr" style="text-align: justify; ">Reference:</p><p dir="ltr" style="text-align: justify; ">Prognostic factors for auto transplanted third molars with completely formed roots. Xia, Jiajia et al. The Journal of the American Dental Association, Volume 0, Issue 0</p><div style="text-align: justify;"><br></div><p dir="ltr" style="text-align: justify; ">Keywords:</p><p dir="ltr" style="text-align: justify; ">Third molars, completely, formed, roots, suitable, donors, replacing, missing, teeth, study, Xia, Jiajia, third molar, success rate, survival rate, inflammatory root resorption, survival analysis </p><div style="text-align: justify;"><br></div><div style="text-align: justify;"><br></div></div><p style="text-align: justify; "><br></p>

129. Pfizer Gets CDSCO Panel nod to Import Abrocitinib tablets for moderate to severe atopic dermatitis

     Thu, 26 Dec 2024 12:30:51 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/01/22/230672-pfizer-50.webp' /><div class="pasted-from-word-wrapper"><p style="text-align: justify;"><b>New Delhi:</b> Pharmaceutical major <a href="https://medicaldialogues.in/news/industry/pharma/pfizer-astrazeneca-and-several-other-drugmakers-in-race-to-join-weight-loss-drug-market-140315">Pfizer</a> Products India has got the go-ahead from the Subject Expert Committee (SEC) functional under the Central Drug Standard Control Organization (CDSCO) to import <a href="https://medicaldialogues.in/news/industry/pharma/conduct-active-surveillance-study-cdsco-panel-tells-pfizer-on-abrocitinib-tablets-135516">Abrocitinib</a> tablets 50 mg, 100 mg, and 200 mg for sale or for distribution for the treatment of moderate-to-severe <a href="https://speciality.medicaldialogues.in/atopic-dermatitis-patients-at-higher-risk-of-osteoporosis">atopic dermatitis</a> in adults and adolescents 12 years and older who are candidates for systemic therapy.</p><p style="text-align: justify;">However, this nod is subject to the condition that the firm should conduct a Phase IV clinical trial study.</p><p style="text-align: justify;">This came after Pfizer Products India presented its application for grant of permission to import Abrocitinib tablets 50mg, 100mg, and 200mg for sale or for distribution along with Phase III clinical study data to the committee.</p><p style="text-align: justify;">The committee noted that the proposed additional indication of Abrocitinib tablets 50 mg, 100 mg, and 200 mg is approved in the USA, Europe, and other countries.</p><p style="text-align: justify;">Abrocitinib is an oral small-molecule inhibitor of Janus kinase 1 (JAK1). Janus kinases are intracellular enzymes involved in transduction pathways that regulate hematopoiesis and immune cell function. The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signalling pathway plays a central role in the pathogenesis of a variety of autoimmune and inflammatory diseases, including atopic dermatitis, a chronic inflammatory skin disease with complex pathogenesis. Atopic dermatitis is characterized by epidermal hyperplasia, skin barrier dysfunction, and the aberrant activation of immune cells. </p><p style="text-align: justify;">At the recent SEC meeting for dermatology and allergy held on 5th and 6th December 2024, the expert panel reviewed the application presented by Phizer Product India to import Abrocitinib tablets 50mg, 100mg, and 200mg for sale or distribution along with Phase III clinical study data.</p><p style="text-align: justify;">After detailed deliberation, the committee recommended the grant of import permission for the sale or distribution of Abrocitinib tablets 50 mg, 100 mg, and 200 mg indicated for the treatment of moderate-to-severe atopic dermatitis in adults and adolescents 12 years and older who are candidates for systemic therapy, subject to the condition that the firm should conduct a Phase IV clinical trial study.</p><p style="text-align: justify;">Accordingly, the expert panel suggested that the firm should submit the Phase IV clinical trial protocol to CDSCO within 3 months from the date of approval of the drug product for review by the committee.</p><p style="text-align: justify; ">Also Read:<a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/industry/pharma/msd-pharmaceutical-gets-cdsco-panel-nod-to-study-mk-1084-140006">MSD Pharmaceutical Gets CDSCO Panel Nod To study MK-1084</a></p></div><div class="hocal-draggable" draggable="true"><div class="read-this-also-wrap"><div></div></div></div>

130. Medgenome labs faces Rs 7 crore lawsuit for alleged negligence in genetic testing

     Thu, 26 Dec 2024 12:30:03 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/26/266605-mdtv-2024-12-26t164329916.webp' /><div class="pasted-from-word-wrapper"><div class="pasted-from-word-wrapper"><p style="text-align: justify; ">In a case of alleged <a href="https://medicaldialogues.in/topics/medical-negligence">medical negligence</a>, the wife of a serving soldier, has filed a Rs 7 crore lawsuit in a consumer court against MedGenome Labs Limited, Bengaluru, and M/S College of American Pathologists. The lawsuit claims that errors in <a href="https://medicaldialogues.in/topics/genetic-testing">genetic testing</a> resulted in severe consequences for her family.</p><div id="ATS_mid1"></div><p style="text-align: justify;">According to Hatkar, her son, born on December 12, 2017, was later diagnosed with two rare conditions: Ichthyosis and Penoscrotal Hypospadias. In October 2020, a genetic test conducted at a hospital in Pune revealed a NIPAL4 mutation, confirming a diagnosis of autosomal recessive congenital ichthyosis, a severe genetic disorder.</p></div><div class="pasted-from-word-wrapper"><div><b><i></i></b></div><div style="text-align: justify;"><i><b>For more information, click on the link below:</b></i></div></div><div class="pasted-from-word-wrapper"><div style="text-align: justify;"><i><a href="https://medicaldialogues.in/news/health/rs-7-crore-lawsuit-against-medgenome-labs-for-alleged-medical-negligence-in-genetic-testing-140426#:~:text=Mumbai:%20In%20a%20case%20of,severe%20consequences%20for%20her%20family."><b>Rs 7 crore Lawsuit against Medgenome Labs for Alleged Medical Negligence in Genetic Testing</b></a></i></div></div></div>

131. HC sets aside NCDRC order imposing Rs 93 lakh compensation on doctor

     Thu, 26 Dec 2024 12:15:25 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/26/266606-mdtv-2024-12-26t164627588.webp' /><div class="pasted-from-word-wrapper"><div class="pasted-from-word-wrapper"><p style="text-align: justify; ">The Lucknow bench of the <a href="https://medicaldialogues.in/topics/allahabad-high-court">Allahabad High Court</a> bench recently set aside an order by the National Consumer Disputes Redressal Commission (<a href="https://medicaldialogues.in/topics/ncdrc">NCDRC</a>) directing the doctors and a hospital-owner to pay Rs 93 lakh compensation to a patient who had to suffer while undergoing c-section at the facility.</p><div id="ATS_mid1"></div><p style="text-align: justify;">Earlier the State Commission had granted Rs 95 lakh compensation in the patient's favour. However, later, one member of NCDRC dismissed the complaint while the other reduced it to Rs 93 lakh. When the matter was referred to a third member, the order of R 93 lakh compensation was upheld.</p></div><div class="pasted-from-word-wrapper"><div><p style="text-align: justify; "><i><b>For more information, click on the link below:</b></i></p></div></div><div class="pasted-from-word-wrapper"><div style="text-align: justify;"><i><a href="https://medicaldialogues.in/news/health/medico-legal/hc-sets-aside-ncdrc-order-slapping-rs-93-lakh-compensation-on-doctor-140418#:~:text=Lucknow:%20The%20Lucknow%20bench%20of,c-section%20at%20the%20facility."><b>HC Sets Aside NCDRC Order Slapping Rs 93 Lakh Compensation on Doctor</b></a></i></div></div></div>

132. Merck to discontinue bacterial infection drug Zinplava

     Thu, 26 Dec 2024 12:14:29 -0000

     <img src='https://medicaldialogues.in/h-upload/2022/10/29/189269-merck-new.webp' /><p style="text-align: justify; "><span style="background-color: rgb(255, 255, 255);"><a href="https://medicaldialogues.in/topics/merck">Merck </a>will discontinue its&nbsp;</span>antibody-drug Zinplava<span style="background-color: rgb(255, 255, 255);">&nbsp;for a bacterial infection that can lead to fatal <a href="https://medicaldialogues.in/topics/diarrhea">diarrhea</a>, according to the <a href="https://medicaldialogues.in/topics/USFDA">U.S. Food and Drug Administration</a>'s website.</span></p><div class="pasted-from-word-wrapper"><div data-testid="paragraph-1" class="text__text__1FZLe text__dark-grey__3Ml43 text__regular__2N1Xr text__small__1kGq2 body__full_width__ekUdw body__small_body__2vQyf article-body__paragraph__2-BtD" style="text-align: justify; ">Zinplava, first approved by the regulator in 2016 for prevention of the recurrence of Clostridioides difficile infections (CDI),&nbsp;<span style="background-color: rgb(249, 249, 249);">a bacterial infection often&nbsp;</span><span style="background-color: rgb(249, 249, 249);">caused by prolonged use of antibiotics. CDI&nbsp;</span>can lead to potentially fatal diarrhea and inflammation of the colon.</div><div data-testid="paragraph-2" class="text__text__1FZLe text__dark-grey__3Ml43 text__regular__2N1Xr text__small__1kGq2 body__full_width__ekUdw body__small_body__2vQyf article-body__paragraph__2-BtD"><div data-testid="paragraph-3" class="text__text__1FZLe text__dark-grey__3Ml43 text__regular__2N1Xr text__small__1kGq2 body__full_width__ekUdw body__small_body__2vQyf article-body__paragraph__2-BtD" style="text-align: justify; "><span style="background-color: rgb(249, 249, 249);">The FDA’s website states that the discontinuation of Zinplava will take effect on January 31, but no reason was cited for this decision.</span></div><div data-testid="paragraph-3" class="text__text__1FZLe text__dark-grey__3Ml43 text__regular__2N1Xr text__small__1kGq2 body__full_width__ekUdw body__small_body__2vQyf article-body__paragraph__2-BtD"><p style="text-align: justify; ">The drugmaker did not immediately comment on the matter, Reuters reported.</p><p>Medical Dialogues team had earlier reported that the Company had announced the discontinuation of the clinical development programs for vibostolimab, an anti-TIGIT antibody, and favezelimab, an anti-LAG-3 antibody. Vibostolimab was being evaluated as an investigational fixed-dose combination with pembrolizumab (KEYTRUDA ) in the KeyVibe program. Favezelimab was being evaluated as an investigational fixed-dose combination with pembrolizumab in the KEYFORM program.</p></div><div data-testid="paragraph-3" class="text__text__1FZLe text__dark-grey__3Ml43 text__regular__2N1Xr text__small__1kGq2 body__full_width__ekUdw body__small_body__2vQyf article-body__paragraph__2-BtD"><p style="text-align: justify; "><b><i>Read also: <a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/industry/pharma/merck-discontinues-clinical-development-programs-for-vibostolimab-favezelimab-140049">Merck discontinues clinical development programs for vibostolimab, favezelimab</a></i></b></p></div></div></div><div class="pasted-from-word-wrapper"><div class="hocal-draggable" draggable="true"><div class="read-this-also-wrap"><div></div></div></div><div class="pasted-from-word-wrapper"><div data-testid="paragraph-2" class="text__text__1FZLe text__dark-grey__3Ml43 text__regular__2N1Xr text__small__1kGq2 body__full_width__ekUdw body__small_body__2vQyf article-body__paragraph__2-BtD"><div data-testid="paragraph-3" class="text__text__1FZLe text__dark-grey__3Ml43 text__regular__2N1Xr text__small__1kGq2 body__full_width__ekUdw body__small_body__2vQyf article-body__paragraph__2-BtD"><p style="text-align: justify; "><br></p></div></div></div></div><div class="pasted-from-word-wrapper"><div data-testid="paragraph-2" class="text__text__1FZLe text__dark-grey__3Ml43 text__regular__2N1Xr text__small__1kGq2 body__full_width__ekUdw body__small_body__2vQyf article-body__paragraph__2-BtD"><div data-testid="paragraph-3" class="text__text__1FZLe text__dark-grey__3Ml43 text__regular__2N1Xr text__small__1kGq2 body__full_width__ekUdw body__small_body__2vQyf article-body__paragraph__2-BtD"><p style="text-align: justify; "><br></p></div></div></div>

133. 5 doctors suspended after pregnant woman's death at GMC Rajouri

     Thu, 26 Dec 2024 12:12:42 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/26/266609-mdtv-2024-12-26t165159583.webp' /><div class="pasted-from-word-wrapper"><div class="pasted-from-word-wrapper"><div class="pasted-from-word-wrapper"><p style="text-align: justify; ">In response to allegations of <a href="https://medicaldialogues.in/topics/medical-negligence" target="_blank">medical negligence</a> leading to the death of a pregnant woman at the Government Medical College (GMC) Rajouri, five doctors have been suspended, and two doctors along with eight other staff members have been issued show-cause notices.</p></div><div class="pasted-from-word-wrapper"><p style="text-align: justify;">Five doctors of the Government Medical College (GMC) Rajouri were suspended following the death of a <a href="https://medicaldialogues.in/topics/pregnant-women" target="_blank">pregnant woman</a> that sparked concerns about alleged<a href="https://medicaldialogues.in/topics/medical-negligence" target="_blank"> medical negligence</a>, officials said on Tuesday.</p></div></div><div class="pasted-from-word-wrapper"><div><p style="text-align: justify;"><i><b>For more information, click on the link below:</b></i></p></div></div><div class="pasted-from-word-wrapper"><div style="text-align: justify;"><i><a href="https://medicaldialogues.in/news/health/doctors/5-gmc-rajouri-doctors-suspended-10-issued-notice-after-death-of-pregnant-woman-140428"><b>5 GMC Rajouri doctors suspended, 10 issued notice after death of pregnant woman</b></a></i></div></div></div>

134. Bombay HC grants MBBS admission to aspirant denied seat due to technical issues

     Thu, 26 Dec 2024 12:10:45 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/26/266608-mdtv-2024-12-26t164916823.webp' /><div class="pasted-from-word-wrapper"><div class="pasted-from-word-wrapper"><p style="text-align: justify; ">Coming to the aid of an <a href="https://medicaldialogues.in/topics/mbbs-aspirant">MBBS Aspirant</a>, who was denied admission based on technical issues with her caste certificates, the Bombay High Court bench recently directed SSPM Medical College to admit her in the first-year <a href="https://medicaldialogues.in/topics/mbbs-course">MBBS course</a> by creating a supernumerary seat for her under the institutional stray vacancy round.</p><div id="ATS_mid1"></div><p style="text-align: justify;"><i>"...it is held that the petitioner is entitled to be admitted at the First Year MBBS Course at the respondent no.7 – College under the Institutional Stray Vacancy by directing creation of a supernumerary seat. The petitioner would be liable to pay tuition fees and other fees as payable by a student who has secured admission in the Institutional Stray Vacancy Round," </i>the HC bench comprising Justices Rajesh S. Patil and A.S. Chandurkar ordered.</p></div><div class="pasted-from-word-wrapper"><div><p style="text-align: justify;"><i><b>For more information, click on the link below:</b></i></p></div></div><div class="pasted-from-word-wrapper"><div style="text-align: justify;"><i><a href="https://medicaldialogues.in/news/education/medical-admissions/relief-granted-bombay-hc-grants-admission-to-mbbs-aspirant-denied-seat-due-to-technical-issues-140417#:~:text=Mumbai:%20Coming%20to%20the%20aid,under%20the%20institutional%20stray%20vacancy"><b>Relief Granted! Bombay HC Grants Admission to MBBS Aspirant Denied Seat due to technical issues</b></a></i></div></div></div>

135. Health Bulletin 26/ December/ 2024

     Thu, 26 Dec 2024 11:58:34 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/26/266603-health-bulletin-80.webp' /><p style="text-align: justify; "><b>Here are the top health news for the day:</b></p><div class="pasted-from-word-wrapper"><div style="text-align: justify;"><b>Medgenome Labs faces Rs 7 crore lawsuit for alleged negligence in Genetic Testing</b></div></div><div class="pasted-from-word-wrapper"><p style="text-align: justify;"> In a case of alleged <a href="https://medicaldialogues.in/topics/medical-negligence">medical negligence</a>, the wife of a serving soldier has filed a Rs 7 crore lawsuit in a consumer court against MedGenome Labs Limited, Bengaluru, and M/S College of American Pathologists. The lawsuit claims that errors in <a href="https://medicaldialogues.in/topics/genetic-testing">genetic testing</a> resulted in severe consequences for her family.</p><div id="ATS_mid1"></div><p style="text-align: justify;">According to Hatkar, her son, born on December 12, 2017, was later diagnosed with two rare conditions: Ichthyosis and Penoscrotal Hypospadias. In October 2020, a genetic test conducted at a hospital in Pune revealed a NIPAL4 mutation, confirming a diagnosis of autosomal recessive congenital ichthyosis, a severe genetic disorder.</p></div><div class="pasted-from-word-wrapper"><div><b><i> </i></b></div><div style="text-align: justify;"><b><i>For more information, click on the link below:</i></b></div></div><div class="pasted-from-word-wrapper"><div style="text-align: justify;"><b><i><a href="https://medicaldialogues.in/news/health/rs-7-crore-lawsuit-against-medgenome-labs-for-alleged-medical-negligence-in-genetic-testing-140426#:~:text=Mumbai%3A%20In%20a%20case%20of,severe%20consequences%20for%20her%20family.">Rs 7 crore Lawsuit against Medgenome Labs for Alleged Medical Negligence in Genetic Testing</a></i></b></div></div><div class="pasted-from-word-wrapper"><div style="text-align: justify;"><b>HC sets aside NCDRC order imposing Rs 93 lakh compensation on doctor</b></div></div><div class="pasted-from-word-wrapper"><p style="text-align: justify;">The Lucknow bench of the <a href="https://medicaldialogues.in/topics/allahabad-high-court">Allahabad High Court</a> bench recently set aside an order by the National Consumer Disputes Redressal Commission (<a href="https://medicaldialogues.in/topics/ncdrc">NCDRC</a>) directing the doctors and a hospital-owner to pay Rs 93 lakh compensation to a patient who had to suffer while undergoing c-section at the facility.</p><div id="ATS_mid1"></div><p style="text-align: justify;">Earlier the State Commission had granted Rs 95 lakh compensation in the patient's favour. However, later, one member of NCDRC dismissed the complaint while the other reduced it to Rs 93 lakh. When the matter was referred to a third member, the order of R 93 lakh compensation was upheld.</p></div><div class="pasted-from-word-wrapper"><div><p style="text-align: justify;"><b><i>For more information, click on the link below:</i></b></p></div></div><div class="pasted-from-word-wrapper"><div style="text-align: justify;"><b><i><a href="https://medicaldialogues.in/news/health/medico-legal/hc-sets-aside-ncdrc-order-slapping-rs-93-lakh-compensation-on-doctor-140418#:~:text=Lucknow%3A%20The%20Lucknow%20bench%20of,c%2Dsection%20at%20the%20facility.">HC Sets Aside NCDRC Order Slapping Rs 93 Lakh Compensation on Doctor</a></i></b></div></div><div class="pasted-from-word-wrapper"><div style="text-align: justify;"><b>Bombay HC grants MBBS admission to aspirant denied seat due to technical issues</b></div></div><div class="pasted-from-word-wrapper"><p style="text-align: justify;">Coming to the aid of an <a href="https://medicaldialogues.in/topics/mbbs-aspirant">MBBS Aspirant</a>, who was denied admission based on technical issues with her caste certificates, the Bombay High Court bench recently directed SSPM Medical College to admit her in the first-year <a href="https://medicaldialogues.in/topics/mbbs-course">MBBS course</a> by creating a supernumerary seat for her under the institutional stray vacancy round.</p><div id="ATS_mid1"></div><p style="text-align: justify;"><i>"...it is held that the petitioner is entitled to be admitted at the First Year MBBS Course at the respondent no.7 – College under the Institutional Stray Vacancy by directing creation of a supernumerary seat. The petitioner would be liable to pay tuition fees and other fees as payable by a student who has secured admission in the Institutional Stray Vacancy Round," </i>the HC bench comprising Justices Rajesh S. Patil and A.S. Chandurkar ordered.</p></div><div class="pasted-from-word-wrapper"><div><p style="text-align: justify;"><b><i>For more information, click on the link below:</i></b></p></div></div><div class="pasted-from-word-wrapper"><div style="text-align: justify;"><b><i><a href="https://medicaldialogues.in/news/education/medical-admissions/relief-granted-bombay-hc-grants-admission-to-mbbs-aspirant-denied-seat-due-to-technical-issues-140417#:~:text=Mumbai%3A%20Coming%20to%20the%20aid,under%20the%20institutional%20stray%20vacancy">Relief Granted! Bombay HC Grants Admission to MBBS Aspirant Denied Seat due to technical issues</a></i></b></div></div><div class="pasted-from-word-wrapper"><div style="text-align: justify;"><b>5 doctors suspended after pregnant woman's death at GMC Rajouri</b></div></div><div class="pasted-from-word-wrapper"><div class="pasted-from-word-wrapper"><p style="text-align: justify;">In response to allegations of <a href="https://medicaldialogues.in/topics/medical-negligence" target="_blank">medical negligence</a> leading to the death of a pregnant woman at the Government Medical College (GMC) Rajouri, five doctors have been suspended, and two doctors along with eight other staff members have been issued show-cause notices.</p></div><div class="pasted-from-word-wrapper"><p style="text-align: justify;">Five doctors of the Government Medical College (GMC) Rajouri were suspended following the death of a <a href="https://medicaldialogues.in/topics/pregnant-women" target="_blank">pregnant woman</a> that sparked concerns about alleged<a href="https://medicaldialogues.in/topics/medical-negligence" target="_blank"> medical negligence</a>, officials said on Tuesday.</p></div></div><div class="pasted-from-word-wrapper"><div><p style="text-align: justify;"><b><i>For more information, click on the link below:</i></b></p></div></div><div class="pasted-from-word-wrapper"><div style="text-align: justify; "><b><i><a href="https://medicaldialogues.in/news/health/doctors/5-gmc-rajouri-doctors-suspended-10-issued-notice-after-death-of-pregnant-woman-140428">5 GMC Rajouri doctors suspended, 10 issued notice after death of pregnant woman</a></i></b></div></div>

136. Fire Breaks out at Greater Noida Hospital

     Thu, 26 Dec 2024 11:45:00 -0000

     <img src='https://medicaldialogues.in/h-upload/2022/09/27/186356-hospital-fire.webp' /><p><b>Noida:</b> A major <a href="https://medicaldialogues.in/topics/fire">fire erupted</a> at Swasthtam Hospital in Greater Noida, <a href="https://medicaldialogues.in/state-news/uttar-pradesh">Uttar Pradesh</a>, on Thursday, causing widespread panic among patients and staff. The fire quickly spread, triggering a swift response from emergency services.</p><p>According to initial reports, the blaze started on the floor above the hospital pharmacy, likely due to a short circuit. The fire caused widespread chaos throughout the building, forcing authorities to evacuate the hospital to ensure the safety of everyone inside.&nbsp;</p><p>Sparks from the malfunctioning transformer fell onto the balcony of the first floor, leading to the rapid spread of flames inside the hospital. In addition to the hospital's building, a motorcycle parked near the transformer also caught fire due to the falling sparks. </p><p>As soon as the fire started, the hospital staff acted quickly to ensure the safety of the patients and staff. The building was immediately evacuated, and hospital employees attempted to extinguish the fire using fire extinguishers.</p><p> A video of the incident, which has since surfaced, shows flames rising from the upper floor of the hospital, while staff members are seen working to control the blaze using fire extinguishers.<br></p><p><br></p><div class="hocal-draggable" draggable="true"><div class="h-embed" contenteditable="false"><div class="h-embed-wrapper"><blockquote contenteditable="false" class="twitter-tweet" data-media-max-width="560"><p lang="en" dir="ltr">VIDEO | Fire breaks out in a private hospital in <a href="https://twitter.com/hashtag/GreaterNoida?src=hash&amp;ref_src=twsrc%5Etfw">#GreaterNoida</a>. More details area awaited.<br><br>(Source: Third Party)<br> <br>(Full video available on PTI Videos - <a href="https://t.co/n147TvrpG7">https://t.co/n147TvrpG7</a>) <a href="https://t.co/6WoL5JEjM3">pic.twitter.com/6WoL5JEjM3</a></p>— Press Trust of India (@PTI_News) <a href="https://twitter.com/PTI_News/status/1872167549582078371?ref_src=twsrc%5Etfw">December 26, 2024</a></blockquote> </div></div></div><p><br></p><p><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/hospital-diagnostics/fire-incident-at-pgis-nehru-hospital-chandigarh-patients-evacuated-118586"><b>Also Read: Fire Incident at PGI's Nehru Hospital, Chandigarh, patients evacuated</b></a></p><div class="pasted-from-word-wrapper"><div><span style="background-color: rgb(249, 249, 249);">Speaking to </span><a href="https://timesofindia.indiatimes.com/city/noida/fire-breaks-out-at-greater-noidas-private-hospital/articleshow/116674075.cms" rel="nofollow">TOI</a><span style="background-color: rgb(249, 249, 249);">, Pradeep Kumar Chaubey, chief fire officer (CFO) of the district said, "The video circulating on social media gave the impression that the fire was inside the hospital, but this was not the case. It originated from a transformer near the premises, and the hospital itself was unharmed."</span></div></div><p>There was a short circuit in the transformer installed outside the hospital, the sparks of which fell on the balcony of the first floor of the hospital, after which the fire spread in the hospital as well. As soon as the information about the fire in the hospital was received, the fire brigade team also reached the spot, after which the fire was controlled.</p><p><b style="background-color: rgb(255, 255, 255);"><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/hospital-diagnostics/jhansi-hospital-fire-one-more-rescued-infant-dies-toll-rises-to-12-138312" style="background-color: rgb(255, 255, 255);">Also Read: Jhansi Hospital Fire: One more rescued infant dies, toll rises to 12</a></b></p>

137. TSMC Crackdown on Quackery, 400 FIRs filed against Quacks

     Thu, 26 Dec 2024 11:00:00 -0000

     <img src='https://medicaldialogues.in/h-upload/2022/07/20/181388-stop-quackery.webp' /><p style="text-align: justify; ">Hyderabad: In an effort to safeguard the public health and curb the growing menace of quacks posing as Rural Medical Practitioners (RMPs) in Telangana, the&nbsp;<a href="https://medicaldialogues.in/topics/telangana-state-medical-council" target="_blank">Telangana State Medical Council</a>&nbsp;(TSMC) has filed 400 FIRs over the past year and issued notices to 40 doctors suspected of aiding these illegal practitioners.</p><p style="text-align: justify; ">This initiative targets individuals practising allopathy under the guise of <a href="https://medicaldialogues.in/rmps-and-pmps" target="_blank" style="background-color: rgb(249, 249, 249);">Rural Medical Practitioners</a> (RMPs) without holding an MBBS degree.</p><div class="hocal-draggable" draggable="true"><div class="read-this-also-wrap"><div></div></div></div><div class="pasted-from-word-wrapper"><p style="text-align: justify; ">Recognizing the urgent need to curb quackery, the current senior office-bearers of the Telangana State Medical Council have launched a concerted effort to address the issue. For the first time, the Telangana State Medical Council has teamed up with the TS Drug Control Administration (TSDCA), to take legal action on individuals with no MBBS degree but practising allopathy, reports <a href="https://telanganatoday.com/medical-council-files-400-firs-against-quacks-in-telangana#:~:text=Hyderabad%3A%20In%20the%20fight%20against,on%2040%20doctors%20suspected%20of" target="_blank" rel="nofollow">Telangana Today</a>.</p></div><div class="pasted-from-word-wrapper"><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/doctors/telangana-govt-doctors-stage-black-badge-protest-over-removal-of-jagtial-hospital-superintendent-140340">Also Read:Telangana Govt doctors stage black badge protest over Removal of Jagtial Hospital Superintendent</a></div><div class="pasted-from-word-wrapper"><p style="text-align: justify; ">In addition to focusing on curbing quackery, the Telangana State Medical Council (TSMC) has introduced several reforms that benefit registered doctors in the state. Over the past year, the Council's office-bearers reduced the registration and renewal fees by 50 per cent for all doctors. Moreover, senior doctors above the age of 65 have been exempted from paying renewal fees altogether. &nbsp; &nbsp;</p> <p style="text-align: justify; ">The TSMC has collaborated with the National Medical Commission (NMC) to conduct a training and workshop aimed at improving the handling of misconduct and appeal cases. The training, held in Hyderabad, was attended by professors from various government medical colleges in the state. The State Medical Council has rolled out online renewals and is now issuing good-standing certificates online, eliminating the need for doctors to visit in person and saving them valuable time, reports the Daily. &nbsp; &nbsp;</p></div><div class="hocal-draggable" draggable="true"><div class="read-this-also-wrap"><a class="also-read-media-wrap" href="https://medicaldialogues.in/ayush/ayurveda/news/8th-national-siddha-day-contribution-of-siddha-in-national-ayush-mission-commendable-says-ayush-secretary-140215"><img class="also-read-media" data-src="https://medicaldialogues.in/h-upload/2024/12/21/265878-national-ayush-mission.webp"></a><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/ayush/ayurveda/news/8th-national-siddha-day-contribution-of-siddha-in-national-ayush-mission-commendable-says-ayush-secretary-140215"><span class="read-this-also">Also Read:</span>8th National Siddha Day: Contribution of Siddha in National Ayush Mission Commendable, says AYUSH Secretary</a><div></div></div></div><div class="pasted-from-word-wrapper"><p style="text-align: justify; ">As per the recent media report by Telangana Today, vice-chairman of TSMC, Dr G Srinivas said, “Earlier, doctors used to stand in lone queues to get such paperwork done. There was a time when doctors used to visit the Council office and reserve their position in the queue by marking it with their names on a piece of paper. Now, everything is online.” &nbsp; &nbsp;&nbsp;</p> <p style="text-align: justify; ">The Council also recently granted accreditation to six scientific doctor associations, including IMA Warangal, API (Association of Physicians of India), and ISA, to conduct Continuing Professional Development (CPD) programs in district areas. These programs are designed to offer half or one credit point, under the guidelines set by the National Medical Commission (NMC). &nbsp;</p></div>

138. Rare Disease Show Episode 21: Understanding C3 Glomerulopathy with Dr Anil Kumar B T

     Thu, 26 Dec 2024 10:50:52 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/26/266597-mdtv-16.webp' /><p align="justify">Medical Dialogues presents a <a href="https://medicaldialogues.in/channels/rare-disease-show">rare disease</a> series, delving into the realm of uncommon <a href="https://medicaldialogues.in/top-medical-news">medical</a> conditions. Rare diseases are medical conditions that affect only a small percentage of the population.</p><p align="justify"> Throughout this series, we'll discuss these rare diseases in various episodes, with medical experts providing clear explanations and insights. </p><p align="justify">Rare Disease Show Episode 21: In today's show we will cover C3 Glomerulopathy: Dense Deposit Disease and C3 Glomerulonephritis. </p><p align="justify"> C3 Glomerulopathy is a rare group of kidney disorders caused by abnormal activation of the complement system, a part of the immune system. It includes two main types: Dense Deposit Disease (DDD) and C3 Glomerulonephritis (C3GN).</p><p align="justify"> Both conditions lead to the deposition of complement protein C3 in the glomeruli, the kidney's filtering units, causing inflammation and damage. Symptoms may include blood in urine (haematuria), protein in urine (proteinuria), swelling, and high blood pressure. </p><p align="justify">Over time, they can progress to chronic kidney disease or kidney failure. Diagnosis involves kidney biopsy, laboratory tests, and imaging studies. Treatment focuses on managing symptoms, slowing disease progression, and addressing underlying immune dysfunction, often using medications like corticosteroids or complement inhibitors. </p><p align="justify">In this episode, Dr Anil Kumar B T, HOD and Sr Consultant - Nephrologist and Transplant Physician at Gleneagles BGS Hospital, Kengeri, Bengaluru shares his insights by addressing questions asked by the Medical Dialogues team- </p><p align="justify">1. Could you explain what C3 Glomerulopathy is and how it differs from other kidney diseases, most importantly why does this classify as a rare disease?</p><p align="justify"> 2. What is the underlying pathophysiology of Dense Deposit Disease (DDD) and C3 Glomerulonephritis (C3GN)? How do these diseases impact the kidney’s ability to function? </p><p align="justify">3. What are the common symptoms and signs that might indicate a person has DDD or C3GN? </p><p align="justify">4. How is C3 Glomerulopathy diagnosed? What tests and biomarkers are most helpful in diagnosing these conditions? </p><p align="justify">5. What are the typical progression patterns of DDD and C3GN? How quickly do they typically lead to kidney failure? </p><p align="justify">6. How does the presence of C3 Glomerulopathy influence the prognosis after kidney transplantation? </p><p align="justify">7. How are C3 Glomerulopathy patients typically managed before they need a transplant? </p><p align="justify">8. What role do complement inhibitors (like eculizumab) play in the treatment of DDD and C3GN? </p><p align="justify">9. What are the challenges in performing kidney transplants in patients with C3 Glomerulopathy?</p><p align="justify"> 10. Are there any specific protocols you follow to minimize the risk of recurrence in kidney transplant recipients with these conditions? </p><p align="justify">11. What are the long-term monitoring and follow-up requirements for kidney transplant patients with a history of C3 Glomerulopathy? </p><p align="justify">12. Are there any promising clinical trials or new therapies that could potentially improve outcomes for patients with these conditions?</p>

139. Amit Agrawal takes charge as Secretary of Department of Pharma

     Thu, 26 Dec 2024 10:07:47 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/26/266581-amit-agrawal-50.webp' /><p><span style="text-align: justify;">New Delhi: Amit Agrawal, IAS has assumed the role of Secretary of the <a href="https://medicaldialogues.in/topics/department-of-pharma">Department of Pharmaceuticals</a>,&nbsp;Ministry of Chemicals and Fertilizers. Aggrawal succeeds Arunish Chawla, who has been appointed as Secretary of Department of Revenue, Ministry of Finance.</span></p><p style="text-align: justify; ">In a recent notification, Secretary of Appointments Committee of the Cabinet and Establishment officer said, " Appointments Committee of the Cabinet (ACC) has approved the appointment of Shri Arunish Chawla, IAS (BH:92), Secretary, Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers as Secretary, Department of Revenue, Ministry of Finance. He will continue to hold the additional charge of Secretary, Ministry of Culture till the appointment of a regular incumbent or until further orders whichever is earlier."</p><p style="text-align: justify; ">"Shri Amit Agrawal, IAS (CG:93), Chief Executive Officer, Unique Identification Authority of India as Secretary, Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers vice Shri Arunish Chawla, IAS (BH:92) upon his appointment as Secretary, Department of Revenue, Ministry of Finance," it further stated.</p><div class="pasted-from-word-wrapper"><div style="text-align: justify; "><span style="background-color: rgb(249, 249, 249);">Arunish will continue to hold the additional charge of Secretary, Ministry of Culture till the appointment of a regular incumbent or until further orders whichever is earlier.</span></div><div style="text-align: justify; "><span style="background-color: rgb(249, 249, 249);">Amit Agrawal is an officer of the 1993 batch IAS from the Chhattisgarh cadre.&nbsp;</span><span style="background-color: rgb(249, 249, 249);">A graduate from the Indian Institute of Technology, Kanpur, he held several important positions both at the Centre and states of Chhattisgarh and Madhya Pradesh. He holds the position of&nbsp;</span><span style="background-color: rgb(249, 249, 249);">Chief Executive Officer of&nbsp;</span><span style="background-color: rgb(249, 249, 249);">Unique Identification Authority of India.&nbsp;</span><span style="background-color: rgb(249, 249, 249);">Prior to joining UIDAI as CEO, he was Additional Secretary in the Ministry of Electronics and Information Technology (MeitY). Before that he was Additional Secretary and Joint Secretary in the Ministry of Finance.&nbsp;</span><span style="background-color: rgb(249, 249, 249);">In Chhattisgarh, he served as the Finance Secretary and the Secretary in charge of the Departments of Commercial Tax and Technical Education in the State Government among other roles.</span></div><div style="text-align: justify; "><b><i>Read also: <a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/industry/medical-devices/dop-releases-rs-500-crore-operational-guidelines-for-strengthening-of-medical-device-industry-scheme-138144" style="background-color: rgb(255, 255, 255);">DoP Releases Rs 500 Crore Operational Guidelines for Strengthening of Medical Device Industry Scheme</a></i></b></div></div>

140. Lack of Pre-Op Investigations, Informed Consent: NCDRC upholds Rs 50 lakh compensation on Fortis Hospital Neurosurgeons

     Thu, 26 Dec 2024 09:48:19 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/05/17/238476-medical-negligence-1.webp' /><p style="text-align: justify; "><b>New Delhi:</b>&nbsp;The <a href="https://medicaldialogues.in/topics/national-consumer-disputes-redressal-commission">National Consumer Disputes Redressal Commission</a> (NCDRC) recently upheld Rs 50 lakh <a href="https://medicaldialogues.in/topics/compensation">compensation</a> slapped against Fortis Hospital doctors for medical negligence while treating a patient suffering from 'Mobile Atlanto Axial Dislocation' or AAD.</p><p style="text-align: justify; ">However, it exonerated the hospital and its Medical Superintendent after noting that there was no evidence to establish even vicarious liability on the hospital.</p><p style="text-align: justify; ">The history of the case goes back to 2011 when the complainant's son, who was suffering from AAD due to childhood injury, got admitted to Fortis Escort Hospital in Jaipur for surgery.</p><p style="text-align: justify; ">AAD is related to injury to the spinal cord and the cervical area which leads to progressive neurological deterioration including high cervical myelopathy (pressure on the spinal cord) with symptoms of weakness, spasticity (stiffness), wasting (atrophy of muscles) and respiratory compromise.</p><p style="text-align: justify; ">Since investigations were already done in September 2011, the surgery was conducted at Fortis Hospital on 24.11.2011 without conducting any further investigations. Two days later, the patient was discharged and subsequently, the patient expired during hospitalisation at Mittal Hospital on 01.05.2012 due to cardiac arrest.&nbsp;</p><p style="text-align: justify; ">The hospital had also issued a certificate earlier on 08.04.2012 stating that the patient had been brought on 26.12.2011 in a Critical Care Ambulance on ventilator and that he had continued to be on the ventilator since then as he could not be weaned off the ventilator since his left lung was collapsed with quadriplegia.</p><p style="text-align: justify; ">When the complainants approached the State Commission, Rajasthan seeking compensation, the State Consumer Court opined that due to negligence of the treating doctors and negligence caused during the operation, the patient's health deteriorated day by day and finally the patient died on 01.05.2012. Accordingly, it had directed the Fortis Hospital and its treating doctors to pay Rs 50 lakh in compensation to the complainants.</p><p style="text-align: justify; ">Challenging the State Commission's order, the hospital and the doctors filed an appeal before the Apex Consumer Court i.e. NCDRC. They argued that the patient was diagnosed with cranio vertebral junction (CVJ) and was advised dynamic (flexion, extension, neutral) X Ray of the CVJ. On 14.09.2011 the earlier test reports of the Department of Neurosurgery SMS Medical College were reviewed. A line of treatment for the disease, including need for surgery and attendant risks were informed and immediate surgery advised. Consequently, the patient was admitted to the hospital, where two surgeries were done on 23/24.11.2011. Thereafter, he was discharged against medical advice and was shifted to Alwar in a critical condition while on ventilator considering the high cost of medicare in the treating hospital.</p><p style="text-align: justify; ">As per the hospital and the doctors, AAD was a serious disease caused due to fracture of the odontoid process of the C2 vertebral body due to fall from height of about 20 feet. Any sudden movement of the neck forward would result in quadriplegia or weakness in all four limbs and pentaplagoa (weakness in all four limbs as well as compromised respiration).</p><p style="text-align: justify; ">The hospital and its doctors claimed that the patient had not been provided adequate treatment for nearly 15 years and therefore suffered neurological deterioration. They also submitted that the informed consent for the surgery had been obtained from the patient and attendants and was done in the supervision of the the treating doctors and a team of doctors as per prescribed medical techniques and procedures.</p><p style="text-align: justify; ">Further, they argued that the complainant had not specifically proven which procedure or treatment was done incorrectly and that the alleged weakness and condition post-surgery was a natural situation in such a complicated surgery and could not be attributed to any incorrect surgery or failure, especially when the patient survived for months after the surgery. It was argued that proper neurological postsurgery care was no provided which was very important.</p><p style="text-align: justify; ">Appealing before NCDRC bench, the hospital and its doctors argued that as per the settled principles of law, in the case of medical negligence, it was necessary for the complainant to establish his case with cogent evidence. They relied on the Supreme Court order in the case of Jacob Mathew Vs State of Punjab &amp; Anr., and Martin F D’Souza vs Mohammad Ishfaq and other legal precedence.</p><p style="text-align: justify; ">Relying on these judgments, they also argued that no guarantee was given by any doctor or surgeon that the patient would be cured and that every death in the institutionalised environment of the hospital did not necessarily amount to medical negligence on a hypothetical assumption of lack of due medical care.</p><p style="text-align: justify; ">On the other hand, the complainants argued that before the surgery, the patient had weakness in his limbs for two months including numbness in the upper limbs hands but was conscious and following verbal commands. The power in his four limbs was 4/5 grip and his chest was clear. Therefore, his condition was normal and he was breathing normally.</p><p style="text-align: justify; ">The complainants argued that there was no case of urgency to operate the patient. However, the doctors performed the surgery on the upper spine of the patient in undue haste and without proper pre-operative essential investigations because of greed of money.</p><p style="text-align: justify; ">Further, it was alleged that apart from some lab investigations of the blood, no fresh MRI, CT scan or X-ray of cervical spine or other investigations such as myelogram was conducted to visualize the state of the spinal cord or any malformation or syringomyelia. CT guided needle aspiration biopsy or pre-operative respiratory tissue culture was done. It was claimed that the hospital and the doctors acted negligently on the presumptive diagnosis tha the patient was suffering from mobile AAD based on the old MRI and CT scan reports of SMS Hospital dated 13.09.2011.</p><p style="text-align: justify; ">Referring to the discharge summary and CT scan report dated 30.11.2011, the complainants argued that following the trans oral decompression surgery, bony pieces (osteophytes) at C3-C4 level were noted in the MRI of cervical spine dated 05.12.2011 which confirmed the presence of bony components in the spinal canal.</p><p style="text-align: justify; ">The bony pieces left in the canal were compressing the cord since spinal cord had thinned at that level. This was a post operation development due to negligence of the treating doctors and the hospital since they had not been seen in earlier CT scan and MRI done at SMS Hospital, alleged the complainant. Reliance was placed on Supreme Court judgments in the case of Dr Balaram Prasad vs Dr Kunal and others, Magesh vs Dr Mehta etc. It was submitted that a civil liability case is governed by the principle of res ipsa loquitur. Therefore, once the initial burden had been discharged by making out a case of negligence the onus was on the hospital and doctors to establish that there was no lack of care or diligence.</p><p style="text-align: justify; ">After considering the arguments by both the sides, the NCDRC bench noted that in matters where an allegation of medical negligence is made against a doctor or hospital (or both), it is the settled proposition of law that the definition of ‘service’ under Section 2(1)(d) of the Act has to be understood on broad parameters and it cannot exclude service rendered by a medical practitioner. It has also been well laid down that the jurisprudential concept of negligence differs in civil and criminal law, the Commission noted.</p><p style="text-align: justify; ">Referring to the Supreme Court order in the case of Jacob Mathew, the NCDRC bench noted, <i>"The essential components of negligence, as recognized, are three: existence of a duty to take care, which is owed by the defendant to the complainant; failure to attain that standard of care, thereby committing a breach of such duty; and “resulting damage”, which is both casually connected with such breach and has been suffered by the complainant. If these three ingredients are made out on the basis of evidence, the defendant should be held liable in negligence."</i></p><p style="text-align: justify; ">The top consumer court also referred to Supreme Court orders in the case of V. Kishan Rao Vs. Nikhil Super Speciality Hospital &amp; Anr.,Indian Medical Association vs V.P. Shantha &amp; Ors., and Dr. J.J. Merchant &amp; Ors vs Shrinath Chaturvedi, and observed, <i>"From the record it is apparent that the appellant hospital and the appellant doctors had not prescribed or conducted pre-surgery investigations as alleged by the respondent. Surgical procedures were embarked upon essentially on the basis of tests done at SMS, Hospital, Jaipur without evaluation of the patient through tests at the appellant hospital except some pre-surgery test conducted on admission of the patient in the appellant hospital. No evidence has been brought on record by the appellants to counter the allegations in this regard by the respondent."</i></p><p style="text-align: justify; ">Perusing the material on record, the Commission also observed that prior consent was only obtained for the surgical procedure relating to internal fixation of posterior arches on 23/24.11.2011 and there was no documents to indicate that prior consent for any other procedure had been obtained.&nbsp;</p><p style="text-align: justify; "><i>"The appellants were mandated to obtain prior informed consent for the second operation for Trans Oral Decompression on 28/29.11.2011. No documentary evidence is available for the same. Thus, as per the principles laid down in Jacob Matthew (supra), it is evident that the appellant hospital and the appellant doctors who owed the respondent’s son a duty of care in respect of the medical procedures/ operations for AAD breached that standard of care. The post operative MRI reports also indicate that there was no material change in the patient’s condition," </i>observed the consumer court.</p><p style="text-align: justify; ">Accordingly, agreeing with the Ste Commission's order, the NCDRC bench noted, <i>"It is evident from the above that the appellant doctors failed to establish why the surgeries were performed without the requisite pre-operation investigations and instead relied upon investigations conducted elsewhere earlier and why tracheostomy was undertaken without prior consent. Medical negligence on part of the appellant doctors (Appellants 2 and 3) is therefore clearly established in this case although the State Commission, on the basis of the doctrine of res ipsa , held the appellants to be jointly and severally held liable to pay compensation to the respondent. As regards the quantum of compensation awarded, a lump sum award in the case of death appears reasonable as it covers both the costs and compensation."</i></p><p style="text-align: justify; ">Therefore, the Commission held that the <a href="https://medicaldialogues.in/topics/state-consumer-disputes-redressal-commission">State Consumer Court</a>'s order did not suffer from any legal infirmity and did not warrant interference. However, the Commission opined that the liability of the appellant hospital had not been established and therefore, the order fastening liability on the hospital was not established.</p><p style="text-align: justify; "><i>"The case of the respondent is that the doctors rushed the deceased patient into surgery without adhering to the established protocol of pre-operative surgeries and thereafter conducted surgical interventions without following the standard operating procedure of prior informed consent being obtained. There is no specific allegation of negligence on part of the hospital (appellant no. 1) to establish even vicarious liability or on appellant no. 2 for any failure to provide medical services,"</i> observed the NCDRC bench while exonering the hospital and its Medical Superintendent.</p><p style="text-align: justify; "><b><i>To view the order, click on the link below:</i></b></p><p style="text-align: justify; "><a href="https://medicaldialogues.in/pdf_upload/fortis-hospital-ncdrc-266541.pdf"><b><i>https://medicaldialogues.in/pdf_upload/fortis-hospital-ncdrc-266541.pdf</i></b></a></p><p style="text-align: justify; "><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/medico-legal/hc-sets-aside-ncdrc-order-slapping-rs-93-lakh-compensation-on-doctor-140418" style="background-color: rgb(255, 255, 255);"><b><i>Also Read: HC Sets Aside NCDRC Order Slapping Rs 93 Lakh Compensation on Doctor</i></b></a></p>

141. Increase MBBS Seats in Private Medical Colleges to Provide EWS Reservation: MP HC order

     Thu, 26 Dec 2024 09:44:45 -0000

     <img src='https://medicaldialogues.in/h-upload/2022/09/26/186283-madhya-pradesh-high-court.webp' /><p style="text-align: justify; "><b>Bhopal:</b>&nbsp;Noting that there is no provision for <a href="https://medicaldialogues.in/topics/ews-quota">EWS seats</a> in the private medical colleges, a Division bench of the <a href="https://medicaldialogues.in/topics/madhya-pradesh-high-court">Madhya Pradesh High Court</a> on Monday asked the State Government to increase the seats in the private medical colleges to provide reservation to the candidates belonging to Economically Weaker Section (EWS) category.</p><p style="text-align: justify; ">Further, the Division bench of the HC comprising Chief Justice Suresh Kumar Kait and Justice Vivek Jain also took cognisance of the fact that there is no provision for EWS seats in the private medical colleges under the rules framed in the State. The bench opined that this violated the 103rd amendment providing a separate quota for EWS candidates.</p><p style="text-align: justify; ">Accordingly, the State was granted a year's time by the HC bench to complete the formalities regarding the infrastructure and other things before the seats were hiked, TOI has reported.</p><p style="text-align: justify; ">These observations were made by the Court while considering the plea by a Jabalpur-based student Atharva Chaturvedi. After appearing in the National Eligibility-cum-Entrance Test (NEET) as an EWS candidate, he secured 530 of 720 percentile marks.</p><p style="text-align: justify; "><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/education/medical-admissions/medical-colleges-cannot-take-ews-admissions-beyond-permitted-seats-national-medical-commission-warning-119094" style="background-color: rgb(255, 255, 255);"><b><i>Also Read: Medical Colleges CANNOT take EWS Admissions Beyond Permitted Seats: National Medical Commission Warning</i></b></a></p><p style="text-align: justify; ">As per the latest media report by the <a href="https://timesofindia.indiatimes.com/city/bhopal/hc-orders-state-to-hike-ews-seats-in-pvt-medical-colleges/articleshow/116606799.cms" rel="nofollow">Times of India</a>, allegedly, even though NRI candidates with lesser marks and government school quota general category students with lesser marks secured admission in the private medical colleges, the petitioner student was denied admission.</p><p style="text-align: justify; ">Therefore, the petitioner challenged the State Government's notification which specified the rules for admission to medical colleges. He argued that in the private medical colleges, EWS seats were not reserved even though the same reservation is available in the government medical colleges.</p><p style="text-align: justify; ">Further, the petitioner contended that even though the Central Government issued a notification in this regard in 2019 itself, it was not followed by the Madhya Pradesh Government. As a result, EWS candidates were deprived of getting a seat in a private medical college.</p><p style="text-align: justify; ">On the other hand, the State Government submitted that the candidates were well aware of the rules at the time of appearing in the NEET exam. Further, the State argued that since the admission process for this academic session was already complete, rules could not be changed for admissions at this point of time.</p><p style="text-align: justify; ">Apart from this, the State also highlighted that the National Medical Commission had not given any directions to increase the seats in private medical colleges and therefore, EWS quota seats were not kept in private medical colleges.</p><p style="text-align: justify; ">While appreciating the arguments of the 19-year-old boy, the Court allowed the plea with a direction to the State Government to increase the seats in the private medical colleges for the EWS candidates.</p><p style="text-align: justify; ">Medical Dialogues had earlier reported that last year NMC had warned medical colleges not to admit MBBS students under the Economically Weaker Section (EWS) quota beyond the permitted seats.&nbsp;</p><p style="text-align: justify; ">Issuing a notice in this regard on 20.10.2023, <a href="https://medicaldialogues.in/topics/nmc">NMC</a> had highlighted the practice adopted by medical institutes admitting additional students for the MBBS course under the Economical Weaker Section quota over and above the sanctioned seat.</p><p style="text-align: justify; ">Back then the Commission had warned that all institutes were "required to admit the sanctioned number of students including EWS category within the permitted seat quota," further adding that "no additional seat shall be permitted by the National Medical Commission".</p><p style="text-align: justify; "><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/mdtv/healthshorts/hc-puts-hold-on-mbbs-seat-cancellations-in-nri-quota-forgery-case-139231" style="background-color: rgb(255, 255, 255);"><b><i>Also Read: HC puts hold on MBBS seat cancellations in NRI quota forgery case</i></b></a></p>

142. 23-year-old MBBS Student held for transferring Rs 8 lakh to Chinese gang via cryptocurrency

     Thu, 26 Dec 2024 09:34:41 -0000

     <img src='https://medicaldialogues.in/h-upload/2023/01/09/197115-cyber-fraud-3.webp' /><p><b>Indore: </b>In a recent&nbsp;<a href="https://medicaldialogues.in/topics/cyber-fraud" rel="nofollow">cyber fraud</a> case, Indore Police have arrested a 23-year-old&nbsp;<a href="https://medicaldialogues.in/topics/mbbs-student">MBBS student</a>&nbsp;for his his role in converting and transferring approximately Rs 8 lakh of defrauded money into cryptocurrency, which was then sent to an international gang. The arrest followed an investigation into a case where a city-based software engineer was cheated of Rs 1.35 lakh.</p><p>The accused, identified as a resident of Jodhpur and a third-year MBBS student at Government Medical College (GMC) Alibag, Maharashtra, was apprehended for his role in facilitating the conversion of stolen funds into cryptocurrency, which he then transferred to a Chinese crypto wallet.</p><p><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/doctors/crypto-investment-scam-hyderabad-doctor-cheated-of-rs-11-crore-139590" style="background-color: rgb(255, 255, 255);"><b>Also Read: Crypto Investment Scam: Hyderabad doctor cheated of Rs 11 crore</b></a><br></p><p>The arrest was made following a detailed investigation, led by Deputy Commissioner of Police (DCP) Rajesh Kumar Tripathi. During interrogation, it was revealed that the suspect had been supplying bank accounts to a gang in exchange for a commission, facilitating cyber fraud activities. He was also found to be linked to five Chinese nationals through a group on the Telegram messaging app.</p><p>As per the recent media report, Tripathi told <a href="https://timesofindia.indiatimes.com/city/jaipur/mbbs-student-held-for-laundering-8-lakh-to-chinese-gang-via-crypto/articleshow/116662451.cms" rel="nofollow">TOI</a>, "We came to know that Vishnoi used to convert the cyber fraud money deposited in Indian bank accounts into cryptocurrency and send it to the Chinese gang. We are investigating thoroughly the role of the Chinese gang in carrying out cyber crimes in India."</p><p>According to Additional Deputy Commissioner of Police Rajesh Dandotia, the accused, converted money obtained through cyber fraud into cryptocurrency via an account on the exchange platform Binance. He then transferred the converted funds to a Chinese crypto wallet, identified by the alias ‘TLX’, using a QR code. Dandotia further revealed that the accused had so far laundered approximately Rs 8 lakh by converting it into cryptocurrency and sending it to the ‘TLX’ wallet. </p><p>In addition, Dandotia also revealed that the accused communicated with the Chinese youth through a chatbot equipped with a translation feature, allowing conversations in both English and Chinese. As part of their investigation into the transfer of cyber fraud funds to the Chinese gang, the Indore police have sent official requests for information to Telegram and Binance. &nbsp;</p><div class="pasted-from-word-wrapper"><b><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/doctors/odisha-doctor-loses-rs-75000-in-cyber-fraud-139755">Also Read: Odisha doctor loses Rs 75000 in Cyber Fraud</a></b></div>

143. Medical Bulletin 26/ December/ 2024

     Thu, 26 Dec 2024 09:30:00 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/26/266538-top-medical-50.webp' /><p style="text-align: justify; "><b>Here are the top medical news for the day:</b></p><div class="pasted-from-word-wrapper"><div style="text-align: justify;"><b>Researchers Unveil Efficacy and Safety of New Migraine Drug</b></div><div style="text-align: justify;">A drug recently approved to prevent migraine may start working right away, according to a study published online issue of Neurology®, the medical journal of the American Academy of Neurology. The study looked at the drug atogepant, which is a calcitonin gene-related peptide (CGRP) receptor antagonist taken by mouth.</div><div style="text-align: justify;">In the study, people taking the drug atogepant were less likely to have a migraine on the first day of taking the drug compared to those taking a placebo. They also had fewer migraines per week during each of the first four weeks of the study and fewer migraines during the study overall than those taking a placebo.</div><div style="text-align: justify;">For this study, researchers looked at the data from three trials on the safety and effectiveness of atogepant over 12 weeks to focus on how rapidly improvements appeared. There were 3 trials - ADVANCE trial, ELEVATE trial and PROGRESS trial, which enrolled people with episodic migraine.</div><div style="text-align: justify;">People with episodic migraine experience up to 14 migraine days per month. People with chronic migraine experience at least 15 days with headache per month, with at least eight days being characteristic of migraine. On the first day of the study, 12% of those taking the drug in the first trial, the ADVANCE trial had a migraine, compared to 25% of those taking placebo. In the second trial, the ELEVATE trial, the numbers were 15% and 26%. For the third trial, the PROGRESS trial, the numbers were 51% and 61%. When researchers adjusted for other factors that could affect the rate of migraine, they found that people taking the drug were 61% less likely to have a migraine in the first trial, 47% less likely in the second trial, and 37% less likely in the third trial. </div><div style="text-align: justify;">Reference: Lipton, R. B., Gandhi, P., Tassorelli, C., Reuter, U., Harriott, A. M., Holle-Lee, D., Gottschalk, C. H., Neel, B., Liu, Y., Guo, H., Stokes, J., Nagy, K., Dabruzzo, B., &amp; Smith, J. H. (2025, January 28). Early improvements with atogepant for the preventive treatment of migraine: Results from 3 randomized phase 3 trials. Neurology, 104(2), Article 0000000000210212. https://doi.org/10.1212/WNL.0000000000210212</div><div></div><div></div><div></div><div style="text-align: justify;"><b>Simple Scan Could Predict Risk of Serious Cardiac Events</b></div><div style="text-align: justify;">The researchers, led by Frederick H. Epstein, PhD, of the University of Virginia’s Department of Biomedical Engineering, are seeking to use magnetic resonance imaging (MRI) to assess the composition of adipose tissue – fat – that surrounds the heart. The researchers have published their findings in the scientific journal Magnetic Resonance in Medicine. </div><div style="text-align: justify;">Analyzing this tissue could let doctors identify patients at greatest risk for potentially deadly cardiac problems and to predict how well those patients may respond to treatments. </div><div style="text-align: justify;">Early testing of the technique has produced encouraging signs that the approach could be a powerful tool to improve patient care.</div><div style="text-align: justify;">The UVA researchers would use MRI to assess the amount and composition of the fat. The imaging technology essentially lets them see inside the body without the need for surgery. By analyzing the amounts of saturated fatty acids, monosaturated fatty acids and polyunsaturated fatty acids – fats commonly associated with our diets – in the epicardial adipose tissue, doctors may be able to identify patients who could face heart problems even before symptoms appear. Identifying and correcting this problem has the potential to slow down the progression of heart disease.</div><div style="text-align: justify;">By developing innovative imaging approaches, the scientists are now able to get the images they need in the span of a single breath hold.</div><div style="text-align: justify;">The UVA team has already tested their technology in both the lab and in a limited number of human patients. They found that the fat around the heart in patients who were obese and had suffered heart attacks was comprised of an excessive amount of saturated fatty acids. </div><div style="text-align: justify;">Reference: Echols JT, Wang S, Patel AR, Hogwood AC, Abbate A, Epstein FH. Fatty acid composition MRI of epicardial adipose tissue: Methods and detection of proinflammatory biomarkers in ST-segment elevation myocardial infarction patients. Magn Reson Med. 2025; 93: 519-535. doi: 10.1002/mrm.30285</div><div></div><div></div><div></div><div></div><div></div><div style="text-align: justify;"><b>Can Cancer Cells Revert to Normal Cells?</b></div><div style="text-align: justify;">A research team led by Professor Kwang-Hyun Cho from the Department of Bio and Brain Engineering has developed a technology that can treat colon cancer by converting cancer cells into a state resembling normal colon cells without killing them, thus avoiding side effects.</div><div style="text-align: justify;">The research team focused on the observation that during the oncogenesis process, normal cells regress along their differentiation trajectory.</div><div style="text-align: justify;">Building on this insight, they developed a technology to create a digital twin of the gene network associated with the differentiation trajectory of normal cells.</div><div style="text-align: justify;">Through simulation analysis, the team systematically identified master molecular switches that induce normal cell differentiation.</div><div style="text-align: justify;">When these switches were applied to colon cancer cells, the cancer cells reverted to a normal-like state, a result confirmed through molecular and cellular experiments as well as animal studies.</div><div style="text-align: justify;">This research demonstrates that cancer cell reversion can be systematically achieved by analyzing and utilizing the digital twin of the cancer cell gene network, rather than relying on serendipitous discoveries.</div><div style="text-align: justify;">The findings hold significant promise for developing reversible cancer therapies that can be applied to various types of cancer.</div><div style="text-align: justify;">Professor Kwang-Hyun Cho remarked, "The fact that cancer cells can be converted back to normal cells is an astonishing phenomenon. This study proves that such reversion can be systematically induced."</div><div style="text-align: justify;">He further emphasized, "This research introduces the novel concept of reversible cancer therapy by reverting cancer cells to normal cells. It also develops foundational technology for identifying targets for cancer reversion through the systematic analysis of normal cell differentiation trajectories."</div><div style="text-align: justify;">Reference: https://news.kaist.ac.kr/newsen/html/news/?mode=V&amp;mng_no=42710</div></div>

144. Allegedly Frustrated with life, 2nd-year MBBS at AIIMS Bhubaneswar ends life

     Thu, 26 Dec 2024 08:58:14 -0000

     <img src='https://medicaldialogues.in/h-upload/2023/01/09/197056-suicide.webp' /><p style="text-align: justify; "><b>Bhubaneswar: </b>Feeling frustrated over life and possibly distressed over his father's financial issues, a 21-year-old second-year MBBS student of the All India Institute of Medical Sciences (AIIMS) Bhubaneswar allegedly committed <a href="https://medicaldialogues.in/topics/suicide" target="_blank">suicide</a> by hanging from the ceiling in his hostel room on Wednesday moments before going on a trip to Puri with his father.&nbsp;</p><p style="text-align: justify; ">A suicide note written by the student was recovered by the police which stated, "Nobody was responsible for his death and expressed his frustration over his life." Moreover, before taking the extreme step, the student also sent an audio message to his younger brother advising him to pursue his dream of becoming a doctor by staying in Assam and asking him not to sell the land in their hometown.&nbsp;</p><p style="text-align: justify; "><b>Also read- <a href="IGIMS 2nd year PG Radiology ends life by hanging" target="_blank">IGIMS 2nd year PG Radiology end=s life by hanging</a></b></p><p style="text-align: justify; ">Although the exact reason behind the student's death is unclear, the police suspect that the student was possibly disturbed by his family going through some financial issues. The deceased was a native of Assam who was studying at AIIMS in Bhubaneswar, Odisha.&nbsp;</p><p style="text-align: justify; ">As per a <a href="https://timesofindia.indiatimes.com/city/bhubaneswar/expressed-frustration-over-his-life-aiims-bhubaneswar-mbbs-student-from-assam-ends-life/articleshow/116672110.cms" rel="nofollow">TOI </a>news report, the incident took place after the student arrived in the city from Assam with his father on December 24 to appear for his second-year exam on Wednesday. He stayed in his hometown for 10 days. Since his father had accompanied him, he planned a trip to Puri with his father to visit the Shree Jagannath temple. Therefore, his father was staying at a nearby guest house.&nbsp;</p><p style="text-align: justify; ">The police confirmed that the father had a chat over the phone with his son on Tuesday morning and planned the trip. “His father stayed in a hotel at night after having dinner together. His father mentioned that he received a call from his son on Tuesday morning, and they planned to visit Jagannath Temple, Puri together in the morning,” said the police.&nbsp;</p><p style="text-align: justify; ">However, the father was unable to get in touch with his son after some time. Despite calling him multiple times, the student did not respond. Before taking the extreme step, the student sent an audio message to his younger brother. The brother then alerted their father about the message.&nbsp;</p><p style="text-align: justify; ">Feeling worried, the student's father rushed to the hostel around 9.30 am. When he reached the hostel, he found that the door was locked from the inside and no response was coming from inside the room. His father, along with some students, broke the door and found him hanging from the ceiling fan at around 10.30 am.</p><p style="text-align: justify; ">Following this, the police were alerted and they reached the spot immediately. They conducted a preliminary investigation and found the note written by the student.&nbsp;</p><p style="text-align: justify; ">Speaking to TOI, Abhimanyu Das, Inspector-in-Charge of Khandagiri police station said, “We are investigating the case after registering an unnatural death case,” said Abhimanyu Das, Inspector-in-Charge of Khandagiri police station.</p><p style="text-align: justify; "><b>Also read- <a href="https://medicaldialogues.in/news/education/medical-colleges/kozhikode-gmc-nursing-student-commits-suicide-140176" target="_blank">Kozhikode GMC nursing student commits suicide</a></b></p>

145. Free Treatment for Sexual Violence, Acid Attack Survivors Mandatory at All Hospitals: Delhi HC

     Thu, 26 Dec 2024 08:49:27 -0000

     <img src='https://medicaldialogues.in/h-upload/2020/07/01/131102-free-medical-treatment.webp' /><div class="pasted-from-word-wrapper"><p><span style="text-align: justify;">New Delhi:&nbsp;</span><span style="text-align: justify;">The <a href="https://medicaldialogues.in/topics/delhi-high-court" target="_blank">Delhi High Court</a> has&nbsp;</span>mandated that all government and private hospitals provide&nbsp;<a href="https://medicaldialogues.in/topics/free-medical-treatment" target="_blank">free medical treatment</a>&nbsp;to victims of sexual violence, acid attacks, and rape. The court made this observation while hearing the case of a 16-year-old rape survivor who was made to wait for medical treatment.</p><p><span style="text-align: justify;">According to a UNI report, a bench comprising Justices Prathiba M Singh and Amit Sharma, in its December 10 order, mandated that medical establishments must offer first aid, diagnostic tests, lab work, and other necessary treatments at no cost.</span></p></div><div class="pasted-from-word-wrapper"><p style="text-align: justify;">The court warned that failure to comply could result in penalties, including imprisonment or fines.</p><p style="text-align: justify;">The court underscored that hospitals are obligated under the Bharatiya Nagarik Suraksha Sanhita (BNSS), the Protection of Children from Sexual Offences (Pocso) Rules, 2020, and guidelines issued by the Union Health Ministry to ensure seamless and free treatment for survivors.</p><p style="text-align: justify;"><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/free-medical-treatment-to-all-citizens-above-age-70-under-ayushman-bharat-scheme-president-murmu-130782"><b><i>Also Read:Free medical treatment to all citizens above age 70 under Ayushman Bharat Scheme: President Murmu</i></b></a></p><p style="text-align: justify;">“Despite clear legal provisions, survivors of sexual violence and acid attacks continue to face significant challenges in accessing free medical care. It is the responsibility of all hospitals, nursing homes, clinics, and medical centres to provide comprehensive free medical treatment to such survivors,” the court observed.</p><p style="text-align: justify;">Under Section 397 of BNSS and Rule 6(4) of the Pocso Rules, hospitals have a legal obligation to provide free first aid and medical care to survivors.</p><p style="text-align: justify;">The bench stated, “Failing to provide such treatment to survivors is a criminal offence, and all doctors, nurses, administrators, and paramedical staff must be made aware of this mandate”, news agency UNI reported.</p><p style="text-align: justify;">The court also directed hospitals to prominently display boards at entrances and reception areas in both English and local languages, stating: “Free out-patient and in-patient medical treatment is available for victims / survivors of sexual assault, rape, gangrape, acid attacks, etc.”</p><p style="text-align: justify;">The Court’s directive came from a case involving a 16-year-old survivor whose father appealed a city court’s conviction of aggravated penetrative sexual assault.</p><p style="text-align: justify;">The Delhi State Legal Services Authority (DSLSA) informed the High Court that the survivor initially faced hurdles in obtaining free treatment.</p><p style="text-align: justify;">DSLSA counsel Abhinav Pandey highlighted the lack of compliance, noting that persuading a private hospital to treat the survivor without charge required significant effort.</p><p style="text-align: justify;">To ensure comprehensive support for survivors, the Court ordered hospitals to provide physical and mental counselling.</p><p style="text-align: justify;">The Court directed that pregnancy checks be conducted and offer contraception when required.</p><p style="text-align: justify;">The Court directed that all the hospital/nursing home staff should be sensitised about legal obligations regarding free treatment.</p><p style="text-align: justify;">The Court emphasized that the hospital staff should avoid insisting on identification proof in emergency cases.</p><p style="text-align: justify;">The Court directed the hospitals to eliminate barriers for survivors seeking medical care, ensure accountability across medical establishments, and create a survivor-friendly healthcare environment.</p><p style="text-align: justify;"><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/centre-to-roll-out-nationwide-cashless-medical-treatment-for-accident-victims-121249"><b><i>Also Read:Centre to roll out nationwide cashless medical treatment for accident victims</i></b></a></p><div></div><div class="hocal-draggable" draggable="true"><div class="read-this-also-wrap"><div></div></div></div></div>

146. UP DGME notifies on SRMS Bareilly PG Medical fee

     Thu, 26 Dec 2024 08:30:00 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/11/29/262801-fees.webp' /><p style="text-align: justify; "><b>Uttar Pradesh-</b>&nbsp;Through a recent notice, the UPDGME has notified that the Sri Ramamurthy Memorial Institute of Medical Sciences (SRMS), Bareilly has issued a letter to the Uttar Pradesh Director General, Medical Education and Training (<a href="https://medicaldialogues.in/topics/updgme" target="_blank">UPDGME</a>) regarding the charging fees from the students of PG 2024 admitted to the college in the postgraduate course (MD / MS) courses.</p><div class="pasted-from-word-wrapper"><p dir="ltr" style="text-align: justify; ">As per the letter, SRMS has informed the candidates who have taken admission through counselling at the designated nodal centre of UP National Eligibility and Entrance Test-Postgraduate (<a href="https://medicaldialogues.in/topics/neet-pg" target="_blank">NEET PG</a>) 2024 at Shri Ramamurthi Memorial Institute of Medical Sciences, Bareilly Mahavidyalaya, to complete the <a href="https://medicaldialogues.in/topics/medical-college-admission" target="_blank">admission</a> process in the following courses at reduced tuition fees fixed by the college. In a total of 14 courses, the tuition fees have been reduced by the SRMS.</p><p dir="ltr" style="text-align: justify; "><b><i>These are as follows-</i></b></p></div><div class="pasted-from-word-wrapper"><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/education/medical-admissions/up-dgme-begins-neet-2024-special-vacancy-round-counselling-138535"><b>Also Read:&nbsp;</b>UP DGME Begins NEET 2024 Special Vacancy Round Counselling</a></div><div class="pasted-from-word-wrapper"><div dir="ltr"><table style="text-align: justify; "><colgroup><col width="52"><col width="260"><col width="156"><col width="156"></colgroup><tbody><tr><td><p dir="ltr" style="text-align: center; "><b>S.NO</b></p></td><td><p dir="ltr" style="text-align: center; "><b>BRANCH NAME</b></p></td><td><p dir="ltr" style="text-align: center; "><b>ANNUALLY TUITION FEES DECIDE BY UP GOVERNMENT FOR SESSION 2024-25 (RS)</b></p></td><td><p dir="ltr" style="text-align: center; "><b>ANNUALLY TUITION FEES DECIDED FOR COLLEGE FOR SESSION 2024-25 (RS)</b></p></td></tr><tr><td><p dir="ltr">1</p></td><td><p dir="ltr">M.S. Otorhinolaryngology (ENT)</p></td><td><p dir="ltr">25,09,957/-</p></td><td><p dir="ltr">22,00,000/-</p></td></tr><tr><td><p dir="ltr">2</p></td><td><p dir="ltr">M.D. Psychiatry.</p></td><td><p dir="ltr">25,09,957/-</p></td><td><p dir="ltr">23,00,000/-</p></td></tr><tr><td><p dir="ltr">3</p></td><td><p dir="ltr">M.D. Anaesthesiology.</p></td><td><p dir="ltr">25,09,957/-</p></td><td><p dir="ltr">22,00,000/-</p></td></tr><tr><td><p dir="ltr">4</p></td><td><p dir="ltr">M.D. Emergency Medicine.</p></td><td><p dir="ltr">25,09,957/-</p></td><td><p dir="ltr">22,00,000/-</p></td></tr><tr><td><p dir="ltr">5</p></td><td><p dir="ltr">M.D. Radiation Oncology</p></td><td><p dir="ltr">25,09,957/-</p></td><td><p dir="ltr">16,00,000/-</p></td></tr><tr><td><p dir="ltr">6</p></td><td><p dir="ltr">M.D. Pathology.</p></td><td><p dir="ltr">13,51,477/-</p></td><td><p dir="ltr">9,00,000/-</p></td></tr><tr><td><p dir="ltr">7</p></td><td><p dir="ltr">M.D. Immuno Haematology &amp; Blood Transfusion.</p></td><td><p dir="ltr">25,09,957/-</p></td><td><p dir="ltr">50,000/-</p></td></tr><tr><td><p dir="ltr">8</p></td><td><p dir="ltr">M.D. Community Medicine</p></td><td><p dir="ltr">9,65,384/-</p></td><td><p dir="ltr">36,000/-</p></td></tr><tr><td><p dir="ltr">9</p></td><td><p dir="ltr">M.D. Microbiology</p></td><td><p dir="ltr">9,65,384/-</p></td><td><p dir="ltr">36,000/-</p></td></tr><tr><td><p dir="ltr">10</p></td><td><p dir="ltr">M.D. Pharmacology.</p></td><td><p dir="ltr">9,65,384/-</p></td><td><p dir="ltr">36,000/-</p></td></tr><tr><td><p dir="ltr">11</p></td><td><p dir="ltr">M.D. Anatomy</p></td><td><p dir="ltr">9,65,384/-</p></td><td><p dir="ltr">36,000/-</p></td></tr><tr><td><p dir="ltr">12</p></td><td><p dir="ltr">M.D. Biochemistry</p></td><td><p dir="ltr">9,65,384/-</p></td><td><p dir="ltr">36,000/-</p></td></tr><tr><td><p dir="ltr">13</p></td><td><p dir="ltr">M.D. Physiology</p></td><td><p dir="ltr">9,65,384/-</p></td><td><p dir="ltr">36,000/-</p></td></tr><tr><td><p dir="ltr">14</p></td><td><p dir="ltr">M.D. Forensic Medicine</p></td><td><p dir="ltr">9,65,384/-</p></td><td><p dir="ltr">36,000/-</p></td></tr><tr><td></td><td></td><td></td><td></td></tr></tbody></table></div><p>The Department of Medical Education plays a pivotal role in developing medical and para-medical personnel to cater to the state's health needs. The department also has a role to play in establishing and maintaining well-equipped teaching institutions, which are the premier referral centres from peripheral hospitals. Research is another area of activity for the medical education department. The directorate facilitates comprehensive medical and dental education via various medical, dental and paramedical colleges in the state of Uttar Pradesh. On the other hand, it also provides standard medical facilities to the patients. The Department of Medical Education was bifurcated in the year 1981 from the department of Medical Health Services.&nbsp;</p><p dir="ltr" style="text-align: justify; "><b><u><i>To view the letter, click the link below</i></u></b></p><p dir="ltr" style="text-align: justify; "><a href="https://medicaldialogues.in/pdf_upload/srms-bareilly-offers-reduced-tuition-fees-for-pg-medical-courses-issues-official-notice-to-updgme-262802.pdf" target="_blank">https://medicaldialogues.in/pdf_upload/srms-bareilly-offers-reduced-tuition-fees-for-pg-medical-courses-issues-official-notice-to-updgme-262802.pdf</a></p></div><div class="pasted-from-word-wrapper"><div></div></div>

147. 260 Seats Available for BNYS, BSMS Courses, TN Health Releases Tentative Vacancy List

     Thu, 26 Dec 2024 08:28:47 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/26/266547-seat-matrix.webp' /><p style="text-align: justify; "><b>Tamil Nadu- </b>Tamil Nadu (<a href="https://medicaldialogues.in/topics/tamil-nadu" target="_blank">TN) Health</a> has released the tentative <a href="https://medicaldialogues.in/topics/tentative-vacancy-position" target="_blank">vacancy position</a> for BNYS Courses (Yoga &amp; Naturopathy) and BSMS Courses for the academic year 2024-25. The vacancy position has been released on the TN Health official website, therefore, candidates can check and download the same from it.</p><div class="pasted-from-word-wrapper"><p dir="ltr" style="text-align: justify; ">As per the vacancy position, a total of 260 seats are vacant in BNYS and BSMS Courses, of these, 253 seats are vacant across 17 colleges for the BNYS Courses (Yoga &amp; Naturopathy) and a total of 7 seats are vacant across 2 colleges for BSMS courses in Tamil Nadu. Below are the detailed vacancies-</p></div><div class="pasted-from-word-wrapper"><a class="also-read-media-wrap" href="https://medicaldialogues.in/news/education/ayush/tn-health-releases-counselling-schedule-and-fee-payment-details-for-ayush-diploma-courses-2024-25-140411"></a><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/education/ayush/tn-health-releases-counselling-schedule-and-fee-payment-details-for-ayush-diploma-courses-2024-25-140411"><b>Also Read:&nbsp;</b>TN Health Releases Counselling Schedule and Fee Payment Details for Ayush Diploma Courses 2024-25</a></div><div class="pasted-from-word-wrapper"><p dir="ltr" style="text-align: justify; "><b><u>TENTATIVE VACANCY POSITION FOR <a href="https://medicaldialogues.in/topics/bnys-course-fees" target="_blank">BNYS</a> COURSE [YOGA &amp; NATUROPATHY] 2024-2025 SESSION</u></b></p><div dir="ltr"><table style="text-align: justify; "><colgroup><col width="52"><col width="364"><col width="208"></colgroup><tbody><tr><td><p dir="ltr" style="text-align: center; "><b>S.NO</b></p></td><td><p dir="ltr" style="text-align: center; "><b>COLLEGES</b></p></td><td><p dir="ltr" style="text-align: center; "><b>VACANT SEATS</b></p></td></tr><tr><td><p dir="ltr">1</p></td><td><p dir="ltr">J.S.S. INSTITUTE OF NATUROPATHY &amp; YOGIC SCIENCE, COIMBATORE.</p></td><td><p dir="ltr">12</p></td></tr><tr><td><p dir="ltr">2</p></td><td><p dir="ltr">SIVARAJ NATUROPATHY &amp; YOGA MEDICAL COLLEGE, SALEM.</p></td><td><p dir="ltr">6</p></td></tr><tr><td><p dir="ltr">3</p></td><td><p dir="ltr">SREE RAMAKRISHNA MEDICAL COLLEGE OF NATUROPATHY AND YOGIC SCIENCES, KULASEKHARAM.</p></td><td><p dir="ltr">2</p></td></tr><tr><td><p dir="ltr">4</p></td><td><p dir="ltr">EXCEL MEDICAL COLLEGE FOR NATUROPATHY AND YOGA, NAMAKKAL.</p></td><td><p dir="ltr">2</p></td></tr><tr><td><p dir="ltr">5</p></td><td><p dir="ltr">NANDHA NATUROPATHY AND YOGA MEDICAL COLLEGE, ERODE.</p></td><td><p dir="ltr">1</p></td></tr><tr><td><p dir="ltr">6</p></td><td><p dir="ltr">ANNAI COLLEGE OF NATUROPATHY AND YOGA SCIENCE, KUMBAKONAM.</p></td><td><p dir="ltr">2</p></td></tr><tr><td><p dir="ltr">7</p></td><td><p dir="ltr">KRISHNA NATUROPATHY AND YOGA MEDICAL COLLEGE, TRICHY.</p></td><td><p dir="ltr">28</p></td></tr><tr><td><p dir="ltr">8</p></td><td><p dir="ltr">MOTHER TERASA NATUROPATHY AND YOGA MEDICAL COLLEGE, PUDUKKOTTAI.</p></td><td><p dir="ltr">20</p></td></tr><tr><td><p dir="ltr">9</p></td><td><p dir="ltr">S.THANGAPAZHAM MEDICAL COLLEGE OF YOGA AND NATUROPATHY AND RC, TENKASI.</p></td><td><p dir="ltr">2</p></td></tr><tr><td><p dir="ltr">10</p></td><td><p dir="ltr">KONGU NATUROPATHY AND YOGA MEDICAL COLLEGE, ERODE.</p></td><td><p dir="ltr">4</p></td></tr><tr><td><p dir="ltr">11</p></td><td><p dir="ltr">SIR ISSAC NEWTON NATUROPATHY AND YOGA MEDICAL COLLEGE, NAGAPATTINAM.</p></td><td><p dir="ltr">20</p></td></tr><tr><td><p dir="ltr">12</p></td><td><p dir="ltr">ATTHI NATUROPATHY AND YOGA MEDICAL COLLEGE, GUDIYATTAM, VELLORE.</p></td><td><p dir="ltr">8</p></td></tr><tr><td><p dir="ltr">13</p></td><td><p dir="ltr">SHRI INDRA GANESAN INSTITUTE OF MEDICAL SCIENCE NATUROPATHY AND YOGA MEDICAL COLLEGE, TRICHY.</p></td><td><p dir="ltr">19</p></td></tr><tr><td><p dir="ltr">14</p></td><td><p dir="ltr">SONA MEDICAL COLLEGE OF NATUROPATHY AND YOGA, SALEM.</p></td><td><p dir="ltr">49</p></td></tr><tr><td><p dir="ltr">15</p></td><td><p dir="ltr">G.T.N. MEDICAL COLLEGE OF NATUROPATHY AND YOGA, DINDIGUL.</p></td><td><p dir="ltr">1</p></td></tr><tr><td><p dir="ltr">16</p></td><td><p dir="ltr">IMMANUEL ARASAR NATUROPATHY AND YOGA MEDICAL COLLEGE, K K DIST.</p></td><td><p dir="ltr">77</p></td></tr><tr><td></td><td><p dir="ltr" style="text-align: center; "><b>TOTAL</b></p></td><td><p dir="ltr" style="text-align: center; "><b>253</b></p></td></tr></tbody></table></div><p dir="ltr" style="text-align: justify; "><b><u>TENTATIVE VACANCY POSITION IN IM AND H MEDICAL COLLEGES FOR [AUSH] UG COURSES 2024-2025</u></b></p><div dir="ltr"><table style="text-align: justify; "><colgroup><col width="52"><col width="364"><col width="208"></colgroup><tbody><tr><td><p dir="ltr" style="text-align: center; ">S.NO</p></td><td><p dir="ltr" style="text-align: center; ">COLLEGES</p></td><td><p dir="ltr" style="text-align: center; ">VACANT SEATS</p></td></tr><tr><td><p dir="ltr">1</p></td><td><p dir="ltr">MARIA SIDDHA MEDICAL COLLEGE.</p></td><td><p dir="ltr">4</p></td></tr><tr><td><p dir="ltr">2</p></td><td><p dir="ltr">SHRI INDRA GANESAN INSTITUTE OF MEDICAL SCIENCE - SIDDHA MEDICAL COLLEGE.</p></td><td><p dir="ltr">3</p></td></tr><tr><td></td><td><p dir="ltr" style="text-align: center; "><b>TOTAL</b></p></td><td><p dir="ltr" style="text-align: center; "><b>7</b></p></td></tr></tbody></table></div><p>The Department of Medical Education plays a pivotal role in developing medical and para-medical personnel to cater to the health needs of the State. The department also has a role to play in establishing and maintaining well-equipped teaching institutions, which are the premier referral centres with state-of-the-art equipment and technology. Research is another area of activity for the Medical Education Department.&nbsp;</p><p dir="ltr" style="text-align: justify; "><b><u><i>To view the seat matrix, click the link below</i></u></b></p><p dir="ltr" style="text-align: justify; "><a href="https://medicaldialogues.in/pdf_upload/seat-matrix-1-266548.pdf" target="_blank">https://medicaldialogues.in/pdf_upload/seat-matrix-1-266548.pdf</a></p></div><div class="pasted-from-word-wrapper"><p dir="ltr" style="text-align: justify; "><a href="https://medicaldialogues.in/pdf_upload/seat-matrix-2-266549.pdf" target="_blank">https://medicaldialogues.in/pdf_upload/seat-matrix-2-266549.pdf</a></p></div><div class="pasted-from-word-wrapper"><div></div></div>

148. Delhi: 60-year-old Doctor falls victim to honey trap, duped of Rs 9 lakh

     Thu, 26 Dec 2024 08:00:00 -0000

     <img src='https://medicaldialogues.in/h-upload/2022/09/19/185810-arrested.webp' /><div class="pasted-from-word-wrapper"><p><span style="text-align: justify;"><b>New Delhi: </b>The Delhi Police Crime Branch has busted a honey trap racket,&nbsp;</span>arresting<span style="text-align: justify;">&nbsp;three persons for impersonating police officers and allegedly running a gang t</span>hat targeted men, extorting money by threatening them with rape cases. The racket was exposed after a 60-year-old doctor from Dwarka filed a complaint.&nbsp;</p><p><span style="text-align: justify;">The Crime Branch on Wednesday claimed to have busted a gang of fake policemen who would extort people after setting up honey traps in outer Delhi's Kanjhawala area, police said.&nbsp;</span><span style="text-align: justify;">Three fake Delhi Police identity cards and a Delhi Police head constable rank uniform were also recovered from the accused.</span></p><p>The racket came to light after a 60-year-old doctor in Dwarka was duped of Rs 9 lakh by these accused following which he reported the incident to the police leading to the discovery of these fraudsters.</p><p>In August 2024, the doctor received a call from a woman who asked him to come to her house to treat her ailing mother. He agreed and went to her flat near Janakpuri Metro Station only to find that there was no sick patient and she was trying to seduce him. Moments later, the accused posing as police officers busted into the room and threatened the doctor with a criminal case.&nbsp;</p><p>However, the fake police officers asked the doctor to give him some money to put aside the case. In fear, the doctor handed them the money. Later, he realised that he was scammed and filed a police complaint at Bindapur police station. A case under relevant sections of the BNS was registered. Four accused, including two women, were arrested but two were absconding.&nbsp;</p><p style="text-align: justify; ">According to the PTI report, “Neeraj Tyagi alias Dheeraj alias Dheeru, 42 Years, of Tilak Nagar, Ashish Mathur, 31, of Karala, and Deepak alias Sajan, 30, of Kharkhoda were arrested near Budh Vihar Nala, Main Kanjhawala Road on Tuesday,” Additional Commissioner of Police (crime) Sanjay Bhatia said.&nbsp;</p><p style="text-align: justify;">The accused were taken to the Crime Branch office for further interrogations where they tried to escape from custody but were overpowered, Bhatia added. Neeraj and Deepak were wanted in a honey trap case of Bindapur in the Dwarka district, he said.</p><p style="text-align: justify;"><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/doctors/ludhiana-doctor-gets-extortion-call-asked-to-pay-rs-2-crore-127564"><b><i>Also Read:Ludhiana doctor gets extortion call, asked to pay Rs 2 crore</i></b></a></p><p style="text-align: justify;">As per an <a href="https://indianexpress.com/article/cities/delhi/for-years-a-honey-trapping-gang-extorted-people-in-delhi-their-jig-was-up-this-month-9744456/" rel="nofollow" style="background-color: rgb(249, 249, 249);">Indian Express</a> news report, the 'honeytrap' gang made women seduce male victims and then men, impersonating police officers, used to “raid” the locations. They would extort money from their targets by threatening to implicate them in rape cases.<br></p><p style="text-align: justify;">“The doctor went to the address of the girl, located near the Janakpuri Metro station, West Delhi. There, she served him snacks. The girl unbuttoned the doctor’s shirt and four people, including two in police uniform, entered the room, police said in a statement. The girl escaped and all four people caught the doctor and allegedly extorted Rs nine lakh from him by threatening arrest in a criminal case, it stated.</p><p style="text-align: justify; ">Police told The Daily, "The first case by the gang came to light in 2019, where Ashish had hatched a plan to extort a man in Rohini. One of the women asked a man for a lift near BSA hospital. The man, who was on a two-wheeler, took her to her home where she invited him in. She then lured the man into getting physical with her… and as soon as she came close, Ashish, along with his two associates, entered the room dressed as policemen. They then asked for Rs 50,000 from the man and threatened him with a criminal case if he didn’t comply."</p><p style="text-align: justify; ">"However, the man only had Rs 8,000 which he gave to the accused. The accused dropped him off near BSA hospital and fled. The victim then filed a police complaint at North Rohini police station,” the police officer added.</p><p style="text-align: justify; ">The recent arrest was made after the police received a tip-off about the gang's location. They were on their way to meet another associate for scamming another victim to extort money in modus operandi.&nbsp;</p><p style="text-align: justify; ">Additional commissioner of police (crime) Sanjay Bhatia told <a href="https://www.hindustantimes.com/cities/delhi-news/honeytrap-gang-held-for-extorting-delhi-doctor-101735146096379.html" rel="nofollow">HT</a>, “In the evening, team members spotted a Hyundai i20 car and signalled its driver to stop. Three occupants identified themselves as Delhi Police personnel and produced their police IDs. One head constable uniform was also there in the car. They tried to flee when asked to accompany the police team to the crime branch office for further verification. However, they were overpowered."</p><p style="text-align: justify; ">According to the police, the gang comprised 10-12 men and at least five women. An investigation is underway to identify more men involved in the racket.&nbsp;</p><p style="text-align: justify;"><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/doctors/delhi-doctor-falls-victim-to-sextortion-racket-loses-rs-86-lakh-125519"><b><i>Also Read:Delhi doctor falls victim to sextortion racket, loses Rs 8.6 lakh</i></b></a></p><div class="hocal-draggable" draggable="true"><div class="read-this-also-wrap"><div></div></div></div></div>

149. From Rs 1.38 lakh to Rs 50 lakh per annum: Check out the fee for pursuing

     Thu, 26 Dec 2024 07:20:50 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/26/266540-dnb-course-fee.webp' /><p><span style="background-color: rgb(255, 255, 255);">Gujarat:&nbsp;</span>The Director of Medical Education (DME Gujarat) has announced the fee structure for MD/MS/Diploma admissions across medical colleges in Gujarat for the 2024-25 academic year. MS General Surgery remains a highly sought-after specialty for postgraduate medical aspirants. The fee structure under the General Quota (GQ) and Management Quota (MQ) varies widely, accommodating a range of financial capacities.</p><p>For MS General Surgery, the fees under GQ and MQ vary significantly across institutions. The highest GQ fee of ₹33 lakh per year is charged by Pramukhswami Medical College, Karamsad, and Dr. N.D. Desai Faculty of Medical Science and Research, Nadiad. The highest MQ fee is ₹50 lakh per year, charged by Dr. N.D. Desai Faculty of Medical Science and Research, Nadiad. Meanwhile, government-run colleges such as B.J. Medical College, Baroda, Bhavnagar, Surat, Jamnagar, and Rajkot offer the lowest GQ fee of ₹1.308 lakh per year. The lowest MQ fee, ₹15 lakh per year, is offered by GMERS Medical Colleges in Gotri and Gandhinagar. These options cater to students across varying financial capacities, from economical government institutions to premium private colleges.</p><p>The 23 medical colleges for which the fee has been defined include Narendra Modi Medical College, Ahmedabad, B. J. Medical College, Ahmedabad, C.U. Shah Medical College, Surendranagar, GCS Medical College and Center, Ahmedabad, GMERS Medical College, Sola, Ahmedabad, Government Medical College, Baroda, Government Medical College, Bhavnagar, Government Medical College, Surat, Gujarat Adani Institute of Medical Sciences, Bhuj, M. P. Shah Medical College, Jamnagar, P. D. U. Medical College, Rajkot, Pramukh Swami Medical College, Karamsad, Smt. N.H.L. Municipal Medical College, Ahmedabad, Surat Municipal Institute of Medical Education &amp; Research (SMIMER), Surat, GMERS Medical College, Gotri, Baroda, GMERS Medical College, Gandhinagar, Parul Institute of Medical Science and Research, Vadodara, M.K SHAH MEDICAL COLLGE, Ahmedabad, Smt. G. R. Doshi &amp; Smt. KM Mehta Institute of Kidney Diseases &amp; Research center, Ahmedabad, Zydus Medical College and Hospital, Dahod, Shantabaa Medical College, Amreli, Dr. N. D. Desai Faculty of Medical Science and Research, Nadiad, Nootan Medical College &amp; Research Centre, Visnagar.</p><p><b><u>Here is the fee structure for MS General Surgery across all 23 medical colleges in Gujarat:</u></b></p><div class="pasted-from-word-wrapper"><table border="0" cellpadding="0" cellspacing="0" width="576"> <colgroup><col width="64"> <col width="200"> <col width="110"> <col width="101" span="2"> </colgroup><tbody><tr height="58"> <td height="58" class="xl65" width="64">S.no</td> <td class="xl65" width="200">College Name</td> <td class="xl65" width="110">General Quota (GQ) (₹)</td> <td class="xl65" width="101">Management Quota (MQ) (₹)</td> <td class="xl65" width="101">NRI Quota (in $)</td> </tr> <tr height="39"> <td height="39" class="xl65" width="64">1</td> <td class="xl65" width="200">Narendra Modi Medical College, Ahmedabad</td> <td class="xl65" width="110">9.67 lakh</td> <td class="xl65" width="101">27 lakh</td> <td class="xl65" width="101">0.5175$</td> </tr> <tr height="39"> <td height="39" class="xl65" width="64">2</td> <td class="xl65" width="200">B.J. Medical College, Ahmedabad</td> <td class="xl65" width="110">1.308 lakh</td> <td class="xl65" width="101">NA</td> <td class="xl65" width="101">NA</td> </tr> <tr height="39"> <td height="39" class="xl65" width="64">3</td> <td class="xl65" width="200">C.U. Shah Medical College, Surendranagar</td> <td class="xl65" width="110">23.00 lakh</td> <td class="xl65" width="101">35.00 lakh</td> <td class="xl65" width="101">42</td> </tr> <tr height="39"> <td height="39" class="xl65" width="64">4</td> <td class="xl65" width="200">GCS Medical College, Ahmedabad</td> <td class="xl65" width="110">15.00 Lakh</td> <td class="xl65" width="101">27.00 lakh</td> <td class="xl65" width="101">27</td> </tr> <tr height="39"> <td height="39" class="xl65" width="64">5</td> <td class="xl65" width="200">GMERS Medical College, Sola</td> <td class="xl65" width="110">NA</td> <td class="xl65" width="101">NA</td> <td class="xl65" width="101">NA</td> </tr> <tr height="39"> <td height="39" class="xl65" width="64">7</td> <td class="xl65" width="200">Govt. Medical College, Baroda</td> <td class="xl65" width="110">1.308 lakh</td> <td class="xl65" width="101">NA</td> <td class="xl65" width="101">NA</td> </tr> <tr height="39"> <td height="39" class="xl65" width="64">8</td> <td class="xl65" width="200">Govt. Medical College, Bhavnagar</td> <td class="xl65" width="110">1.308 lakh</td> <td class="xl65" width="101">NA</td> <td class="xl65" width="101">NA</td> </tr> <tr height="21"> <td height="21" class="xl65" width="64">9</td> <td class="xl65" width="200">Govt. Medical College, Surat</td> <td class="xl65" width="110">1.308 lakh</td> <td class="xl65" width="101">NA</td> <td class="xl65" width="101">NA</td> </tr> <tr height="39"> <td height="39" class="xl65" width="64">10</td> <td class="xl65" width="200">Gujarat Adani Institute of Medical Sciences, Bhuj</td> <td class="xl65" width="110">24.00 lakh</td> <td class="xl65" width="101">32.00 lakh</td> <td class="xl65" width="101">40</td> </tr> <tr height="39"> <td height="39" class="xl65" width="64">11</td> <td class="xl65" width="200">M. P. Shah Medical College, Jamnagar</td> <td class="xl65" width="110">1.308 lakh</td> <td class="xl65" width="101">NA</td> <td class="xl65" width="101">NA</td> </tr> <tr height="39"> <td height="39" class="xl65" width="64">12</td> <td class="xl65" width="200">P. D. U. Medical College, Rajkot</td> <td class="xl65" width="110">1.308 lakh</td> <td class="xl65" width="101">NA</td> <td class="xl65" width="101">NA</td> </tr> <tr height="39"> <td height="39" class="xl65" width="64">13</td> <td class="xl65" width="200">Pramukhswami Medical College, Karamsad</td> <td class="xl65" width="110">33.00 lakh</td> <td class="xl65" width="101">45.00 lakh</td> <td class="xl65" width="101">60</td> </tr> <tr height="39"> <td height="39" class="xl65" width="64">14</td> <td class="xl65" width="200">Smt. N.H.L. Municipal Medical College, Ahmedabad</td> <td class="xl65" width="110">7.93 lakh</td> <td class="xl65" width="101">23.76 lakh</td> <td class="xl65" width="101">0.5625$</td> </tr> <tr height="58"> <td height="58" class="xl65" width="64">15</td> <td class="xl65" width="200">Surat Municipal Institute of Medical Education &amp; Research (SMIMER), Surat</td> <td class="xl65" width="110">18.64 lakh</td> <td class="xl65" width="101">37.15</td> <td class="xl65" width="101">0.64$</td> </tr> <tr height="39"> <td height="39" class="xl65" width="64">16</td> <td class="xl65" width="200">GMERS Medical College, Gotri</td> <td class="xl65" width="110">10 lakh</td> <td class="xl65" width="101">15.00 lakh</td> <td class="xl65" width="101">30</td> </tr> <tr height="39"> <td height="39" class="xl65" width="64">17</td> <td class="xl65" width="200">GMERS Medical College, Gandhinagar</td> <td class="xl65" width="110">10 lakh</td> <td class="xl65" width="101">15.00 lakh</td> <td class="xl65" width="101">30</td> </tr> <tr height="39"> <td height="39" class="xl65" width="64">18</td> <td class="xl65" width="200">Parul Institute of Medical Sciences, Vadodara</td> <td class="xl65" width="110">30.00 lakh</td> <td class="xl65" width="101">42.00 lakh</td> <td class="xl65" width="101">NA</td> </tr> <tr height="39"> <td height="39" class="xl65" width="64">19</td> <td class="xl65" width="200">M.K SHAH MEDICAL COLLGE, Ahmedabad</td> <td class="xl65" width="110">22 lakh</td> <td class="xl65" width="101">30.00 lakh</td> <td class="xl65" width="101">0.63$</td> </tr> <tr height="94"> <td height="94" class="xl65" width="64">20</td> <td class="xl65" width="200">Smt. G. R. Doshi &amp; Smt. K M Mehta Institute of Kidney Diseases &amp; Research center, Ahmedabad</td> <td class="xl65" width="110">NA</td> <td class="xl65" width="101">NA</td> <td class="xl65" width="101">NA</td> </tr> <tr height="39"> <td height="39" class="xl65" width="64">21</td> <td class="xl65" width="200">Zydus Medical College, Dahod</td> <td class="xl65" width="110">28.00 lakh</td> <td class="xl65" width="101">40.00 lakh</td> <td class="xl65" width="101">NA</td> </tr> <tr height="39"> <td height="39" class="xl65" width="64">22</td> <td class="xl65" width="200">Shantabaa Medical College, Amreli</td> <td class="xl65" width="110">NA</td> <td class="xl65" width="101">NA</td> <td class="xl65" width="101">NA</td> </tr> <tr height="58"> <td height="58" class="xl65" width="64">23</td> <td class="xl65" width="200">Dr. N. D. Desai Faculty of Medical Science and Research, Nadiad</td> <td class="xl65" width="110">33.00 lakh</td> <td class="xl65" width="101">50.00 lakh</td> <td class="xl65" width="101">NA</td> </tr> <tr height="39"> <td height="39" class="xl65" width="64">24</td> <td class="xl65" width="200">Nootan Medical College &amp; Research Centre, Visnagar</td> <td class="xl65" width="110">22</td> <td class="xl65" width="101">NA</td> <td class="xl65" width="101">NA</td> </tr></tbody></table></div><p><b><i><u>To view the official Notice, Click here :&nbsp;&nbsp;</u><a href="https://medicaldialogues.in/pdf_upload/tuition-fees-pg-2024-25-266539.pdf" target="_blank">https://medicaldialogues.in/pdf_upload/tuition-fees-pg-2024-25-266539.pdf</a></i></b></p><p><b><u></u></b></p>

150. Prohibited drugs worth over Rs 25 lakh seized; medical store owner, 2 others arrested

     Thu, 26 Dec 2024 07:00:03 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/26/266555-raid-50-1.webp' /><p style="text-align: justify; "><span style="background-color: rgb(255, 255, 255);">Jamshedpur:&nbsp;</span>The East Singhbhum District Police have seized banned drugs worth over Rs 25 lakh in raids conducted at some places, including a medical store in Olidih area, according to officials. The raid has led to the arrest of three people including the medical store owner.</p><div class="pasted-from-word-wrapper"><p>Acting on a tip-off, a police raid team headed by SP (Rural) Rishava Garg conducted the raids on Sunday and recovered banned drugs like cough syrup bottles and specific medicines, they said. </p><div class="pasted-from-word-wrapper"><div id="postexcerpt"><div class="third-para"><p>According to PTI, Senior Superintendent of Police Kishore Kaushal said, “We will not rule out the possibility of the involvement of more people in this illegal trade…the medical store has been sealed”.&nbsp;</p></div></div><div id="postcontent"><p>Further investigation is underway.</p><p>In mid-December, spurious drugs worth Rs 1.85 crore were seized by the Food and Drug Administration (FDA) personnel. The seizure followed raids conducted at a godown in Bhiwandi and another establishment in Mira Road area over the past few months.</p><p>Earlier, Delhi Police seized 30 kilograms of Alprazolam tablets worth Rs one crore in the international market. Two drug peddlers, identified as Laxman (32) and Pankaj (18), arrested in connection with the seizure.</p></div></div></div><p style="text-align: justify; "><b><i>Read also: <a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/industry/pharma/thane-spurious-drugs-worth-rs-185-crore-seized-2-booked-139869">Thane: Spurious drugs worth Rs 1.85 crore seized, 2 booked</a></i></b></p>

151. RG Kar Rape-Murder: Calcutta HC directs parents to seek clarification on fresh probe

     Thu, 26 Dec 2024 06:47:12 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/11/16/261055-calcutta-high-court.webp' /><div class="pasted-from-word-wrapper"><p><span style="text-align: justify;">Kolkata: The&nbsp;</span><a href="https://medicaldialogues.in/topics/calcutta-high-court" target="_blank">Calcutta High Court</a><span style="background-color: rgb(255, 255, 255);"> on Tuesday&nbsp;</span>instructed the counsel for the parents of the woman PG trainee doctor, who was raped and murdered at&nbsp;<a href="https://medicaldialogues.in/topics/r-g-kar-medical-college-and-hospital" target="_blank">RG Kar Medical College &amp; Hospital</a>&nbsp;in August, to seek clarification from the Supreme Court and a division bench of the High Court regarding their petition for a fresh investigation into the case.</p><p><span style="text-align: justify;">According to an IANS report, as the petition for a fresh probe, filed by the parents of the victim, came up for hearing at the single-judge bench of Justice Tirthankar Ghosh, he observed that first there is a need for clarification on whether the ongoing probe in the matter by Central Bureau of Investigation (CBI) in the matter is monitored by the Supreme Court or not.</span></p></div><div class="pasted-from-word-wrapper"><p style="text-align: justify;">The next date of hearing has been scheduled for January 15 next year and by then the petitioners will have to get clarifications either from the apex court or from any division bench of the Calcutta High Court in the matter.</p><p style="text-align: justify; ">"There is no problem in hearing the matter. But a clarification is required whether the probe is court-monitored or not," Justice Ghosh observed.</p><p style="text-align: justify;"><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/doctors/-no-evidence-of-possible-struggle-inside-seminar-hall-says-forensic-report-in-rg-kar-case-140439"><b><i>Also Read:' No evidence of possible struggle' inside seminar hall, says Forensic Report in RG Kar Case</i></b></a></p><p style="text-align: justify;">On Tuesday, the <a href="https://medicaldialogues.in/topics/CBI/" target="_blank">CBI </a>counsel informed Justice Ghosh’s bench that the probe in the matter by the central agency is being monitored by the apex court of the country. However, the counsel for the petitioners refuted that claim by the CBI counsel.</p><p style="text-align: justify;">Thereafter Justice Ghosh asked for the clarifications on this claim and counter-claim either from the Supreme Court or a division bench of Calcutta High Court before further hearing in the matter.</p><p style="text-align: justify;">Reacting to the observation of the court on Tuesday, the victim’s father told media persons that he would go as far as possible to get justice for his daughter.</p><p style="text-align: justify;">"There might be some delay in the process. But we will be waiting with patience. My only aim is to secure justice for my daughter in whatever way possible," he said, news agency IANS reported.</p><p style="text-align: justify;">On December 19, the victim’s parents approached Justice Ghosh’s bench seeking court direction for a fresh probe in the matter. The victim’s parents have claimed that they do not have any faith in the course of the current investigation by the central agency in the matter and hence they want a fresh investigation from the beginning in the matter.</p><p style="text-align: justify;">Since the time a special court in Kolkata last week granted default bail to two individuals accused of tampering with the evidence since the CBI was unable to file a supplementary charge sheet against them within 90 days from the day of their arrest, the victim’s parents, as well as the representatives of the state’s medical fraternity, had been accusing the CBI of gross incompetence in the matter.</p><p style="text-align: justify;">Those two accused persons were the former principal of R.G. Kar Sandip Ghosh and the former SHO of Tala Police Station Abhijit Mondal. Ghosh is still behind bars because of the pending parallel probe by the CBI against him in the case of financial irregularities at R.G. Kar, while Mondal is already out on bail.</p><p style="text-align: justify;">The CBI so far has filed only one charge sheet in the case where civic volunteer Sanjay Roy had been identified as the "sole prime accused" in the rape and murder.</p><p style="text-align: justify;">Recently, the victim’s parents have also changed their counsel representing them at the Supreme Court.</p><p style="text-align: justify;"><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/mdtv/healthshorts/calcutta-hc-grants-conditional-nod-for-doctors-protest-in-rg-kar-rape-murder-case-140249"><b><i>Also Read:Calcutta HC grants conditional nod for doctors' protest in RG Kar rape-murder case</i></b></a></p><div class="hocal-draggable" draggable="true"><div class="read-this-also-wrap"><div></div></div></div></div>

152. Gland Pharma arm Fontenay facility gets 10 observations from France drug regulator

     Thu, 26 Dec 2024 06:00:36 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/02/16/232395-gland-pharma-50.webp' /><p style="text-align: justify; "><b>Telangana</b>:&nbsp;<span style="background-color: rgb(255, 255, 255);">Through a recent BSE filing,&nbsp;<a href="https://medicaldialogues.in/topics/gland-pharma">Gland Pharma</a> has informed that its&nbsp;</span>material subsidiary,&nbsp;<a href="https://medicaldialogues.in/topics/Cenexi">Cenexi</a>'s Fontenay manufacturing facility gets ten observations from the Agence nationale de sécurité du médicament et des produits de santé (ANSM), France, at the conclusion of a Good Manufacturing Practices (GMP) inspection</p><p style="text-align: justify; ">The facility was inspected between December 9th to 19th, 2024.</p><p style="text-align: justify; "><span style="background-color: rgb(255, 255, 255);">"The said inspection was concluded, and the Facility received an official notification on December 24, 2024, citing 10 (TEN) observations," the Company stated.</span></p><div class="pasted-from-word-wrapper"><div style="text-align: justify; ">"Cenexi is committed to working closely with the ANSM to address the observations and will provide further updates to the exchanges as they become available," it added.</div><div style="text-align: justify; ">Medical Dialogues team had earlier reported that&nbsp;<span style="background-color: rgb(249, 249, 249);">the United States Food and Drug Administration (US FDA) had concluded an inspection of the Company's Pashamylaram Facility at Hyderabad for Good Manufacturing Practices (GMP) with three 483 Observations.</span></div><div style="text-align: justify; "><b><i>Read also: <a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/industry/pharma/usfda-nod-to-gland-pharma-vitamin-k-deficiency-treatment-drug-139671" style="background-color: rgb(255, 255, 255);">USFDA nod to Gland Pharma Vitamin K deficiency treatment drug</a></i></b></div></div><div class="pasted-from-word-wrapper"><div class="hocal-draggable" draggable="true"><div class="read-this-also-wrap"><div></div></div></div><div class="pasted-from-word-wrapper"><div style="text-align: justify; "><p>Gland Pharma was established in 1978 in Hyderabad and has grown over the years from a contract manufacturer of small-volume liquid parenteral products to become growing injectable-focused companies, with a global footprint across 60 countries, including the United States, Europe, Canada, Australia, India, and other markets. It operates primarily under a business-to-business (B2B) model and develops, manufactures, and markets sterile injectables. It has a wide range of injectables, including vials, ampoules, pre-filled syringes, lyophilized vials, dry powders, infusions, oncology, and ophthalmic solutions. </p><p><b><i>Read also: <a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/industry/pharma/gland-pharma-vice-president-strategy-investments-investor-relations-ankit-gupta-tenders-resignation-139166">Gland Pharma Vice President (Strategy, Investments &amp; Investor Relations) Ankit Gupta tenders resignation</a></i></b></p></div></div></div>

153. Agartala Medical College GBP Hospital workers stage protest over unpaid wages

     Thu, 26 Dec 2024 06:00:12 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/09/24/254063-non-medical-teachers-protest-at-jantar-mantar-against-nmc-policies.webp' /><p><b>Agartala:</b>&nbsp;Outsourcing workers at&nbsp;<a href="https://medicaldialogues.in/topics/agartala-govt-medical-college">Agartala Government Medical College&nbsp;</a>(AGMC) and GBP Hospital staged a protest over delayed payments and inadequate wages. The march, led by the Akhil Safai Mazdoor Sangh, ended with a mass sit-in demonstration at the GBP Hospital premises.</p><p>According to the protesting workers, a total of 509 salaried employees are currently employed under outsourcing contractors at both Agartala Medical College and GBP Hospital. These workers, who carry out essential tasks such as sanitation, support services, and maintenance, have been receiving a modest salary of Rs 9,000 per month. The workers alleged that their salaries have not been paid for the past three months, which has led to the protest.</p><p><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/doctors/25-percent-salary-hike-likely-for-doctors-under-contract-with-maharashtra-bmc-120118" style="background-color: rgb(255, 255, 255);"><b>Also Read: 25 percent salary hike likely for Doctors under contract with Maharashtra BMC</b></a></p><p>Speaking to&nbsp;<a href="https://tripurachronicle.in/local-news/agartala-government-medical-college-and-gbp-hospital-workers-protest-over-unpaid-salaries/" rel="nofollow">Tripura Chronicle</a>, the worker stated, “We have been working at Agartala Medical College and GBP Hospital for a long time, but the contractors are making excuses when it comes to salary payment. We are not being paid on a specific date every month, which is causing various problems for us”.</p><p>The delay in salary payments has had a severe impact on the workers' livelihoods. Providing essential services in sanitation, security, and support roles at the hospitals, the workers have expressed their frustration over the ongoing non-payment of wages. They have raised their concerns and are demanding immediate action to resolve the issue. However, both the contractors and the hospital management have yet to respond to the workers' demands. &nbsp;</p><p><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/doctors/salary-delay-gmc-sringars-resident-doctors-threaten-protest-126081" style="background-color: rgb(255, 255, 255);"><b>Also Read: Salary Delay: GMC Sringar's resident doctors threaten protest</b></a></p><p>Medical Dialogues had earlier reported that in a concerning development, resident doctors at Government Medical College (GMC), Srinagar, have issued a stern warning of protest due to persistent delays in salary payments. The Resident Doctors Association (RDA) released a statement highlighting the distressing situation faced by resident doctors at GMC Srinagar, citing prolonged delays in salary payments, exceeding five months in some instances, over the past year.</p>

154. J&K: Dialysis Centres to be set up at 11 SDHs, CHCs

     Thu, 26 Dec 2024 05:00:33 -0000

     <img src='https://medicaldialogues.in/h-upload/2023/02/22/202697-dialysis.webp' /><p><b>Ganderbal:</b> In a move to address the healthcare challenges faced by kidney patients, the Health Department of <a href="https://medicaldialogues.in/state-news/jammu-kashmir">Jammu and Kashmir</a> is set to establish a <a href="https://medicaldialogues.in/topics/dialysis-centre">dialysis centre</a> at the Sub-District Hospital (SDH) Kangan, located in the central Kashmir’s Ganderbal district. </p><p>According to officials, SDH Kangan is one of 11 health facilities across Kashmir where the Directorate of Health Services Kashmir (DHSK) has planned to establish dialysis centres. The project aims to provide convenience to the kidney patients. Following this, the Directorate has already written to the Chief Engineer of the Mechanical Engineering Department Kashmir to prepare detailed estimates for the installation of the dialysis centres. This includes the installation of essential infrastructure like water loops, storage systems, transfer pumps, electrical backups with stabilizers, and other allied works.</p><p><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/hospital-diagnostics/safdarjung-hospital-launches-new-haemodialysis-centre-for-better-dialysis-107175" style="background-color: rgb(255, 255, 255);"><b>Also Read: Safdarjung hospital launches new haemodialysis centre for better dialysis</b></a></p><p>The Chief Engineer has been asked to submit the estimates within seven days in consultation with the respective Block Medical Officers to expedite the approval process. This move is expected to speed up the setup of the dialysis unit. In addition to SDH Kangan, the 11 health facilities identified for the establishment of dialysis centres include SDH Dooru in Anantnag; CHC Pattan and CHC Chandoosa in Baramulla; CHC Chaar-e-Shareef, CHC Nagam, and CHC Pakherpora in Budgam; SDH Kralpora in Kupwara; SDH DH Pora in Kulgam; SDH Zainapora in Shopian; and SDH Tral in Pulwama.&nbsp;</p><p><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/state-news/delhi/fortis-vasant-kunj-opens-16-bedded-dialysis-center-in-association-with-fresenius-medical-care-63824"><b>Also Read: Fortis Vasant Kunj opens 16 bedded dialysis center in association with Fresenius Medical Care</b></a></p><p>As per the recent media report in <a href="https://www.greaterkashmir.com/kashmir/authorities-to-run-dialysis-centre-at-sdh-kangan/#google_vignette" rel="nofollow">Greater Kashmir</a>, member of the Legislative Assembly Kangan Mian Mehar Ali has expressed gratitude to the Secretary of Health and Medical Education department and Director of Health Services Kashmir for starting the process of establishing a dialysis center in SDH Kangan. He said this will enable the patients to receive required treatment without any hardship. </p><p>Currently, patients requiring dialysis face immense hardships due to the unavailability of such centres in many parts of the region. As a result, most patients often have to travel for hours, incur travel costs, and lose wages, which has led to financial strain for their families. </p><p>Moreover, a patient from Kangan mentioned that, in the absence of a government-run facility in such areas, patients are forced to seek treatment at private dialysis centres, which involve high costs, adding significant financial strain to their already challenging medical conditions. This decentralization of dialysis services will not only improve access to care but also help reduce the patient load in tertiary hospitals in larger cities.</p>

155. WHO calls for transformative action towards greener future in pharmaceutical manufacturing, distribution

     Thu, 26 Dec 2024 04:30:53 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/26/266587-globe-50.webp' /><p style="text-align: justify; ">The <a href="https://medicaldialogues.in/topics/world-health-organisation">World Health Organization</a>&nbsp;(WHO), through its Department of Regulation and Prequalification, has issued a call for action to drive sustainability in the pharmaceutical sector. Entitled “Greener pharmaceuticals’ regulatory highway,” this initiative underscores the urgent need for innovative regulatory practices to reduce the environmental footprint of medical products while maintaining high standards of safety and efficacy.</p><div class="pasted-from-word-wrapper"><p style="text-align: justify; ">“Addressing the environmental impact of healthcare products is no longer optional – it is imperative,” said Dr Yukiko Nakatani, WHO Assistant Director-General for Access to Medicines and Health Products. “The transformation of regulatory practices will be pivotal in shaping a pharmaceutical industry that meets today’s health needs without compromising the planet’s future.”</p><p style="text-align: justify; ">As climate change continues to exacerbate health risks worldwide, modern health systems, contributing to approximately 5% of global carbon emissions, must prioritize sustainability. This call for action urges global regulatory bodies and stakeholders in the pharmaceutical and healthcare industries to adopt innovative practices that prioritize sustainability and reduce environmental impact.</p><p style="text-align: justify; ">Key proposals outlined in the initiative include:</p><ul data-list="0" data-level="1"><li style="text-align: justify; ">Establishing new standards and guidance that promote sustainable manufacturing, packaging, distribution, and use of medical products, ensuring environmental benefits alongside health improvements.</li><li style="text-align: justify; ">Leveraging digital transformation by enhancing reliance mechanisms and regulatory capacity through digitization, with a particular focus on low- and middle-income countries.</li><li style="text-align: justify; ">Streamlining innovative regulatory procedures fostering earlier collaboration between regulators and manufacturers to accelerate the adoption of eco-friendly innovations.</li></ul><p style="text-align: justify; ">“Health systems should lead by example in mitigating environmental impact,” said Dr Rogerio Gaspar, WHO Director for Regulation and Prequalification. “This initiative will catalyze the global transformation required to align health sector operations with sustainability goals. It represents a critical step toward a greener, healthier future.”</p><p style="text-align: justify; ">"By adopting cleaner production techniques, redesigning synthetic processes, and investing in renewable energy for manufacturing, the pharmaceutical sector can significantly mitigate its environmental impact. WHO also encourages greater transparency and accountability in supply chain practices and sustainable procurement standards to ensure widespread adoption of green solutions," the release stated.</p><p style="text-align: justify; ">This call aligns with key frameworks such as the WHO Global Strategy on Health, Environment, and Climate Change, and is bolstered by global agreements such as the COP28 Declaration. It also builds on critical insights from recent studies, including Unitaid’s 2023 “From milligrams to megatons” report, which highlighted that up to 95% of greenhouse gas emissions for select medicines originate from raw material acquisition and manufacturing processes. This stresses the urgent need for sustainability-driven research and development (R&amp;D) in active pharmaceutical ingredients (APIs) and manufacturing processes.</p><p style="text-align: justify; ">WHO Department of Regulation and Prequalification plans to develop a comprehensive white paper on sustainable regulatory practices, to be discussed at a global summit in late 2025. This forum will bring together experts from public health, regulatory authorities, the pharmaceutical industry, and procurement agencies to explore and advance transformative actions within the pharmaceutical supply chain, driving impactful and lasting change across the sector.</p><p style="text-align: justify; "><b><i>Read also: <a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/mdtv/pulmonology/videos/bolster-efforts-to-end-tb-in-who-south-east-asia-region-140100">Bolster efforts to end TB in WHO South-East Asia Region</a></i></b></p></div>

156. Fact Check: Can papaya, oats and banana drink eliminate constipation in just 3 days?

     Thu, 26 Dec 2024 04:30:00 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/24/266321-knee-pain.webp' /><p style="text-align: justify; ">An Instagram post claims that <a href="https://medicaldialogues.in/fact-check/fact-check-can-papaya-eliminate-intestinal-parasites-136313">papaya</a>, oats and <a href="https://health.medicaldialogues.in/fact-check/dental-and-oral-health-fact-check/fact-check-can-rubbing-banana-peel-on-teeth-for-2-minutes-every-day-help-with-teeth-whitening-140370">banana</a> drink can eliminate <a href="https://health.medicaldialogues.in/search?search=constipation">constipation</a> in just 3 days. The claim by the user is Misleading.</p><h3 style="text-align: justify; "><b>Claim</b></h3><p style="text-align: justify; ">An Instagram post claims that papaya, oats and banana drink can eliminate constipation in just 3 days. In the reel the user <a href="https://www.instagram.com/plan.cures/" rel="nofollow">plan.cures</a>&nbsp;says to take a papaya peel and&nbsp;cut it into pieces and then mix it with banana and oats and you&nbsp;can create a natural drink capable of cleansing, your intestines and eliminating constipation in just three days. The user talks about the recipe of the drink and says, "Let's take a cup of oats soaked in water for 10 minutes. Oats are rich in soluble fiber which will increase the size of your stool making it easier to pass. Now cut half a papaya into pieces, the enzyme and fiber combination in papaya gives it a mild natural laxative effect Promoting regular bowel movements without being harsh on the digestive system. Now will also add a banana. Not only will it improve the flavor of our drink but also contain fructooligosaccharides,&nbsp; a type of fiber that feeds, the good bacteria in your gut. Keeping these bacteria, healthy helps improve digestion, and keeps your bowel movements regular. After 10 minutes, strain the oats place all the ingredients in a blender along with a litre or 33 oz of skim milk blend for a few minutes and our drink will be ready." The user further talks about the consumption of the drink and adds, "Drink one, glass, a day before breakfast." As per the user doing this for three consecutive days and your intestines will be cleansed and healthy.&nbsp;</p><p style="text-align: justify; ">The claim can be accessed <a href="https://www.instagram.com/reel/DCn07U3S4eP/" rel="nofollow">here</a>.</p><h3 style="text-align: justify; "><b>Fact Check</b></h3><p style="text-align: justify; ">The user claims that papaya, oats and banana drink can eliminate constipation in just 3 days is Misleading.The drink may help alleviate mild constipation due to its fiber and nutrient content, but it is not a guaranteed cure for constipation that too in just three days&nbsp;</p><h3 style="text-align: justify; "><b>What is Constipation?</b></h3><p style="text-align: justify; ">As per <a href="https://www.hopkinsmedicine.org/health/conditions-and-diseases/constipation" rel="nofollow">Johns Hopkins Medicine</a>, “Constipation is a condition in which a person has uncomfortable or infrequent bowel movements. Generally, a person is considered to be constipated when bowel movements result in passage of small amounts of hard, dry stool, usually fewer than three times a week.”</p><p style="text-align: justify; ">Constipation can be caused by medications, lack of exercise, insufficient liquids or fiber, IBS, ignoring bowel urges, lifestyle changes (like travel, pregnancy, and aging), intestinal function issues, and laxative abuse.</p><div contenteditable="false" data-width="100%" style="width:100%px;" class="image-and-caption-wrapper clearfix hocalwire-draggable float-left"><img src="https://medicaldialogues.in/h-upload/2024/12/24/266318-profile.webp" draggable="true" class="hocalwire-draggable float-left" data-float-none="true" data-uid="23690u9fmSP5zdpMQz6U1ZgKYlQLdiTUT3rpB6750437" data-watermark="false" style="text-align: justify; width: 100%; float: left;" info-selector="#info_item_1735036750259"><div class="inside_editor_caption image_caption hocalwire-draggable float-left" id="info_item_1735036750259"></div></div><p style="text-align: justify; "><b>Dr. Amit Yelsangikar, Consultant - Medical Gastroenterology, Aster CMI Hospital, Bangalore</b> explained, " Constipation is a common gastrointestinal condition characterized by infrequent bowel movements or difficulty in passing stools. It is typically defined as having fewer than three bowel movements per week, and it may be accompanied by symptoms such as straining during defecation, hard or lumpy stools, and a sensation of incomplete evacuation. Various factors can contribute to constipation, including dietary habits, lack of physical activity, dehydration, and certain medical conditions or medications. Understanding the underlying causes and symptoms of constipation is essential for effective management and treatment of this condition."</p><h3><b>What are the types of Constipation? </b></h3><p><a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC3206562/" rel="nofollow">Constipation</a> can be categorized as acute or chronic. Acute constipation is usually short-term and may result from dietary changes, dehydration, or temporary illness. It often resolves with lifestyle modifications and over-the-counter remedies. Chronic constipation, however, persists for more than three months and is a more serious condition. It cannot be effectively treated with natural remedies alone and requires medical attention to identify and manage underlying causes for long-term relief.</p><h3 style="text-align: justify; "><b>Can Constipation Be Cured?</b></h3><p style="text-align: justify; "><a href="https://www.niddk.nih.gov/health-information/digestive-diseases/constipation/treatment" rel="nofollow">Constipation</a> can often be effectively managed and, in many cases, cured by addressing its underlying causes through lifestyle changes, dietary adjustments, and, if necessary, medical interventions. Increasing fiber intake, staying hydrated, and engaging in regular physical activity can help regulate bowel movements and alleviate symptoms. Establishing a routine for bowel movements, known as bowel training, can also improve regularity. Over-the-counter treatments, such as fiber supplements, stool softeners, or laxatives, may provide temporary relief, while prescription medications like lubiprostone, linaclotide, or prucalopride are options for chronic cases. For muscle-related issues, biofeedback therapy may retrain bowel movement control. In severe cases, surgery might be required. With the right combination of these approaches, constipation can often be resolved or significantly improved.</p><div contenteditable="false" data-width="252" style="width:252px;" class="image-and-caption-wrapper clearfix hocalwire-draggable float-left"><img src="https://medicaldialogues.in/h-upload/2024/12/24/266319-profile-1.webp" draggable="true" class="hocalwire-draggable float-left" data-float-none="true" data-uid="236907taayNgz3he5Hyi7dR3HczzdsHLqVMAI6839376" data-watermark="false" style="text-align: justify; width: 100%; float: left;" info-selector="#info_item_1735036839144"><div class="inside_editor_caption image_caption hocalwire-draggable float-left" id="info_item_1735036839144"></div></div><p style="text-align: justify; "><b>Dr. Anupama N K, Consultant - Medical Gastroenterology, Aster CMI Hospital, Bangalore</b> said, "Constipation, characterized by infrequent bowel movements or difficulty in passing stools, can often be alleviated through various interventions. These may include dietary modifications, such as increasing fiber intake, ensuring adequate hydration, and incorporating regular physical activity into one’s routine. Additionally, over-the-counter laxatives and other medications may provide relief for some patients. In more persistent cases, it is advisable to consult a healthcare professional who can offer tailored treatment options and investigate any underlying causes that may be contributing to the issue. Ultimately, while constipation can often be managed and improved, the approach to treatment may vary based on individual circumstances and health conditions."</p><h3 style="text-align: justify; "><b>What are the nutritional benefits of papaya, oats and bananas?</b></h3><p style="text-align: justify; "><a href="https://www.mdpi.com/1424-2818/14/8/683" rel="nofollow">Papaya</a> (<i>Carica papaya L.</i>) is a tropical fruit is a popular fruit in India, known for its abundance of bioactive compounds such as carpaines, benzyl isothiocyanate (BITC), benzyl glucosinolates, latex, papain, zeaxanthin, and choline. Its seeds, leaves, and fruit offer numerous health benefits, including antioxidant properties, digestive support, and potential nutraceutical applications. Papayas are an excellent source of vitamins A, B, C, E, and K, along with folate, pantothenic acid, magnesium, copper, calcium, and potassium. They are also rich in fiber, antioxidants, and vitamin C. Papaya contains the enzyme <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC6682863/#B5-nutrients-11-01608" rel="nofollow">papain</a>, which aids in improving intestinal motility and reducing transit time. It is also beneficial in treating traumas, allergies, and sports injuries, with its healing effects largely due to papain’s enzymatic action.&nbsp;</p><p style="text-align: justify; "><a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC8625765/#abstract1" rel="nofollow">Oats</a> are a highly nutritious cereal crop, celebrated for their rich composition of bioactive compounds that promote health. A primary benefit comes from beta-glucan, a soluble fiber known for its cholesterol-lowering and antidiabetic properties, making oats a valuable dietary choice for heart and metabolic health. Additionally, oats are packed with phenolic acids, tocols, sterols, and exhibit anti-inflammatory and antioxidant effects. Regular oat consumption supports gut health by improving microbiota and strengthens the immune system through immunomodulatory effects.&nbsp;</p><p style="text-align: justify; "><a href="https://www.researchgate.net/publication/352793672_Health_benefits_of_banana_Musa-_A_review_study" rel="nofollow">Banana</a> (<i>Musa paradisiaca Linn</i>) is low calorie (1 banana- approx. 116 kcal), low fat and rich in vitamins and minerals. It also has certain antifungal, antibiotic, antimicrobial, antidiabetic, antioxidant, and anti-inflammatory properties. Bananas are also a good source of potassium as well an excellent source of vitamins A, B-6, C, and D.</p><h3 style="text-align: justify; "><b>Can papaya, oats and banana drink eliminate constipation in just 3 days?</b></h3><p style="text-align: justify; ">While papaya, oats, and bananas may help relieve constipation due to their high fiber and water content, claiming a drink made of these ingredients will eliminate constipation in just 3 days is not supported by any scientific evidence or medical consensus. While these ingredients may provide relief from constipation, they are unlikely to eliminate chronic constipation in 3 days. Hence, the claim is Misleading.</p><p style="text-align: justify; ">Papaya, known for its rich nutrient profile and digestive benefits, has been increasingly studied for its potential role in alleviating gastrointestinal issues, especially constipation. <a href="https://ejournal.unklab.ac.id/index.php/8ISCABS/article/view/709#:~:text=Results%3A%20The%20results%20showed%20that,82.5%25%20effective%20for%20overcoming%20constipation." rel="nofollow">Nilawati Soputri et. al.</a> concluded in their study that papaya has the potential to act as a natural remedy or an alternative treatment for effectively managing constipation.</p><p style="text-align: justify; ">Similarly, a study conducted by <a href="https://www.researchgate.net/publication/385244723_The_Benefits_of_Papaya_for_Digestive_Health_and_Weight_Loss" rel="nofollow">Sheed Iseal et. al.</a> found that papaya, rich in enzymes like papain, aids in protein digestion, thereby improving overall digestive health and reducing symptoms like bloating and constipation. Additionally, its high fiber content promotes regular bowel movements, supporting optimal gastrointestinal function.</p><p style="text-align: justify; ">Oats, a nutrient-dense whole grain, are well-known for their high fiber content and numerous health benefits, particularly in supporting digestive health. In a systematic review, <a href="https://pubmed.ncbi.nlm.nih.gov/25267242/" rel="nofollow">Thies et. al.</a> found that oats or oat bran can significantly increase stool weight and reduce constipation in humans because of the high fiber levels in oats.</p><p style="text-align: justify; ">Bananas have gained attention for their role in supporting intestinal health and addressing digestive issues like constipation. The study published in the <b><i><a href="https://www.researchgate.net/publication/264091259_Banana_Resistant_Starch_and_Its_Effects_on_Constipation_Model_Mice" rel="nofollow">Journal of Medicinal Foods </a></i></b>concluded that Baana Resistant Starch effectively enhances intestinal motility by accelerating small intestine movement and reducing defecation onset time, without affecting body weight or food intake. This suggests its potential utility in managing constipation.</p><p style="text-align: justify; ">While scientific evidence supports that papaya, oats, and bananas may aid in managing constipation, there is no medical consensus or scientific evidence to back the claim that a combination of these ingredients for a drink can eliminate constipation in 3 days. Also, these ingredients could be beneficial in managing constipation, but chronic constipation requires more comprehensive treatment.</p><p style="text-align: justify; ">Responding to the claim <b>Dr. Amit Yelsangikar, Consultant - Medical Gastroenterology, Aster CMI Hospital, Bangalore</b> said, "This blend of ingredients is noted for its high fiber content, which can aid in promoting regular bowel movements. Papaya contains enzymes that may facilitate digestion, while oats are renowned for their soluble fiber that helps to soften stools. Additionally, bananas contribute both fiber and potassium, which are essential for maintaining healthy digestive function. Therefore, incorporating this specific drink into one’s diet could prove to be an effective natural remedy for individuals struggling with constipation over a short timeframe."</p><p style="text-align: justify; "><b>Dr. Anupama N K, Consultant - Medical Gastroenterology, Aster CMI Hospital, Bangalore</b> further said, "This mixture of ingredients is recognized for its abundant fiber content, which can assist in encouraging regular bowel movements. Papaya is rich in enzymes that may support digestion, while oats are well-known for their soluble fiber, which helps in softening stools. Moreover, bananas provide a combination of fiber both of which play a crucial role in maintaining healthy digestive function. Consequently, adding this particular drink to one’s diet could serve as a natural and effective remedy for individuals experiencing constipation."</p><h3 style="text-align: justify; "><b>Medical Dialogues Final Take</b></h3><p style="text-align: justify; ">The ingredients papaya oats, and banana may aid digestion and alleviate mild constipation due to their fiber and nutrient content. It is also important to note that these ingredients may relieve constipation temporarily but are not effective in addressing chronic constipation permanently. Further, there is no scientific evidence or medical consensus to support the claim that the combination of these ingredients for a drink will eliminate constipation in just 3 days.</p><p style="text-align: justify; ">Hence, the claim by the user is Misleading.</p>

157. Delhi AIIMS Hosts SARANSH Workshop to Boost Evidence-Based Healthcare

     Thu, 26 Dec 2024 04:00:59 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/25/266396-aiims-delhi-6.webp' /><div class="pasted-from-word-wrapper"><p style="text-align: justify; ">New Delhi: The All India Institute of Medical Sciences (AIIMS), New Delhi, in collaboration with the Department of Health Research (DHR) under the Ministry of Health and Family Welfare (MoHFW), organized the SARANSH workshop, a key initiative aimed to enhance regional capabilities for conducting systematic reviews across the country.</p><p style="text-align: justify; ">The SARANSH (Systematic Reviews and Networking Support in Health) program is a flagship initiative by DHR aimed at building regional capacity for conducting systematic reviews across the country.<br></p><p style="text-align: justify;">According to an ANI report, this workshop was inaugurated by Prof M Srinivas- Director, Prof KK Verma- Dean (Academics), and Prof. Govind Makharia- Associate Dean (Research) of AIIMS.</p><p style="text-align: justify;">The workshop was conducted to empower medical facilities from seven northern states and Union Territories of India to undertake high-quality systematic reviews that can strengthen evidence-based healthcare practices in the region.</p><p style="text-align: justify;"><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/hospital-diagnostics/aiims-csir-join-hands-to-advance-medical-research-healthcare-delivery-140235"><b><i>Also Read:AIIMS, CSIR join hands to advance medical research, healthcare delivery</i></b></a></p><p style="text-align: justify;">The five-day event brought together clinicians, researchers, and academicians from Delhi, Haryana, Chandigarh, Punjab, Himachal Pradesh, Jammu and Kashmir, and also Ladakh.</p><p style="text-align: justify;">The program focussed on hands-on training in systematic review methodology, which will serve as a critical tool for synthesizing and integrating clinical research findings to address key healthcare challenges in India.</p><p style="text-align: justify;">The workshop was meticulously designed to train participants in conducting systematic reviews to inform clinical decision-making and health policy and enhance regional research capacities by creating a network of skilled professionals adept at synthesizing evidence. It also aimed to foster collaboration between clinical facilities and research institutions across northern states, news agency ANI reported.</p><p style="text-align: justify;">The workshop was led by an eminent panel of experts from AIIMS, ICMR and DHR who shared insights into the conceptual and practical aspects of systematic reviews. Enthusiastic participants engaged in hands-on training, learning how to frame research questions, perform literature searches, assess the quality of evidence, and apply advanced statistical techniques.</p><p style="text-align: justify;">The program was supported and sponsored by DHR, the initiative reaffirms the government's commitment to strengthening India's healthcare research ecosystem.</p><p style="text-align: justify;">Participants praised the workshop as a much-needed step toward bridging the gap between research and practice.</p><p style="text-align: justify;">The SARANSH workshop is a significant step forward in India's journey toward achieving excellence in healthcare delivery through evidence-based practice. With its success, the stage is set for future initiatives to strengthen research and innovation in healthcare across the nation.</p><p style="text-align: justify;"><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/hospital-diagnostics/aiims-signs-mou-with-wipro-ge-healthcare-to-set-up-ai-health-innovation-hub-139818"><b><i>Also Read:AIIMS signs MoU with Wipro GE Healthcare to set up AI health innovation hub</i></b></a></p><div class="hocal-draggable" draggable="true"><div class="read-this-also-wrap"><div></div></div></div></div>

158. Sacubitril-valsartan may help prevent heart damage related to chemotherapy, suggests study

     Thu, 26 Dec 2024 03:45:52 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/08/28/249904-heart-disease-50-1.webp' /><div class="pasted-from-word-wrapper"><p style="text-align: justify; ">A commonly prescribed medication for heart failure was linked to a lower risk of heart damage, or cardiotoxicity, among high-risk cancer patients undergoing<a href="https://medicaldialogues.in/topics/chemotherapy"> chemotherapy </a>treatment using <a href="https://medicaldialogues.in/topics/anthracyclines">anthracyclines,</a> according to preliminary late-breaking science presented at the American Heart Association’s.</p><p style="text-align: justify;">“We have identified a promising new strategy for protecting the heart during cancer treatment, with the potential to impact patient care significantly and future research in heart disease and cancer,” said study lead author Marcely Bonatto, M.D., a cardiologist and specialist in heart failure and heart transplantation at the Heart Institute, University of São Paulo in Curitiba, Brazil. “Importantly, our strategy enables early identification of people at high risk for developing heart dysfunction, allowing for timely interventions to prevent further loss of heart function.”</p><p style="text-align: justify; "><a href="https://medicaldialogues.in/topics/heart-failure">Heart failure</a> occurs when damage prevents the heart from pumping blood well enough to supply the body with blood and nutrients. Anthracyclines are a class of chemotherapy medications used to treat many types of cancer, including breast cancer, <a href="https://medicaldialogues.in/topics/leukemia">leukemia</a>, lymphoma and sarcoma. However, one of their potential side effects is cardiomyopathy, a disease of the heart muscle that makes it harder for the heart to pump blood to the rest of the body. Cardiomyopathy is a form of cardiotoxicity that refers to heart damage caused by cancer treatments involving chemotherapy.</p><p style="text-align: justify;">The SARAH clinical trial examined the effects of the heart-failure medication sacubitril-valsartan, an angiotensin receptor neprilysin inhibitor or ARNI, on preventing further heart damage among 114 patients undergoing chemotherapy treatment with anthracyclines for<a href="https://medicaldialogues.in/topics/breast-cancer"> breast cancer</a>, lymphoma, sarcoma or leukemia.</p><p style="text-align: justify;">The study found:</p><ul><li style="text-align: justify;">Compared to a placebo, sacubitril/valsartan was associated with a 77% decrease in relative risk of further heart damage among people who already had signs of damage. Patients’ reduction in the incidence of cardiotoxicity was assessed from the moment treatment began until the end of the intervention—at 24 weeks.</li><li style="text-align: justify;">Participants began with a 24/26 mg dose of sacubitril/valsartan twice daily, which was titrated every two weeks until they reached a target dose of 97/103 mg twice daily, or the highest dose that patients were able to tolerate without side effects. The medication was generally well tolerated, the researchers noted.</li><li style="text-align: justify;">Compared to participants who received a placebo, those in the sacubitril/valsartan group were much less likely to develop additional heart damage by the end of the 24-week intervention period. Participants in the treatment group improved their GLS (global longitudinal strain), a marker of heart contractility, by an average of 2.55%, while participants in the placebo group experienced an average 6.65% decline in GLS.</li></ul><p style="text-align: justify;">“Our findings highlight the importance of identifying patients with high-risk who are most likely to benefit from heart protection, and therefore, minimize unnecessary side effects and health care costs for low-risk people,” Bonatto said. “Accurately identifying which people will benefit from these strategies remains a significant challenge.”</p><p style="text-align: justify; ">The study had several limitations, including that all participants were at high risk for heart damage and were receiving anthracyclines for chemotherapy-113 received doxorubicin and 1 received daunorubicin-so the findings may not apply to people with lower risk or those treated with different chemotherapy medications. Other limitations are that the study could not account for heart damage after the six-month follow-up and did not look at other factors like survival or quality of life. The study also took place in a single hospital in Brazil, so the findings may not apply to patients treated in other hospitals. Additional research is needed on more diverse patient groups because the study participants were mostly white and female.</p><p style="text-align: justify; ">Reference:</p><p style="text-align: justify; ">A common heart failure medication may help prevent heart damage related to chemotherapy, American Heart Association, Meeting:AHA Scientific Sessions 2024.</p></div>

159. Semaglutide with Metformin Improves Liver Health and Pancreatic Function in T2DM and NAFLD: Study Reveals

     Thu, 26 Dec 2024 03:30:13 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/03/15/234312-fatty-liver-disease-50.webp' /><p style="text-align: justify; "><strong>China</strong>: A recent study revealed that combining <a href="https://medicaldialogues.in/topics/semaglutide">semaglutide </a>and <a href="https://medicaldialogues.in/topics/metformin">metformin </a>significantly improved liver inflammation, fibrosis, and pancreatic beta-cell function in patients with<a href="https://medicaldialogues.in/topics/t2dm"> type 2 diabetes (T2DM)</a> and <a href="https://medicaldialogues.in/topics/non-alcoholic-fatty-liver-disease">non-alcoholic fatty liver disease (NAFLD)</a>.</p><div class="pasted-from-word-wrapper"><p style="text-align: justify; ">"Compared to metformin alone, the combination therapy resulted in lower liver enzyme levels (ALT, AST), reduced fibrosis, better glycemic control (lower HbA1c), and enhanced beta-cell function," the researchers reported. The findings were published online in the <em>Journal of Diabetes and its Complications</em> on December 9, 2024. </p><p style="text-align: justify; ">Type 2 diabetes mellitus and non-alcoholic fatty liver disease often coexist, driven by underlying insulin resistance and systemic inflammation. There is an urgent need for effective management strategies targeting both metabolic disorders. Keeping this in mind, Rong Ren, Department of Endocrinology, Shanxi Provincial Integrated TCM And WM Hospital, Taiyuan, China, and colleagues examined the impact of combining semaglutide, a glucagon-like peptide-1 receptor agonist, with metformin on liver inflammation and pancreatic beta-cell function in patients with T2DM and NAFLD. </p><p style="text-align: justify; ">For this purpose, the researchers conducted a retrospective analysis of 261 patients with T2DM and NAFLD treated at our institution between January 2021 and December 2023. The participants were categorized into two groups: 127 patients received metformin alone (M group), while 134 patients received a combination of semaglutide and metformin (SAM group).</p><p style="text-align: justify; ">Liver inflammation and fibrosis were evaluated using alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (γ-GTP), and the FIB-4 index. Pancreatic beta-cell function and insulin sensitivity were assessed based on the Matsuda index, HbA1c, fasting glucose, and the oral disposition index (DIo). </p><p style="text-align: justify; ">The investigation uncovered the following findings:</p><p style="text-align: justify; "><span style="background-color: rgb(255, 255, 255);">Post-treatment, the SAM group exhibited significantly greater improvements in liver inflammation markers compared to the M group:</span></p><p style="text-align: justify; ">•&nbsp;<strong style="background-color: rgb(255, 255, 255);">ALT levels</strong><span style="background-color: rgb(255, 255, 255);">: 23.59 ± 5.67 U/L in SAM vs. 25.56 ± 5.46 U/L in M</span><span style="background-color: rgb(255, 255, 255);"></span></p><p style="text-align: justify; ">•&nbsp;<strong style="background-color: rgb(255, 255, 255);">AST levels</strong><span style="background-color: rgb(255, 255, 255);">: 18.97 ± 3.94 U/L in SAM vs. 20.15 ± 3.95 U/L in M</span><span style="background-color: rgb(255, 255, 255);"></span></p><p style="text-align: justify; ">•&nbsp;<span style="background-color: rgb(255, 255, 255);">The SAM group demonstrated reduced fibrosis as indicated by the FIB-4 index:</span><span style="background-color: rgb(255, 255, 255);"></span></p><p style="text-align: justify; ">•&nbsp;<strong style="background-color: rgb(255, 255, 255);">FIB-4 index</strong><span style="background-color: rgb(255, 255, 255);">: 1.05 ± 0.44 in SAM vs. 1.16 ± 0.51 in M</span><span style="background-color: rgb(255, 255, 255);"></span></p><p style="text-align: justify; ">•&nbsp;<span style="background-color: rgb(255, 255, 255);">Enhanced beta-cell function was observed in the SAM group:</span><span style="background-color: rgb(255, 255, 255);"></span></p><p style="text-align: justify; ">•&nbsp;<strong style="background-color: rgb(255, 255, 255);">Matsuda index</strong><span style="background-color: rgb(255, 255, 255);">: 5.18 ± 1.09 in SAM vs. 4.84 ± 1.15 in M</span><span style="background-color: rgb(255, 255, 255);"></span></p><p style="text-align: justify; ">•&nbsp;<strong style="background-color: rgb(255, 255, 255);">DIo (oral disposition index)</strong><span style="background-color: rgb(255, 255, 255);">: 0.18 ± 0.06 in SAM vs. 0.16 ± 0.05 in M</span><span style="background-color: rgb(255, 255, 255);"></span></p><p style="text-align: justify; "><span style="background-color: rgb(255, 255, 255);"></span><span>•&nbsp;</span><span style="background-color: rgb(255, 255, 255);">Glycemic control was superior in the SAM group, as reflected by reduced HbA1c levels.</span></p><p style="text-align: justify; ">The authors highlight that combining semaglutide and metformin effectively improves liver inflammation, fibrosis, beta-cell function, and insulin sensitivity in patients with T2DM and NAFLD. Their findings suggest that the beneficial effects of semaglutide combined with metformin on liver function are independent of body weight loss and glycemic control.</p><p style="text-align: justify; ">"These results emphasize the potential role of semaglutide as a key therapeutic option in the comprehensive management of metabolic and liver-related disorders," they concluded.</p><p style="text-align: justify; ">Reference:</p><p style="text-align: justify; ">Ren, R., Pei, Y., Kong, L., &amp; Shi, Y. (2024). The effect of semaglutide combined with metformin on liver inflammation and pancreatic beta-cell function in patients with type 2 diabetes and non-alcoholic fatty liver disease. Journal of Diabetes and its Complications, 108932. https://doi.org/10.1016/j.jdiacomp.2024.108932</p></div>

160. KAIST Researchers Unveil Method to Revert Cancer Cells to Normal Colon Cells

     Thu, 26 Dec 2024 03:00:00 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/26/266537-mdtv-2024-12-26t113106850.webp' /><div class="pasted-from-word-wrapper"><div style="text-align: justify; ">A research team led by Professor Kwang-Hyun Cho from the Department of Bio and Brain Engineering has developed a technology that can treat<a href="https://medicaldialogues.in/topics/colon-cancer"> colon cancer</a> by converting <a href="https://medicaldialogues.in/topics/cancer-cells">cancer cells</a> into a state resembling normal colon cells without killing them, thus avoiding side effects.</div><div style="text-align: justify;">The research team focused on the observation that during the oncogenesis process, normal cells regress along their differentiation trajectory.</div><div style="text-align: justify;">Building on this insight, they developed a technology to create a digital twin of the gene network associated with the differentiation trajectory of normal cells.</div><div style="text-align: justify;">Through simulation analysis, the team systematically identified master molecular switches that induce normal cell differentiation.</div><div style="text-align: justify;">When these switches were applied to colon cancer cells, the cancer cells reverted to a normal-like state, a result confirmed through molecular and cellular experiments as well as animal studies.</div><div style="text-align: justify;">This research demonstrates that cancer cell reversion can be systematically achieved by analyzing and utilizing the digital twin of the cancer cell gene network, rather than relying on serendipitous discoveries.</div><div style="text-align: justify;">The findings hold significant promise for developing reversible cancer therapies that can be applied to various types of cancer.</div><div style="text-align: justify;">Professor Kwang-Hyun Cho remarked, "The fact that cancer cells can be converted back to normal cells is an astonishing phenomenon. This study proves that such reversion can be systematically induced."</div><div style="text-align: justify;">He further emphasized, "This research introduces the novel concept of reversible cancer therapy by reverting cancer cells to normal cells. It also develops foundational technology for identifying targets for cancer reversion through the systematic analysis of normal cell differentiation trajectories."</div><div style="text-align: justify;">Reference: https://news.kaist.ac.kr/newsen/html/news/?mode=V&amp;mng_no=42710</div><div></div><div></div></div>

161. Simple Scan May Identify Patients at Risk For Serious Heart Problems: Study Finds

     Thu, 26 Dec 2024 02:45:00 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/26/266531-mdtv-2024-12-26t113044348.webp' /><div class="pasted-from-word-wrapper"><div style="text-align: justify; ">The researchers, led by Frederick H. Epstein, PhD, of the University of Virginia;s Department of Biomedical Engineering, are seeking to use magnetic resonance imaging (<a href="https://medicaldialogues.in/topics/MRI">MRI</a>) to assess the composition of adipose tissue – fat – that surrounds the heart. The researchers have published their findings in the scientific journal <i><a href="https://medicaldialogues.in/topics/Magnetic-Resonance-in-Medicine">Magnetic Resonance in Medicine</a></i>. </div><div style="text-align: justify;">Analyzing this tissue could let doctors identify patients at greatest risk for potentially deadly <a href="https://medicaldialogues.in/topics/cardiac-problems">cardiac problems</a> and to predict how well those patients may respond to treatments. </div><div style="text-align: justify;">Early testing of the technique has produced encouraging signs that the approach could be a powerful tool to improve patient care.</div><div style="text-align: justify;">The UVA researchers would use MRI to assess the amount and composition of the fat. The imaging technology essentially lets them see inside the body without the need for surgery. By analyzing the amounts of saturated fatty acids, monosaturated fatty acids and polyunsaturated fatty acids – fats commonly associated with our diets – in the epicardial adipose tissue, doctors may be able to identify patients who could face heart problems even before symptoms appear. Identifying and correcting this problem has the potential to slow down the progression of heart disease.</div><div style="text-align: justify;">By developing innovative imaging approaches, the scientists are now able to get the images they need in the span of a single breath hold.</div><div style="text-align: justify;">The UVA team has already tested their technology in both the lab and in a limited number of human patients. They found that the fat around the heart in patients who were obese and had suffered heart attacks was comprised of an excessive amount of saturated fatty acids. </div><div style="text-align: justify;">Reference: Echols JT, Wang S, Patel AR, Hogwood AC, Abbate A, Epstein FH. Fatty acid composition MRI of epicardial adipose tissue: Methods and detection of proinflammatory biomarkers in ST-segment elevation myocardial infarction patients. Magn Reson Med. 2025; 93: 519-535. doi: 10.1002/mrm.30285</div><div></div></div>

162. Systolic BP of less than 120 mm Hg reduced CVD risk in adults with Type 2 diabetes, suggests study

     Thu, 26 Dec 2024 02:30:50 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/04/24/236774-type-2-diabetes-50-1.webp' /><div class="pasted-from-word-wrapper"><p style="text-align: justify; ">An intensive treatment approach to lowering high systolic blood pressure in people with Type 2 <a href="https://medicaldialogues.in/topics/diabetes" target="_blank">diabetes </a>led to a reduced risk of heart attack, stroke, heart failure and death due to cardiovascular disease when compared to a standard treatment approach, according to late-breaking science presented today at the <a href="https://medicaldialogues.in/topics/american-heart-association" target="_blank">American Heart Association’s</a> Scientific Sessions 2024. The meeting, Nov. 16-18, 2024, in Chicago, is a premier global exchange of the latest scientific advancements, research and evidence-based clinical practice updates in cardiovascular science.</p><p style="text-align: justify;">“We found that for most people with Type 2 diabetes, lowering systolic blood pressure to less than 120 mm Hg reduced the risk of major cardiovascular events,” said lead study author Guang Ning, M.D., Ph.D., an elected member of the Chinese Academy of Engineering and a professor at Ruijin Hospital at Shanghai Jiao Tong University School of Medicine in Shanghai, China. “These findings provide strong support for a more intensive systolic blood pressure target in people with Type 2 diabetes for the prevention of major cardiovascular events.”</p><p style="text-align: justify;">A person living with Type 2 diabetes is twice as likely to have high blood pressure than someone without Type 2 diabetes. Elevated blood sugar levels can cause damage to blood vessels and impair kidney function, leading to elevated blood pressure. Almost three-fourths of adults with Type 2 diabetes are estimated to also have high blood pressure, according to the U.S. Centers for Disease Control and Prevention data, and when blood pressure levels are consistently elevated, lifestyle modification and medication are recommended. If unmanaged, high blood pressure can cause damage over time and increase the risk of heart attack, stroke, heart failure, kidney problems and more.</p><p style="text-align: justify;">The goal of the BPROAD study was to determine whether an intensive systolic blood pressure reduction approach to a target of lower than 120 mm Hg was more effective in reducing the risk of major cardiovascular events, including non-fatal stroke, non-fatal myocardial infarction, treated or hospitalized heart failure, and cardiovascular death than a standard systolic blood pressure reduction approach to a target of lower than 140 mm Hg among people with Type 2 diabetes.</p><p style="text-align: justify;">The BPROAD study included 12,821 adults at 145 study sites located in 25 provinces or municipalities across mainland China were enrolled in the study. All participants had Type 2 diabetes, elevated systolic blood pressure and an increased risk of cardiovascular disease. In this study, the criteria for elevated systolic blood pressure was ≥140 mm Hg without antihypertensive medications or ≥130 mm Hg and taking at least one anti-hypertensive medication.</p><p style="text-align: justify;">The results found:</p><p style="text-align: justify;">The mean systolic blood pressure levels of the participants at the four-year visit was 120.6 mm Hg in the intensive treatment group and 132.1 mm Hg in the standard treatment group.</p><p style="text-align: justify;">The people who received the intensive treatment had a 21% lower relative risk of major cardiovascular events, compared with those who received the standard treatment during the follow-up period.</p><p style="text-align: justify;">Non-fatal stroke, non-fatal heart attack, hospitalization or treatment for heart failure, or cardiovascular deaths occurred in 393 participants (1.65% per year) in the intensive treatment group and 492 participants (2.09% per year) in the standard treatment group.</p><p style="text-align: justify;">Serious adverse events such as hospitalization were generally similar between the two treatment groups. However, blood pressure levels that were too low with symptoms (symptomatic hypotension) and high potassium levels (hyperkalemia) occurred more frequently among participants in the intensive treatment group.</p><p style="text-align: justify;">“Our study results are consistent with another study of patients with hypertension but without diabetes, which found a significantly 27% reduction in the incidence of cardiovascular diseases,” said Ning. “Future clinical practice guidelines will hopefully consider these results when making recommendations for blood pressure targets for people with Type 2 diabetes. Beneficial future research could focus on profiling those with the largest benefit and the lowest harm in an intensive blood pressure treatment group.”</p></div>

163. New Migraine Drug May Start Working Right Away: Researchers

     Thu, 26 Dec 2024 02:30:00 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/26/266529-mdtv-2024-12-26t112938114.webp' /><div class="pasted-from-word-wrapper"><div style="text-align: justify; ">A drug recently approved to prevent <a href="https://medicaldialogues.in/topics/migraine">migraine </a>may start working right away, according to a study published online issue of Neurology, the medical journal of the<i><a href="https://medicaldialogues.in/topics/american-academy-of-neurology"> American Academy of Neurology</a></i>. The study looked at the drug <a href="https://medicaldialogues.in/topics/atogepant">atogepant</a>, which is a calcitonin gene-related peptide (CGRP) receptor antagonist taken by mouth.</div><div style="text-align: justify;">In the study, people taking the drug atogepant were less likely to have a migraine on the first day of taking the drug compared to those taking a placebo. They also had fewer migraines per week during each of the first four weeks of the study and fewer migraines during the study overall than those taking a <a href="https://medicaldialogues.in/topics/placebo">placebo</a>.</div><div style="text-align: justify;">For this study, researchers looked at the data from three trials on the safety and effectiveness of atogepant over 12 weeks to focus on how rapidly improvements appeared. There were 3 trials - ADVANCE trial, ELEVATE trial and PROGRESS trial, which enrolled people with episodic migraine.</div><div style="text-align: justify;">People with episodic migraine experience up to 14 migraine days per month. People with chronic migraine experience at least 15 days with headache per month, with at least eight days being characteristic of migraine. On the first day of the study, 12% of those taking the drug in the first trial, the ADVANCE trial had a migraine, compared to 25% of those taking placebo. In the second trial, the ELEVATE trial, the numbers were 15% and 26%. For the third trial, the PROGRESS trial, the numbers were 51% and 61%. When researchers adjusted for other factors that could affect the rate of migraine, they found that people taking the drug were 61% less likely to have a migraine in the first trial, 47% less likely in the second trial, and 37% less likely in the third trial. </div><div style="text-align: justify;">Reference: Lipton, R. B., Gandhi, P., Tassorelli, C., Reuter, U., Harriott, A. M., Holle-Lee, D., Gottschalk, C. H., Neel, B., Liu, Y., Guo, H., Stokes, J., Nagy, K., Dabruzzo, B., &amp; Smith, J. H. (2025, January 28). Early improvements with atogepant for the preventive treatment of migraine: Results from 3 randomized phase 3 trials. Neurology, 104(2), Article 0000000000210212. https://doi.org/10.1212/WNL.0000000000210212</div><div></div></div>

164. Hypoalbuminemia excellent prognostic biomarker for mortality in status epilepticus unravels study

     Wed, 25 Dec 2024 20:15:22 -0000

     <img src='https://medicaldialogues.in/h-upload/2023/04/20/207859-epilepsy.webp' /><p style="text-align: justify;">Researchers have established that hypoalbuminemia is an independent and strong predictor for both short- and long-term mortality in patients diagnosed with status epilepticus (SE). This accessible biomarker indicates the general condition of a patient and can greatly help improve the existing scoring models, such as the Status Epilepticus Severity Score (STESS). A recent study was conducted by Francesco and colleagues which was published in the <i>European Journal of Neurology</i>.</p><div class="pasted-from-word-wrapper"><p dir="ltr" style="text-align: justify;">It was a prospective observational cohort study done at the University Hospital of Geneva, Switzerland, during 2015 to 2023, with an enrollment of 496 adults with non-hypoxic status epilepticus. The outcomes investigated were in-hospital and 6-month mortality. Hypoalbuminemia was correlated with demographic, comorbidities, and clinical outcomes. The association between hypoalbuminemia and mortality was established using binomial regression models. The study also conducted an exploratory analysis by replacing the age variable in STESS with hypoalbuminemia, creating the Albumin-STESS (A-STESS) score. The predictive performance of STESS and A-STESS was compared using the area under the curve (AUC).</p><p dir="ltr" style="text-align: justify;">Key Findings</p><p dir="ltr" style="text-align: justify;">Mortality Rates:</p><p dir="ltr" style="text-align: justify;">• Among the 496 patients, 46 (9.3%) died during hospitalization.</p><p dir="ltr" style="text-align: justify;"><span>•&nbsp;</span>Follow-up data at six months were available for 364 patients, and among them, 86 (23.6%) had died.</p><p dir="ltr" style="text-align: justify;">Hypoalbuminemia and Mortality:</p><p dir="ltr" style="text-align: justify;">• Hypoalbuminemia independently correlated with in-hospital mortality (p=0.005, OR=3.35, 95% CI=1.43–7.86) and 6-month mortality (p=0.001, OR=3.59, 95% CI=1.75–7.35).</p><p dir="ltr" style="text-align: justify;">STESS vs. A-STESS:</p><p dir="ltr" style="text-align: justify;">• The original STESS had an AUC of 0.754 (95% CI=0.656–0.836) for in-hospital mortality prediction and 0.684 (95% CI=0.613–0.755) for 6-month mortality.</p><p dir="ltr" style="text-align: justify;">• A-STESS significantly improved predictive accuracy with an AUC of 0.837 (95% CI=0.760–0.916; p=0.002) for in-hospital mortality and 0.739 (95% CI=0.688–0.826; p=0.033) for 6-month mortality.</p><p dir="ltr" style="text-align: justify;">A-STESS Performance:</p><p dir="ltr" style="text-align: justify;">• An A-STESS score of ≥3 showed optimal balance between sensitivity and specificity for mortality prediction:</p><p dir="ltr" style="text-align: justify;">• In-hospital mortality: Sensitivity=0.88, Specificity=0.68, Accuracy=0.70</p><p dir="ltr" style="text-align: justify;">• 6-month mortality: Sensitivity=0.67, Specificity=0.73, Accuracy=0.72</p><p dir="ltr" style="text-align: justify;">This study demonstrates that hypoalbuminemia is an excellent prognostic biomarker for mortality in status epilepticus. It was found that the integration of hypoalbuminemia into the STESS scoring system significantly increases the predictive power of STESS for both short and long-term outcomes. It would be useful to find therapeutic interventions like albumin supplementation that improve patient outcome in future research by validation of the A-STESS model.</p><p dir="ltr" style="text-align: justify;">Reference:</p><p dir="ltr" style="text-align: justify;">Misirocchi F, Quintard H, Rossetti AO, Florindo I, Sarbu OE, Kleinschmidt A, Schaller K, Seeck M, De Stefano P. Hypoalbuminemia in status epilepticus is a biomarker of short- and long-term mortality: A 9-year cohort study. Eur J Neurol. 2025 Jan;32(1):e16573. doi: 10.1111/ene.16573. PMID: 39711115; PMCID: PMC11664120. </p><div style="text-align: justify;"></div></div>

165. Gestational diabetes early in pregnancy tied to risk of postpartum glucose intolerance, finds study

     Wed, 25 Dec 2024 16:15:00 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/05/263705-images-91.webp' /><p style="text-align: justify; ">Gestational diabetes early in pregnancy tied to risk of postpartum glucose intolerance finds a study published in the Journal of Diabetes Investigation.</p><div class="pasted-from-word-wrapper"><p dir="ltr" style="text-align: justify; ">A study was done to compare perinatal outcomes and postpartum glucose tolerance between women diagnosed with gestational diabetes mellitus (GDM) before 20 weeks of gestation (EGDM) and those diagnosed at or after 24 weeks of gestation (LGDM) in a Japanese population. </p><p dir="ltr" style="text-align: justify; ">Data were obtained from a prospective GDM registry. Multivariate analysis was conducted to examine the association between the timing of GDM diagnosis (EGDM vs LGDM) and perinatal outcomes (preterm birth, small for gestational age, large for gestational age, pregnancy-induced hypertension, and neonatal hypoglycemia), as well as postpartum glucose intolerance. Results: A total of 1,275 mother-infant pairs were analyzed for perinatal outcomes. </p><p dir="ltr" style="text-align: justify; ">Of these, 924 women underwent postpartum testing for glucose intolerance. No significant differences in perinatal outcomes were observed between the EGDM and LGDM groups, except that overweight/obese women with EGDM had 2.5-fold higher rate of preterm birth than those with LGDM. </p><p dir="ltr" style="text-align: justify; ">Postpartum glucose intolerance was 1.5 times more likely in the EGDM group than in the LGDM group. Women with EGDM had a significantly higher risk of postpartum glucose intolerance than those with LGDM, despite similar perinatal outcomes between the two groups.</p><p dir="ltr" style="text-align: justify; ">Reference:</p><p dir="ltr" style="text-align: justify; ">Yokoyama M, Miyakoshi K, Iwama N, Yamashita H, Yasuhi I, Kawasaki M, Arata N, Sato S, Imura Y, Waguri M, Kawaguchi H, Masaoka N, Nakajima Y, Hiramatsu Y, Sugiyama T; DREAMBee Study Gestational Diabetes Mellitus Group. Gestational diabetes in early pregnancy is associated with postpartum glucose intolerance: A perspective from the diabetes and pregnancy outcome for mother and baby study in Japan. J Diabetes Investig. 2024 Nov 28. doi: 10.1111/jdi.14368. Epub ahead of print. PMID: 39610144.</p><div style="text-align: justify;"></div><div style="text-align: justify;"></div><div style="text-align: justify;"></div><div style="text-align: justify;"></div></div>

166. Revolutionizing Hip Surgery Recovery: Enhancing Functional Outcomes Through Innovative Pain Management Strategies, study finds

     Wed, 25 Dec 2024 15:45:06 -0000

     <img src='https://medicaldialogues.in/h-upload/2022/07/16/180958-hip-surgery.webp' /><p style="text-align: justify; ">In the past, hip surgeries concentrated on fixing surgical issues and managing pain around the operation, paying little attention to post-surgery functional improvement. Today, modern healthcare integrates Enhanced Recovery After Surgery (ERAS) protocols, focusing on pain relief, early mobility, and effective recovery post-surgery to enhance functional outcomes without significant postoperative limitations. Recent study aimed to compare the functional outcomes of the pericapsular nerve group (PENG) block and the supra-inguinal fascia iliaca (SIFI) block in hip surgery patients. Sixty patients undergoing hip surgeries were randomly assigned to receive either the PENG block or SIFI block postoperatively. The blocks were administered under ultrasound guidance using 0.2% ropivacaine and dexamethasone. Functional outcomes were assessed by measuring quadriceps muscle strength, weight-bearing capacity, and analgesic efficacy. The results showed that the PENG block group exhibited higher quadriceps strength at 24 and 48 hours post-surgery compared to the SIFI block group. Additionally, more patients in the PENG block group achieved superior weight-bearing grades at 24 hours post-surgery. The PENG block group also reported lower pain scores at 24 hours post-surgery, longer duration of analgesia, and lower opioid consumption compared to the SIFI block group.</p><p style="text-align: justify;">Importance of Early Ambulation</p><p style="text-align: justify;">The study highlighted the importance of early ambulation and functional recovery in hip surgery patients, emphasizing the need for improved postoperative outcomes. The PENG block was found to provide better functional outcomes in terms of quadriceps strength, weight-bearing capacity, and postoperative analgesia compared to the SIFI block. The study adhered to ethical guidelines, randomizing patients into groups and maintaining blinding during the block administration and outcome assessments. The use of 0.2% ropivacaine in both blocks supported early mobilization and safety postoperatively. The findings suggested that the PENG block may promote early ambulation, reduce pain, and improve motor function recovery, ultimately lowering the risk of complications associated with prolonged immobilization.</p><p style="text-align: justify;">Study Conclusion</p><p style="text-align: justify;">Overall, the study concluded that the PENG block demonstrated superior functional outcomes in hip surgeries compared to the SIFI block. This research contributes to enhancing the understanding of regional analgesia techniques in hip surgery and emphasizes the importance of optimizing postoperative functional recovery, pain management, and early ambulation in improving patient outcomes. Further research is recommended to evaluate the maximum weight-bearing capacity in patients undergoing hip surgeries with these blocks.</p><p style="text-align: justify;">Key Points</p><p style="text-align: justify;">1. The study aimed to compare functional outcomes between the pericapsular nerve group (PENG) block and the supra-inguinal fascia iliaca (SIFI) block in hip surgery patients. Sixty patients undergoing hip surgeries were randomly assigned to receive either the PENG or SIFI block postoperatively, with functional outcomes evaluated through quadriceps muscle strength, weight-bearing capacity, and analgesic efficacy measurements.</p><p style="text-align: justify;">2. Results showed that the PENG block group had higher quadriceps strength at 24 and 48 hours post-surgery, superior weight-bearing at 24 hours post-surgery, lower pain scores at 24 hours post-surgery, longer duration of analgesia, and lower opioid consumption compared to the SIFI block group. These findings suggest the superiority of the PENG block in functional outcomes and pain management in hip surgery patients.</p><p style="text-align: justify;">3. The importance of early ambulation and functional recovery in hip surgery patients was emphasized, underscoring the need for improved postoperative outcomes. The study highlighted that the PENG block provided better functional outcomes in terms of quadriceps strength, weight-bearing capacity, and postoperative analgesia compared to the SIFI block.</p><p style="text-align: justify;">4. The study adhered to ethical guidelines by randomizing patients, maintaining blinding during block administration and outcome assessments, and utilizing 0.2% ropivacaine in both blocks to support early mobilization and safety postoperatively. These measures ensured the reliability and integrity of the study results.</p><p style="text-align: justify;">5. The findings suggested that the PENG block may promote early ambulation, reduce pain, and enhance motor function recovery, potentially lowering the risk of complications associated with prolonged immobilization in hip surgery patients. The research indicated that optimizing postoperative functional recovery and pain management is crucial for improving patient outcomes in hip surgeries.</p><p style="text-align: justify;">6. In conclusion, the study demonstrated that the PENG block yielded superior functional outcomes in hip surgeries compared to the SIFI block. The research contributes to advancing knowledge on regional analgesia techniques in hip surgery and emphasizes the significance of enhancing postoperative functional recovery, pain management, and early ambulation to optimize patient outcomes. Further research is recommended to assess the maximum weight-bearing capacity in hip surgery patients receiving these blocks, indicating a potential direction for future investigations in this field.</p><p style="text-align: justify;">Reference –</p><p style="text-align: justify;">Tanusha Saini et al. (2024). Pericapsular Nerve Group (PENG) Block Versus Supra-Inguinal Fascia Iliaca (SIFI) Block For Functional Outcome In Patients Undergoing Hip Surgeries – A Randomised Controlled Study. *Indian Journal Of Anaesthesia*. https://doi.org/10.4103/ija.ija_838_24.</p>

167. Study reveals CV Risk Profiles of Different Hormone Therapies and their Clinical Implications for Menopausal Treatment

     Wed, 25 Dec 2024 15:30:20 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/02/23/232860-menopause-50.webp' /><p style="text-align: justify; ">A groundbreaking Swedish study found that oral contraceptives are associated with an increased risk of cardiovascular disease in women around the menopause period, as per results that were published in the journal The BMJ.</p><div class="pasted-from-word-wrapper"> <p style="text-align: justify;">Cardiovascular diseases are the leading cause of death globally. Despite developing at a later stage than men, women develop cardiovascular diseases during the midlife period that coincide with the menopausal period. This phase of life is characterized by a decrease in estrogen and an increase in follicle-stimulating hormone concentrations that affect the neuroendocrine system. This condition is treated by systemic menopausal hormonal therapy. Systemic menopausal therapy that contains estrogen mitigates the vasomotor symptoms. However, research has shown that systemic menopausal therapy can affect cardiovascular health. Due to knowledge gaps between the effects of menopausal therapy on cardiovascular health, researchers conducted a trial to assess the impact of contemporary menopausal hormone therapy on the risk of cardiovascular disease according to the route of administration and combination of hormones.</p></div><div class="hocal-draggable" draggable="true"><div class="read-this-also-wrap"><a class="also-read-media-wrap" href="https://medicaldialogues.in/diabetes-endocrinology/news/study-reveals-increased-autoimmune-disease-risk-in-women-with-primary-ovarian-insufficiency-139448"><img class="also-read-media" data-src="https://medicaldialogues.in/h-upload/2024/12/05/263576-primary-ovarian-insufficiency.webp"></a><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/diabetes-endocrinology/news/study-reveals-increased-autoimmune-disease-risk-in-women-with-primary-ovarian-insufficiency-139448"><span class="read-this-also">Also Read:&nbsp;</span>Study Reveals Increased Autoimmune Disease Risk in Women with Primary Ovarian Insufficiency</a></div></div><div class="pasted-from-word-wrapper"> <p style="text-align: justify;">A Nationwide register-based emulated target trial was carried out from Swedish national registries involving 9,19,614 women aged 50-58 who did not use hormone therapy in the previous two years. A total of 138 nested trials were conducted beginning each month from July 2007 until December 2018. For every trial, the prescription registry data of that particular month was used to identify women who had not used hormone therapy in the previous two years. These identified women were assigned to one of eight treatment groups: oral combined continuous, oral combined sequential, oral unopposed estrogen, oral estrogen with local progestin, tibolone, transdermal combined, transdermal unopposed estrogen, or non-initiators of menopausal hormone therapy.</p> <p style="text-align: justify;">Hazard ratios with 95% confidence intervals were calculated for venous thromboembolism, ischemic heart disease, cerebral infarction, and myocardial infarction, both individually and as part of a composite cardiovascular disease outcome. Contrasting initiators assessed treatment effects to non-initiators in observational analogs of "intention-to-treat" analyses and continuous users to never users in "per protocol" analyses.</p> <p style="text-align: justify;">Findings:</p> <ul><li style="text-align: justify;">The trial included 77 512 women who were initiators of any menopausal hormone therapy and 842 102 women who were non-initiators. </li><li style="text-align: justify;">Out of them, 24 089 women had an event recorded during the follow-up: </li></ul> <table border="1" cellspacing="0" cellpadding="0" style="text-align: justify;"> <tbody><tr> <td width="312" valign="top"> <p>10 360 (43.0%)</p> </td> <td width="312" valign="top"> <p>ischemic heart disease event</p> </td> </tr> <tr> <td width="312" valign="top"> <p>4098 (17.0%)</p> </td> <td width="312" valign="top"> <p>cerebral infarction event</p> </td> </tr> <tr> <td width="312" valign="top"> <p>4312 (17.9%) </p> </td> <td width="312" valign="top"> <p>myocardial infarction event</p> </td> </tr> <tr> <td width="312" valign="top"> <p>9196 (38.2%) had a </p> </td> <td width="312" valign="top"> <p>venous thromboembolic event</p> </td> </tr> </tbody></table> <p style="text-align: justify;"> </p> <ul><li style="text-align: justify;">When compared to non-initiators, tibolone was associated with an increased risk of cardiovascular disease in intention-to-treat analyses. </li><li style="text-align: justify;">An increased risk of ischemic heart disease was seen with the initiators of tibolone or oral estrogen-progestin therapy. </li><li style="text-align: justify;">Venous thromboembolism risk was increased in oral continuous estrogen-progestin therapy, sequential therapy, and estrogen-only therapy. </li><li style="text-align: justify; ">Tibolone usage was associated with an increased risk of cerebral infarction and myocardial infarction as per protocol analyses.</li></ul></div><div class="hocal-draggable" draggable="true"><div class="read-this-also-wrap"><a class="also-read-media-wrap" href="https://medicaldialogues.in/obstetrics-gynaecology/news/replacing-animal-products-with-plant-based-foods-tied-to-92-reduction-in-hot-flashes-in-postmenopausal-women-finds-new-study-138773"><img class="also-read-media" data-src="https://medicaldialogues.in/h-upload/2024/09/10/251926-hot-flashes-50.webp"></a><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/obstetrics-gynaecology/news/replacing-animal-products-with-plant-based-foods-tied-to-92-reduction-in-hot-flashes-in-postmenopausal-women-finds-new-study-138773"><span class="read-this-also">Also Read:&nbsp;</span>Replacing animal products with plant-based foods tied to 92% reduction in hot flashes in postmenopausal women, finds new study</a></div></div><div class="pasted-from-word-wrapper"> <p style="text-align: justify;">The study concluded that menopausal therapy is associated with increased cardiovascular disease outcomes, with estrogen-progestin therapy causing heart disease and venous thromboembolism, while tibolone was associated with ischemic heart disease, cerebral infarction, and myocardial infarction but not venous thromboembolism. The choice of hormonal therapy should be individualized based on the patient’s cardiovascular risk profile. Clinicians should consider cardiovascular health and tailor it according to the patient’s needs. </p> <p style="text-align: justify; ">Further reading: Contemporary menopausal hormone therapy and risk of cardiovascular disease: Swedish nationwide register based emulated target trial. doi:<a href="https://www.bmj.com/content/387/bmj-2023-078784" rel="nofollow">https://doi.org/10.1136/bmj-2023-078784</a>.</p></div>

168. Cochlear implantations may improve speech and auditory outcomes in pediatric patients with sensorineural hearing loss: Study

     Wed, 25 Dec 2024 15:30:12 -0000

     <img src='https://medicaldialogues.in/h-upload/2020/07/10/131518-cochlear-implant-device.webp' /><p style="text-align: justify; ">A new study published in <i>The Laryngoscope</i> journal showed that possibilities for cochlear implantation (CI) are growing as research shows benefits in previously thought-inappropriate groups. Sensorineural hearing loss (SNHL) has an uncertain origin and pathophysiology and is the clinical manifestation of cochlear nerve deficit (CND), which is defined as a short or nonexistent cochlear branch of the vestibulocochlear nerve. The patients with congenital SNHL had a 2.5 to 21.2% incidence of CND.</p><p style="text-align: justify; ">It is challenging to distinguish the CN from other nerves in the internal acoustic meatus (IAM) because of the limits of the present MRI resolution. The use of cochlear implants in patients with CND is still debatable since some research on CI recipients with CND has shown very poor outcomes, while other studies have shown minimal speech discrimination and detection. </p><p style="text-align: justify; ">Based on MRI results of the IAM's nerves and the CN's size, this research has devised a new IAM nerve grading system and a CN classification system, as follows: Grades 0–III denoted aplasia, which is the observation of 0, 1, 2, and 3 nerve bundles in the IAM. Thereby, Susmita Chennareddy and colleagues undertook this study to investigate the speech and auditory outcomes of CI in young bilateral SNHL patients with radiographically confirmed CND before and after surgery.</p><p style="text-align: justify; ">The two primary databases (Embase and Ovid MEDLINE) were searched to find pre- and postoperative results of children with CND verified by magnetic resonance imaging who received CI. The variance in speech and auditory outcomes within and across studies was taken into consideration using a random-effects model.</p><p style="text-align: justify; ">A total of 16 studies, including 248 individuals with cochlear nerve hypoplasia or aplasia who had CI, were added for final inclusion following abstract screening of 818 different papers. The following tests of language development and speech perception were examined in various studies: Categories of Auditory Performance, Auditory Level, Meaningful Auditory Integration Scale, Meaningful Use of Speech Scale, Speech Intelligibility Rating, Speech Perception Category and Speech Awareness Thresholds.</p><p style="text-align: justify; ">After CI, children patients with CND showed improved speech perception, according to pooled results. Overall, as studies show benefits in individuals previously considered unsuitable, the list of indications for CI is growing. In children with bilateral SNHL and CND, this study shows a worldwide improvement in speech and auditory outcomes with CI.</p><p style="text-align: justify; ">Reference:</p><p style="text-align: justify; ">Chennareddy, S., Liu, K. H., Mavrommatis, M. A., Kao, D. D., Govindan, A., Schwam, Z. G., &amp; Cosetti, M. K. (2024). Cochlear Implantation in Pediatric Cochlear Nerve Deficiency: A Systematic Review and Meta‐Analysis. In The Laryngoscope. Wiley. <a href="https://onlinelibrary.wiley.com/doi/abs/10.1002/lary.31888" rel="nofollow">https://doi.org/10.1002/lary.31888</a></p>

169. Can the heart heal itself? New study says it can

     Wed, 25 Dec 2024 15:15:26 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/23/266087-heart-50.webp' /><p style="text-align: justify; ">A research team co-led by a physician-scientist at the University of Arizona College of Medicine-Tucson’s Sarver Heart Center found that a subset of artificial heart patients can regenerate heart muscle, which may open the door to new ways to treat and perhaps someday cure <a href="https://medicaldialogues.in/topics/heart-failure">heart failure</a>. The results were published in the journal<i> Circulation. </i></p><p style="text-align: justify;">According to the Centers for Disease Control and Prevention, heart failure affects nearly 7 million U.S. adults and is responsible for 14% of deaths per year. There is no cure for heart failure, though medications can slow its progression. The only treatment for advanced heart failure, other than a transplant, is pump replacement through an artificial heart, called a left ventricular assist device, which can help the heart pump blood. </p><p style="text-align: justify; ">“Skeletal muscle has a significant ability to regenerate after injury. If you’re playing soccer and you tear a muscle, you need to rest it, and it heals,” said Hesham Sadek, MD, PhD, director of the Sarver Heart Center and chief of the Division of Cardiology at the U of A College of Medicine – Tucson’s Department of Medicine. “When a heart muscle is injured, it doesn’t grow back. We have nothing to reverse heart muscle loss.” </p><p style="text-align: justify;">Sadek led a collaboration between international experts to investigate whether heart muscles can regenerate. The study was funded through a grant awarded to Sadek by the Leducq Foundation Transatlantic Networks of Excellence Program, which brings together American and European investigators to tackle big problems. </p><p style="text-align: justify;">The project began with tissue from artificial heart patients provided by colleagues at the University of Utah Health and School of Medicine led by Stavros Drakos, MD, PhD, a pioneer in left ventricular assist device-mediated recovery. </p><p style="text-align: justify;">Jonas Frisén, MD, PhD, and Olaf Bergmann, MD, PhD, of the Karolinska Institute in Stockholm, led teams in Sweden and Germany and used their own innovative method of carbon dating human heart tissue to track whether these samples contained newly generated cells. </p><p style="text-align: justify;">The investigators found that patients with artificial hearts regenerated muscle cells at more than six times the rate of healthy hearts. </p><p style="text-align: justify;">“This is the strongest evidence we have, so far, that human heart muscle cells can actually regenerate, which really is exciting, because it solidifies the notion that there is an intrinsic capacity of the human heart to regenerate,” Sadek said. “It also strongly supports the hypothesis that the inability of the heart muscle to ‘rest’ is a major driver of the heart’s lost ability to regenerate shortly after birth. It may be possible to target the molecular pathways involved in cell division to enhance the heart’s ability to regenerate.” </p><p style="text-align: justify;">Finding better ways to treat heart failure is a top priority for Sadek and the Sarver Heart Center. This study builds on Sadek’s prior research into rest and heart muscle regeneration. </p><p style="text-align: justify;">In 2011, Sadek published a paper in Science showing that while heart muscle cells actively divide in utero, they stop dividing shortly after birth to devote their energy to pumping blood through the body nonstop, with no time for breaks. </p><p style="text-align: justify;">In 2014, he published evidence of cell division in patients with artificial hearts, hinting that their heart muscle cells might have been regenerating. </p><p style="text-align: justify;">These findings, combined with other research teams’ observations that a minority of artificial heart patients could have their devices removed after experiencing a reversal of symptoms, led him to wonder if the artificial heart provides cardiac muscles the equivalent of bedrest in a person recovering from a soccer injury. </p><p style="text-align: justify;">“The pump pushes blood into the aorta, bypassing the heart,” he said. “The heart is essentially resting.” </p><p style="text-align: justify; ">Sadek’s previous studies indicated that this rest might be beneficial for the heart muscle cells, but he needed to design an experiment to determine whether patients with artificial hearts were actually regenerating muscles. </p><p style="text-align: justify;">“Irrefutable evidence of heart muscle regeneration has never been shown before in humans,” he said. “This study provided direct evidence.” </p><p style="text-align: justify; ">Next, Sadek wants to figure out why only about 25% of patients are “responders” to artificial hearts, meaning that their cardiac muscle regenerates. </p><p style="text-align: justify; ">“It’s not clear why some patients respond and some don’t, but it’s very clear that the ones who respond have the ability to regenerate heart muscle,” he said. “The exciting part now is to determine how we can make everyone a responder, because if you can, you can essentially cure heart failure. The beauty of this is that a mechanical heart is not a therapy we hope to deliver to our patients in the future – these devices are tried and true, and we’ve been using them for years.”</p><p style="text-align: justify; ">Reference:</p><p style="text-align: justify; ">Wouter Derks, Julian Rode, Sofia Collin, A Latent Cardiomyocyte Regeneration Potential in Human Heart Disease, Circulation,&nbsp;<a href="https://doi.org/10.1161/CIRCULATIONAHA.123.067156" rel="nofollow">https://doi.org/10.1161/CIRCULATIONAHA.123.067156</a></p>

170. Study identifies genetic cause for yellow nail syndrome

     Wed, 25 Dec 2024 15:00:54 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/24/266329-yellow-nail-syndrome-50.webp' /><p style="text-align: justify; ">An analysis of genetic sequencing data and gene and protein expression studies from patients with yellow nail syndrome (YNS) found that defects in the planar cell polarity (PCP) pathway play a significant role in the pathogenesis of YNS. According to the authors, this is the first demonstration of a mechanism explaining YNS development, especially in its congenital form. This study is published in <i>Annals of Internal Medicine. </i></p><p style="text-align: justify;">YNS is a rare disease characterized by the triad of yellow dystrophic nails, <a href="https://medicaldialogues.in/topics/lymphedema">lymphedema</a>, and <a href="https://medicaldialogues.in/topics/chronic-lung-disease">chronic lung disease</a>. The cause of YNS remains largely unknown, although some evidence points to lymphatic vessel development defects as a manifestation of the disease. The genetic cause of YNS, whether congenital or late-onset, remains unknown. </p><p style="text-align: justify; ">Researchers from the Genetics Institute and Genomics Center, Tel Aviv Sourasky Medical Center and colleagues studied genetic data from six patients with congenital YNS (cYNS) and five with sporadic YNS (sYNS) to determine the genetic mechanisms underlying the disease. Among the patients with cYNS, their first symptoms appeared prenatally or shortly after birth. </p><p style="text-align: justify; ">The median age for onset of symptoms for those with sYNS was 12 years. Yellow nails and lung disease were the presenting symptoms in most patients with YNS. The researchers examined next generation sequencing data for all patients with YNS to identify and analyze genetic variants. CELSR1 was highlighted as the principal candidate disease-causing gene with autosomal recessive inheritance. The researchers found that all but one patient with cYNS had biallelic variants in CELSR1. </p><p style="text-align: justify; ">The remaining patient had a heterozygous loss-of-function variant in FZD6. Both CELSR1 and FZD6 are core molecules in the Wnt/PCP pathway. None of the patients with sYNS had candidate variants in either CELSR1 or FZD6. </p><p style="text-align: justify; ">The researchers then extracted RNA from all patients to assess the Wnt/PCP pathway expression, and found that the pathway is disrupted both in cYNS patients with genetic variants and, to a lesser degree, in sYNS patients without genetic defects. These results suggest a strong case for the involvement of Wnt/PCP signaling and PCP defects in the pathogenesis of YNS.</p><p style="text-align: justify; ">Reference:</p><p style="text-align: justify; ">Alina Kurolap, Chofit Chai Gadot, Impaired Wnt/Planar Cell Polarity Signaling in Yellow Nail Syndrome, Annals of Internal Medicine,&nbsp;<a href=" https://doi.org/10.7326/ANNALS-24-01101" rel="nofollow"> https://doi.org/10.7326/ANNALS-24-01101</a></p>

171. Vagus nerve stimulation relieves severe depression, reports research

     Wed, 25 Dec 2024 15:00:43 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/02/14/232269-depression-50.webp' /><p style="text-align: justify; ">People with severe, treatment-resistant depression who received a nerve-stimulating therapy showed significant improvement in depressive symptoms, quality of life and ability to complete everyday tasks after a year, according to the results of a national, multicenter clinical trial led by Washington University School of Medicine in St. Louis. The findings are published Dec. 18 in a pair of papers in the journal <i>Brain Stimulation</i>. </p><p style="text-align: justify; ">The study involved nearly 500 participants at 84 sites across the U.S. All of the participants suffered from severe depression that could not be treated effectively with medication or other approaches. This study represents one arm of the RECOVER trial; the other arm addresses bipolar depression and is ongoing. Three quarters of the participants were so ill they were unable to work. Each participant was implanted with a device that stimulates the left vagus nerve-a major conduit between the brain and the internal organs-but only half the devices were turned on. The researchers tracked the participants’ responses using multiple validated assessment tools. While the primary assessment tool revealed no significant differences between the on and off groups, many of the other measures showed significant benefits to using the device. </p><p style="text-align: justify;">“These patients are extremely ill, and most have been for a very long time,” said Charles R. Conway, MD, a professor of psychiatry at WashU Medicine and the principal investigator of the RECOVER trial. “On average, each patient had already tried 13 treatments that failed to help them before they enrolled in the trial, and they had spent more than half of their lives sick with depression. But despite that super-high level of sustained illness, we still see statistically significant, measurable improvements in depressive symptoms, quality of life and functional outcomes.” </p><p style="text-align: justify;">The improvements observed are potentially life-changing for these patients with severe, refractory depression, Conway said. Severe depression can render people “paralyzed by life,” unable to accomplish the tasks of daily living. The amount of improvement experienced by the participants could be the difference between being unable to get out of bed and being productive and effectively interacting with loved ones, Conway said. </p><p style="text-align: justify;">A <a href="https://medicaldialogues.in/topics/vagus-nerve-stimulation">vagus nerve stimulation </a>device was approved by the Food and Drug Administration (FDA) nearly two decades ago for treatment-resistant depression, but it has not become widely available. Between the cost of the device itself and the surgery to implant it, the therapy can be unaffordable for many patients, as the Centers for Medicare and Medicaid Services (CMS) and most private insurance plans currently don’t cover it. </p><p style="text-align: justify;">Designed with an eye toward gathering the data that CMS needs to determine whether to cover the therapy, the RECOVER study aims to evaluate the effectiveness of vagus nerve stimulation therapy for treatment-resistant depression, both alone and as part of bipolar disorder. Many private health insurance companies follow the lead of CMS when it comes to coverage, so a decision by CMS to cover the device and the implantation surgery could make the therapy available to many more people. CMS helped design the RECOVER study and provided some funding. </p><p style="text-align: justify;">Vagus nerve stimulation therapy for treatment-resistant depression involves implanting a pacemaker-like device under the skin in the chest with a wire connected to the left vagus nerve in the neck. The device is part of the VNS Therapy System manufactured by LivaNova USA, Inc., which also sponsored and funded the trial in partnership with CMS. </p><p style="text-align: justify;">The VNS Therapy device emits stimulation to the nerve, which in turn sends electrical pulses to areas of the brain associated with mood regulation. In this study, 493 people were implanted with devices and approximately half (249) of the devices were activated for the 12-month randomized control period. The other half of the devices did not have active stimulation during the control period. </p><p style="text-align: justify;">The first two months of the 12-month trial period were dedicated to getting the devices’ electrical parameters properly adjusted to each patient. Starting in month three, the researchers obtained monthly evaluations of the participants’ depressive symptoms using four validated assessment tools, two of which were completed by blinded, off-site clinicians on the research team, one by an on-site psychiatrist or psychologist, and one by the patients themselves. The participants also rated their own quality of life and ability to perform the tasks of daily living every three months using three validated tools for quality of life and two for functional abilities. </p><p style="text-align: justify;">All participants were already in treatment for depression and continued seeing their treating mental-health providers during the trial. Providers were discouraged from starting patients on new antidepressant treatments during the trial, but those who were already receiving treatments were encouraged to continue with them. Outcomes were measured in terms of the percentage of time participants experienced relief of depressive symptoms. </p><p style="text-align: justify;">Overall, people with activated devices spent significantly more time with improved symptoms than did those with inactive devices. Complete remission was rare and did not differ between groups. People with activated devices also reported significant improvement in quality of life and functional abilities. </p><p style="text-align: justify;">“What’s really important here is that patients themselves were reporting that their lives were improving,” Conway said. “You have a population of people that has been failed by a ridiculously high number of treatments, including very aggressive treatments such as electroconvulsive therapy. And they’re not just saying, ‘Yeah, I feel a little better.’ They’re saying they are seeing meaningful improvements in their ability to function and live their lives. And the nice thing about vagus nerve stimulation, we know from other studies, is that when the patient responds, the effects usually stick.” </p><p style="text-align: justify;">Most of the improvements weren’t seen until the last three months of the trial. This finding was unsurprising, given that potential improvements from vagus nerve stimulation are known to progress slowly over the first year of treatment. At the end of the year, the devices that had been off during the 12-month control period were turned on. The primary outcome measure failed to show a significant difference between the two treatment groups, because the off group reported more improvement than expected, particularly in the last several weeks. Of note, all participants knew that the devices would be activated at year’s end, which may have affected those in the control group who knew potential relief was forthcoming, said Conway. </p><p style="text-align: justify; ">The participants will be followed for another four years to determine how long the effects last and how much the participants ultimately benefit. In addition, researchers are working on identifying patients’ characteristics tied to the greatest response.</p><p style="text-align: justify; ">Reference:</p><p style="text-align: justify; ">Conway, Charles R. et al., Vagus Nerve Stimulation in Treatment-Resistant Depression: A One-Year, Randomized, Sham-Controlled Trial, Brain Stimulation, DOI:10.1016/j.brs.2024.12.1191.</p>

172. Development of global innovative drug in eye drop form for treating dry age-related macular degeneration

     Wed, 25 Dec 2024 15:00:34 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/23/266085-eye-drop-50-1.webp' /><p style="text-align: justify; "><a href="https://medicaldialogues.in/topics/age-related-macular-degeneration">Age related macular degeneration </a>(AMD) is the leading cause of<a href="https://medicaldialogues.in/topics/vision-loss"> vision loss</a> in individuals over 65, characterized by abnormal changes in the macular, resulting in reduced vision and distorted objects. Dry AMD accounts for 90% of all AMD cases, with relatively mild vision impairment; however, approximately 30% progress to the severe vision loss associated with wet AMD within 10 years. The only FDA-approved treatments for dry AMD as of 2023 are two injectable drugs, which are limited by concerns over complications from intravitreal injections and modest efficacy in restoring vision. </p><p style="text-align: justify;">The research team led by Dr. Moon-Hyeong Seo from the Natural Product Drug Development Center at the Korea Institute of Science and Technology (KIST, President Oh Sang-Rok) has developed a new therapeutic agent for dry AMD that can be administered as eye drops. Eye drops are the most preferred drug delivery method in the ophthalmic market, yet developing eye drop formulations targeting the retina, located in the posterior segment of the eye, remains a significant challenge. </p><p style="text-align: justify;">To address the limitations of injection-based treatments, the research team focused on the inflammatory signaling pathway of Toll-like receptors (TLRs), which are known to play a critical role in AMD pathogenesis. By extracting peptide sequences from tens of thousands of proteins with structures similar to natural TLR signaling proteins, they established an extensive library of over 190,000 peptide drug candidates. Utilizing advanced technology for rapidly screening peptides that specifically bind to TLR signaling proteins, they successfully identified multiple candidate peptides capable of inhibiting interactions between these proteins. </p><p style="text-align: justify;">The researchers validated the therapeutic efficacy of the peptides by administering them as eye drops to mice with induced dry AMD. The treated group exhibited retinal cell protection and significantly reduced retinal degeneration, comparable to normal mice. This demonstrated that peptide-based eye drops could effectively replace existing injectable therapies for dry AMD. </p><p style="text-align: justify;">This new therapeutic agent, delivered in eye drop form, offers enhanced treatment convenience and adherence for patients while reducing complications and costs associated with repetitive invasive treatments. Furthermore, the non-invasive and safe nature of the therapy provides a novel treatment option that improves both efficacy and patient satisfaction. This innovation is expected to revolutionize the treatment accessibility of AMD and other related ophthalmic conditions. </p><p style="text-align: justify; ">Dr. Seo stated, “The KIST Natural Product Drug Development Center, established in September to focus on mission-driven research, aims to develop global drugs targeting aging-related diseases, including cancer and ophthalmic conditions. We plan to pursue collaborative research with domestic and international pharmaceutical companies to advance global clinical trials for this innovative dry AMD therapeutic.”</p><p style="text-align: justify; ">Reference:</p><p style="text-align: justify; ">Yun Lim, Tae Kyeom Kang, Meong Il Kim, Dohyeon Kim, Ji Yul Kim, Sang Hoon Jung, Keunwan Park, Wook-Bin Lee, Moon-Hyeong Seo, Massively Parallel Screening of Toll/Interleukin-1 Receptor (TIR)-Derived Peptides Reveals Multiple Toll-Like Receptors (TLRs)-Targeting Immunomodulatory Peptides, Advanced Science,&nbsp;<a href="https://doi.org/10.1002/advs.202406018" rel="nofollow">https://doi.org/10.1002/advs.202406018</a></p>

173. New Clinical Trial Supports QX004N's Safety and Effectiveness for Patients With Plaque Psoriasis

     Wed, 25 Dec 2024 15:00:30 -0000

     <img src='https://medicaldialogues.in/h-upload/2022/12/09/193307-plaque-psoriasis.webp' /><p style="text-align: justify; ">China: A new randomized clinical trial has demonstrated that QX004N, a humanized anti-IL-23 <a href="https://medicaldialogues.in/topics/monoclonal-antibody">monoclonal antibody,</a> offers superior safety and efficacy compared to a placebo in patients with moderate to severe<a href="https://medicaldialogues.in/topics/plaque-psoriasis"> plaque psoriasis</a>. The findings, published in<em> <a href="https://speciality.medicaldialogues.in/topics/jama-dermatology">JAMA Dermatology</a>,</em> emphasize the potential of QX004N as a promising treatment option for individuals struggling with this chronic skin condition.</p><div class="pasted-from-word-wrapper"><p style="text-align: justify; ">Results revealed that QX004N was well-tolerated and exhibited greater therapeutic benefit, achieving a higher rate of skin clearance than the placebo.</p><p style="text-align: justify; ">Psoriasis is a chronic, immune-driven skin condition with a significant need for effective biologic treatment options. IL-23 is a cytokine involved in inflammation and immune system regulation, and targeting it has been a key focus in developing new psoriasis treatments. QX004N, by inhibiting IL-23, addresses the immune dysfunction central to plaque psoriasis, aiming to reduce inflammation and control disease progression.</p><p style="text-align: justify; ">Against the above background, Xiaojiao Li, Phase I Clinical Trial Center, the First Hospital of Jilin University, Changchun, China, and colleagues aimed to evaluate the safety, pharmacokinetics, and efficacy of QX004N in both healthy individuals and patients with moderate to severe plaque psoriasis in China. </p><p style="text-align: justify; ">For this purpose, the researchers conducted a two-part randomized clinical trial in China to evaluate the safety, pharmacokinetics, and efficacy of QX004N. Part 1 was a first-in-human, single-ascending-dose phase 1a trial from November 2, 2021, to January 16, 2023, involving healthy participants receiving QX004N (10–600 mg) or placebo in a 4:1 ratio. Part 2 was a double-blind, multiple dose-escalation phase 1b trial from February 15, 2023, to January 5, 2024, involving patients with moderate to severe plaque psoriasis assigned similarly to receive 150 mg, 300 mg, or 600 mg of QX004N or placebo every two weeks.</p><p style="text-align: justify; ">The primary outcome of part 1 focused on safety and pharmacokinetics, while the primary endpoint of part 2 was achieving a 75% improvement in Psoriasis Area and Severity Index (PASI 75) by week 12. </p><p style="text-align: justify; ">The following were the key findings of the study:</p><ul><li style="text-align: justify; ">The Phase 1a clinical trial enrolled 55 healthy participants with a mean age of 35.9 years (54.5% female).</li><li style="text-align: justify; ">The phase 1b clinical trial included 30 patients with moderate to severe plaque psoriasis.</li><li style="text-align: justify; ">In part 2, the mean age of QX004N-treated participants was 41.4 years (79.2% male), while the mean age of the placebo group was 35.3 years (83.3% male).</li><li style="text-align: justify; ">QX004N demonstrated linear pharmacokinetics and was well tolerated by healthy participants and psoriasis patients.</li><li style="text-align: justify; ">Most adverse events were mild to moderate, with no drug-related serious adverse events reported.</li><li style="text-align: justify; ">At week 12, 100% of patients receiving QX004N in the 150-mg, 300-mg, and 600-mg doses achieved PASI 75 (75% improvement in PASI), significantly higher than the 33.3% observed in the placebo group.</li><li style="text-align: justify; ">At week 16, 100% of QX004N-treated participants achieved PASI 90 (90% improvement in PASI).</li><li style="text-align: justify; ">The maximum proportion of participants achieving an Investigator’s Global Assessment score of 0 or 1 was 100% across all three QX004N dose groups.</li></ul><p style="text-align: justify; ">The authors concluded that this phase 1a and 1b randomized clinical trial demonstrated that QX004N is safe and well-tolerated in healthy individuals and patients with moderate to severe plaque psoriasis in China. Treatment with QX004N at doses of 150 mg to 600 mg biweekly resulted in 100% of patients achieving a PASI 75 response by week 12, sustained through week 24, which was significantly higher than the placebo group.</p><p style="text-align: justify; ">"These findings support the continued development of QX004N as a promising treatment option for improving outcomes in patients with moderate to severe plaque psoriasis," they wrote.</p><p style="text-align: justify; ">Reference:</p><p style="text-align: justify; ">Li X, Li B, Yang D, et al. Safety and Efficacy of Anti–IL-23 Monoclonal Antibody QX004N for Patients With Psoriasis: A Randomized Clinical Trial. JAMA Dermatol. Published online December 11, 2024. doi:10.1001/jamadermatol.2024.5059</p></div><p style="text-align: justify; "><br></p>

174. Prophylactic Trimetazidine may prevent contrast induced AKI in patients undergoing CAG or PCI: Study

     Wed, 25 Dec 2024 14:45:28 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/24/266377-toxics-12-00620-g001.webp' /><p style="text-align: justify; ">Prophylactic Trimetazidine may prevent contrast induced AKI in patients undergoing CAG or PCI suggests a study published in the BMC Nephrology.</p><div class="pasted-from-word-wrapper"><p dir="ltr" style="text-align: justify; ">Contrast-induced acute kidney injury (CI-AKI) is a known complication after coronary angiography (CAG) or percutaneous coronary intervention (PCI). Clinical evidence suggests that trimetazidine (TMZ), an anti-ischemic drug, may prevent CI-AKI. </p><p dir="ltr" style="text-align: justify; ">We aimed to evaluate the role of trimetazidine in preventing CI-AKI in patients with pre-existing renal dysfunction undergoing CAG or PCI. They searched PubMed, Cochrane Library, EBSCOhost, Web of Science, and Google Scholar databases from January 2004 to January 2024. We reviewed RCTs involving participants aged ≥ 18 years with pre-existing renal insufficiency who underwent CAG or PCI. </p><p dir="ltr" style="text-align: justify; ">Outcomes should include the incidence of CI-AKI, adverse events, and changes in serum creatinine (Scr) levels at different time intervals. Two reviewers independently extracted the data, evaluated the quality and relevance of the studies, and graded the strength of evidence for each study through consensus. </p><p dir="ltr" style="text-align: justify; ">Results: Nine RCTs met the inclusion criteria and assessed the role of TMZ in patients with renal dysfunction who underwent CAG or PCI. All RCTs showed a significant decrease in the incidence of CI-AKI in the TMZ group compared to the control group (RR 0.36, 95% CI, [0.25, 0.52] P &lt; 0.001). Changes in Scr at 24 h (SMD -0.33, 95% CI, [-0.56, -0.10], P = 0.01), at 48 h (SMD -0.27, 95% CI, [-0.46, -0.09], P = 0.01), and 72 h (SMD -0.32, 95% CI, [-0.56, -0.07], P = 0.01) were statistically significant in the TMZ group compared to the control group. </p><p dir="ltr" style="text-align: justify; ">However, the changes in Scr beyond 72 h following CAG or PCI were statistically insignificant in the TMZ group when compared to the control group (SMD -0.22, 95% CI, [-0.52, 0.09], P = 0.16). The incidence of adverse effects was lower in the TMZ group than in the control group, and the difference was statistically significant (RR 0.51, 95% CI, [0.29, 0.90]; P = 0.02).</p><p dir="ltr" style="text-align: justify; ">The addition of TMZ to standard hydration protocols may offer a promising strategy for lowering the incidence of CI-AKI, adverse events, and postoperative SCr levels in patients with renal insufficiency within 72 h after CAG or PCI. However, large-scale RCTs are necessary to definitively establish the efficacy and safety of TMZ in patients with renal insufficiency after CAG or PCI.</p><div style="text-align: justify;"></div><p dir="ltr" style="text-align: justify; ">Reference:</p><p dir="ltr" style="text-align: justify; ">Lukwaro, A., Lu, Y., Chen, J. et al. Trimetazidine as an adjunct to standard hydration reduces the incidence of contrast-induced acute kidney injury in patients with renal insufficiency undergoing coronary angiography or percutaneous cardiac intervention: a systematic review and meta-analysis.. BMC Nephrol 25, 471 (2024). https://doi.org/10.1186/s12882-024-03872-9</p><div style="text-align: justify;"></div></div>

175. LNG-IUD safe and effective for managing heavy menstrual bleeding in adolescents with inherited bleeding disorders: Study

     Wed, 25 Dec 2024 14:45:14 -0000

     <img src='https://medicaldialogues.in/h-upload/2022/02/06/169901-hormonal-iuds.webp' /><p style="text-align: justify; ">One in four adolescents with heavy menstrual bleeding (HMB) since menarche may have an inherited bleeding disorder (IBD). Levonorgestrel-containing intrauterine devices (LNG-IUDs) are the preferred treatment for HMB in adolescents owing to the substantial and extended reduction in bleeding and favorable side effect profile. Medical management alone is frequently insufficient in persons with IBDs, yet several barriers impact the use of LNG-IUDs in those with IBDs, including a lack of standardized periprocedural guidelines, perceived higher bleeding risk associated with IUD insertion complications, and placement-related pain. In addition, a recent history of HMB increases the risk of IUD expulsion threefold. Moreover, first spontaneous IUD expulsion is more frequent among adolescents, potentially because of small uterine size. Expulsion risk factors include young age, history of anemia, concurrent bleeding disorder diagnosis, and abnormal uterine bleeding. While the LNG-IUD is as effective for HMB treatment in adolescents with IBDs as those without IBDs, a key barrier to securing this extended efficacy is a more frequent IUD expulsion rate within 30 days of insertion. Importantly, expulsions after 30 days are not more frequent than in adolescents without IBDs.</p><div class="pasted-from-word-wrapper"> <p style="text-align: justify;">Cygan et al hypothesize dthat prophylactic menstrual suppression after IUD insertion may reduce early (≤30 days) device expulsion. The primary objective was to examine the rates of early IUD expulsion in adolescents with IBDs with concurrent menstrual suppression.</p> <p style="text-align: justify;">The Penn State Health Women and Girls Bleeding Disorder Clinic provides women's health services for patients with suspected or confirmed IBDs, including Ehlers-Danlos syndrome. This retrospective study included adolescent girls (aged 10–21 years) with known or suspected IBDs undergoing IUD insertion between November 1st, 2019 and September 7th, 2022. According to the clinic practice pattern, participants continued their prior hormonal therapy for at least 30 days after insertion. IUD insertion was within 60 days of the last depot medroxyprogesterone acetate injection to ensure adequate coverage for 30 days. Assessed data included the incidence of IUD expulsion, bleeding disorder diagnosis, mode of menstrual suppression in the first 30 days after insertion, subjective reported bleeding profiles at follow-up, and any observed complications. Bleeding patterns were categorized as amenorrheic, light, normal, or heavy.</p> <p style="text-align: justify;">Chart review identified 24 IUD insertions in 22 adolescents. First follow-up for all 24 insertions occurred approximately 30 days after insertion (mean 30 days). </p> <p style="text-align: justify;">For patients initially seen at 30 days, a second follow-up visit was reviewed to confirm at least 30-day compliance with menstrual suppression, evaluate bleeding pattern, and assess IUD status. </p> <p style="text-align: justify;">Hormonal menstrual suppression was utilized for 22 of 24 (92%) insertions. </p> <p style="text-align: justify;">Menstrual suppression was shown to be effective, with 14 of 24 patients (58%) reporting light bleeding and seven of 24 patients (29%) reporting amenorrhea. </p> <p style="text-align: justify;">Altogether, no early expulsions because of excess bleeding were noted after any of the 24 IUD insertions. There were no expulsions because of heavy bleeding before 30 days for 21 of 22 individuals. One individual with type IIA von Willebrand disease had two expulsions (the first within 30 days of insertion and the second within 4 months [137 days]), neither associated with excessive bleeding. </p> <p style="text-align: justify;">Given the absence of HMB, expulsions in this youngest individual in the cohort were likely attributable to uterine size. A subsequent 19.5-mg LNGIUD inserted 1 year later remained in place for &gt;12 months. One individual experienced partial expulsion in the setting of excess bleeding more than 6 months after placement, supporting the relationship between heavy blood flow and displacement of the IUD from the endometrial cavity. One IUD was electively removed within 4 months because of cramping without excessive bleeding. No other expulsions were observed at the final follow-up. This includes five individuals evaluated through 6 months and 11 individuals followed through 12 months. </p> <p style="text-align: justify;">At final follow-up, for those whose IUDs remained in place, bleeding was well controlled; 11 of 19 (58%) had amenorrhea and seven of 19 (36%) had light bleeding. In addition, there was no uterine perforation, hemorrhage, or bleeding that required further hemostatic interventions.</p> <p style="text-align: justify;">No early (≤30 days after insertion) IUD expulsions because of heavy bleeding were observed. If the risk for IUD expulsion in IBDs is decreased during the first menses following insertion, the LNG-IUD's favorable bleeding profile may contribute to lower rates of late expulsion once patients experience a reduction in monthly blood loss. While acknowledging that this study is limited by loss of follow-up and subjective assessment of bleeding profile improvement, the absence of early expulsion observed here in the context of menstrual suppression is a promising improvement over similarly sized studies that have reported higher rates of IUD expulsion in adolescents with IBDs. The LNG-IUD is a safe and effective method of managing HMB in adolescents with IBDs. Concurrent menstrual suppression for at least 30 days after insertion, to prevent bleeding-related early expulsion in this population, may maximize safety and minimize complications for this at-risk group.</p> <p style="text-align: justify;">Source: CYGAN et al.; Int J Gynecol Obstet. 2024;00:1–4. DOI: 10.1002/ijgo.16063</p></div>

176. Women with Endometriosis and uterine fibroids likely to have Premature death, suggests study

     Wed, 25 Dec 2024 14:45:06 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/04/10/235928-endometriosis-50.webp' /><p style="text-align: justify; ">A new study published in the <i>British Medical Journal</i> showed that women who have a history of uterine fibroids and endometriosis may be more likely to die young after they have finished having children. With clinically significant prevalences of 10% and 15% to 30%, respectively, endometriosis and uterine fibroids are prevalent conditions among women in their reproductive years. </p><p style="text-align: justify; ">Growth of endometrial-like tissue outside the uterus is a hallmark of endometriosis. Uterine fibroids, on the other hand, are smooth muscle cell-based, non-cancerous tumors that usually develop inside or near the myometrium. But uterine fibroids and endometriosis have similar genetic roots, and they grow through a combination of proinflammatory, immunological, and endocrine mechanisms. As a result, Yi-Xin Wang looked at how endometriosis and uterine fibroids affected the long-term risk of premature death in women from the Nurses' Health Study II (NHSII), which has been conducted every two years for 30 years in the United States.</p><p style="text-align: justify; ">In 1989, 110,091 women between the ages of 25 and 42 who had never had a hysterectomy previously were diagnosed with cancer, cardiovascular disease, or endometriosis or fibroids were included. The key performance indicators Hazard ratios (calculated using Cox proportional hazards models) for overall and cause-specific premature death based on uterine fibroids confirmed by ultrasound or hysterectomy or endometriosis verified by laparoscopy and reported in biennial questionnaires.</p><p style="text-align: justify; ">Over the course of 2994,354 person years of follow-up, 4356 premature deaths were documented, including 90 from respiratory illnesses, 304 from cardiovascular disorders, and 1459 from cancer. Women with and without laparoscopically diagnosed endometriosis had crude incidences of all-cause premature death of 2.01 and 1.40 per 1000 person years, respectively.</p><p style="text-align: justify; ">Laparoscopically verified endometriosis was linked to a hazard ratio of 1.19 for premature mortality in age-adjusted models and these models were reinforced after controlling for behavioral variables and other possible confounders. In cause-specific mortality studies, uterine fibroids verified by ultrasound or hysterectomy were linked to a higher chance of dying from a malignant tumor of gynecological organs, but not to all cause premature death.</p><p style="text-align: justify; ">Women who reported both endometriosis and uterine fibroids had a higher risk of premature mortality from all causes. Overall, women who had a history of endometriosis and uterine fibroids were more likely to die young and die from gynecological malignancies.</p><p style="text-align: justify; ">Source:</p><p style="text-align: justify; ">Wang, Y.-X., Farland, L. V., Gaskins, A. J., Wang, S., Terry, K. L., Rexrode, K. M., Rich-Edwards, J. W., Tamimi, R., Chavarro, J. E., &amp; Missmer, S. A. (2024). Endometriosis and uterine fibroids and risk of premature mortality: prospective cohort study. In BMJ (p. e078797). BMJ. <a href="https://www.bmj.com/content/387/bmj-2023-078797" rel="nofollow">https://doi.org/10.1136/bmj-2023-078797</a></p>

177. Sarcopenic obesity may increase risk of knee osteoarthritis, finds research

     Wed, 25 Dec 2024 14:45:00 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/13/264760-knee.webp' /><p style="text-align: justify; ">A new study published in the <i>PLOS ONE</i> journal showed that in middle-aged and older Chinese people, obesity, sarcopenic obesity, and low muscular strength were linked to an increased risk of occurrence of symptomatic knee osteoarthritis (OA) seven years later.</p><p style="text-align: justify; ">The growing number of people at risk for osteoarthritis and other health issues is a result of the changing aging demographics and the rising incidence of obesity. About 80% of all cases of OA worldwide are caused by knee OA, which is a common ailment. Sarcopenia is a physiological phenomenon that naturally happens with aging and is characterized by a loss of muscle mass and strength that can be increased by co-morbid illness states. </p><p style="text-align: justify; ">Also, obesity raises the risk of sarcopenia due to ectopically accumulated lipids and chronic inflammation in skeletal muscle. This study examined whether reduced muscular strength may mediate the effects of obesity on the start of knee OA in middle-aged and older Chinese populations, as well as the possible impacts of muscle strength and sarcopenic obesity on the incidence of knee OA.</p><p style="text-align: justify; ">The China Health and Retirement Longitudinal Study yielded a total of 12,043 participants. Using Poisson regression models, the effects of sarcopenic obesity on the development of knee OA were computed. The mediating proportion of muscular strength on the relationship between obesity and incidence of knee OA was estimated using mediation analysis.</p><p style="text-align: justify; ">A total of 12,043 people were included in the trial, and 2,008 of them developed knee OA. Poisson analysis showed a causal relationship between the start of knee OA and both abdominal and overall obesity. The participants who had the greatest degree of normalized grip strength were 0.33 times less likely to experience incident knee OA than those in the control group, and chair-rising time was linked to a 0.65-fold higher risk of incident knee OA.</p><p style="text-align: justify; ">Similar findings were found via sensitivity analysis. When compared to the reference group, the participants with sarcopenic obesity had an approximately twofold increased incidence of acute knee OA. The relationship between obesity and the incidence of knee OA was mediated by normalized grip strength and chair-rising time. Overall, the study found that incidence-symptomatic knee OA is influenced by sarcopenic obesity and low muscular strength in middle-aged and older Chinese individuals.&nbsp;</p><p style="text-align: justify; ">Source:</p><p style="text-align: justify; ">Yan, L., Ge, H., Wang, Z., Shen, A., Xu, Q., Jiang, D., &amp; Cao, Y. (2024). Roles of low muscle strength and sarcopenic obesity on incident symptomatic knee osteoarthritis: A longitudinal cohort study. In S. Agostini (Ed.), PLOS ONE (Vol. 19, Issue 10, p. e0311423). Public Library of Science (PLoS). <a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0311423#sec022" rel="nofollow">https://doi.org/10.1371/journal.pone.0311423</a></p>

178. Increased maternal butylparaben exposure elevates risk of asthma: Study

     Wed, 25 Dec 2024 14:45:00 -0000

     <img src='https://medicaldialogues.in/h-upload/2023/08/31/217977-skin-cream.webp' /><p style="text-align: justify; ">A recent study published in the <i>Environmental Pollution</i> journal highlighted how prenatal exposure to certain chemicals, commonly found in everyday products, may contribute to asthma development in children. This study analyzed the effects of maternal urinary phenol concentrations during early pregnancy on childhood asthma risk at age four.</p><p style="text-align: justify; ">The research examined a total of 3,513 mother-child pairs enrolled in the Japan Environment and Children's Study (JECS) Sub-Cohort Study. Maternal urine samples, collected during the first trimester of pregnancy, were tested for 24 types of phenols, including parabens, bisphenol A, octylphenol, and nonylphenol. Also, phenol levels varied widely among participants. One key finding was that methylparaben was present at high concentrations in almost all samples, with an average level of 267.7 ng/ml and a large variation across individuals.</p><p style="text-align: justify; ">The analysis revealed significant associations between prenatal exposure to certain phenols and the risk of asthma in children. High levels of butylparaben in maternal urine were linked to a 54% increase in the odds of asthma onset by age four. Meanwhile, exposure to 4-nonylphenol showed a gender-specific effect where the boys born to mothers with detectable levels of this compound had more than double the odds of developing asthma (odds ratio: 2.09), and the girls showed no significant increase in risk.</p><p style="text-align: justify; ">These findings underline the complexity of phenol exposure and its potential to impact children's health differently based on gender and chemical type. While the mechanisms remain unclear, the results indicate that certain phenols act as endocrine disruptors, possibly influencing respiratory health through hormonal pathways.</p><p style="text-align: justify; ">The study provides a crucial step toward understanding the risks of prenatal chemical exposure. Given that many of these phenols are widely used in consumer products, the findings emphasize the need for increased awareness and potential regulation to minimize exposure during pregnancy. And so, avoiding products containing butylparaben or nonylphenol during pregnancy might help reduce the risk of asthma in children.</p><p style="text-align: justify; ">Overall, these findings will inspire further studies to investigate the biological pathways involved and inform future public health guidelines to protect vulnerable populations, particularly pregnant women and children.</p><p style="text-align: justify; ">Reference:</p><p style="text-align: justify; ">Kuraoka, S., Oda, M., Ohba, T., Mitsubuchi, H., Nakamura, K., Katoh, T., Kamijima, M., Yamazaki, S., Ohya, Y., Kishi, R., Yaegashi, N., Hashimoto, K., Mori, C., Ito, S., Yamagata, Z., Inadera, H., Nakayama, T., Sobue, T., Shima, M., … Katoh, T. (2024). Association of phenol exposure during pregnancy and asthma development in children: The Japan Environment and Children’s study. In Environmental Pollution (Vol. 361, p. 124801). Elsevier BV. <a href="https://www.sciencedirect.com/science/article/pii/S026974912401515X" rel="nofollow">https://doi.org/10.1016/j.envpol.2024.124801</a></p>

179. Risk of bleeding after dental extractions rather low among patients on antiplatelet therapy, suggests study

     Wed, 25 Dec 2024 14:30:14 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/26/266527-untitled-design-2024-12-26t110602069.webp' /><p style="text-align: justify; ">A study published in BMC Oral Health suggests that the risk of bleeding after dental extractions is rather low among patients on antiplatelet therapy.</p><div class="pasted-from-word-wrapper"><p dir="ltr" style="text-align: justify; ">This retrospective study aimed to identify high-risk dental extraction patients and the timing of postoperative haemorrhage to evaluate whether preventive hospitalization should be considered in patients on antiplatelet medication (AP) or anticoagulants. </p><p dir="ltr" style="text-align: justify; ">The study included 1595 procedures; 1319 were conducted under monotherapy (Group I: AP; Group II: indirect oral anticoagulant [IAC]; Group III: direct oral anticoagulant [DOAC]) and 276 under dual therapy (Group IV: double AP; Group V: AP and IAC; Group VI: AP and DOAC). </p><p dir="ltr" style="text-align: justify; ">We evaluated the incidence, frequency and timing of haemorrhage, hospitalization rate, and treatment of bleeding incidents.</p><p dir="ltr" style="text-align: justify; "> Results: The incidence of hemorrhagic events was significantly higher in the dual therapy groups compared to the monotherapy groups (p &lt; 0.001). Comparing the procedures under monotherapy, those on DOAC (Group III) had a significantly higher risk of postoperative bleeding than Groups I and II (p &lt; 0.001) and a higher rate of repeated bleeding episodes (p = 0.035).</p><p dir="ltr" style="text-align: justify; ">Regarding bleeding incidents, 44% (dual therapy) vs. 51.1% (monotherapy) occurred on the day of surgery. The bleeding risk after dental extractions is overall low and patients were often hospitalized preventively due to their comorbidities rather than actual bleeding risk. Patients should be instructed about local compression, and surgeries should be completed in the morning to avoid emergency visits. However, patients with cardiovascular diseases and dual therapy had a higher risk of postoperative haemorrhage. Thus, hospitalization is to be considered in these cases.</p><div style="text-align: justify;"></div><p dir="ltr" style="text-align: justify; ">Reference:</p><p dir="ltr" style="text-align: justify; ">Katz, M.S., Benidamou, R., Ooms, M. et al. Influence of antiplatelet medication and anticoagulation therapy after dental extractions on hospitalization: a retrospective 10-year study. BMC Oral Health 24, 1485 (2024). https://doi.org/10.1186/s12903-024-05275-6</p><div style="text-align: justify;"></div><div style="text-align: justify;"></div><div style="text-align: justify;"></div><div style="text-align: justify;"></div></div>

180. BDR Pharmaceuticals Gets CDSCO Panel Nod for bioequvalence study of Abiraterone Acetate Oral Suspension

     Wed, 25 Dec 2024 12:45:25 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/06/04/240158-bdr-pharmaceuticals-new-50.webp' /><div class="pasted-from-word-wrapper"></div><div class="pasted-from-word-wrapper"><p style="text-align: justify;"><b>New Delhi:</b> BDR Pharmaceuticals has got approval from the Subject Expert Committee (SEC) functional under the Central Drug Standard Control Organization (CDSCO) to conduct the bioequivalence (BE) study of the anticancer drug Abiraterone Acetate Oral Suspension 1000mg/5ml.</p><p style="text-align: justify;">This came after BDR Pharmaceuticals presented the BE protocol in fasting condition before the Committee.</p><p style="text-align: justify;">However, the expert panel stated that the protocol needs to include the test of HbA1c, lipid profile, ECG, CBC, LFT, and KFT at the time of screening and completion of Period I and Period II. Further, it added that the sample size should be increased to 38 subjects.</p><p style="text-align: justify;">In addition, the expert panel stated that the firm has to justify the use of Abiraterone Acetate Oral Suspension 1000 mg/5 ml as the suspension is not approved anywhere in the world and Abiraterone Tablets 250 mg/500 mg are approved in the country.</p><p style="text-align: justify;">Abiraterone is an antiandrogen used in the treatment of metastatic castration-resistant prostate cancer and metastatic high-risk castration-sensitive prostate cancer. Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumor tissues, to regulate androgen biosynthesis.</p><p style="text-align: justify;">At the recent SEC meeting for oncology held on 10th December 2024, the expert panel reviewed the BE protocol. After detailed deliberation, the committee recommended the conduct of the BE study in fasting conditions with the following:</p><p style="text-align: justify;">1) Protocol needs to include the test of HbA1c, lipid profile, ECG, CBC, LFT, and KFT at the time of screening and completion of Period I and Period II. Further, the sample size should be increased to 38 subjects.</p><p style="text-align: justify;">2) Further, the firm has to justify the use of Abiraterone Acetate Oral Suspension 1000 mg/5 ml, as the suspension is not approved anywhere in the world and Abiraterone Tablets 250 mg/500 mg are approved in the country.</p><p style="text-align: justify; ">Also Read: <a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/industry/pharma/conduct-phase-iii-ct-cdsco-panel-tells-zydus-healthcare-on-fdc-dextromethorphan-phenylephrine-syrup-140201">Conduct Phase III CT: CDSCO Panel Tells Zydus Healthcare on FDC Dextromethorphan, Phenylephrine Syrup</a></p></div><div class="pasted-from-word-wrapper"></div><div class="hocal-draggable" draggable="true"><div class="read-this-also-wrap"><div></div></div></div>

181. Pharma company faces UCPMP probe over Rs 1.91 Crore spent on Doctors' Travel

     Wed, 25 Dec 2024 12:15:33 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/25/266470-mdtv-2024-12-25t160711878.webp' /><div class="pasted-from-word-wrapper"><div class="pasted-from-word-wrapper"><p style="text-align: justify; ">In a first of its kind case under the Uniform Code for Pharmaceutical Marketing Practices (UCPMP) 2024, the Apex Committee for Pharma Marketing Practices has issued a reprimand against AbbVie Healthcare India Private Ltd, a subsidiary of US-based AbbVie Inc., for unethical marketing practices. The company was allegedly found guilty of sponsoring international trips for nearly Rs 1.91 crore for 30 Healthcare Professionals (HCPs) under the pretense of professional development, contravening the <a href="https://medicaldialogues.in/news/industry/pharma/ucpmp-2024-5-major-takeaways-for-indian-pharma-marketers-125925">UCPMP guidelines</a>.</p><div id="ATS_mid1"></div><div class="inside-post-ad-1 inside-post-ad ads_common_inside_post" id="inside_post_content_ad_1"></div><div class="pasted-from-word-wrapper"><div class="pasted-from-word-wrapper"><div class="pasted-from-word-wrapper"><p style="text-align: justify;">The case began with an anonymous complaint submitted to the Department of Pharmaceuticals (DoP) on May 21, 2024. The complaint, supported by internal company documents, alleged that AbbVie provided foreign travel and accommodation for 30 doctors attending the Aesthetics &amp; Anti-Aging Medicine World Congress 2024 held in Monaco (February 1–3, 2024) and Paris (March 26–29, 2024). The alleged expenses totaled Rs 1.91 crore, covering flights and hotel stays.</p></div></div></div></div><div class="pasted-from-word-wrapper"><div><p style="text-align: justify; "><i><b>For more information, click on the link below:</b></i></p></div></div><div class="pasted-from-word-wrapper"><div style="text-align: justify;"><i><a href="https://medicaldialogues.in/news/industry/pharma/rs-191-crore-spent-on-doctors-travel-pharma-company-faces-ucpmp-heat-soon-action-against-30-doctors-140347#:~:text=The%20findings%20revealed%20that%20AbbVie's,and%20Juvederm%20was%20deemed%20insufficient."><b>Rs 1.91 Crore spent on Doctors Travel: Pharma Company faces UCPMP heat, soon action against 30 doctors</b></a></i></div></div></div>

182. Telangana Govt doctors protest over Removal of Jagtial Hospital Superintendent

     Wed, 25 Dec 2024 12:15:32 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/25/266472-mdtv-2024-12-25t161819635.webp' /><div class="pasted-from-word-wrapper"><div class="pasted-from-word-wrapper"><p style="text-align: justify; ">A <a href="https://medicaldialogues.in/topics/black-badge-protest" target="_blank">black-badge protest</a> was recently organised by the Telangana Teaching Government Doctors Association (TTGDA) where doctors from several government medical colleges in the state participated to protest against the removal of Jagtial Government General Hospital Superintendent Dr L Ramulu from his position over allegations of <a href="https://medicaldialogues.in/topics/dereliction-of-duty" target="_blank">dereliction of duty</a>.</p><div id="ATS_mid1"></div><p style="text-align: justify; ">Condemning the humiliation against the senior doctor, the association called the move “baseless and outrageous,” highlighting that such treatment given to a senior doctor was unacceptable. It clarified that Dr Ramulu was not managing his position by choice but was managing responsibilities in the absence of the additional DME.</p></div><div class="pasted-from-word-wrapper"><div><p style="text-align: justify; "><i><b>For more information, click on the link below:</b></i></p></div></div><div class="pasted-from-word-wrapper"><div style="text-align: justify;"><i><a href="https://medicaldialogues.in/news/health/doctors/telangana-govt-doctors-stage-black-badge-protest-over-removal-of-jagtial-hospital-superintendent-140340#:~:text=Hyderabad%3A%20A%20black%2Dbadge%20protest,L%20Ramulu%20from%20his%20position"><b>Telangana Govt doctors stage black badge protest over Removal of Jagtial Hospital Superintendent</b></a></i></div></div></div>

183. IMA to unveil 'Doctors Employment Exchange' portal on December 27

     Wed, 25 Dec 2024 12:10:54 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/24/266341-untitled-design-2024-12-24t174535038.webp' /><p style="text-align: justify; "><b>Coimbatore:&nbsp;</b>In response to the growing issue of unemployment among medical graduates nationwide, the <a href="https://medicaldialogues.in/topics/indian-medical-association" target="_blank" style="background-color: rgb(249, 249, 249);">Indian Medical Association</a> (IMA) has developed an online platform called ‘Doctors Employment Exchange’, which is expected to launch on December 27. &nbsp;</p><p style="text-align: justify; ">The platform will be inaugurated on December 27 which will help to create job opportunities for these young doctors in private hospitals across India and abroad. It will work as a bridge between doctors and hospitals. More details about the registration process will be shared during the official launch.</p><p style="text-align: justify; "><b>Also read- <a href="https://medicaldialogues.in/news/health/doctors/doctors-staff-at-muktsar-hospital-attacked-by-armed-mob-hospital-vandalized-140321" target="_blank">Doctors, Staff at Muktsar Hospital attacked by Armed Mob; Hospital vandalized</a></b></p><p style="text-align: justify; ">Speaking to <a href="https://www.newindianexpress.com/states/tamil-nadu/2024/Dec/23/indian-medical-association-to-launch-job-portal-for-doctors-on-december-27" rel="nofollow">TNIE</a>, the Chairman of the Hospital Board of India Dr K M Abul Hasan said, "Thousands of qualified doctors are unemployed as we have around 1.1 lakh doctors passing out of 706 medical colleges every year nationwide. On the other side, the creation of new posts is becoming a difficult task in the government sector. To address the issue, we have created the ‘Doctors Employment Exchange’ which would act as a bridge between hospitals and doctors."</p><p style="text-align: justify; ">"Unemployment in the health sector, especially in the field of physicians, is overlooked. We took the initiative to fix the issue. Initially, we have brought the hospitals from the Gulf countries. Work is underway to enlist at least 80,000 hospitals, including those from the UK, USA, and Canada. A separate domestic section has also been created." he added. &nbsp;</p><p style="text-align: justify; ">Medical Dialogues had earlier reported that the Indian Medical Association (IMA) pointed out that in the country, particularly Karnataka, is paving the way for a unique solution—exporting doctors to various countries.</p><p style="text-align: justify; ">Dr RV Asokan, President of IMA, revealed plans to establish a facilitation and information centre that will assist doctors and medical professionals in securing employment overseas. This initiative, in collaboration with the National Medical Association and the Overseas Medical Graduates’ Association, aims to provide a sense of security to doctors seeking employment abroad.</p><p style="text-align: justify; "><b>Also read- <a href="https://medicaldialogues.in/state-news/karnataka/ima-initiates-plan-to-help-young-doctors-get-jobs-abroad-123287" target="_blank">IMA initiates plan to help young doctors get jobs abroad</a></b></p>

184. Telangana Medical Council files 400 FIRs against Quacks

     Wed, 25 Dec 2024 12:00:30 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/25/266471-mdtv-2024-12-25t161546144.webp' /><div class="pasted-from-word-wrapper"><div style="text-align: justify; ">The Telangana State Medical Council (TSMC) has launched a concerted effort to combat quackery, marking the first time in the state that legal action has been taken against individuals practising allopathy without an MBBS degree. The TSMC, in collaboration with the Telangana State Drug Control Administration (TSDCA), has filed 400 FIRs over the past year against such quacks and has served notices on 40 doctors suspected of aiding them. This initiative is a significant step in addressing the growing threat to public health posed by unauthorized practitioners masquerading as Rural Medical Practitioners (RMPs).</div><div></div><div style="text-align: justify;">In addition to tackling quackery, the TSMC has implemented reforms to reduce the financial burden on doctors. Over the last year, the Council has cut registration and renewal fees by 50%, and senior doctors above 65 have been exempted from renewal fees. The TSMC has also partnered with the National Medical Commission (NMC) to conduct training workshops for professors in government medical colleges on misconduct and appeals.</div></div>

185. Latur doctor held for murdering Hospital Security Guard

     Wed, 25 Dec 2024 11:55:40 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/25/266468-mdtv-2024-12-25t155836262.webp' /><div class="pasted-from-word-wrapper"><div class="pasted-from-word-wrapper"><p style="text-align: justify; ">A doctor from Maharashtra's Latur, accused of murdering a security guard at his hospital, was arrested in Haridwar, Uttarakhand, on Monday after being on the run for several days, police said.</p><p style="text-align: justify; ">According to the PTI report, the doctor, Pramod Ghuge, and his nephew Aniket Munde were booked after the victim, Balu Bharat Dongre, employed as a security guard at the absconding physician's hospital in Latur, died on December 12 and his family alleged murder, said police.</p></div><div class="pasted-from-word-wrapper"><div style="text-align: justify; "><i><b>For more information, click on the link below:</b></i></div></div><div class="pasted-from-word-wrapper"><div style="text-align: justify;"><i><a href="https://medicaldialogues.in/news/health/doctors/latur-doctor-arrested-for-murder-of-hospital-security-guard-140336"><b>Latur doctor arrested for murder of Hospital Security Guard</b></a></i></div></div></div>

186. Parliamentary Panel Slams NPPA for 50% Price Hike, Demands Answers

     Wed, 25 Dec 2024 11:32:26 -0000

     <img src='https://medicaldialogues.in/h-upload/2023/11/10/225090-nppa-2.webp' /><p style="text-align: justify; "><b>New Delhi:</b>&nbsp;The Parliamentary Standing Committee on Chemicals and Fertilisers has slammed the National Pharmaceutical Pricing Authority (NPPA) for allowing a 50% price hike in 11 drug formulations and has sought a detailed note on the matter.</p><div class="pasted-from-word-wrapper"><p style="text-align: justify;">In its fifth report, titled ‘Demand for Grants’, the Committee expressed serious concerns regarding the Authority’s price regulation mechanisms. Highlighting the steep increase in the prices of essential medicines, the Committee criticized the NPPA for permitting price hikes that disproportionately impact economically weaker sections of society.</p><p style="text-align: justify;">The Committee found that the <a href="https://medicaldialogues.in/search?search=nppa#gsc.tab=0&amp;gsc.q=nppa&amp;gsc.page=1">NPPA </a>had notified ceiling prices for 920 essential medicines, including oxygen, general anesthetics, and opioids.</p><p style="text-align: justify;">In its report, the Panel further noted that while the selling prices of <a href="https://medicaldialogues.in/search?search=essential+medicine#gsc.tab=0&amp;gsc.q=essential%20medicine&amp;gsc.page=1">essential medicines</a> are adjusted based on changes in the Wholesale Price Index (WPI), the NPPA also monitors the pricing of non-essential medicines to ensure manufacturers do not hike the Maximum Retail Price (MRP) by more than 10% in a year.</p><p style="text-align: justify;">However, the Committee observed that the NPPA had issued an order dated 15th October 2024, increasing the prices of 11 drug formulations by 50%. Admittedly, this was done in response to several applications requesting a price hike to accommodate rising production costs over the years.</p><p style="text-align: justify;"><b><i>Also Read:<a href="https://medicaldialogues.in/news/industry/pharma/nppa-approves-50-percent-price-increase-of-8-essential-drugs-details-136478"> NPPA Approves 50 percent Price Increase of 8 essential drugs, details</a></i></b></p><p style="text-align: justify;">Dismayed, the Committee observed;</p><blockquote style="text-align: justify;">“With serious concern that in the face of apparent increasing prices of medicines affecting the whole nation, particularly hard hitting the poorest of the poor, the NPPA, which has the ambit of monitoring and enforcement of pricing of medicines, has allowed this situation to prevail.”</blockquote><blockquote style="text-align: justify; ">“The Committee, therefore, desires a detailed note be furnished on this price hike.”</blockquote></div>

187. Doctors at Delhi AIIMS Developing Low-cost Adaptive Cellular Therapy for Multiple Myeloma

     Wed, 25 Dec 2024 11:30:30 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/25/266408-mdtv-2024-12-25t122821314.webp' /><div class="pasted-from-word-wrapper" style="text-align: justify; "><b>New Delhi: </b>Doctors at the premier health institute, the All India Institute of Medical Sciences<b>&nbsp;</b><a href="https://medicaldialogues.in/topics/AIIMS">AIIMS</a>&nbsp;Delhi&nbsp;<span style="background-color: rgb(249, 249, 249);">are working on an innovative, low-cost antibody-based adaptive cellular therapy for treating multiple myeloma, a type of blood cancer.</span></div><div class="pasted-from-word-wrapper"><div style="text-align: justify;">This kind of therapy is expected to make advanced treatments like <a href="https://medicaldialogues.in/topics/CAR-T-cell">CAR-T cell</a> therapies more affordable and accessible for patients in India.</div><div style="text-align: justify;"></div></div><div class="pasted-from-word-wrapper"><div class="pasted-from-word-wrapper"><div style="text-align: justify; "><b><i>Read also: <a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/education/medical-colleges/aiims-to-open-registration-for-2nd-prof-mbbs-professional-examinations-january-2025-140349">AIIMS to open registration for 2nd Prof MBBS Professional Examinations January 2025</a></i></b></div></div><div class="hocal-draggable" draggable="true"><div class="read-this-also-wrap"><div></div></div></div><div class="pasted-from-word-wrapper"><div></div></div></div><div class="pasted-from-word-wrapper"><div style="text-align: justify;"></div></div><div class="pasted-from-word-wrapper"><div style="text-align: justify; ">The Chimeric antigen receptor (CAR) T-cell therapy is a form of adaptive cellular therapy in which a patient’s T cells are isolated, genetically modified and infused back in the patients body to recognise and kill the cancer cells, said Dr Mayank Singh, Additional Professor in the Department of Medical Oncology at Dr B R Ambedkar Institute Rotary Cancer Hospital, (BRAIRCH), AIIMS here.</div><div></div><div style="text-align: justify;">It is based on targeting B-cell maturation antigen (<a href="https://medicaldialogues.in/topics/BCMA">BCMA</a>) which helps to target specific tumour antigens which are found cancer cells specially in cases multiple myeloma.</div><div></div><div style="text-align: justify;">According to the PTI report, Singh said, “So the therapy developed by the AIIMS researchers recognises BCMA as a target on multiple myeloma cells to eliminate them”.</div><div></div><div style="text-align: justify;">As of now, the therapy has been tested on animal models and has shown promising outcomes, he said.</div></div><div class="pasted-from-word-wrapper"><div style="text-align: justify;">“We intend to take this CAR-T cell therapy for phase-1 clinical trials on humans in the near future to collect substantial evidence regarding its safety and efficacy. Our aim is to bring the cost of this therapy significantly down. There are other forms of CAR-T cell therapies but the cost of which are significantly high,” he said.</div><div></div><div style="text-align: justify;">Cancer is a life threatening disease characterized by uncontrolled growth of cancerous cells. Generally all the cancer cells are derived from a single cell which has undergone a sequence of mutation which have converted them to cancerous cell and these cells are involved in different symptoms associated with cancer, Singh explained.</div><div></div><div style="text-align: justify;">Cancer cells proliferate at a very rapid pace which deprive normal cells of nutrients resulting in cancer associated cachexia.</div><div></div><div style="text-align: justify;">Multiple myeloma is a form cancer of the plasma cells which are a type of white blood cell (WBC) that produces antibodies against infection. When these cells become cancerous, they multiply at rapid pace and crowd out normal blood-forming cells in the bone marrow. This form of cancer is often associated with relapse, Singh said.</div><div></div><div style="text-align: justify;">Traditional cancer treatments like chemo/radiotherapy target rapidly dividing cells but this approach leads to cytotoxicity in normal cells as well leading to severe side effects associated with cancer treatment often leading to fatal outcome, he said.</div></div><div class="pasted-from-word-wrapper"><div style="text-align: justify;">Last two decades have seen emergence of targeted therapies in cancer which is associated with targeting inherent vulnerabilities of cancer cells like too much dependence on one protein for cancer cells which has improved outcome in cancer treatments however cancer cells eventually develop resistance to these agents which leads to cancer relapse, he elaborated.</div><div></div><div style="text-align: justify;">Last decade has seen the emergence of immunotherapy as one of the cornerstones of cancer therapeutics with monoclonal antibodies being used to target cancer cells.</div><div></div><div style="text-align: justify;">In a classical approach often these antibodies against a cancer target are loaded with the drug of interest for targeted delivery of chemotherapeutic drug thereby reducing the off target effect and improving their effectiveness, Singh said.</div><div></div><div style="text-align: justify;">“Antibody based therapies have ushered a new era in cancer therapeutics including development of cellular CAR-T cell therapies which include components of these antibodies to target the antigen on the cancerous cell. Immunotherapies however remain expensive thereby being out of reach for majority of the population in countries like India,” he explained, news agency PTI reported.</div><div></div><div style="text-align: justify;">According to latest data from National Cancer Registry, the estimated number of incident cases of cancer in India in 2022 was found to be 14,61,427. Furthermore, one in nine people are likely to develop cancer in his or her lifetime.</div></div><div class="pasted-from-word-wrapper"><div style="text-align: justify;">The problem of delayed diagnosis combined with limited access to world class therapies is bound to create a significate health burden on India as cases are expected to rise exponentially in coming decade, Singh said.</div><div></div><div style="text-align: justify;">The research group spearheaded by Singh has subsequently filed for an Indian patent for the antibody and in process of filing patent for their CAR-T cell therapy.</div><div></div><div style="text-align: justify;">“The CAR-T cell therapies has changed the way we approach and treat cancer. Development of CAR-T cell therapy has been in the nascent state in India despite the rapid pace it is moving around the world,” he said.</div><div style="text-align: justify;"><b><i>Read also: <a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/education/aiims-postpones-ini-ss-january-2025-seat-allotment-process-revised-schedule-to-be-announced-soon-140304">AIIMS Postpones INI SS January 2025 Seat Allotment Process, Revised Schedule to Be Announced Soon</a></i></b></div></div><div class="pasted-from-word-wrapper"><div></div></div><div class="pasted-from-word-wrapper"><div></div></div><div class="pasted-from-word-wrapper"><div></div></div><div class="pasted-from-word-wrapper"><div></div><div></div></div><div class="pasted-from-word-wrapper"></div>

188. Health Bulletin 25/ December/ 2024

     Wed, 25 Dec 2024 11:28:45 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/25/266466-health-bulletin-79.webp' /><p style="text-align: justify; "><b>Here are the top health news for the day:</b></p><div class="pasted-from-word-wrapper"><div style="text-align: justify;"><b>Latur doctor held for murdering Hospital Security Guard</b></div></div><div class="pasted-from-word-wrapper"><p style="text-align: justify;"> A doctor from Maharashtra's Latur, accused of murdering a security guard at his hospital, was arrested in Haridwar, Uttarakhand, on Monday after being on the run for several days, police said.</p><p style="text-align: justify;">According to the PTI report, the doctor, Pramod Ghuge, and his nephew Aniket Munde were booked after the victim, Balu Bharat Dongre, employed as a security guard at the absconding physician's hospital in Latur, died on December 12 and his family alleged murder, said police.</p></div><div class="pasted-from-word-wrapper"><div style="text-align: justify;"><b><i>For more information, click on the link below:</i></b></div></div><div class="pasted-from-word-wrapper"><div style="text-align: justify;"><b><i><a href="https://medicaldialogues.in/news/health/doctors/latur-doctor-arrested-for-murder-of-hospital-security-guard-140336">Latur doctor arrested for murder of Hospital Security Guard</a></i></b></div></div><div class="pasted-from-word-wrapper"><div style="text-align: justify;"><b>Pharma company faces UCPMP probe over Rs 1.91 Crore spent on Doctors' Travel</b></div></div><div class="pasted-from-word-wrapper"><p style="text-align: justify;">In a first-of-its-kind case under the Uniform Code for Pharmaceutical Marketing Practices (UCPMP) 2024, the Apex Committee for Pharma Marketing Practices has issued a reprimand against AbbVie Healthcare India Private Ltd, a subsidiary of US-based AbbVie Inc., for unethical marketing practices. The company was allegedly found guilty of sponsoring international trips for nearly Rs 1.91 crore for 30 Healthcare Professionals (HCPs) under the pretense of professional development, contravening the <a href="https://medicaldialogues.in/news/industry/pharma/ucpmp-2024-5-major-takeaways-for-indian-pharma-marketers-125925">UCPMP guidelines</a>.</p><div id="ATS_mid1"></div><div class="inside-post-ad-1 inside-post-ad ads_common_inside_post" id="inside_post_content_ad_1"></div><div class="pasted-from-word-wrapper"><div class="pasted-from-word-wrapper"><div class="pasted-from-word-wrapper"><p style="text-align: justify;">The case began with an anonymous complaint submitted to the Department of Pharmaceuticals (DoP) on May 21, 2024. The complaint, supported by internal company documents, alleged that AbbVie provided foreign travel and accommodation for 30 doctors attending the Aesthetics &amp; Anti-Aging Medicine World Congress 2024 held in Monaco (February 1–3, 2024) and Paris (March 26–29, 2024). The alleged expenses totaled Rs 1.91 crore, covering flights and hotel stays.</p></div></div></div></div><div class="pasted-from-word-wrapper"><div><p style="text-align: justify;"><b><i>For more information, click on the link below:</i></b></p></div></div><div class="pasted-from-word-wrapper"><div style="text-align: justify;"><b><i><a href="https://medicaldialogues.in/news/industry/pharma/rs-191-crore-spent-on-doctors-travel-pharma-company-faces-ucpmp-heat-soon-action-against-30-doctors-140347#:~:text=The%20findings%20revealed%20that%20AbbVie's,and%20Juvederm%20was%20deemed%20insufficient.">Rs 1.91 Crore spent on Doctors Travel: Pharma Company faces UCPMP heat, soon action against 30 doctors</a></i></b></div></div><div class="pasted-from-word-wrapper"><div style="text-align: justify;"><b>Telangana Medical Council files 400 FIRs against quacks</b></div></div><div class="pasted-from-word-wrapper"><div style="text-align: justify;">The Telangana State Medical Council (TSMC) has launched a concerted effort to combat quackery, marking the first time in the state that legal action has been taken against individuals practising allopathy without an MBBS degree. The TSMC, in collaboration with the Telangana State Drug Control Administration (TSDCA), has filed 400 FIRs over the past year against such quacks, and has served notices on 40 doctors suspected of aiding them. This initiative is a significant step in addressing the growing threat to public health posed by unauthorized practitioners masquerading as Rural Medical Practitioners (RMPs).</div><div></div><div style="text-align: justify;">In addition to tackling quackery, the TSMC has implemented reforms to reduce the financial burden on doctors. Over the last year, the Council has cut registration and renewal fees by 50%, and senior doctors above 65 have been exempted from renewal fees. The TSMC has also partnered with the National Medical Commission (NMC) to conduct training workshops for professors in government medical colleges on misconduct and appeals.</div></div><div class="pasted-from-word-wrapper"><div style="text-align: justify;"><b>Telangana Govt doctors protest over Removal of Jagtial Hospital Superintendent</b></div></div><div class="pasted-from-word-wrapper"><p style="text-align: justify;"> A <a href="https://medicaldialogues.in/topics/black-badge-protest" target="_blank">black-badge protest</a> was recently organised by the Telangana Teaching Government Doctors Association (TTGDA) where doctors from several government medical colleges in the state participated to protest against the removal of Jagtial Government General Hospital Superintendent Dr L Ramulu from his position over allegations of <a href="https://medicaldialogues.in/topics/dereliction-of-duty" target="_blank">dereliction of duty</a>.</p><div id="ATS_mid1"></div><p style="text-align: justify;">Condemning the humiliation against the senior doctor, the association called the move “baseless and outrageous,” highlighting that such treatment given to a senior doctor was unacceptable. It clarified that Dr Ramulu was not managing his position by choice but was managing responsibilities in the absence of the additional DME.</p></div><div class="pasted-from-word-wrapper"><div><p style="text-align: justify;"><b><i>For more information, click on the link below:</i></b></p></div></div><div class="pasted-from-word-wrapper"><div style="text-align: justify; "><b><i><a href="https://medicaldialogues.in/news/health/doctors/telangana-govt-doctors-stage-black-badge-protest-over-removal-of-jagtial-hospital-superintendent-140340#:~:text=Hyderabad%3A%20A%20black%2Dbadge%20protest,L%20Ramulu%20from%20his%20position">Telangana Govt doctors stage black badge protest over Removal of Jagtial Hospital Superintendent</a></i></b></div></div>

189. Bristol Myers Squibb gets European Commission nod for Opdivo plus Yervoy to treat colorectal cancer

     Wed, 25 Dec 2024 11:22:58 -0000

     <img src='https://medicaldialogues.in/h-upload/2023/01/10/197365-bristol-myers-squibb-4.webp' /><p><b style="text-align: justify;">Princeton:&nbsp;</b><span style="text-align: justify;"><a href="https://medicaldialogues.in/topics/bristol-myers-squibb">Bristol Myers Squibb</a></span><span style="text-align: justify;"><a href="https://medicaldialogues.in/topics/bristol-myers-squibb">&nbsp;</a>has announced that the European Commission (EC) has approved </span><span style="text-align: justify;"><a href="https://medicaldialogues.in/topics/Opdivo">Opdivo&nbsp;</a>(</span><span style="text-align: justify;"><a href="https://medicaldialogues.in/topics/nivolumab">nivolumab</a>)&nbsp;plus </span><span style="text-align: justify;"><a href="https://medicaldialogues.in/topics/Yervoy">Yervoy</a>&nbsp;(</span><span style="text-align: justify;"><a href="https://medicaldialogues.in/topics/ipilimumab">ipilimumab</a>)&nbsp;</span><b style="text-align: justify;"></b><span style="text-align: justify;">for the first-line treatment of adult patients with microsatellite instability–high (MSI-H) or mismatch repair deficient (dMMR) unresectable or metastatic<a href="https://medicaldialogues.in/topics/colorectal-cancer"> colorectal cancer</a> (mCRC).</span></p><div class="pasted-from-word-wrapper"><p style="text-align: justify; ">“Colorectal cancer is the second leading cause of cancer death in Europe and patients are in need of new treatment options that delay disease progression. Approximately 5-7% of metastatic colorectal cancer patients have MSI-H/dMMR tumors and these patients are less likely to benefit from conventional chemotherapy and typically have poor prognosis outcomes,” said Dana Walker, M.D., M.S.C.E., vice president, Opdivo global program lead, Bristol Myers Squibb. “The EC’s decision to approve Opdivo plus Yervoy represents a significant milestone for this patient population in the European Union and underscores our commitment to advancing treatment options.”</p><p>Opdivo is a programmed death-1 (PD-1) immune checkpoint inhibitor that is designed to uniquely harness the body’s own immune system to help restore anti-tumor immune response. By harnessing the body’s own immune system to fight cancer, Opdivo has become an important treatment option across multiple cancers.</p><p style="text-align: justify; ">The decision is based on results from the CheckMate -8HW trial, which were presented at medical congresses earlier this year. These data formed the basis for the Company’s application to the European Medicines Agency (EMA). In the study, Opdivo plus Yervoy demonstrated a statistically significant and clinically meaningful improvement in the dual primary endpoint of progression-free survival (PFS) and reduced the risk of disease progression or death by 79% compared to the investigator’s choice of chemotherapy as assessed by Blinded Independent Central Review (BICR). The safety profile for the dual immunotherapy combination remained consistent with previously reported data and was manageable with established protocols, with no new safety signals identified.</p><p style="text-align: justify; ">Colorectal cancer (CRC) is cancer that develops in the colon or the rectum, which are part of the body’s digestive or gastrointestinal system. CRC is the third most commonly diagnosed cancer in the world. In 2020, it is estimated that there were approximately 1,931,000 new cases of the disease; it is the second leading cause of cancer-related deaths among men and women combined.</p><p style="text-align: justify; ">Mismatch repair deficiency (dMMR) occurs when the proteins that repair mismatch errors in DNA replication are missing or non-functional, leading to microsatellite instability-high (MSI-H) tumors. Approximately 5-7% of metastatic CRC patients have dMMR or MSI-H tumors. These patients are less likely to benefit from conventional chemotherapy and typically have a poor prognosis.</p><p style="text-align: justify; ">This approval by the EC for Opdivo plus Yervoy for the first-line treatment of adult patients with MSI-H or dMMR unresectable or mCRC is valid in all 27 member states of the European Union (EU), as well as Iceland, Liechtenstein and Norway. In addition to approval in colorectal cancer, Opdivo- based options are also approved for treatment of multiple tumor types in the EU.</p><p style="text-align: justify; "><b><i>Read also: <a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/industry/pharma/bristol-myers-squibb-gets-positive-chmp-opinion-for-opdivo-plus-yervoy-to-treat-adult-with-msi-h-or-dmmr-metastatic-colorectal-cancer-138295">Bristol Myers Squibb gets positive CHMP opinion for Opdivo plus Yervoy to treat adult with MSI-H or dMMR metastatic Colorectal Cancer</a></i></b></p></div><div class="pasted-from-word-wrapper"><div class="hocal-draggable" draggable="true"><div class="read-this-also-wrap"><div></div></div></div><div class="pasted-from-word-wrapper"><p style="text-align: justify; "><br></p></div></div><div class="pasted-from-word-wrapper"><p style="text-align: justify; "><br></p></div>

190. Want to pursue MD Radiology or Radiodiagnosis in Gujarat? Check out fees at 23 medical colleges

     Wed, 25 Dec 2024 10:57:48 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/25/266475-fee-deposition.webp' /><p><strong style="background-color: rgb(255, 255, 255);">Gujarat:</strong><span style="background-color: rgb(255, 255, 255);"> The Director of Medical Education </span><span style="background-color: rgb(255, 255, 255);">(</span><a href="https://medicaldialogues.in/topics/dme-gujarat" target="_blank" style="background-color: rgb(255, 255, 255);">DME Gujarat</a><span style="background-color: rgb(255, 255, 255);">) has released the&nbsp;</span><a href="https://medicaldialogues.in/topics/fee-structure/page-2" target="_blank" style="background-color: rgb(255, 255, 255);">fee structure</a><span style="background-color: rgb(255, 255, 255);">&nbsp;</span><span style="background-color: rgb(255, 255, 255);">for MD/MS/Diploma admissions at various medical colleges across the state for the academic year 2024-25. Among these, MD Radiology and MD Radiodiagnosis remain highly sought-after specialties for postgraduate medical aspirants.&nbsp;</span></p><p>The fee structure for MD Anatomy in Gujarat reveals significant variations across colleges under the General Quota (GQ) and Management Quota (MQ). The highest GQ fee is charged by Surat Municipal Institute of Medical Education &amp; Research (SMIMER), Surat, at ₹12.5 lakh, while the highest MQ fee is ₹4 lakh, shared by C.U. Shah Medical College, Surendranagar, Pramukhswami Medical College, Karamsad, and GCS Medical College, Ahmedabad. On the other hand, the lowest GQ fee is offered by Parul Institute of Medical Sciences, Vadodara, at ₹0.01 lakh, and the lowest MQ fee is charged by Zydus Medical College, Dahod, at ₹0.15 lakh. This wide range of fees provides options for students with varying financial capacities, from affordable government institutions to premium private colleges.</p><p><b><u>Here is a comprehensive list of MD Radiology and MD Radiodiagnosis fees for all 23 medical colleges in Gujarat, grouped by college and category:</u></b></p><p><b>Narendra Modi Medical College, Ahmedabad</b></p><ul class="hocalwire-editor-list"><li>General Quota (GQ): ₹9.67 lakh per year</li><li>Management Quota (MQ): ₹33 lakh per year</li><li>NRI Quota: ₹0.63255 lakh per year</li></ul><p><b>B.J. Medical College, Ahmedabad</b></p><ul class="hocalwire-editor-list"><li>General Quota (GQ): ₹1.308 lakh per year (Includes ₹0.3 lakh tuition fee + ₹1.008 lakh refundable deposit)</li></ul><p><b>C.U. Shah Medical College, Surendranagar</b></p><ul class="hocalwire-editor-list"><li>General Quota (GQ): ₹9 lakh per year</li><li>Management Quota (MQ): ₹15 lakh per year</li><li>NRI Quota: ₹56.00 lakh per year</li></ul><p><b>GCS Medical College, Ahmedabad</b></p><ul class="hocalwire-editor-list"><li>General Quota (GQ): ₹29 lakh per year</li><li>Management Quota (MQ): ₹40 lakh per year</li><li>NRI Quota: ₹40.00 lakh per year</li></ul><p><b>GMERS Medical College, Sola, Ahmedabad</b></p><ul class="hocalwire-editor-list"><li>General Quota (GQ): ₹11.25 lakh per year</li><li>Management Quota (MQ): ₹16.88 lakh per year</li><li>NRI Quota: ₹33.75 lakh per year</li></ul><p><b>Govt. Medical College, Baroda</b></p><ul class="hocalwire-editor-list"><li>General Quota (GQ): ₹1.308 lakh per year (Includes ₹0.3 lakh tuition fee + ₹1.008 lakh refundable deposit)</li></ul><p><b>Govt. Medical College, Bhavnagar</b></p><ul class="hocalwire-editor-list"><li>General Quota (GQ): ₹1.308 lakh per year (Includes ₹0.3 lakh tuition fee + ₹1.008 lakh refundable deposit)</li></ul><p><b>Govt. Medical College, Surat</b></p><ul class="hocalwire-editor-list"><li>General Quota (GQ): ₹1.308 lakh per year (Includes ₹0.3 lakh tuition fee + ₹1.008 lakh refundable deposit)</li></ul><p><b>Gujarat Adani Institute of Medical Sciences, Bhuj</b></p><ul class="hocalwire-editor-list"><li>General Quota (GQ): ₹33 lakh per year</li><li>Management Quota (MQ): ₹48 lakh per year</li><li>NRI Quota: NA</li></ul><p><b>Gujarat Adani Institute of Medical Sciences, Bhuj</b></p><ul class="hocalwire-editor-list"><li>General Quota (GQ): ₹33.00 lakh per year<br></li><li>Management Quota (MQ): ₹48.00 lakh per year<br></li><li>NRI Quota: NA</li></ul><div class="pasted-from-word-wrapper"><p><b>M. P. Shah Medical College, Jamnagar&nbsp;</b></p><ul class="hocalwire-editor-list"><li>General Quota (GQ): ₹1.308 lakh per year (Includes ₹0.3 lakh tuition fee + ₹1.008 lakh refundable deposit)</li></ul></div><div class="pasted-from-word-wrapper"><p><b>P. D. U. Medical College, Rajkot</b></p><ul class="hocalwire-editor-list"><li>General Quota (GQ): ₹1.308 lakh per year (Includes ₹0.3 lakh tuition fee + ₹1.008 lakh refundable deposit)</li></ul></div><div class="pasted-from-word-wrapper"><p><b>Pramukh Swami Medical College, Karamsad</b></p><ul class="hocalwire-editor-list"><li>General Quota (GQ): ₹46.00 lakh per year<br></li><li>Management Quota (MQ): ₹52.00 lakh per year<br></li><li>NRI Quota: ₹65.00lakh per year</li></ul></div><p><b>Smt. N.H.L. Municipal Medical College, Ahmedabad</b></p><ul class="hocalwire-editor-list"><li>General Quota (GQ): ₹7.93 lakh per year<br></li><li>Management Quota (MQ): ₹41.58 lakh per year<br></li><li>NRI Quota:0.6875$</li></ul><p><b>GMERS Medical College, Valsad</b></p><ul class="hocalwire-editor-list"><li>General Quota (GQ): ₹8.75 lakh per year</li><li>Management Quota (MQ): ₹16 lakh per year</li><li>NRI Quota: ₹33.75 lakh per year</li></ul><p><b>Surat Municipal Institute of Medical Education &amp; Research (SMIMER), Surat</b></p><ul class="hocalwire-editor-list"><li>General Quota (GQ): ₹18.64 lakh per year<br></li><li>Management Quota (MQ): ₹41.50 lakh per year<br></li><li>NRI Quota: 0.64$</li></ul><p><b>GMERS Medical College, Gotri, Baroda</b></p><ul class="hocalwire-editor-list"><li>NA</li><li>NA</li><li>NA</li></ul><div class="pasted-from-word-wrapper"><p><b>GMERS Medical College, Gandhinagar</b></p><ul class="hocalwire-editor-list"><li>NA</li><li>NA</li><li>NA</li></ul></div><p><b>Parul Institute of Medical Sciences, Vadodara</b></p><ul class="hocalwire-editor-list"><li>General Quota (GQ): ₹42.00 lakh per year</li><li>Management Quota (MQ): ₹52.00 lakh per year</li><li>NRI Quota: NA&nbsp;</li></ul><p><b>M.K SHAH MEDICAL COLLGE, Ahmedabad&nbsp;</b></p><ul class="hocalwire-editor-list"><li>General Quota (GQ): ₹33.00 lakh per year</li><li>Management Quota (MQ): ₹45.50 lakh per year</li><li>NRI Quota: 0.72$ (IN USD)</li></ul><p><b style="color: rgb(0, 0, 0);">Smt. G. R. Doshi &amp; Smt. K M Mehta Institute of Kidney Diseases &amp; Research center, Ahmedabad</b></p><ul class="hocalwire-editor-list"><li><span style="color: rgb(68, 68, 68); background-color: rgb(255, 255, 255);">General Quota (GQ):NA</span></li><li><span style="color: rgb(68, 68, 68); background-color: rgb(255, 255, 255);">Management Quota (MQ):NA</span></li><li><span style="color: rgb(68, 68, 68); background-color: rgb(255, 255, 255);">NRI Quota:NA</span></li></ul><p><b>Zydus Medical College, Dahod</b></p><ul class="hocalwire-editor-list"><li>General Quota (GQ): ₹35.20 lakh per year</li><li>Management Quota (MQ): ₹58.19 lakh per year</li><li>NRI Quota: NA</li></ul><p><b>Shantabaa Medical College,Amreli&nbsp;</b></p><ul class="hocalwire-editor-list"><li>NA</li><li>NA</li><li>NA</li></ul><p><b style="color: rgb(0, 0, 0);">Dr. N. D. Desai Faculty of Medical Science and Research, Nadiad</b></p><ul class="hocalwire-editor-list"><li><span style="color: rgb(68, 68, 68); background-color: rgb(255, 255, 255);">General Quota (GQ): NA&nbsp;</span></li><li>Management Quota (MQ): NA</li><li>NRI Quota: NA</li></ul><p><b style="color: rgb(0, 0, 0);">Nootan Medical College &amp; Research&nbsp;Centre, Visnagar</b></p><ul class="hocalwire-editor-list"><li>General Quota (GQ): ₹44.00 lakh per year</li><li>Management Quota (MQ): ₹52.00 lakh per year</li><li>NRI Quota: NA</li></ul><p><b><i>To view the official Notice, Click here :&nbsp;&nbsp;<a href="https://medicaldialogues.in/pdf_upload/tuition-fees-pg-2024-25-1-266459.pdf" target="_blank">https://medicaldialogues.in/pdf_upload/tuition-fees-pg-2024-25-1-266459.pdf</a></i></b></p>

191. Ayush for All: National Ayush Mission empowering communities with accessible, affordable healthcare

     Wed, 25 Dec 2024 10:43:44 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/25/266424-prataprao-jadhav.webp' /><div class="pasted-from-word-wrapper"><p><span style="text-align: justify;">New Delhi: The Ministry of Ayush launched a film series titled ''Ayush for All: Holistic Health Care through National Ayush Mission'' yesterday, showcasing the remarkable progress and transformative impact of the National Ayush Mission (NAM).</span></p><p style="text-align: justify; ">The series was unveiled by Shri <a href="https://medicaldialogues.in/topics/prataprao-jadhav" target="_blank">Prataprao Jadhav</a>, the Union Minister of State (IC), Ministry of Ayush and Union Minister of State, Ministry of Health &amp; Family Welfare, Government of India. The launch of the series is in line with the efforts of the Ministry of Ayush underscoring the government’s commitment to bring equitable, affordable, and holistic healthcare to every citizen, including those in the remotest corners of the country.</p><p style="text-align: justify;">The National Ayush Mission (NAM), a Centrally Sponsored Scheme, aims to strengthen Ayush healthcare services, promote preventive care through Ayushman Arogya Mandir (Ayush), and integrate Ayush systems into mainstream public health. NAM also emphasizes the development of Ayush educational institutions to enhance the quality of education and research.</p><p style="text-align: justify;"><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/ayush/homeopathy/news/shri-prataprao-jadhav-lauds-nhrimh-kottayam-for-its-efforts-in-research-publications-140342"><b><i>Also Read:Shri Prataprao Jadhav Lauds NHRIMH, Kottayam for its Efforts in Research Publications</i></b></a></p><p style="text-align: justify;">Moreover, the scheme has supported the establishment of 167 Integrated Ayush Hospitals and upgraded 416 Ayush Hospitals and 5036 dispensaries. Co-location initiatives benefitted 2322 PHCs, 715 CHCs, and 314 DHs annually. Essential Ayush medicines were supplied to 996 hospitals and 12,405 dispensaries each year. NAM also supported 16 new Ayush educational institutions and upgraded 112 others. Additionally, 3883 Yoga Wellness Centres, 1055 Ayush Grams, and 12,500 Ayushman Arogya Mandir (Ayush) were established, promoting holistic wellness nationwide.</p><p style="text-align: justify;">The Minister highlighted the success of NAM and said, “The National Ayush Mission has empowered communities to with accessible and cost-effective healthcare based on traditional practices. This film series is a step towards making information about our initiatives readily accessible to the public, showcasing Ayush’s pivotal role in reducing disease burden and promoting wellness across the nation.”</p><p style="text-align: justify;">The series highlights real-life stories of transformation, demonstrating how NAM, in collaboration with state/UT governments, has improved healthcare access and reduced out-of-pocket expenditures for rural and underserved populations.</p><p style="text-align: justify;">Vaidya Rajesh Kotecha, Secretary, Ministry of Ayush said, "The National Ayush Mission focuses on strengthening Ayush healthcare services, establishing Ayushman Arogya Mandir (Ayush), and promoting medical pluralism. These initiatives are transforming public health and improving access to preventive and promotive care across the nation."</p><p style="text-align: justify;">Ms Kavita Garg, Joint Secretary, Ministry of Ayush mentioned, “As part of the Ministry’s digital outreach efforts, the series will be available on the official YouTube channel of the Ministry of Ayush, ensuring convenient access for all citizens.”</p><p style="text-align: justify;">The National Ayush Mission has been a significant initiative in revolutionizing healthcare delivery in distant corners of the country. By bridging the gap in healthcare access and promoting a holistic wellness model, NAM continues to transform lives and contribute to a healthier, more sustainable India.</p><p style="text-align: justify;"><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/ayush/ayurveda/news/8th-national-siddha-day-contribution-of-siddha-in-national-ayush-mission-commendable-says-ayush-secretary-140215"><b><i>Also Read:8th National Siddha Day: Contribution of Siddha in National Ayush Mission Commendable, says AYUSH Secretary</i></b></a></p><div class="hocal-draggable" draggable="true"><div class="read-this-also-wrap"><div></div></div></div></div>

192. Delay in NEET PG Kerala State Counselling: MCC urged to Postpone 3rd Round of Counselling

     Wed, 25 Dec 2024 10:24:11 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/21/265956-pg-medical-admission-2024.webp' /><p style="text-align: justify; "><b>Thiruvananthapuram:</b>&nbsp;Citing delays in the completion of the second round of State-level counselling in several States, the postgraduate medical aspirants from Kerala have urged the Medical Counselling Committee (MCC) to postpone the third round of <a href="https://medicaldialogues.in/topics/all-india-quota">All India Quota</a> (AIQ) counselling for the National Eligibility-cum-Entrance Test Postgraduate (NEET-PG) examination.</p><p style="text-align: justify; ">As per the schedule, the Medical Counselling Committee (MCC), the authority in charge of monitoring the counselling and seat allocation process for the medical courses in India, will conduct the third round of AIQ counselling for admission to deemed, central and other universities from December 26 to January 1.</p><p style="text-align: justify; ">Normally, AIQ and State Counselling processes run concurrently and therefore, students can make informed choices. After the State Counselling processes, the vacant seats usually get carried forward to the subsequent AIQ counselling round.</p><p style="text-align: justify; ">However, this year, the PG medical counselling in various States including Madhya Pradesh, Telangana and Rajasthan, were delayed or suspended due to the ongoing legal proceedings. Due to this, several seats that normally should have been included in the third round of AIQ counselling are still unavailable.</p><p style="text-align: justify; "><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/education/medical-admissions/neet-pg-state-counseling-delayed-telangana-pg-aspirants-cry-foul-140331" style="background-color: rgb(255, 255, 255);"><b><i>Also Read: NEET PG State counseling Delayed, Telangana PG Aspirants Cry Foul</i></b></a></p><p style="text-align: justify; ">Kerala has a limited number of PG medical seats. Therefore, typically, many candidates rely on vacancies in other States across the country to secure admission.</p><p style="text-align: justify; ">Referring to the issue, aspirants have argued that if the third round of AIQ counselling proceeded as scheduled, these seats would not be accounted for in the AIQ counselling process and therefore, deserving candidates will lose the opportunity to secure a seat based on their merit.&nbsp;</p><p style="text-align: justify; ">They pointed out that these vacant seats may be allocated in the stray round of counselling, where lower-ranke candidates often fill them, potentially denying higher-ranked candidates a fair chance, a candidate lamented.</p><p style="text-align: justify; ">As per the latest media report by <a href="https://www.thehindu.com/news/national/kerala/neet-pg-aspirants-seek-postponement-of-aiq-counselling-due-to-state-level-holdups/article69023416.ece" rel="nofollow">The Hindu</a>, the aspirants have requested the authorities to postpone the AIQ 3rd round of counselling by one week to allow the completion of State-level counselling. They believe this delay would ensure that all the vacant seats would be included in the third round of State counselling and all the candidates would get a fair chance based on their merit.</p><p style="text-align: justify; ">Medical Dialogues had earlier reported that more than 8000 PG medical aspirants in Telangana were facing uncertainty regarding their future due to the non-release of merit list for the State-level counselling by the Kaloji Narayana Rao University of Health Sciences (<a href="https://medicaldialogues.in/topics/kaloji-narayana-university-of-health-sciences">KNRUHS</a>). Due to the disruption in the Central and State Counselling, PG medical aspirants are unaware of their rankings even though they registered for the State Counselling weeks ago.</p><p style="text-align: justify; ">These issues are being raised by the PG medical aspirants when the plea seeking transparency in the <a href="https://medicaldialogues.in/topics/neet-pg">NEET PG</a> exam is already pending before the Supreme Court bench. The case has been postponed several times and now it is listed for further hearing before the top court bench on January 7, 2024.</p><p style="text-align: justify; "><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/education/neet-pg-2024-plea-deferred-again-sc-to-hear-matter-likely-on-january-7-2025-139585" style="background-color: rgb(255, 255, 255);"><b><i>Also Read: NEET PG 2024 Plea Deferred Again! SC to Hear Matter likely on January 7, 2025</i></b></a></p>

193. ' No evidence of possible struggle' inside seminar hall, says Forensic Report in RG Kar Case

     Wed, 25 Dec 2024 09:30:18 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/25/266412-untitled-design-2024-12-25t124645230.webp' /><p style="text-align: justify; "><b>Kolkata:&nbsp;</b>A forensic report from the Central Forensic Science Laboratory (CFSL) regarding the death of a PG doctor at <a href="https://medicaldialogues.in/topics/r-g-kar-medical-college-and-hospital" target="_blank">RG Kar Medical College and Hospital</a> has stirred controversy and raised suspicions. The report made a shocking revelation that no signs of a possible struggle or resistance were found at the crime scene in the seminar room of the hospital where the lady doctor was allegedly raped and murdered on August 9. &nbsp;</p><p style="text-align: justify; ">Four months ago, a trainee doctor at RG Kar Medical College and Hospital in Kolkata was tragically raped and murdered in a seminar room of the same hospital during her night shift. In response to this heinous act, both junior and senior doctors from various associations protested and 7 junior doctors were on an indefinite hunger strike, calling for justice for Abhaya and urging for strict action against the culprits.&nbsp;</p><p style="text-align: justify; ">However, the CFSL report released on September 11 has come to light recently, uncovering an unexpected development that has raised doubt about what exactly had happened to the doctor on that night of August 9.&nbsp;</p><p style="text-align: justify; "><b>Also read- <a href="https://medicaldialogues.in/news/health/doctors/doctor-rape-murder-case-calcutta-hc-allows-doctors-to-continue-protest-at-esplanade-140339" target="_blank">Doctor Rape-Murder Case: Calcutta HC allows Doctors to continue protest at Esplanade</a></b></p><p style="text-align: justify; ">According to the report, the evidence of possible struggle shown by the victim to the assailant or fight between them was found missing in the shown area of occurrence, i.e., the wooden stage mattress and adjoining area inside the seminar hall.</p><p style="text-align: justify; "><i>"Except the mattress located on the wooden stage, no biological stains could be detected on, around, or underneath the rest of the wooden stage portion or wooden table with the blue sheet top. Except the mattress located on the wooden stage, no biological stains could be detected on the floor surface in the seminar room, which was stated to be the place of offense," </i>stated the report.&nbsp;</p><p style="text-align: justify; ">The report also added that the remnants of demolished broken bricks and tiles were scanned for the presence of biological clue materials. However, no logically suspected biological materials related to the case could be detected from the adjacent rooms, including the HOD’s room, library, and other doctor’s rooms.</p><blockquote style="text-align: justify;">"The cut mark portions observed on this mattress that were reasonably corresponding to the head and lower abdomen area of an injured victim who stated/happens to be lying on this mattress. However, the evidence of possible struggle shown by the victim to the assailant or fight in between them (in this case under reference) was found missing in the shown area of occurrence, i.e., the wooden stage mattress and adjoining area inside the seminar hall," revealed the report.&nbsp;</blockquote><p style="text-align: justify; ">Highlighting that no one could enter the seminar room unnoticed, the report said, "There is less possibility that someone (in the presence of the official attendees present in the 24x7 operational hospital corridor, doctor’s duty-nursing station area) can enter into the seminar hall unnoticed for committing an offence."</p><p style="text-align: justify; ">Medical Dialogues had recently reported that the Calcutta High Court on Monday upheld a December 20 order allowing a demonstration during the Christmas season to demand speedy justice for the RG Kar hospital trainee doctor who was allegedly raped and murdered in August.</p><p style="text-align: justify; "><b>Also read- <a href="https://medicaldialogues.in/news/health/doctors/kolkata-rape-murder-case-doctors-body-plan-10-day-demonstration-139865" target="_blank">Kolkata Rape-Murder Case: Doctors' body plan 10-day demonstration</a></b></p>

194. Medical Bulletin 25/ December/ 2024

     Wed, 25 Dec 2024 09:30:00 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/25/266402-top-medical-49.webp' /><p style="text-align: justify; "><b>Here are the top medical news for the day:</b></p><div class="pasted-from-word-wrapper"><div style="text-align: justify; "><b>Skin Like Material to Investigate Infections from Intravenous Catheters</b></div><div style="text-align: justify; ">Published in the journal Scientific Reports, researchers have created realistic, skin-like replicas made of Ecoflex, a type of silicone rubber that can potentially serve as a platform to evaluate risks of bacterial infections from intravenous catheters and test wearable sensors, among other biomedical applications. The study found that EcoFlex-based skin replicas can be engineered to mimic actual skin textures, wettability, and elasticity, simulating the conditions where bacteria grow and adhere.</div><div style="text-align: justify; "> “We have been slow in finding solutions for preventing infections from intravenous catheters,” said Majed Othman Althumayri, a graduate student in the Texas A&amp;M Department of Biomedical Engineering and primary author of the paper. “A reason could be that we lack good platforms to test new catheter designs or wearable biosensor technologies and train staff so that the number of infections can be reduced.”</div><div style="text-align: justify; ">To address this gap, the researchers turned to Ecoflex 00-35, a fast-curing, biocompatible rubber used for various applications, including prosthetics for special effects. First, they created molds of common intravenous insertion sites, such as the elbows, hands and forearms. Then, by pouring Ecoflex into the molds that contained artificial bones and tubes acting as veins, the researchers created skin-like replicas. </div><div style="text-align: justify;">Next, the researchers tested if the Ecoflex skin replicas had properties that matched that of real skin. They measured the replicas’ wettability, bacterial adhesion and mechanical properties, such as elasticity and resilience. The researchers found that the Ecoflex models could replicate human skin roughness within a 7.5% error margin. Further, high-resolution imaging showed that bacteria could adhere to the skin replica and grow on it. </div><div style="text-align: justify; ">Then, in a key experiment, the researchers simulated an intravenous catheter insertion into an Ecoflex hand replica that they created. This artificial hand effectively modeled phases of bacterial growth, showing promise that these replicas can be used for implementing infection control measures and improving the design of medical devices like catheters.</div><div style="text-align: justify;">However, the researchers noted that their current experiments do not entirely model real-world conditions. </div><div style="text-align: justify;">Reference: Althumayri, M.O., Tarman, A.Y. &amp; Ceylan Koydemir, H. Bioinspired skin-like in vitro model for investigating catheter-related bloodstream infections. Sci Rep 14, 26167 (2024). https://doi.org/10.1038/s41598-024-76652-y</div><div></div><div></div><div></div><div></div><div></div><div></div><div style="text-align: justify; "><b>Two Neurotransmitters May Play Key Role in Meal Initiation</b></div><div style="text-align: justify;">A new study published in the journal Metabolism reveals brain circuits and chemical messengers that contribute to the regulation of meal initiation and food intake. The findings have implications for the development of improved therapies to manage obesity, a worldwide epidemic.</div><div style="text-align: justify;">“It’s well known that serotonin, a neurotransmitter in the brain, can suppress food intake. This finding led to the development of drugs that interact with serotonin or its receptors to regulate food consumption and obesity,” said corresponding author Dr. Yong Xu, professor of pediatrics – nutrition and associate director of basic sciences at the USDA/ARS Children’s Nutrition Research Center at Baylor. “However, some of these drugs have unwanted side effects, and they are no longer offered to patients. There is a need to better understand how the brain regulates food intake to improve drug design.”</div><div style="text-align: justify;">In this study, researchers focused on a little-known component of the serotonin regulation of food intake. They looked for brain circuits and neurotransmitters that regulate the activity of serotonin-producing neurons, activating or inhibiting them at the appropriate periods to reach balanced food consumption</div><div style="text-align: justify;">Serotonin is primarily synthesized by neurons in the dorsal Raphe nucleus (DRN) in the midbrain. Serotonin neurons in the DRN project to numerous brain regions, including the arcuate of the hypothalamus (ARH). The team showed that the ARH circuit and two neurotransmitters, GABA and dopamine, play a key role in meal initiation.</div><div style="text-align: justify; ">“Working with animal models, we found that when the animals are hungry, serotonin-producing neurons in the DRN are inhibited by GABA and dopamine. This reduces the levels of serotonin in the brain, which allows the initiation of a meal,” Xu explained. “As the animals feed and reach satiety, the inhibitory signals on serotonin neurons are reduced and more serotonin is produced to inhibit feeding via projections to the ARH.”</div><div style="text-align: justify;">“What's unique about this is that GABA and dopamine act synergistically – when both are present, serotonin neurons appear to be more inhibited than when only one of the neurotransmitters is present,” Xu said.</div><div style="text-align: justify;">Reference: Serotonin neurons integrate GABA and dopamine inputs to regulate meal initiation, Conde, Kristine M. et al., Metabolism - Clinical and Experimental, Volume 163, 156099</div><div></div><div></div><div></div><div></div><div></div><div></div><div></div><div></div><div></div><div style="text-align: justify; "><b>More Blood Transfusions Improve 6-month Survival in Anemic Heart Attack Patients: Study Finds</b></div><div style="text-align: justify; ">Giving more blood to anemic patients after a heart attack may save lives, according to a Rutgers Health–led study. The study, published in NEJM Evidence, affirms research conducted in 2023 that suggested mortality rate or recurrent heart attacks were more frequent in anemic patients who received less blood.</div><div style="text-align: justify;">Researchers acquired data from the four clinical trials evaluating blood transfusion in 4,311 patients with heart attacks. These trials included patients who had a heart attack and low blood count. Half the patients received less blood transfusions and the other half received more blood transfusions. The trials compared the frequency of death at 30 days or recurrent heart attacks and death at six months.</div><div style="text-align: justify;">The results of this analysis, didn’t definitively establish that giving less blood transfusions increased a patients’ risk of death or heart attack at 30 days, but did suggest that using less transfusions was associated with an increased risk of death at six months.</div><div style="text-align: justify;">In the original clinical trial, a large percentage of patients had suffered a previous heart attack, heart failure, diabetes or kidney disease. The average age of participants was 72, with 45% women.</div><div style="text-align: justify;">The researchers compared the frequency of the main outcome of death or recurrent heart attack at 30 days after enrollment into the trial. Although not statistically significant, the study found the frequency of mortality or recurrent heart attack was 2.4% lower when a liberal approach was used.</div><div style="text-align: justify;">“The results of this analysis show that giving more blood to anemic patients with heart attacks can save lives at six months,” Jeffrey L. Carson, provost and Distinguished Professor of medicine at Rutgers Robert Wood Johnson Medical School, said.</div><div></div><div></div><div style="text-align: justify; "><b>Blood Pressure Medicine May Reduce Tremors in Parkinson’s Disease</b></div><div style="text-align: justify; ">Propranolol, is a beta-blocker that inhibits the action of stress hormones. It was developed for high blood pressure and heart arrhythmias, has been around for a long time, and is already used as a standard treatment for essential tremor -- a condition in which people experience tremors without other neurological symptoms. There were already indications that propranolol might reduce tremors in Parkinson's, but until now, no thorough research has explored its potential effects.</div><div style="text-align: justify;">Researchers studied 27 people with Parkinson's who experienced tremors. They were given propranolol on one day and a placebo on another day. A device on their hands measured the intensity of their tremors, while an MRI scan mapped brain activity. This was done both at rest and during a task involving stressful mathematical calculations. The stress response was measured by pupil size and heart rate, both of which increased during the calculations. As expected, without medication, tremors worsened during stress.</div><div style="text-align: justify;">The study showed that propranolol reduced tremors both at rest and during stress. The MRI scans revealed how this works: after taking the medication, the brain circuit responsible for tremors showed less activity. </div><div style="text-align: justify;">Researchers also noted that propranolol worked to reduce tremors at rest as well. </div><div style="text-align: justify; ">Reference: https://www.radboudumc.nl/en/news-items/2024/propranolol-reduces-tremors-in-parkinson-s-disease</div></div>

195. Rajasthan PG Medical Counselling 2024: 1099 Seats Vacant available for Round 2

     Wed, 25 Dec 2024 09:00:20 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/25/266428-seat-matrix.webp' /><p style="text-align: justify; "><b>Rajasthan- </b>Rajasthan Counselling Board has released the Postgraduate (PG) Medical vacant seat matrix for Round 2 for the academic year 2024. The seat matrix has been released on its official website, therefore, candidates can check the vacant seat details from it.</p><div class="pasted-from-word-wrapper"><p dir="ltr" style="text-align: justify; ">As per the seat matrix, a total of 1099 seats are vacant in PG Medical Round 2 2024. The allotment process of Round 2 for State Medical PG seats (MD/MS)/Post MBBS DNB/Post MBBS Diploma 2024-25 has already begun and will end on 28 December 2024.</p></div><div class="pasted-from-word-wrapper"><a class="also-read-media-wrap" href="https://medicaldialogues.in/news/education/medical-admissions/rajasthan-neet-pg-counselling-2024-check-round-2-schedule-140303"></a><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/education/medical-admissions/rajasthan-neet-pg-counselling-2024-check-round-2-schedule-140303"><b>Also Read:&nbsp;</b>Rajasthan NEET PG Counselling 2024-Check Round 2 Schedule</a></div><div class="pasted-from-word-wrapper"><p dir="ltr" style="text-align: justify; "><b><u>SEAT MATRIX</u></b></p><div dir="ltr"><table style="text-align: justify; "><colgroup><col width="53"><col width="363"><col width="208"></colgroup><tbody><tr><td><p dir="ltr" style="text-align: center; "><b>S.NO</b></p></td><td><p dir="ltr" style="text-align: center; "><b>INSTITUTE</b></p></td><td><p dir="ltr" style="text-align: center; "><b>VACANT SEATS</b></p></td></tr><tr><td><p dir="ltr">1</p></td><td><p dir="ltr">SMS MC Jaipur.</p></td><td><p dir="ltr">95</p></td></tr><tr><td><p dir="ltr">2</p></td><td><p dir="ltr">SP MC Bikaner.</p></td><td><p dir="ltr">31</p></td></tr><tr><td><p dir="ltr">3</p></td><td><p dir="ltr">SN MC Jodhpur.</p></td><td><p dir="ltr">35</p></td></tr><tr><td><p dir="ltr">4</p></td><td><p dir="ltr">RNT MC Udaipur.</p></td><td><p dir="ltr">24</p></td></tr><tr><td><p dir="ltr">5</p></td><td><p dir="ltr">JLN MC Ajmer.</p></td><td><p dir="ltr">33</p></td></tr><tr><td><p dir="ltr">6</p></td><td><p dir="ltr">GMC, Kota.</p></td><td><p dir="ltr">27</p></td></tr><tr><td><p dir="ltr">7</p></td><td><p dir="ltr">Jhalawar MC.</p></td><td><p dir="ltr">19</p></td></tr><tr><td><p dir="ltr">8</p></td><td><p dir="ltr">RUHS.</p></td><td><p dir="ltr">8</p></td></tr><tr><td><p dir="ltr">9</p></td><td><p dir="ltr">Bharatpur.</p></td><td><p dir="ltr">5</p></td></tr><tr><td><p dir="ltr">10</p></td><td><p dir="ltr">Churu.</p></td><td><p dir="ltr">1</p></td></tr><tr><td><p dir="ltr">11</p></td><td><p dir="ltr">Pali.</p></td><td><p dir="ltr">10</p></td></tr><tr><td><p dir="ltr">12</p></td><td><p dir="ltr">Bhilwara.</p></td><td><p dir="ltr">5</p></td></tr><tr><td><p dir="ltr">13</p></td><td><p dir="ltr">Dungarpur.</p></td><td><p dir="ltr">2</p></td></tr><tr><td><p dir="ltr">14</p></td><td><p dir="ltr">MG MC Jaipur.</p></td><td><p dir="ltr">86</p></td></tr><tr><td><p dir="ltr">15</p></td><td><p dir="ltr">NIMS Jaipur.</p></td><td><p dir="ltr">124</p></td></tr><tr><td><p dir="ltr">16</p></td><td><p dir="ltr">Geetanjali Udaipur.</p></td><td><p dir="ltr">118</p></td></tr><tr><td><p dir="ltr">17</p></td><td><p dir="ltr">Pacific Medical College &amp; Hospital.</p></td><td><p dir="ltr">146</p></td></tr><tr><td><p dir="ltr">18</p></td><td><p dir="ltr">Pacific Institute of Medical Sciences.</p></td><td><p dir="ltr">151</p></td></tr><tr><td><p dir="ltr">19</p></td><td><p dir="ltr">JNU Medical College, Jaipur.</p></td><td><p dir="ltr">67</p></td></tr><tr><td><p dir="ltr">20</p></td><td><p dir="ltr">American Int. Inst. of Med. Sc., Udaip.</p></td><td><p dir="ltr">24</p></td></tr><tr><td><p dir="ltr">21</p></td><td><p dir="ltr">Ananta Institute of Med. Sc., Rajsamand.</p></td><td><p dir="ltr">55</p></td></tr><tr><td><p dir="ltr">22</p></td><td><p dir="ltr">Dr SS Tantia Medical College, Hospital and Research Center, Sriganganagar.</p></td><td><p dir="ltr">33</p></td></tr><tr><td></td><td><p dir="ltr" style="text-align: center; "><b>TOTAL</b></p></td><td><p dir="ltr" style="text-align: center; "><b>1099</b></p></td></tr></tbody></table></div><p dir="ltr" style="text-align: justify; "><b><u>SCHEDULE FOR ALLOTMENT PROCESS (ROUND 2)</u></b></p><div dir="ltr"><table style="text-align: justify; "><colgroup><col width="56"><col width="360"><col width="208"></colgroup><tbody><tr><td><p dir="ltr" style="text-align: center; "><b>S.NO</b></p></td><td><p dir="ltr" style="text-align: center; "><b>PARTICULARS</b></p></td><td><p dir="ltr" style="text-align: center; "><b>DATES</b></p></td></tr><tr><td><p dir="ltr">1</p></td><td><p dir="ltr">Start date for filling out online application form and deposition of required application fee.</p></td><td><p dir="ltr">22 December 2024</p></td></tr><tr><td><p dir="ltr">2</p></td><td><p dir="ltr">Last date for depositing the application fee at the website.</p></td><td><p dir="ltr">26 December 2024 (5.00 pm)</p></td></tr><tr><td><p dir="ltr">3</p></td><td><p dir="ltr">The last date for submitting the online application form is on the website.</p></td><td><p dir="ltr">27 December 2024 (11.45 pm)</p></td></tr><tr><td><p dir="ltr">4</p></td><td><p dir="ltr">Publication of Provisional Seat Matrix.</p></td><td><p dir="ltr">23 December 2024</p></td></tr><tr><td><p dir="ltr">5</p></td><td><p dir="ltr">Deposition of security amount.</p></td><td><p dir="ltr">22 to 26 December 2024 (4.00 pm)</p></td></tr><tr><td><p dir="ltr">6</p></td><td><p dir="ltr">Online choice filling locking of the choices by the candidates.</p></td><td><p dir="ltr">22 to 27 December 2024 (11.45 pm) (choices auto-locked at 11.45 pm on 27.12.2024)</p></td></tr><tr><td><p dir="ltr">7</p></td><td><p dir="ltr">Verification of Disability certificate.</p></td><td><p dir="ltr">28 December 2024, 9.00 am</p></td></tr><tr><td><p dir="ltr">8</p></td><td><p dir="ltr">Printing of the online application form after auto-locking of the choices filled and saved by the candidates.</p></td><td><p dir="ltr">28 December 2024 onwards</p></td></tr><tr><td><p dir="ltr">9</p></td><td><p dir="ltr">Commencement of academic session.</p></td><td><p dir="ltr">20 December 2024</p></td></tr></tbody></table></div><p>Rajasthan Counselling Board invited applications for PG seats (MD &amp; MS), Post MBBS DNB and Post MBBS Diploma Allotment 2024 from 25 September 2024 to 02 October 2024, later the online registration form was re-opened for a period of 2 days from 17 to 18 October 2024.&nbsp;</p><p dir="ltr" style="text-align: justify; "><b><u><i>To view the seat matrix, click the link below</i></u></b></p><p dir="ltr" style="text-align: justify; "><a href="https://medicaldialogues.in/pdf_upload/rajasthan-266429.pdf" target="_blank">https://medicaldialogues.in/pdf_upload/rajasthan-266429.pdf</a></p></div><div class="pasted-from-word-wrapper"><div></div></div>

196. NMC Extends Deadline for PG Medical Course Applications After Karnataka HC Order

     Wed, 25 Dec 2024 08:57:15 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/25/266422-extend.webp' /><p style="text-align: justify; "><b>New Delhi-</b> The National Medical Commission (<a href="https://medicaldialogues.in/health-news/nmc/3" target="_blank">NMC</a>) has once again extended the last date for submission of applications for starting new <a href="https://medicaldialogues.in/topics/pg-medical-courses" target="_blank">postgraduate medical courses</a> in an established medical institution, setting up a new postgraduate medical institute (standalone PG institute) and increase of seats in existing postgraduate medical courses for the academic year 2025-2026.</p><p style="text-align: justify; ">Issuing a public notice, the Apex Medical Commission informed that the Medical Assessment and Rating Board (<a href="https://medicaldialogues.in/topics/marb" target="_blank">MARB</a>) has decided to extend the deadline for submission of applications with immediate effect till tomorrow i.e. 26th December 2024 at 6 PM. Earlier the last date for receipt of applications was 17 October 2024, which was extended from time to time to 08 November 2024 and then to 10 December 2024.</p><p style="text-align: justify; ">The latest extension has been granted by the Commission after the Karnataka High Court issued directions in this regard to NMC. While considering the plea by Kalaburgi-based Mahadevappa Rampure Medical College, the HC bench noted that due to the failure on the part of the medical college to upload the information related to 9 departments, altogether 29 PG seats at the institute would remain vacant. </p><p style="text-align: justify; ">Therefore, adopting a "justice oriented approach", and after considering the peculiar/special facts and circumstances in the matter, the Court directed NMC to open the official website/portal and permit the college to upload the information of the proposed increase in intake of the PG seats of the remaining 9 Departments (29 PG seats) for the Academic year 2025-26 as per the Affiliation of consent granted by RGUHS dated 21.11.2024.</p><p style="text-align: justify; "><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/health-news/nmc/new-pg-medical-courses-institutes-seat-increase-nmc-further-extends-application-deadline-138520" style="background-color: rgb(255, 255, 255);"><b><i>Also Read: New PG Medical Courses, Institutes, Seat Increase: NMC further Extends Application Deadline</i></b></a></p><p style="text-align: justify; ">Consequently, the <a href="https://medicaldialogues.in/topics/medical-assessment-and-rating-board">Medical Assessment and Rating Board</a> (MARB) of NMC decided to extend the deadline further. Moreover, informing the same, NMC has also written to the Principals and Deans of all the Medical Colleges/Medical Institutes of India. Through the letter, NMC has informed inter-alia about MARB to extend the deadline for submission of applications with immediate effect till 6 pm on 26 December 2024.&nbsp;</p><div class="pasted-from-word-wrapper" style="text-align: justify; "><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/health-news/nmc/new-pg-medical-courses-institutes-seat-increase-nmc-further-extends-application-deadline-138520"><b>Also Read:&nbsp;</b>New PG Medical Courses, Institutes, Seat Increase: NMC further Extends Application Deadline</a></div><div class="pasted-from-word-wrapper"><p dir="ltr" style="text-align: justify; ">Referring to its earlier notices, MARB in the notice dated 24.12.2024 mentioned, "Vide Public Notice of even number dated 18.09.2024 of Medical Assessment and Rating Board (MARB) of National medical commission (NMC), New Delhi, applications had been invited for starting of new Post Graduate Medical Courses in an established Medical Institution, establishing a new PostGraduate Medical Institution (standalone PG Institute) and increase of seats in existing Post-Graduate Medical Courses through the web portal for the Academic Year 2025-2026. The last date of receiving of applications was 17.10.2024,which was further extended from time to time ,vide Public Notice of even number dated 16.10.2024,08.11.2024 and 22.11.2024."</p><p dir="ltr" style="text-align: justify; ">"Now, in continuation of above cited public notices of even number and in compliance of directions of Hon'ble High Court of Karnataka dated 19.12.2024 in W.P. No.203808 of 2024 ,MARB has decided to extend the time for submission of applications for a period starting with immediate effect till 6.00 PM of 26.12.2024," MARB further mentioned in the notice, adding that other terms and conditions mentioned in the aforesaid Public Notice of even number dated 18.09.2024 would remain the same.</p><p style="text-align: justify; ">Sharing the MARB notice with the medical institutes across the country, NMC Secretary Dr B Srinivas wrote to the Principal/Dean of all medical institutes and informed about the extension of the last date for submission of applications for starting of new Post-Graduate Medical courses in an established medical institution, establishing a new Post-graduate Medical institution (standalone PG institute) and increase of seats in existing Post-Graduate medical courses for the Academic Year (AY) 2025- 2026.</p><p style="text-align: justify; "><i>"Reference is invited to Public Notice no. M-19011/38/2024/NMC/PGMARB (e-ID 8293796) dated 24-12-2024 issued by the Medical Assessment and Rating Board (MARB) on the above mentioned subject as enclosed herewith informing inter-alia about MARB's decision to extend the time for submission of applications for a period starting with immediate effect till 6 PM of 26- 12-2024. All concerned stakeholders are requested to kindly take note of the same,"</i> the NMC communication dated 24.12.2024 mentioned.</p></div><div class="pasted-from-word-wrapper"><p dir="ltr" style="text-align: justify; ">Medical Dialogues had earlier reported that back in September 2024, the NMC had invited applications for starting new postgraduate medical courses in an established medical institution, setting up a new postgraduate medical institute (standalone PG institute) and increase of seats in existing postgraduate medical courses through a web portal for the academic year 2025-2026.</p><p dir="ltr" style="text-align: justify; ">Along with this, had also instructed the medical colleges/institutes to upload the following three documents in PDF format in the online application form-</p><p dir="ltr" style="text-align: justify; ">1 Valid Essentiality Certificate (EC) in the prescribed Proforma for starting of new Post-Graduate Medical Courses in an established medical institution, establishing a new Post-Graduate medical institution (standalone PG institute) under the heading/column "Essentiality Certificate".</p><p dir="ltr" style="text-align: justify; ">2 Valid Consent of Affiliation (CoA) in the prescribed Proforma, and</p><p dir="ltr" style="text-align: justify; ">3 Justification for the number of requested seats.</p><p dir="ltr" style="text-align: justify; ">The Commission had also clarified that the applications would only be accepted after online payment of the requisite fee through the link generated during the filling of the application.</p><p dir="ltr" style="text-align: justify; "><u style=""><b style=""><i>To view the public notice, click the link below</i></b></u></p><p dir="ltr" style="text-align: justify; "><b><i><a href="https://medicaldialogues.in/pdf_upload/nmc-266413.pdf">https://medicaldialogues.in/pdf_upload/nmc-266413.pdf</a><a href="https://medicaldialogues.in/pdf_upload/nmc-266413.pdf" target="_blank"></a></i></b></p><p dir="ltr" style="text-align: justify; "><b><i>To view the HC order, click on the link below:</i></b></p><p dir="ltr" style="text-align: justify; "><a href="https://medicaldialogues.in/pdf_upload/karnataka-hc-order-266430.pdf"><b><i>https://medicaldialogues.in/pdf_upload/karnataka-hc-order-266430.pdf</i></b></a></p><p dir="ltr" style="text-align: justify; "><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/health-news/nmc/nmc-invites-applications-for-new-pg-medical-courses-setting-up-standalone-pg-institutes-intake-increase-for-2025-2026-here-are-complete-details-135222" style="background-color: rgb(255, 255, 255);"><b><i>Also Read: NMC Invites Applications for New PG Medical Courses, setting up standalone PG institutes, intake increase for 2025-2026, here are complete details</i></b></a></p></div><div class="pasted-from-word-wrapper"><div></div></div>

197. 5 GMC Rajouri doctors suspended, 10 issued notice after death of pregnant woman

     Wed, 25 Dec 2024 08:45:31 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/02/12/232102-suspended-1.webp' /><div class="pasted-from-word-wrapper"><p><span style="text-align: justify;">Rajouri: In response to allegations of&nbsp;</span><a href="https://medicaldialogues.in/topics/medical-negligence" target="_blank">medical negligence</a>&nbsp;leading to the death of a pregnant woman at the Government Medical College (GMC) Rajouri, five doctors have been suspended, and two doctors along with eight other staff members have been issued show-cause notices.</p></div><div class="pasted-from-word-wrapper"><p><span style="text-align: justify;">Five doctors of the Government Medical College (GMC) Rajouri were suspended following the death of a <a href="https://medicaldialogues.in/topics/pregnant-women" target="_blank">pregnant woman</a> that sparked concerns about alleged<a href="https://medicaldialogues.in/topics/medical-negligence" target="_blank"> medical negligence</a>, officials said on Tuesday.</span></p><p style="text-align: justify;">According to the PTI report, Razim Akhter (35) of Badhaal Kotranka died at the <a href="https://medicaldialogues.in/topics/gmc-rajouri" target="_blank">GMC Rajouri</a> on Sunday afternoon. She was five-and-a-half months pregnant and had been admitted with complications. Initially treated at a hospital in Kandi, she was later referred to GMC Rajouri for specialised care.</p><p style="text-align: justify;">Officials said that five doctors have been suspended and attached to the office of the Medical Superintendent of Associated Hospital while two doctors and eight other staff members, including paramedics and support staff, have been issued show-cause notices.</p><p style="text-align: justify; ">The suspended doctors have been identified as Dr Veenu Bharti and Dr Neetu (Department of Obstetrics &amp; Gynaecology) Dr Shakir Ahmed Parray, Dr Shafkat Ulla, and Dr Anif Saleem Rather (Department of Casualty), the officials said.</p><p style="text-align: justify;"><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/doctors/pmjay-fraud-absenteeism-gujarat-medical-council-suspends-2-doctors-for-misconduct-136968"><b><i>Also Read:Gujarat Medical Council suspends 2 doctors for misconduct</i></b></a></p><p style="text-align: justify;">These doctors were on night duty in the Emergency Ward when the woman was under treatment.</p><p style="text-align: justify;">The show-cause notices were issued to two doctors — one from the Department of Obstetrics &amp; Gynaecology and another from the Department of Surgery — along with eight other staff members. They have been directed to provide explanations to the Principal of GMC Rajouri regarding the alleged negligence, they added, news agency PTI reported.</p><p style="text-align: justify;">The incident has drawn criticism from political leaders. Budhal MLA Javed Iqbal Choudhary expressed concern over the woman’s death, while former Rajouri MLA Choudhary Qamar Hussain held a press conference on Tuesday, demanding accountability.</p><p style="text-align: justify;">Before she died, the woman had suffered a tragic loss, losing three of her children to a mysterious illness just last week.</p><p style="text-align: justify;">The GMC Rajouri administration has assured that a thorough investigation is underway, and appropriate action will be taken based on the findings.</p><p style="text-align: justify;"> <a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/doctors/3-resident-doctors-of-gynaecology-dept-suspended-after-woman-delivers-outside-jaipur-hospital-126755"><b><i>Also Read:3 resident doctors of Gynaecology Dept suspended after woman delivers outside Jaipur Hospital</i></b></a></p><div class="hocal-draggable" draggable="true"><div class="read-this-also-wrap"><div></div></div></div></div>

198. Abbott agrees to global continuous glucose monitoring litigation settlement with Dexcom

     Wed, 25 Dec 2024 08:41:50 -0000

     <img src='https://medicaldialogues.in/h-upload/2023/01/11/197660-abbott-3.webp' /><p style="text-align: justify; "><b>Abbott Park:</b>&nbsp;<a href="https://medicaldialogues.in/topics/abbott">Abbott</a> has announced it has reached an agreement with <a href="https://medicaldialogues.in/topics/DexCom">DexCom, Inc</a>.&nbsp;to settle all outstanding patent disputes between the companies in cases related to continuous glucose monitoring products.</p><div class="pasted-from-word-wrapper"><p style="text-align: justify; ">The agreement will result in the dismissal of all pending cases in courts and patent offices worldwide. It also includes a provision that the parties will not litigate patent, trade dress, and design rights disputes with each other for the next 10 years. There are no financial payments associated with the settlement from either Abbott or Dexcom.</p><p style="text-align: justify; ">"Abbott considers this agreement a positive development, as it allows the company to fully focus on supporting people with diabetes with its technologies and services," Abbott stated.</p><p>Details of the settlement are confidential. </p><p>Medical Dialogues team had earlier reported that a review application filed by Abbott Healthcare, alleging that the National Pharmaceutical Pricing Authority (NPPA) used lower Price-to-Retailer (PTR) values for competing brands, Prolomet XL 100mg (by Sun Pharma) and Revelol XL 100mg (by IPCA), which resulted in an unjustifiably lower ceiling price for its Metoprolol 100mg modified-release tablets (Supermet XL 100mg IOS), was dismissed by the Department of Pharmaceuticals (DoP).</p></div><div class="pasted-from-word-wrapper"><div class="pasted-from-word-wrapper"><p style="text-align: justify; "><b><i>Read also: <a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/industry/pharma/abbotts-plea-alleging-nppa-used-outdated-ptr-data-for-metoprolol-pricing-rejected-by-dop-138581">Abbott's Plea Alleging NPPA Used Outdated PTR Data for Metoprolol Pricing Rejected by DoP</a></i></b></p></div></div><div class="pasted-from-word-wrapper"><p style="text-align: justify; ">Abbott is a global healthcare company. Its portfolio of life-changing technologies spans the spectrum of healthcare, with businesses and products in diagnostics, medical devices, nutritionals and branded generic medicines.</p><p style="text-align: justify; "><b><i>Read also: <a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/industry/pharma/abbott-healthcare-gets-cdsco-panel-nod-to-manufacture-market-ursodeoxycholic-acid-for-obstetric-cholestasis-139042">Abbott Healthcare Gets CDSCO Panel Nod To Manufacture Market Ursodeoxycholic acid for Obstetric Cholestasis</a></i></b></p><p style="text-align: justify; "><br></p></div>

199. Major Update: Himachal to pay full salary to allopathic doctors during PG course study leave

     Wed, 25 Dec 2024 08:19:46 -0000

     <img src='https://medicaldialogues.in/h-upload/2023/06/24/212596-salary.webp' /><div class="pasted-from-word-wrapper"><p><span style="text-align: justify;">Shimla:&nbsp;</span>In a landmark decision, the Himachal Pradesh government has announced that allopathic doctors pursuing postgraduate (PG) courses will now receive their full salaries during the study leave period. Previously, doctors on study leave for PG courses were entitled to only 40 percent of their salary.</p><p><span style="text-align: justify;"> Chief Minister Thakur <a href="https://medicaldialogues.in/topics/sukhvinder-singh-sukhu" target="_blank">Sukhvinder Singh Sukhu</a> said here today that the State Government has sanctioned 100 percent salary to those <a href="https://medicaldialogues.in/topics/allopathic-doctors" target="_blank">Allopathic doctors</a> who proceed on study leave for pursuing PG courses and their study will be considered on duty.</span></p><p style="text-align: justify;">&nbsp;He said that the State Government is committed to provide specialized medical services to the people within the State.</p><p style="text-align: justify;"><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/doctors/sc-slams-rajasthan-govt-for-5-month-delay-in-releasing-salaries-of-ayurveda-doctors-135646"><b><i>Also Read:SC Slams Rajasthan Govt for 5-month delay in releasing salaries of Ayurveda Doctors</i></b></a></p><p>Chief Minister Thakur Sukhvinder Singh Sukhu made the announcement, emphasizing the government’s commitment to strengthening the healthcare system in the state. “The State Government is dedicated to providing specialized medical services to the people within the state. By granting full pay during PG studies, we aim to support the dedication of doctors who balance patient care with their educational commitments,” said the Chief Minister.</p><p style="text-align: justify;">By ensuring full pay, the government aims to support their dedication, enhancing both the quality of training for doctors and the healthcare services available to the public. He said that this step will go a long way in fostering a more robust healthcare system in the State.</p><p style="text-align: justify;"><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/hospital-diagnostics/pay-6-months-pending-salaries-to-tvvp-hospital-staff-harish-rao-134760"><b><i>Also Read:Pay 6 months pending salaries to TVVP Hospital staff: Harish Rao</i></b></a></p></div>

200. JIPMER To End Professional Exam Fee Payment Process for 2nd, Final MBBS (December 2024 Session) Tomorrow

     Wed, 25 Dec 2024 08:16:48 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/25/266414-professional-examinations.webp' /><p style="text-align: justify; "><b>Puducherry-</b> Jawaharlal Institute of Postgraduate Medical Education and Research (<a href="https://medicaldialogues.in/topics/jipmer" target="_blank">JIPMER</a>) released a notice regarding the payment of the Professional Examination Fee for the 2nd MBBS and Final <a href="https://medicaldialogues.in/topics/mbbs" target="_blank">MBBS</a> Part II (Additional Batch) for the December 2024 session.</p><div class="pasted-from-word-wrapper"><p dir="ltr" style="text-align: justify; ">As per the notice, the application &amp; online payment of the fee process already started on 24th December 2024 and will end tomorrow i.e. 26th December 2024. Through the notice, the students of the 2nd MBBS and Final MBBS Part II (additional batch) appearing for the Professional Examination December 2024 session are instructed to apply through the JIPMER website link and also remit the examination fees mentioned hereunder online.</p></div><div class="pasted-from-word-wrapper"><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/education/jipmer-calls-for-proposals-to-1st-scientific-advisory-committee-meeting-2025-139422"><b>Also Read:&nbsp;</b>JIPMER Calls for Proposals To 1st Scientific Advisory Committee Meeting 2025</a></div><div class="pasted-from-word-wrapper"><div dir="ltr"><table style="text-align: justify; "><colgroup><col width="55"><col width="257"><col width="156"><col width="156"></colgroup><tbody><tr><td><p dir="ltr" style="text-align: center; "><b>S.NO</b></p></td><td><p dir="ltr" style="text-align: center; "><b>COURSE</b></p></td><td><p dir="ltr" style="text-align: center; "><b>DESCRIPTION</b></p></td><td><p dir="ltr" style="text-align: center; "><b>AMOUNT</b></p></td></tr><tr><td><p dir="ltr">1</p></td><td><p dir="ltr">Final MBBS Part - II</p></td><td><p dir="ltr">Fourth Year</p></td><td><p dir="ltr">750/- (for each Theory Paper)</p><p dir="ltr">750/- (for each Practical)</p></td></tr><tr><td><p dir="ltr">2</p></td><td><p dir="ltr">Second MBBS</p></td><td><p dir="ltr">Second Year</p></td><td><p dir="ltr">750/- (for each Theory Paper)</p><p dir="ltr">750/- (for each Practical)</p></td></tr><tr><td colspan="2" rowspan="2"><p dir="ltr">COMMON TO ALL</p></td><td><p dir="ltr">Application Fee</p></td><td><p dir="ltr">*100/-</p></td></tr><tr><td><p dir="ltr">Statement of Marks</p></td><td><p dir="ltr">250/-</p></td></tr><tr><td colspan="2" rowspan="2"><p dir="ltr">STUDENT WHO ARE APPEARING (FIRST ATTEMPT) FOR FINAL YEAR EXAMS / SEMESTERS</p></td><td><p dir="ltr">Consolidated Statement of Marks</p></td><td><p dir="ltr">1500/-</p></td></tr><tr><td><p dir="ltr">Provisional Pass Certificate</p></td><td><p dir="ltr">250/-</p></td></tr></tbody></table></div><p dir="ltr" style="text-align: justify; ">Moreover, students are also informed to submit the following documents while collecting their Hall Ticket from the academic section on 30th December 2024 at 02.30 pm-</p><p dir="ltr" style="text-align: justify; ">i No due from Hostel.</p><p dir="ltr" style="text-align: justify; ">ii Academic fee receipts (all 4 years).</p><p dir="ltr" style="text-align: justify; ">iii TWO passport-size photographs (write Reg. No. and Name on the backside of the photographs).</p><p dir="ltr" style="text-align: justify; ">The Jawaharlal Institute of Postgraduate Medical Education &amp; Research (JIPMER) is a medical school located in Pondicherry. It is an institute of national importance (<a href="https://medicaldialogues.in/topics/ini" target="_blank">INI</a>) and a tertiary care referral hospital. It is under the direct administrative control of the Ministry of Health and Family Welfare and the Indian Government, with autonomy to run its internal administration. The courses include undergraduate, postgraduate, super speciality, fellowships, PhD programs, post-basic diplomas, and certified courses. Candidates to the courses offered at JIPMER are selected based on All-India level entrance tests NEET and INI-CET.&nbsp;</p><p dir="ltr" style="text-align: justify; "><b><u><i>To view the notice, click the link below</i></u></b></p><p dir="ltr" style="text-align: justify; "><a href="https://medicaldialogues.in/pdf_upload/jipmer-to-end-professional-exam-fee-payment-process-for-2nd-final-mbbs-december-2024-session-tomorrow-266415.pdf" target="_blank">https://medicaldialogues.in/pdf_upload/jipmer-to-end-professional-exam-fee-payment-process-for-2nd-final-mbbs-december-2024-session-tomorrow-266415.pdf</a></p></div><div class="pasted-from-word-wrapper"><div></div></div>

201. HC Sets Aside NCDRC Order Slapping Rs 93 Lakh Compensation on Doctor

     Wed, 25 Dec 2024 08:15:34 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/24/266305-allahabad-high-court.webp' /><p style="text-align: justify; "><b>Lucknow:</b>&nbsp;The Lucknow bench of the <a href="https://medicaldialogues.in/topics/allahabad-high-court">Allahabad High Court</a> bench recently set aside an order by the National Consumer Disputes Redressal Commission (<a href="https://medicaldialogues.in/topics/ncdrc">NCDRC</a>) directing the doctors and a hospital-owner to pay Rs 93 lakh compensation to a patient who had to suffer while undergoing c-section at the facility.</p><p style="text-align: justify; ">Earlier the State Commission had granted Rs 95 lakh compensation in the patient's favour. However, later, one member of NCDRC dismissed the complaint while the other reduced it to Rs 93 lakh. When the matter was referred to a third member, the order of R 93 lakh compensation was upheld.</p><p style="text-align: justify; ">When the matter was challenged before the High Court, the bench noted that <i>"In terms of the proviso of Section 58(3), the powers of the President or the other member to whom the points have been referred for opinion can only delve and decide on those questions alone, he cannot act as a 3rd member to decide the lis. In the present case, from the impugned order, it appears that he has decided the lis and has favoured the view taken by one of the members instead of deciding the five questions referred to them, which is clearly not a proper exercise of power specifically relating to proviso of Section 58 (3) of the Consumer Protection Act."</i></p><p style="text-align: justify; ">The history of the case goes back to 2005 when the petitioner doctor was running a nursing home named Surya Medical Centre. The patient (complainant number 2) was undergoing regular check-ups at the Medical Centre during pregnancy. Her expected date of delivery was 15th October, 2005. However, as per the patient, during her visit to the Nursing Home on 24.09.2024, she was examined by Dr. Pandey and the doctor advised for a C-section operation to save the child's life.</p><p style="text-align: justify; ">As per the patient, based on this opinion, she underwent a c-section operation in the said Nursing Home and during the performance of the said operation, she developed complications. Allegedly, even though the patient required oxygen at the time of surgery, it was not available at the said nursing home because of which she suffered critically.</p><p style="text-align: justify; ">Following this, the patient was taken to another nursing home namely Sanjivani Nursing Home where the follow-up treatment was given. The patient alleged that for further advice the patient approached SGPGI, where it was diagnosed that she was suffering from Hypoxia Ischemic Encephalopathy (HIE).</p><p style="text-align: justify; ">Accusing the treating doctors of medical negligence, the patient filed a complaint before the State Consumer Forum seeking damages. Through an order dated 04.12.2012, the SCDRC passed an order in favour of the complainant awarding an amount of Rs 95 lakh. Challenging this order, three appeals were filed before NCDRC, one by the petitioner and two by the other doctors.</p><p style="text-align: justify; ">During the hearing before the National Commission before a two-judge bench, there was a difference of opinion between two members, one of the presiding members passed an order on 19.03.2021, finding favour with the appellant and quashed the State Commission order.</p><p style="text-align: justify; ">The other member, who was part of the Bench, differed with the view taken by the Chairman and passed the separate order on the same date. In the said order, he upheld the complainant's contention. However, reduced the award from Rs 95 lakh to Rs 93 lakh and the interest was also reduced from 15 per cent to 12 per cent.</p><p style="text-align: justify; ">In terms of the mandate of Section 58(3) of the Consumer Protection Act, a reference was drawn for being referred to the 3rd member. In the said reference order as many as five questions were framed for being answered by the member. In terms of the said reference, the NCDRC passed an order, while recording both the orders passed by the members of the Bench, and from Para 13 onwards, the member, before whom the reference was placed, proceeded to uphold the view taken by one of the members and rejected the view taken by one of the members. Accordingly, the Apex Consumer Court ordered the hospital and its doctors to pay Rs 93 lakh <a href="https://medicaldialogues.in/topics/compensation">compensation</a> further specifying that 85% of the entire amount would be paid by the Proprietor of Surya Medical Centre Dr Dinesh Kumar.</p><p style="text-align: justify; ">Consequently, challenging the NCDRC Order, Dr. Kumar approached the Allahabad High Court. His counsel argued that it was a case of no evidence and also argued that all the factual averments were denied by the petitioners and no evidence was there except for the evidence in the form of affidavits by both parties, which did not indicate or testify the averments as pleaded in the complaint.</p><p style="text-align: justify; ">Therefore, he contended that the State Consumer Forum had erred in granting the compensation to the complainant. Further, reference was also made to the difference in opinion between two members. The counsel also pointed out that five points were referred to for determination and instead of deciding the points as referred to the 3rd member, the 3rd member concurred with one of the views taken by one of the members, which was contrary to the mandate of Section 58(3) of the Consumer Protection Act and specifically of the proviso of Section 58(3) of the Consumer Protection Act.</p><p style="text-align: justify; ">The HC bench noted that the mandate of Section 58(3) of the said Act states the following:</p><p style="text-align: justify; "><i>"(3) Where the members of a Bench differ in opinion on any point, the points shall be decided according to the opinion of the majority, if there is a majority, but if the members are equally divided, they shall state the point or points on which they differ, and make a reference to the President who shall either hear the point or points himself or refer the case for hearing on such point or points by one or more of the other members and such point or points shall be decided according to the opinion of the majority of the members who have heard the case, including those who first heard it:</i></p><p style="text-align: justify; "><i>Provided that the President or the other member, as the case may be, shall give opinion on the point or points so referred within a period of two months from the date of such reference."</i></p><p style="text-align: justify; ">Relying on this, the HC bench noted,<i> "In terms of the proviso of Section 58(3), the powers of the President or the other member to whom the points have been referred for opinion can only delve and decide on those questions alone, he cannot act as a 3rd member to decide the lis. In the present case, from the impugned order, it appears that he has decided the lis and has favoured the view taken by one of the members instead of deciding the five questions referred to them, which is clearly not a proper exercise of power specifically relating to proviso of Section 58 (3) of the Consumer Protection Act. It is equally fairly well settled that the reference Court, is in the form of a Court giving opinion and essentially it does not perform the adjudicative function."</i></p><p style="text-align: justify; ">Referring to the previous orders passed by the Supreme Court, the HC bench concluded that there was an improper exercise of jurisdiction by the member, to whom the question had been referred and therefore, the NCDRC order could not be sustained.</p><p style="text-align: justify; "><i>"In the present case, the order impugned has gone in excess of the powers conferred on the referring member. On the said limited ground, there being an improper exercise of jurisdiction by the member, to whom the question has been referred, the impugned order cannot be sustained and is quashed. The matter shall now be heard afresh by the 3rd member who shall give his opinion on the questions referred and send the matter back to the Division Bench of the National Commission to be decided accordingly,"</i> ordered the HC bench.</p><p style="text-align: justify; "><b><i>To view the order, click on the link below:</i></b></p><p style="text-align: justify; "><a href="https://medicaldialogues.in/pdf_upload/dr-dinesh-kumar-vs-shri-askari-hussain-and-6-others-on-11-december-2024-266324.pdf"><b><i>https://medicaldialogues.in/pdf_upload/dr-dinesh-kumar-vs-shri-askari-hussain-and-6-others-on-11-december-2024-266324.pdf</i></b></a></p><p style="text-align: justify; "><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/medico-legal/higher-degree-of-gross-negligence-is-required-to-hold-a-doctor-liable-ncdrc-exonerates-neurologist-hospital-140316" style="background-color: rgb(255, 255, 255);"><b><i>Also Read: Higher Degree of Gross Negligence is Required to Hold a Doctor Liable- NCDRC Exonerates Neurologist, Hospital</i></b></a></p>

202. Relief Granted! Bombay HC Grants Admission to MBBS Aspirant Denied Seat due to technical issues

     Wed, 25 Dec 2024 08:13:05 -0000

     <img src='https://medicaldialogues.in/h-upload/2022/11/02/189703-bombay-high.webp' /><p style="text-align: justify; "><b>Mumbai:</b>&nbsp;Coming to the aid of an <a href="https://medicaldialogues.in/topics/mbbs-aspirant">MBBS Aspirant</a>, who was denied admission based on technical issues with her caste certificates, the Bombay High Court bench recently directed SSPM Medical College to admit her in the first-year <a href="https://medicaldialogues.in/topics/mbbs-course">MBBS course</a> by creating a supernumerary seat for her under the institutional stray vacancy round.</p><p style="text-align: justify; "><i>"...it is held that the petitioner is entitled to be admitted at the First Year MBBS Course at the respondent no.7 – College under the Institutional Stray Vacancy by directing creation of a supernumerary seat. The petitioner would be liable to pay tuition fees and other fees as payable by a student who has secured admission in the Institutional Stray Vacancy Round," </i>the HC bench comprising Justices Rajesh S. Patil and A.S. Chandurkar ordered.</p><p style="text-align: justify; ">The petitioner student claims to belong to Mali- Other Backward Class. However, she was denied MBBS admission by SSPM Medical College and Lifetime Hospital at the Institutional Level Stray Vacancy Round 2024-2025 that was conducted pursuant to the National Eligibility-cum-Entrance Test Undergraduate (NEET-UG) 2024 examination.</p><p style="text-align: justify; ">As per the petitioner, as required, she had submitted <a href="https://medicaldialogues.in/topics/caste-certificate">Caste Certificate </a>(dated 08/08/2024) along with a Caste Validity Certificate (dated 19/10/2022 issued by the District Caste Scrutiny Committee, Amravati). However, she was denied admission because the date of the Caste Certificate referred to in the Caste Validity Certificate differed from the one submitted by her.</p><p style="text-align: justify; ">Consequently, she approached the <a href="https://medicaldialogues.in/topics/bombay-high-court">Bombay High Court</a> seeking relief under Article 226 of the Constitution of India. Her counsel argued that there was no doubt regarding the fact that the petitioner belonged to Other Backward Class. The counsel submitted that though a reference in the said Caste Validity Certificate was to Caste Certificate dated 21.09.2021, the said Certificate could not be furnished as the same had been misplaced.</p><p style="text-align: justify; ">On account of non-availability of old data, she could not get a duplicate Caste Certificate. Hence the petitioner had submitted a fresh Caste Certificate dated 08/08/2024. It was also argued that once the Scrutiny Committee issued the Validity Certificate, the petitioner's status of belonging to the caste mentioned there was established and the insistence on production of the Caste Certificate was a mere formality. Relying on the judgment in the case of S. Krishna Sradha vs. The State of Andhra Pradesh &amp; Others, counsel argued that the petitioner could not be denied admission on the date of issuing the Caste Validity Certificate, further highlighting that the petitioner approached the College before the cut-off date and therefore should could not have been denied admission on this pretext as well.</p><p style="text-align: justify; ">On the other hand, the counsel for Maharashtra State CET Cell submitted that since the cut-off date for granting admission had been crossed and there was no vacant seat available, the petitioner could not be granted admission.</p><p style="text-align: justify; ">Meanwhile, the counsel for the medical college argued that the petitioner was denied admission as the original Caste Certificate was not submitted. Further, the college's counsel submitted that the Caste Certificate referred to in the Validity Certificate was not submitted by her and a different Caste Certificate had been submitted. It was further submitted that since all seats had now been filled-in, no relief could be granted to the petitioner.</p><p style="text-align: justify; ">After perusing the material on record, the Court noted that the petitioner possessed a Caste Validity Certificate issued by the Competent Authority in terms of the provisions of Section 6(4) of the Maharashtra Scheduled Castes, Scheduled Tribes, De-notified Tribes (Vimukta Jatis), Nomadic Tribes, Other Backward Classes and Special Backward Category (Regulation of Issuance and Verification of) Caste Certificate Act, 2000.</p><p style="text-align: justify; ">The Court noted that the caste claim gets verified based on the Caste Certificate and the issuance of the Validity Certificate indicated that the claimant had proved the claim of belonging to the caste mentioned there.</p><p style="text-align: justify; ">Further, perusing the Validity Certificate, Caste Certificate dated 21.09.2021 and other documents submitted by the petitioner, the HC bench observed, <i>"Since the petitioner was not in possession of the Caste Certificate dated 21/09/2021, she obtained another Caste Certificate from the Sub-Divisional Officer, Morshi dated 08/08/2024. The subsequent Caste Certificate too indicates that the petitioner belongs to Mali caste. The Validity Certificate dated 19/10/2022 certifies that the petitioner’s claim of belonging to Mali caste was found to be valid. It is therefore clear that the social status of the petitioner is not in doubt. The only technicality that comes in the way of the petitioner is the submission of subsequent Caste Certificate dated 08/08/2024 alongwith Validity Certificate dated 19/10/2022. It is for this reason that the College had denied the petitioner her admission."</i></p><p style="text-align: justify; "><i>"In the aforesaid factual background, we do not find it necessary to go into the issue as to whether the petitioner was deliberately denied admission or that higher fees were demanded from her. The only reason furnished by the College for not admitting her is the nonproduction of Caste Certificate dated 21/09/2021 that finds reference in the Validity Certificate issued by the Scrutiny Committee. For this reason, the petitioner has missed the bus,"</i> it further noted.</p><p style="text-align: justify; ">The Court also took note of the fact that the cut-off date for securing admission was 05/11/2024 and there were no vacant seats available where the petitioner could be accommodated after the Institutional Stray Vacancy Round. <i>"The interests of justice however require grant of appropriate relief to the petitioner as she has been denied of her admission on a ground which can be easily explained," </i>the Court noted at this outset.</p><p style="text-align: justify; ">In this regard, the Court referred to the Supreme Court order in the case of Vansh s/o Prakash Dolas vs. The Ministry of Education and the Ministry of Health and Family Welfare and Others, 2024. It also referred to the decision in Vansh s/o Prakash Dolas (supra) in which the Supreme Court examined the issue of wrongful denial of admission in a medical course, and propounded the theory of 'restitutive justice'.</p><p style="text-align: justify; "><i>"Following the ratio of that decision, this Court in Writ Petition No.17047 of 2024 (Mashalkar Prasad vs. Terna Medical College &amp; Hospital) decided on 28/11/2024 has granted restitutive relief to the said petitioner on being satisfied that the said petitioner had been denied admission. We are inclined to follow a similar course since it is now informed that there are no vacant seats available at the College and that the cut off date for seeking admission has crossed,"</i> observed the top court bench.</p><p style="text-align: justify; ">Accordingly, the Court held that the petitioner is entitled to be admitted at the first-year MBBS course at the College under the Institutional Stray Vacancy by directing the creation of a supernumerary seat. The bench further clarified that the petitioner would be liable to pay tuition fees and other fees as payable by a student who has secured admission in the Institutional Stray Vacancy Round.</p><p style="text-align: justify; "><i>"To enable steps for regularizing the petitioner’s admission, the College shall forward the necessary proposal in that regard to the respondent nos. 4 to 6 as well as <a href="https://medicaldialogues.in/topics/nmc">National Medical Commission</a>, New Delhi. If such proposal is forwarded, the concerned parties shall consider the same in the peculiar facts of the present case referred to above,"</i> the Court mentioned in its order.</p><p style="text-align: justify; "><b><i>To view the Court order, click on the link below:</i></b></p><p style="text-align: justify; "><a href="https://medicaldialogues.in/pdf_upload/bombay-hc-order-266410.pdf"><b><i>https://medicaldialogues.in/pdf_upload/bombay-hc-order-266410.pdf</i></b></a></p><p style="text-align: justify; "><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/education/mbbs-aspirant-moves-bombay-hc-over-alleged-overcharging-by-medical-college-138742" style="background-color: rgb(255, 255, 255);"><b><i>Also Read: MBBS Aspirant Moves Bombay HC Over alleged overcharging by medical college</i></b></a></p>

203. AIIMS Declares Fellowship Programme January 2025 Results

     Wed, 25 Dec 2024 08:11:12 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/24/266270-result.webp' /><p style="text-align: justify; "><b>New Delhi-</b> All India Institute of Medical Sciences <a href="https://medicaldialogues.in/topics/aiims-delhi" target="_blank">(AIIMS), New Delhi</a> has declared the result of the Fellowship Programme January 2025 session. The result is declared on the official website of AIIMS, therefore, candidates who have appeared for the exam can check and download it from there.</p><div class="pasted-from-word-wrapper"><p dir="ltr" style="text-align: justify; ">On the basis of (Stage-I) Entrance Examination for <a href="https://medicaldialogues.in/topics/fellowship" target="_blank">Fellowship programme</a> – January 2025 session held on Saturday, the 30th November 2024 and Departmental Clinical, Practical and Lab-based Assessment (Stage-II) through video conferencing mode held from 16 to 20 December 2024 the students mentioned in the result have been selected in different Departments of AIIMS New Delhi for admission to Fellowship Programme for January 2025 Session.</p><p dir="ltr" style="text-align: justify; ">However, the result has been prepared as per the decision of the meeting of the 116th Academic Committee as well as the method of selection mentioned in the Prospectus. The result is provisional and subject to verification of data &amp; records.</p></div><div class="pasted-from-word-wrapper"><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/education/medical-colleges/aiims-announces-schedule-of-pg-professional-exams-for-md-ms-mds-fellowship-programs-details-124953"><b>Also Read:&nbsp;</b>AIIMS Announces Schedule of PG Professional Exams for MD, MS, MDS, Fellowship Programs, details</a></div><div class="pasted-from-word-wrapper"><p dir="ltr" style="text-align: justify; "><b><u>IMPORTANT POINTS</u></b></p><p dir="ltr" style="text-align: justify; ">1 Admission of selected candidates is subject to fulfilment of all eligibility criteria as on 31st January 2025 and subject to verification of original certificates/degrees as well as satisfying all conditions as laid down in the Prospectus. In case of any discrepancy detected at any stage candidature/admission will be cancelled. </p><p dir="ltr" style="text-align: justify; ">2 Candidates not completing the requisite tenure within the last date i.e. 31st January 2025 will not be treated as eligible for admission, under any circumstance, whatsoever. </p><p dir="ltr" style="text-align: justify; ">3 Waiting Lists in each super speciality have been prepared for all the candidates who appeared in the Departmental Clinical/Practical/Lab-based Assessment subject to the availability of candidates. </p><p dir="ltr" style="text-align: justify; ">4 All tie cases have been resolved according to age (Date of Birth); the older candidate is given preference over the younger one. </p><p dir="ltr" style="text-align: justify; "><b><u><i>To view the result, click the link below</i></u></b></p><p dir="ltr" style="text-align: justify; "><a href="https://medicaldialogues.in/pdf_upload/aiims-declares-fellowship-programme-january-2025-results-266272.pdf" target="_blank">https://medicaldialogues.in/pdf_upload/aiims-declares-fellowship-programme-january-2025-results-266272.pdf</a></p></div><div class="pasted-from-word-wrapper"><div></div></div>

204. IGIMS 2nd year PG Radiology ends life by hanging

     Wed, 25 Dec 2024 07:48:26 -0000

     <img src='https://medicaldialogues.in/h-upload/2023/04/27/208427-suicide.webp' /><p style="text-align: justify; "><b>Patna:</b> In an unfortunate incident, a 28-year-old resident doctor and a second-year postgraduate student in the Radiology Department at<a href="https://medicaldialogues.in/topics/igims-patna" target="_blank"> Indira Gandhi Institute of Medical Science (IGIMS), Patna</a> allegedly committed <a href="https://medicaldialogues.in/topics/suicide" target="_blank">suicide</a> by hanging from a towel in the kitchen at his residence in Patna's Shivaji Nagar. No suicide note was recovered from the scene.&nbsp;</p><p style="text-align: justify; ">The medico reportedly used a noose made from a 'gamcha' to hang himself from a hook in the kitchen ceiling. It is unknown why he took the extreme step but the police are investigating every possible angle to determine the reason behind it.&nbsp;</p><p style="text-align: justify; ">Although the student lived in rented accommodation, he came to his house on Monday night as his parents had gone to their native place in Supaul. Therefore the house was empty and he was alone.&nbsp;</p><p style="text-align: justify; "><b>Also read- <a href="https://medicaldialogues.in/news/health/doctors/jodhpur-homeopathic-doctor-dies-by-suicide-over-domestic-dispute-139738" target="_blank">Jodhpur Homeopathic Doctor dies by suicide over domestic dispute</a></b></p><p style="text-align: justify; ">As per a <a href="https://timesofindia.indiatimes.com/city/patna/igims-pg-medico-dies-by-suicide/articleshow/116636029.cms" rel="nofollow">TOI </a>news report, the incident came to light after his family could not reach him through calls on Tuesday morning. Feeling worried about him, his parents contacted the tenant living upstairs in the same building to check up on him. Despite multiple knocks, the tenant received no response.&nbsp;</p><p style="text-align: justify; ">Later, his parents called his friends who tried multiple times to reach him but failed. Following this, his friends went to his house and noticed the door was locked from inside. They broke the door open and found the doctor hanging from the ceiling.&nbsp;</p><p style="text-align: justify; ">Subsequently, the police were informed who reached the spot along with a forensic team and conducted a preliminary investigation. They sent his body for postmortem and recovered his cell phone for further investigation.&nbsp;</p><p style="text-align: justify; ">Dinesh Kumar Pandey, SDPO-II (Law and Order) told TOI, "We received information that a young man died by suicide at Shivaji Nagar. Upon receiving the information, the SHO along with a police team immediately arrived at his residence at Shivaji Nagar. During the probe, it came out that the man was a second-year PG student at the IGIMS. He lived in a rented accommodation near pillar no. 70 in Raja Bazar area. On Monday late night, he went to his house at Shivaji Nagar as his parents had gone to their native place in Supaul," he said.</p><p>"On Tuesday morning, when his family and friends tried to call him around 9 am, they couldn't reach him. A tenant living upstairs in the same building knocked on his door, but when he didn't respond, he informed his friends. Upon arrival of his friends, they broke open the door and found him hanging from a noose made of ‘gamcha' in the kitchen," the SDPO said.</p><p><b>Also read- <a href="https://medicaldialogues.in/news/education/unable-to-get-mbbs-admission-bams-student-commits-suicide-139390" target="_blank">Unable to get MBBS admission, BAMS student commits suicide</a></b></p>

205. Rs 7 crore Lawsuit against Medgenome Labs for Alleged Medical Negligence in Genetic Testing

     Wed, 25 Dec 2024 07:45:21 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/05/17/238476-medical-negligence-1.webp' /><p><b>Mumbai:&nbsp;</b>In a case of alleged&nbsp;<a href="https://medicaldialogues.in/topics/medical-negligence">medical negligence</a>, the wife of a serving soldier, has filed a Rs 7 crore lawsuit in a consumer court against MedGenome Labs Limited, Bengaluru, and M/S College of American Pathologists. The lawsuit claims that errors in&nbsp;<a href="https://medicaldialogues.in/topics/genetic-testing">genetic testing</a>&nbsp;resulted in severe consequences for her family.</p><p>According to Hatkar, her son, born on December 12, 2017, was later diagnosed with two rare conditions: Ichthyosis and Penoscrotal Hypospadias. In October 2020, a genetic test conducted at a hospital in Pune revealed a NIPAL4 mutation, confirming a diagnosis of autosomal recessive congenital ichthyosis, a severe genetic disorder.</p><p>This news pushed the family to take extra precautions when planning for a second child. In 2021 when Hatkar and her husband planned for a second child, they were concerned about the possibility of the new baby inheriting the same disorder. Addressing the couple’s concerns, their doctor recommended prenatal genetic testing (Prenatal Sanger Variant Analysis) and chromosomal analysis to determine whether the unborn baby carried the same NIPAL4 mutation. The couple was assured by the doctor that if the results were negative, they could safely continue the pregnancy.&nbsp;</p><p>Hatkar following the doctor’s medical advice underwent the tests, paying Rs 18,000 and Rs 5,500 to MedGenome Labs Ltd on June 16, 2022. The initial report, dated July 12, 2022, came back “negative”, indicating the absence of the genetic disorder. The lab’s results gave the couple much-needed relief and enabled them to proceed with their pregnancy under the guidance of their doctors. </p><p>If the test had revealed the presence of the mutation, the couple would have considered terminating the pregnancy, in accordance with the law. </p><p>On November 1, 2022, Hatkar gave birth to a healthy baby girl. However, within a day, the newborn began displaying the same alarming signs of Ichthyosis that her older brother had shown at birth. The baby’s skin began to peel, and doctors quickly suspected a recurrence of the condition. Following this, the doctors contacted MedGenome Labs for a re-test of the original sample. </p><p>A revised report, issued on May 5, 2023, disclosed that the sample from June 2022 had, in fact, tested "positive" for the disorder, revealing a serious case of medical negligence. Devastated by the lab results, Hatkar first sent a legal notice to the lab, but after receiving no response, she decided to file a case against MedGenome Labs Limited.</p><p><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/mdtv/healthshorts/tragedy-at-kalaburagi-district-hospital-family-alleges-negligence-in-womans-death-140123"><b>Also Read: Tragedy at Kalaburagi District Hospital: Family alleges negligence in Woman's Death</b></a></p><div class="pasted-from-word-wrapper"><div><span style="background-color: rgb(249, 249, 249);">Speaking to&nbsp;</span><a href="https://www.mid-day.com/mumbai/mumbai-news/article/couple-sues-lab-for-rs-7-crore-after-tests-dont-reveal-childs-rare-condition-23452642" rel="nofollow">Mid-Day</a><span style="background-color: rgb(249, 249, 249);">, Hatkar explained, “Patients with this condition face significant challenges, including severe skin peeling, frequent wounds, intense itching, recurrent infections, and skin bleeding. The condition worsens during weather changes, making it chronic and debilitating.”</span></div></div><p>Children with this condition require immediate and ongoing medical intervention. Intensive therapy must begin within the first few hours of birth, followed by lifelong care that includes regular medication, specialized nursing, continuous support, and tailored education. The family, already burdened by the challenges of their son's condition, was devastated by the severity of the situation. </p><p>As a devoted mother, Hatkar has fully committed herself to caring for her son, while the family continues to struggle with meeting the extensive, round-the-clock care requirements.&nbsp; Hatkar remarked that they had taken every precaution to ensure their second child wouldn’t face the same fate. They had conducted all the necessary tests, yet the contradictory report had shattered their lives. Their grief deepened as they worried about what lay ahead for their daughter.</p><p><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/doctors/fir-against-vascular-surgeon-for-operating-on-wrong-leg-of-patient-at-rajkot-hospital-140173" style="background-color: rgb(255, 255, 255);"><b>Also Read: FIR against Vascular Surgeon for operating on wrong leg of patient at Rajkot Hospital</b></a></p><p>Speaking to Mid-Day, Hemant Ingle, and Imtiyaz Shaikh, representing the Hatkar family said, “This case highlights a severe instance of medical negligence that has profoundly impacted our clients. Despite trusting a reputed diagnostic lab and following medical advice, they were misled by a faulty genetic report that assured them their unborn child was free of the disorder. The subsequent discovery of contradictory findings after the birth of a second child with the same condition demonstrates shocking carelessness and a failure of duty by the lab and associated entities. This negligence has caused our clients immense emotional, physical, and financial distress. Through this lawsuit, we seek accountability, justice, and a deterrent against such lapses in the healthcare system, which can have devastating consequences for families.”</p>

206. GPT Healthcare shares listed with over 16 percent premium

     Wed, 25 Dec 2024 07:41:14 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/05/15/238255-shares-50.webp' /><p><span style="text-align: justify; background-color: rgb(255, 255, 255);">New Delhi:&nbsp;</span><span style="text-align: justify;">GPT Healthcare Ltd shares listed with a premium of over 16 percent on Thursday against the issue price of Rs 186. GPT Healthcare Ltd operates and manages mid-sized multi-specialty hospitals under the ILS Hospitals brand.</span><span style="text-align: justify; background-color: rgb(255, 255, 255);">&nbsp;The stock made its debut at Rs 216.15, up 16.20 percent on the BSE.</span></p><div class="pasted-from-word-wrapper"><div style="text-align: justify;">The company's market valuation stood at Rs 1,653.40 crore, PTI reported.</div><div style="text-align: justify;">The initial share sale of GPT Healthcare Ltd was subscribed 8.52 times on the final day of the offer on Monday.</div><div><div style="text-align: justify;">The price range for the offer was Rs 177-186 apiece.</div><div style="text-align: justify;">GPT Healthcare, founded by Dwarika Prasad Tantia, Om Tantia, and Shree Gopal Tantia, started with an eight-bed hospital in Kolkata in 2000.</div><div style="text-align: justify;">The company operates four full-service multi-specialty hospitals, with a total capacity of 561 beds.</div></div></div><p style="text-align: justify; "><b><i>Read also: <a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/industry/pharma/akums-drugs-ink-pact-with-global-pharma-firm-for-production-supply-of-pharma-formulations-in-european-market-140390">Akums Drugs ink pact with global pharma firm for production, supply of pharma formulations in European market</a></i></b></p><div class="pasted-from-word-wrapper"><div class="hocal-draggable" draggable="true"><div class="read-this-also-wrap"><div></div></div></div><p style="text-align: justify; "><br></p></div><p style="text-align: justify; "><br></p>

207. RG Kar Doctor Rape-Murder: Junior Doctors protest over delay in CBI Probe

     Wed, 25 Dec 2024 07:37:23 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/25/266401-rg-kar-1.webp' /><div class="pasted-from-word-wrapper"><p><span style="text-align: justify;">Kolkata:&nbsp;</span>Junior doctors in West Bengal staged a protest outside the CBI's Salt Lake office on Tuesday, demanding justice for the brutal rape and murder of a postgraduate trainee doctor at RG Kar Medical College Hospital. The doctors accused the agency of unnecessary delays in the investigation.</p><p><span style="text-align: justify;">Agitating junior doctors on Tuesday staged a protest outside the CBI's Salt Lake office here, accusing the agency of unnecessary delay in investigating the RG Kar case and collusion with the Kolkata Police to protect the criminals.</span></p><p style="text-align: justify;">As part of their protest, the junior doctors symbolically locked the gate of the <a href="https://medicaldialogues.in/topics/CBI" target="_blank">CBI </a>office at the CGO Complex, demanding that the agency expedite the probe.</p><p style="text-align: justify; ">According to the PTI report, a confrontation took place when security personnel removed the symbolic lock from the gate, leading to a scuffle between the doctors and policemen deployed at the spot.</p><p style="text-align: justify;">One of the protesting doctors expressed his frustration, saying, “We are losing hope in the way the CBI is handling the investigation. If this continues, it would be better if they shut down their office in Kolkata.” Another doctor added, “Even after so many days, our sister Abhaya has not received justice.</p><p style="text-align: justify;"> The CBI detectives are working with Kolkata Police to protect the perpetrators. We don’t want CBI.” Meanwhile, representatives from the Abhaya Mancha and the Joint Platform of Doctors continued their protest at Dorina Crossing in central Kolkata’s Esplanade area, demanding justice for the deceased doctor.</p><p style="text-align: justify;"><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/doctors/doctor-rape-murder-case-calcutta-hc-allows-doctors-to-continue-protest-at-esplanade-140339"><i><b>Also Read:Doctor Rape-Murder Case: Calcutta HC allows Doctors to continue protest at Esplanade</b></i></a></p><p style="text-align: justify;">The <a href="https://medicaldialogues.in/topics/calcutta-high-court" target="_blank">Calcutta High Court</a> on Monday upheld a December 20 order allowing doctors to hold demonstrations.</p><p style="text-align: justify;">The state had challenged the single bench order by Justice Tirthankar Ghosh, which permitted the Joint Forum of Doctors to stage a sit-in “50 feet away from Dorina Crossing at Esplanade in central Kolkata from December 20-26.” Police had discovered the body of the woman doctor inside <a href="https://medicaldialogues.in/topics/r-g-kar-medical-college-and-hospital" target="_blank">RG Kar hospital </a>on August 9.</p><p style="text-align: justify;">The CBI has since filed a charge-sheet against the prime accused, Sanjay Roy, for the rape-murder of the on-duty doctor.</p><p style="text-align: justify;">According to the charge-sheet, Roy, a civic volunteer with the local police, allegedly committed the crime when the victim was resting in the hospital’s seminar room during a break.</p><p style="text-align: justify;"><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/doctors/kolkata-rape-murder-case-calcutta-hc-grants-conditional-approval-for-doctors-protest-140150"><b><i>Also Read:Kolkata Rape-Murder Case: Calcutta HC Grants Conditional Approval for Doctors' Protest</i></b></a></p><div class="hocal-draggable" draggable="true"><div class="read-this-also-wrap"><div></div></div></div></div>

208. USFDA issues EIR for Biocon Bengaluru facility

     Wed, 25 Dec 2024 07:23:02 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/02/09/231921-biocon-50.webp' /><p style="text-align: justify; "><b>Bengaluru:</b>&nbsp;<a href="https://medicaldialogues.in/topics/biocon">Biocon </a>has received an Establishment Inspection Report (EIR) with a Voluntary Action Indicated (VAI) status from the U.S. Food and Drug Administration (<a href="https://medicaldialogues.in/topics/USFDA">US FDA</a>), for its API facility (Site 1), located at Bengaluru, Karnataka. The inspection stands closed as per 21 CFR20.64(d)(3).</p><p>Voluntary action indicated (VAI) means objectionable conditions or practices were found, but the agency is not prepared to take or recommend any administrative or regulatory action</p><p style="text-align: justify; ">This is based on a surveillance inspection conducted by the agency between the 16th to 20th of September, 2024.</p><p style="text-align: justify; "><b><i>Read also: <a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/industry/pharma/biocon-zentiva-gets-decentralized-procedure-approval-for-generic-diabetes-weight-management-drug-in-eu-140337">Biocon, Zentiva gets Decentralized Procedure approval for generic diabetes, weight management drug in EU</a></i></b></p><div class="pasted-from-word-wrapper"><div class="hocal-draggable" draggable="true"><div class="read-this-also-wrap"><div></div></div></div><p style="text-align: justify; ">Biocon Limited, publicly listed in 2004, is an innovation-led, global biopharmaceutical company. It has developed and commercialized novel biologics, biosimilars and complex small molecule APIs in India and several key global markets, as well as generic formulations in the US and Europe.</p><p style="text-align: justify; "><b><i>Read also: <a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/industry/pharma/biocon-chief-kiran-mazumdar-shaw-conferred-jamsetji-tata-award-by-indian-society-for-quality-139886">Biocon Chief Kiran Mazumdar-Shaw conferred Jamsetji Tata Award by Indian Society for Quality</a></i></b></p></div><div class="pasted-from-word-wrapper"><div class="hocal-draggable" draggable="true"><div class="read-this-also-wrap"><div></div></div></div><div class="pasted-from-word-wrapper"><p style="text-align: justify; "><br></p></div></div><div class="pasted-from-word-wrapper"><p style="text-align: justify; "><br></p></div>

209. TN Health Releases Counselling Schedule and Fee Payment Details for Ayush Diploma Courses 2024-25

     Wed, 25 Dec 2024 07:18:23 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/24/266279-ayush-medicines.webp' /><p>Tamil Nadu (<a href="https://medicaldialogues.in/topics/tamil-nadu" target="_blank">TN Health</a>) has released the Counselling process for Ayush Diploma Courses (DIP/DNT)&nbsp; Diploma in Integrated Pharmacy and Diploma in Nursing Therapy for the Academic year 2024-25.</p><p>The counselling session will be held at Selection Committee, Directorate Of Indian Medicine &amp; Homoeopathy, Aringar Anna Govt. Hospital Of Indian Medicine Campus, Arumbakkam, Chennai 600 106..</p><p><b><u>Counseling Schedule :&nbsp;</u></b></p><div class="pasted-from-word-wrapper"><table border="0" cellpadding="0" cellspacing="0" width="831"> <colgroup><col width="42"> <col width="450"> <col width="145"> <col width="103"> <col width="91"> </colgroup><tbody><tr height="36"> <td height="36" class="xl65" width="42">S. No.</td> <td class="xl65" width="450">Counselling Schedule for</td> <td class="xl65" width="145">Date</td> <td class="xl65" width="103">Time</td> <td class="xl65" width="91">Reporting Time</td> </tr> <tr height="20"> <td height="20" class="xl66" width="42">1.<font class="font6"> </font><font class="font5"> </font></td> <td class="xl66" width="450">All Special Category</td> <td class="xl66" width="145">28.12.2024</td> <td class="xl66" width="103">10.00 A.M.</td> <td class="xl66" width="91">9.30 A.M.</td> </tr> <tr height="20"> <td height="20" class="xl66" width="42">2.<font class="font6"> </font><font class="font5"> </font></td> <td class="xl66" width="450">Male</td> <td class="xl66" width="145">28.12.2024</td> <td class="xl66" width="103">10.00 A.M.</td> <td class="xl66" width="91">9.30 A.M.</td> </tr> <tr height="20"> <td height="20" class="xl66" width="42">3.<font class="font6"> </font><font class="font5"> </font></td> <td class="xl66" width="450">Female</td> <td class="xl66" width="145">28.12.2024</td> <td class="xl66" width="103">12.00 A.M.</td> <td class="xl66" width="91">11.30 A.M.</td> </tr> <tr height="49"> <td colspan="5" height="49" class="xl66" width="831"><i>Note: If male candidates are not available after completion of counselling as per Schedule, then the remaining vacant seats reserved for men will be filled up with female candidates and vice versa.</i></td> </tr></tbody></table></div><p>&nbsp;The Candidates should report physically for counselling before appear in Half an Hour before the Counselling Schedule. </p><p>If any Candidates fails to appear in person at the time of counselling their candidature will not be considered for admission on later date. </p><p>The candidates will be called according to the merit list for this counselling and allotment will be made as per existing vacancy based on their turn and community vacancy as per rules and regulation of Govt. of Tamil Nadu. </p><p>Candidates should remit all the fees (application cost, Processing fee and Advance Tuition fee) as above mentioned by Cash only on the day of Counselling itself. </p><p>The candidates should bring all Original certificates for verification. If candidates are studying in College, Bonafide certificate from that college should be submitted.</p><p>The decision by Director, Directorate of Indian Medicine, Govt. of Tamil Nadu is final in case of any discrepancy.</p><p><b><u>Fee Details:</u></b></p><div class="pasted-from-word-wrapper"><table border="0" cellspacing="0" cellpadding="0"> <tbody><tr> <td width="109" valign="top"> <p>Cost Details</p> </td> <td width="114" valign="top"> <p>OC / BC / BCM / MBC</p> </td> <td width="108" valign="top"> <p>SC / SCA / ST</p> </td> <td width="216" valign="top"> <p>Time of Payment</p> </td> <td width="102" valign="top"> <p>Mode</p> </td> </tr> <tr> <td width="109" valign="top"> <p>Processing Fees</p> </td> <td width="114" valign="top"> <p>Rs. 350/-</p> </td> <td width="108" valign="top"> <p>350/-</p> </td> <td width="216" valign="top"> <p>On the day of Counselling.</p> </td> <td width="102" valign="top"> <p>By Cash</p> </td> </tr> <tr> <td width="109" valign="top"> <p>D.I.P. Tuition Fees</p> </td> <td width="114" valign="top"> <p>Rs. 3600/-</p> </td> <td width="108" valign="top"> <p>Rs. 3600/-</p> </td> <td width="216" valign="top"> <p>On the day of Counselling.</p> </td> <td width="102" valign="top"> <p>By Cash</p> </td> </tr> <tr> <td width="109" valign="top"> <p>D.N.T. Tuition Fees</p> </td> <td width="114" valign="top"> <p>Rs. 7200/-</p> </td> <td width="108" valign="top"> <p>Rs. 7200/-</p> </td> <td width="216" valign="top"> <p>On the day of Counselling.</p> </td> <td width="102" valign="top"> <p>By Cash</p> </td> </tr> </tbody></table></div><p><b><i><u>To view the official Notice, Click here :&nbsp;&nbsp;</u><a href="https://medicaldialogues.in/pdf_upload/n24124372-266271.pdf" target="_blank">https://medicaldialogues.in/pdf_upload/n24124372-266271.pdf</a></i></b></p><p><b><u></u></b></p><div class="pasted-from-word-wrapper"></div>

210. NEET 2024 Special Stray Vacancy Round III Provisional Result out

     Wed, 25 Dec 2024 07:16:32 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/25/266398-result.webp' /><p style="text-align: justify; "><b>New Delhi-</b> The Medical Counselling Committee (<a href="https://medicaldialogues.in/topics/mcc" target="_blank">MCC</a>) has published the provisional result for Special Stray Vacancy Round III of National Eligibility and Entrance Test-Graduate (<a href="https://medicaldialogues.in/topics/neet-ug-2024" target="_blank">NEET UG</a>) counselling for the academic year 2024-25. The provisional result has been published on the official website of MCC in PDF format.</p><div class="pasted-from-word-wrapper"><p dir="ltr" style="text-align: justify; ">As per the official notice in this regard, any discrepancy in the result can be immediately reported to the MCC of DGHS by 11:00 AM today i.e. 25th December 2024. After which, the Provisional Result will be treated as ‘Final’. </p><p dir="ltr" style="text-align: justify; ">The Candidates are further informed that the provisional result is only indicative in nature and subject to change. The candidates cannot claim any right over the allotted seat in the provisional result and the provisional result cannot be challenged before the Court of Law.</p></div><div class="pasted-from-word-wrapper"><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/education/medical-admissions/3-seats-vacant-for-special-stray-vacancy-round-iii-in-mbbs-counselling-2024-mcc-releases-vacant-seat-list-140305"><b>Also Read:&nbsp;</b>3 Seats Vacant for Special Stray Vacancy Round III in MBBS Counselling 2024, MCC Releases Vacant Seat List</a></div><div class="pasted-from-word-wrapper"><p dir="ltr" style="text-align: justify; ">Meanwhile, candidates are advised to approach the allotted college/institute only after the declaration of the Final Result and only after downloading the allotment letter from the MCC website. </p><p dir="ltr" style="text-align: justify; "><b><u>STEPS TO CHECK THE RESULT</u></b></p><p dir="ltr" style="text-align: justify; "><b>STEP 1-</b> Visit the official website of MCC.</p><p dir="ltr" style="text-align: justify; "><b>STEP 2- </b>Click on the UG Medical tab.</p><p dir="ltr" style="text-align: justify; "><b>STEP 3-</b> Click on the ‘Provisional Allotment Result for Special Stray Vacancy Round III of NEET UG <a href="https://medicaldialogues.in/topics/counselling" target="_blank">Counselling</a> 2024’ link under the Current Events section.</p><p dir="ltr" style="text-align: justify; "><b>STEP 4- </b>Download the PDF document.</p><p dir="ltr" style="text-align: justify; "><b>STEP 5-</b> Find your NEET 2024 Rank to check your status.</p><p dir="ltr" style="text-align: justify; ">The Special Stray Vacancy Round III is likely to be the last round of NEET UG 2024 counselling. However, the MCC may extend the round in case of further vacant seats. With this, the choice-filling process for this round was recently concluded which was conducted from December 23 to December 24, 11 am. Following this, the institute reporting process will start from today i.e. December 25 to December 30, 2024, at 5 pm.</p><p dir="ltr" style="text-align: justify; "><b><u><i>To view the notice, click the link below</i></u></b></p><p dir="ltr" style="text-align: justify; "><a href="https://medicaldialogues.in/pdf_upload/mcc-266399.pdf" target="_blank">https://medicaldialogues.in/pdf_upload/mcc-266399.pdf</a></p></div><div class="pasted-from-word-wrapper"><div></div></div>

211. TB treatment costs up to Rs 32000 despite free Govt diagnosis: Report

     Wed, 25 Dec 2024 07:15:10 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/01/23/230764-tuberculosis-50.webp' /><div class="pasted-from-word-wrapper"><p><span style="text-align: justify;">New Delhi:&nbsp;</span>A recent study has revealed that despite free <a href="https://speciality.medicaldialogues.in/topics/tuberculosis" target="_blank">tuberculosis </a>(TB) diagnosis and treatment under the National TB Elimination Program (NTEP), nearly half of those infected face "catastrophic" costs due to lost wages and hospitalization expenses.</p><p style="text-align: justify; ">According to the PTI report, published in the journal Global Health Research and Policy, the research estimated that typically, tuberculosis treatment and care costs a total of USD 386 for an individual.</p><p style="text-align: justify;">The National TB Elimination Program (NTEP) is aimed at achieving a TB-free India by 2025, while the World Health Organization's (WHO) 'End TB Strategy' targets 2035 to end the global epidemic.</p><p style="text-align: justify;">Researchers from the TB Support Network, WHO Country Office for India, New Delhi, and Indian Council for Medical Research-National Institute of Epidemiology, Tamil Nadu, interviewed over 1,400 infected people notified under the National TB Elimination Program, and whose treatment outcome was declared between May 2022 and February 2023.</p><p style="text-align: justify;"><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/mdtv/pulmonology/videos/bolster-efforts-to-end-tb-in-who-south-east-asia-region-140100"><b><i>Also Read:Bolster efforts to end TB in WHO South-East Asia Region</i></b></a></p><p style="text-align: justify;">"Persons with TB (PwTB) in India incur high costs mainly due to lost productivity and hospitalisation. Nearly half of them experience catastrophic costs, especially those from poorer economic quintiles," the authors wrote.</p><p style="text-align: justify;">Direct costs -- incurred mostly before diagnosis or during hospitalisation -- were found to account for 34 per cent of the total costs (about USD 78), while indirect ones typically were found to be almost USD 280.</p><p style="text-align: justify;">Indirect costs due to loss of wages or productivity were found to contribute more to the total costs compared to direct costs.</p><p style="text-align: justify;">Further, infected people younger than 60 years of age, those without a health insurance and those hospitalised experienced higher typical costs, the authors said and added that hospitalisation was the major driver of direct and indirect costs.</p><p style="text-align: justify;">Seeking treatment in the private sector and hospitalisation also increase the risk of incurring catastrophic costs, the team said.</p><p style="text-align: justify;">The costs were calculated using a tool developed by 'Stop TB Partnership', "a hosted entity of the United Nations Office for Project Services (UNOPS), with its Secretariat based in Geneva, Switzerland."</p><p style="text-align: justify;">The authors called for expanding the coverage of health insurance schemes to include people infected with tuberculosis, along with enabling an early notification of having the disease.</p><p style="text-align: justify;">They also recommended sensitive strategies to address social determinants of tuberculosis, which may significantly reduce catastrophic costs incurred by the infected people.</p><p style="text-align: justify;"><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/india-reports-177-per-cent-decline-in-tb-incidence-from-2015-to-2023-who-report-137600"><b><i>Also Read:India reports 17.7 per cent decline in TB incidence from 2015 to 2023: WHO Report</i></b></a></p><div class="hocal-draggable" draggable="true"><div class="read-this-also-wrap"><div></div></div></div></div>

212. Latest Study Finds Fixed-Dose Combination of Paracetamol, Phenylephrine, and Chlorpheniramine Maleate Effective and Safe for Common Cold in Indian Adults

     Wed, 25 Dec 2024 06:04:15 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/12/24/266267-sinarest-1.webp' /><p style="text-align: justify; ">The fixed-dose combination (FDC) of Paracetamol 500 mg, Phenylephrine 10 mg, and Chlorpheniramine maleate 2 mg was effective and safe for the symptomatic treatment of common cold in adults, according to a recent study published in the <i>Journal of The Association of Physicians of India.</i></p><div class="pasted-from-word-wrapper"> <p style="text-align: justify; ">Common cold is an acute and self-limiting upper respiratory tract infection, causing symptoms like fever, nasal congestion, sore throat, and coughing. It generally affects adults 4-6 times annually, with symptoms lasting 5-7 days, and rhinovirus is the most common cause. Despite the viral nature of the infection, antibiotics are often over-prescribed, contributing to antibiotic resistance. Paracetamol, Phenylephrine, and Chlorpheniramine maleate are commonly used to treat symptoms, but limited research exists on the efficacy and safety of their FDC. </p> <p class="pf0" style="text-align: justify; ">This led the researchers to conduct a study evaluating the efficacy and safety of FDC of Paracetamol 500 mg, Phenylephrine 10 mg, and Chlorpheniramine maleate 2 mg for treating common cold symptoms in Indian adults.</p> <p class="pf0" style="text-align: justify; ">Researchers enrolled 420 patients, aged 18 to 65 years, to assess the efficacy and safety of the FDC of the investigational product. Of these, 318 patients completed the study. The FDC was administered as one tablet orally three times, every 8-hourly, for 5 days. The patients visited the clinical trial site on Day 1 (baseline), Day 3 (re-evaluation), and Day 5 (conclusion) for evaluation of efficacy and safety. The efficacy was measured using the total symptom score (TSS), while safety was evaluated based on adverse events reported by the patients.</p> <p style="text-align: justify; "><b>Key findings from the study, are detailed below:</b></p> <p style="text-align: justify; "><b><u>Efficacy assessment:</u></b> </p> <ul><li style="text-align: justify; ">The Total Symptom Score (TSS) decreased significantly from 9.016 at baseline to 5.011 on the second visit and 0.495 on the third, reflecting a 44.42% reduction by the second visit and 94.51% by the third visit over five days.</li><li style="text-align: justify; ">At baseline, 315 patients presented with severe symptoms, while three exhibited moderate symptoms. By the third visit, none had severe symptoms, two had moderate, 48 had mild, and 268 (84.276%) were symptom-free, showing the treatment's efficacy over five days. (Fig. 1A and B)</li></ul></div><div contenteditable="false" data-width="504" style="left:24%;width:504px;" class="image-and-caption-wrapper clearfix hocalwire-draggable float-none"><img src="https://medicaldialogues.in/h-upload/2024/12/24/266265-graphs-241224.webp" draggable="true" class="hocalwire-draggable float-none" data-float-none="true" data-uid="23690Mb4YyoJpkRgjzT0WmAWMC5Ptp0K5wl6M4385868" data-watermark="false" style="width: 100%; float: none;" info-selector="#info_item_1735024387050"><div class="inside_editor_caption image_caption hocalwire-draggable float-none" id="info_item_1735024387050"></div></div><div class="pasted-from-word-wrapper"><p><span style="font-size: 13px;">Fig. 1A and B: (A) Mean TSS on visit first, second, and third; (B) Percentage reduction in the mean TSS on visit second and third compared to baseline</span></p></div><div class="pasted-from-word-wrapper"><p><b><u>Safety assessment:</u></b> </p> <ul><li>During the study, only 13 patients experienced mild adverse effects. Hyperacidity was reported by four patients, and drowsiness by nine patients likely due to the presence of Paracetamol and Chlorpheniramine maleate in the treatment. All adverse events were mild, non-serious, and did not require medical intervention. </li></ul> <p>The researchers concluded that the study provides substantial evidence supporting the efficacy and safety of the FDC containing Paracetamol 500 mg, Phenylephrine 10 mg, and Chlorpheniramine maleate 2 mg for managing common cold symptoms in Indian adults. The findings demonstrated a significant reduction in TSS and a high percentage of patients achieving complete relief. </p> <p>They recommended further randomised clinical trials with a larger sample size to evaluate the treatment's efficacy and potential adverse effects in Indian adults suffering from the common cold.</p></div><div contenteditable="false" data-width="252" style="width:252px;" class="image-and-caption-wrapper clearfix hocalwire-draggable float-left"><img src="https://medicaldialogues.in/h-upload/2024/12/24/266252-profile-40.webp" draggable="true" class="hocalwire-draggable float-left" data-float-none="true" data-uid="23690N0vILT0vR7OZhVZQ4hbJYisQ1kZW8dre2733881" data-watermark="false" style="width: 100%; float: left;" info-selector="#info_item_1735022735447"><div class="inside_editor_caption image_caption hocalwire-draggable float-left" id="info_item_1735022735447"></div></div><div class="pasted-from-word-wrapper"><b>Dr Mayuresh Dilip Kiran, (MD Pharmacology) and lead author of the study</b> said, "The results of our study confirm the efficacy and safety of the fixed-dose combination of Paracetamol, Phenylephrine, and Chlorpheniramine maleate in providing rapid relief from common cold symptoms. With over 84% of patients achieving complete symptom resolution by the fifth day, this combination therapy offers a reliable and well-tolerated option for managing a condition that significantly impacts daily productivity and quality of life".</div><div class="pasted-from-word-wrapper"><br></div><div class="pasted-from-word-wrapper"><br></div><div class="pasted-from-word-wrapper"><br></div><div class="pasted-from-word-wrapper"><br></div><div class="pasted-from-word-wrapper"><br></div><div class="pasted-from-word-wrapper"></div><div class="pasted-from-word-wrapper"></div><div class="pasted-from-word-wrapper"></div><div class="pasted-from-word-wrapper"></div><div class="pasted-from-word-wrapper"></div><p><b>References:</b></p><div class="pasted-from-word-wrapper"> <ol><li>Kiran MD, Waghambare PD, Pawaskar L, Singh A. Fixed-dose Combination Therapy of Paracetamol, Phenylephrine, and Chlorpheniramine Maleate for the Symptomatic Treatment of Common Cold in Indian Adults. J Assoc Physicians India. 2024 Nov;72(11):45-48. doi: 10.59556/japi.72.0729. PMID: 39563116.</li><li>Worrall G. Common cold. Can Fam Physician. 2011 Nov;57(11):1289-90. PMID: 22084460; PMCID: PMC3215607.</li></ol> </div>

213. AstraZeneca, Daiichi Sankyo voluntarily withdraws datopotamab deruxtecan application in EU for lung cancer

     Wed, 25 Dec 2024 06:00:40 -0000

     <img src='https://medicaldialogues.in/h-upload/2023/01/10/197356-astrazeneca-4.webp' /><p><b style="text-align: justify;">Cambridge:</b><span style="text-align: justify;">&nbsp;AstraZeneca and Daiichi Sankyo have voluntarily withdrawn the marketing authorisation application (MAA) in the EU for datopotamab deruxtecan (Dato-DXd) for the treatment of adult patients with locally advanced or metastatic nonsquamous non-small cell lung cancer (NSCLC) based on the TROPION-Lung01 Phase III trial.</span></p><div class="pasted-from-word-wrapper"><p style="text-align: justify; ">The decision to withdraw the MAA was informed by feedback from the Committee for Medicinal Products for Human Use of the European Medicines Agency (EMA). AstraZeneca and Daiichi Sankyo will continue to work to bring datopotamab deruxtecan to patients with lung cancer in the EU who can benefit and are committed to unlocking the potential of this medicine in lung cancer through our robust clinical development programme which includes seven pivotal trials in various lung cancer settings.</p><p style="text-align: justify; ">AstraZeneca and Daiichi Sankyo’s application in the EU for datopotamab deruxtecan for the treatment of hormone receptor (HR)-positive, HER2-negative metastatic breast cancer based on the TROPION-Breast01 Phase III trial remains under review.</p><p style="text-align: justify; ">Datopotamab deruxtecan is a specifically engineered TROP2-directed DXd antibody drug conjugate (ADC) discovered by Daiichi Sankyo and being jointly developed by AstraZeneca and Daiichi Sankyo.</p></div><div class="pasted-from-word-wrapper"><p style="text-align: justify; ">Nearly 2.5 million lung cancer cases were diagnosed globally in 2022. In Europe, nearly half a million lung cancer cases were diagnosed in 2022. Lung cancer is broadly split into small or non-small cell lung cancer, the latter accounting for about 80% of cases. While immunotherapy and targeted therapies have improved outcomes in the 1st-line setting, most patients eventually experience disease progression and receive chemotherapy. For decades, chemotherapy has been the last treatment available for patients with advanced NSCLC, despite limited effectiveness and known side effects.</p><p style="text-align: justify; ">TROP2 is a protein broadly expressed in the majority of NSCLC tumours. There is currently no TROP2-directed ADC approved for the treatment of lung cancer.</p><p style="text-align: justify; "><b><i>Read also: <a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/industry/pharma/pfizer-astrazeneca-and-several-other-drugmakers-in-race-to-join-weight-loss-drug-market-140315">Pfizer, AstraZeneca and several other drugmakers in race to join weight loss drug market</a></i></b></p></div>

214. ICMR Develops AI Tool to Predict IVF Outcomes for Infertile Men

     Wed, 25 Dec 2024 05:45:59 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/05/17/238491-icmr-50-1.webp' /><div class="pasted-from-word-wrapper"><p>New Delhi: The&nbsp;<a href="https://medicaldialogues.in/topics/indian-council-of-medical-research" target="_blank">Indian Council of Medical Research</a>&nbsp;(ICMR), in collaboration with Amity University, has developed an artificial intelligence-based tool aimed at detecting 'Y' chromosome microdeletion (YCMD) — a genetic cause of male infertility — and predicting the outcomes of in-vitro fertilization (IVF) treatments.</p></div><div class="pasted-from-word-wrapper"><p>According to the PTI report, the study regarding the AI tool was published in the Journal of Assisted Reproduction and Genetics last week.&nbsp;</p><p>In nearly 50 per cent of couples experiencing infertility, the problem is with the male partner, said Dr Deepak Modi, senior scientist at ICMR’s National Institute for Research in Reproductive and Child Health (NIRRCH) and the lead author of the study.</p><p>“In them there could be problems with sperm production. One of the leading causes, Y chromosome microdeletion (YCMD) is observed in one in every 10 men with infertility. Because of this genetic defect, the testes are unable to make enough sperm leading to infertility,” Dr Modi said.</p><p><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/medical-organization/icmr-left-indelible-mark-on-indias-healthcare-landscape-says-shri-jp-nadda-138117"><b><i>Also Read:ICMR left indelible mark on India's healthcare landscape, says Shri JP Nadda</i></b></a></p><p>Men with YCMD cannot benefit from medical treatment for improving the sperm count.</p><p>To become fathers, such men require assisted reproductive techniques such as in-vitro fertilization (IVF) for parenthood, he said. &nbsp;</p><p>The AI-based tool — ‘Fertility Predictor’ — developed by the ICMR-NIRRCH in collaboration with Amity University, Noida can predict sperm retrieval rates and success rates of assisted reproductive technology (ART) in men having this genetic problem.</p><p>It also predicts the rate of fertilization, clinical pregnancy and live birth rates based on the type of Y chromosome microdeletion, Dr Modi said. This helps the couples make informed decisions, he said.</p><p>However, Dr Modi cautioned that the male babies born through IVF from men with YCMD will inherit the same defect and will be infertile as it is 100 per cent transmitted from fathers to their sons, news agency PTI reported.</p><p>Developing this tool took about two years by collating data of more than 500 men having YCMD and undergoing ART.</p><p>After applying an artificial intelligence algorithm based on machine learning on this data, the tool could predict the outcomes. This was then validated on another sub-set and it was found to have accuracy of about 80 per cent, Dr Stacy Colaco, a scientist at NIRRCH and the first author of the study, said.</p><p>“Fertility Predictor also provides a numerical output for chance of clinical pregnancy and live birth in men with YCMD. The validation studies indicated its robustness and high accuracy in predicting both these parameters solely based on the type of YCMD,” said Dr Abhishek Sengupta of Amity University, Noida.</p><p> <a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/medical-organization/first-in-the-world-challenge-icmr-calls-for-proposals-to-develop-innovative-health-solutions-137622"><b><i>Also Read:'First in the World Challenge': ICMR calls for proposals to develop innovative health solutions</i></b></a></p><div class="hocal-draggable" draggable="true"><div class="read-this-also-wrap"><div></div></div></div></div>

215. Hamidia Hospital unveils Toy Ward to Alleviate Children's Anxiety during Surgery

     Wed, 25 Dec 2024 05:30:28 -0000

     <img src='https://medicaldialogues.in/h-upload/2024/02/20/232648-pediatric-cancer-50.webp' /><p><b>Bhopal:</b>&nbsp;Bhopal's&nbsp;<a href="https://medicaldialogues.in/topics/hamidia-hospital">Hamidia Hospital</a> has unveiled a unique "Toy Ward" within its <a href="https://medicaldialogues.in/topics/paediatric-surgery">Pediatric Surgery</a> Ward to alleviate the stress and anxiety faced by hospitalized children. The new ward is adorned with colourful decorations, cheerful toys, and bright paintings to create a welcoming and comforting environment for children. </p><p>The goal is to ease the psychological and emotional challenges children often face during hospitalization, helping them cope with medical procedures more positively.&nbsp;</p><p>Dr Kavita N Singh, Dean of Gandhi Medical College (GMC), officially inaugurated the Toy Ward and praised the hospital for its thoughtful initiative in enhancing the treatment experience for children. According to doctors hospitalization is a challenging experience for both children and their families.</p><p><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/state-news/madhya-pradesh/mp-cm-mohan-yadav-inspects-hamidia-hospital-announces-facilities-worth-rs-199-crore-132171"><b>Also Read: MP CM Mohan Yadav inspects Hamidia Hospital, announces facilities worth Rs 199 crore</b></a></p><div class="pasted-from-word-wrapper"><div><span style="background-color: rgb(249, 249, 249);">During their hospital stay, a child's routine is disrupted, and the hospital environment often evokes stress, fear, anxiety, and emotional trauma. This can affect both their physical and psychological well-being, making it more difficult for them to manage medical procedures. To address this, the hospital has worked to create a less intimidating environment, aiming to reduce negative emotions such as fear and anxiety, and ultimately make the treatment experience more positive and less stressful for young patients.</span></div></div><p>Dr Dhirendra Srivastava, head of the Pediatric Surgery Department at Hamidia Hospital, explained that the ward has been specially designed for children who are admitted for surgical procedures. This aids in the children's swift recovery and contributes to their mental well-being. The doctor also mentioned that the new setup is intended to make the hospital environment less stressful for both the children and their families.</p><p><a class="editor-inserted-link" target="_blank" href="https://medicaldialogues.in/news/health/hospital-diagnostics/sir-ganga-ram-hospital-celebrates-national-pediatric-surgery-day-104804"><b>Also Read: Sir Ganga Ram Hospital celebrates National Pediatric Surgery Day</b></a></p><div class="pasted-from-word-wrapper"><div class="hocal-draggable" draggable="true"><div class="read-this-also-wrap"><div></div></div></div><p>As per the recent media report, GMC dean Dr Kavita N Singh told <a href="https://www.freepressjournal.in/bhopal/bhopal-hamidia-hospital-gets-toy-ward-for-children-to-undergo-surgery" rel="nofollow">Free Press Journal</a>, “It is a positive initiative on the part of the hospital administration and it is very important to take care of the happiness and comfort of children during their treatment. The toy ward will give new energy and confidence to the children and serve as an inspiration to other hospitals to take up similar initiatives.”</p></div>

216. Santa Claus Soars Into Lucile Packard Children’s Hospital Stanford, Spreading Holiday Cheer

     Tue, 24 Dec 2024 08:01:00 -0000

     

     Santa Claus makes a special visit to Lucile Packard Children’s Hospital Stanford just before his global journey.

     <div><img width="723" height="768" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4412-scaled-e1734978538566.jpg" class="attachment-768x768 size-768x768 wp-post-image" alt="" style="margin-bottom: 15px;" decoding="async" loading="lazy" /></div> <p><em>Stanford Medicine Life Flight crew makes a special trip to the North Pole, bringing Santa to the hospital</em></p> <figure class="wp-block-image size-large"><img decoding="async" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4412-846x900.jpg" alt="" class="wp-image-26570"/></figure> <p>In a heartwarming holiday tale, Santa Claus made a special visit to <a href="http://www.stanfordchildrens.org">Lucile Packard Children’s Hospital Stanford</a> just before his global journey. Thanks to the incredible crew of <a href="https://stanfordhealthcare.org/health-care-professionals/lifeflight.html">Stanford Medicine Life Flight</a>, a dedicated team of nurses traveled to the North Pole to bring Santa, ensuring that he could share joy with young patients, their families, and the hardworking staff at Stanford Medicine.</p> <p>“When I initially heard the helicopter, I was expecting a patient,” recalled Megan Littleton, MD, pediatric resident. “But realizing it was Santa Claus was surreal. Witnessing our patients light up with joy made it an unforgettable moment.”</p> <p>Santa’s presence has brought holiday joy to sick patients for decades, ensuring that none feel left out during the festive holiday season, even when they can’t be at home.</p> <p>Brad Pratt, who hails from Washington, brought his daughter Kelsey to Packard Children’s for the best medical care. Santa’s visit not only brought joy to Kelsey but also was a morale booster and relief for him. “Seeing the hospital staff extend their care beyond medical needs to bring joy was amazing. It truly boosted our spirits, especially being far from home. Santa’s visit and gifts provided relief and happiness during Kelsey’s recovery,” Brad observed, his voice filled with appreciation.</p> <figure class="wp-block-image size-large"><img decoding="async" width="675" height="900" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_1692-675x900.jpg" alt="" class="wp-image-26544" srcset="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_1692-675x900.jpg 675w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_1692-338x450.jpg 338w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_1692-768x1024.jpg 768w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_1692-1152x1536.jpg 1152w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_1692-1536x2048.jpg 1536w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_1692-scaled.jpg 1920w" sizes="(max-width: 675px) 100vw, 675px" /><figcaption class="wp-element-caption">Lori Eichner and her 3-year-old son, Camden, with Santa.</figcaption></figure> <p>Lori Eichner and her 3-year-old son, Camden, were deeply touched by the visit. “Camden had never met Santa before. We were so surprised and grateful to have a one-on-one moment with him. Since Camden will be here for a few more days, Santa’s visit brought the Christmas spirit right to his bedside,” Lori noted with gratitude.</p> <p>Santa himself shared his joy in making this visit. “I enjoy coming to Lucile Packard Children’s Hospital Stanford to ensure that the children and their families know they are not forgotten. It’s also a chance to express my gratitude to the staff for their incredible care and dedication,” he said warmly.</p> <figure class="wp-block-gallery has-nested-images columns-default is-cropped wp-block-gallery-1 is-layout-flex wp-block-gallery-is-layout-flex"> <figure class="wp-block-image size-large"><img decoding="async" width="543" height="900" data-id="26542" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4444-543x900.jpg" alt="" class="wp-image-26542" srcset="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4444-543x900.jpg 543w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4444-272x450.jpg 272w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4444-768x1272.jpg 768w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4444-927x1536.jpg 927w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4444-1236x2048.jpg 1236w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4444-scaled.jpg 1545w" sizes="(max-width: 543px) 100vw, 543px" /></figure> <figure class="wp-block-image size-large"><img loading="lazy" decoding="async" width="505" height="900" data-id="26540" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4434-505x900.jpg" alt="" class="wp-image-26540" srcset="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4434-505x900.jpg 505w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4434-253x450.jpg 253w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4434-768x1368.jpg 768w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4434-862x1536.jpg 862w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4434-1150x2048.jpg 1150w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4434-scaled.jpg 1437w" sizes="(max-width: 505px) 100vw, 505px" /></figure> </figure> <p>The excitement was palpable throughout the children’s hospital. Linda Lu, RN, along with her fellow nurses, watched from a fourth-floor office window, waving signs and cheering as Santa flew past. “We couldn’t believe it was Santa! His visit was the highlight of our day, and seeing him bring cheer to every room was incredible,” Linda said, her eyes twinkling with joy.</p> <figure class="wp-block-gallery has-nested-images columns-default is-cropped wp-block-gallery-2 is-layout-flex wp-block-gallery-is-layout-flex"> <figure class="wp-block-image size-large"><img loading="lazy" decoding="async" width="675" height="900" data-id="26566" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/Santa-flies-over-LPCH-675x900.jpg" alt="" class="wp-image-26566" srcset="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/Santa-flies-over-LPCH-675x900.jpg 675w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/Santa-flies-over-LPCH-338x450.jpg 338w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/Santa-flies-over-LPCH-768x1024.jpg 768w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/Santa-flies-over-LPCH-1152x1536.jpg 1152w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/Santa-flies-over-LPCH.jpg 1512w" sizes="(max-width: 675px) 100vw, 675px" /></figure> <figure class="wp-block-image size-large"><img loading="lazy" decoding="async" width="675" height="900" data-id="26568" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/Santa_Emily-Otto_LF-Nurse-675x900.jpg" alt="" class="wp-image-26568" srcset="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/Santa_Emily-Otto_LF-Nurse-675x900.jpg 675w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/Santa_Emily-Otto_LF-Nurse-338x450.jpg 338w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/Santa_Emily-Otto_LF-Nurse-768x1024.jpg 768w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/Santa_Emily-Otto_LF-Nurse-1152x1536.jpg 1152w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/Santa_Emily-Otto_LF-Nurse.jpg 1158w" sizes="(max-width: 675px) 100vw, 675px" /></figure> <figure class="wp-block-image size-large"><img loading="lazy" decoding="async" width="900" height="836" data-id="26560" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4417-900x836.jpg" alt="" class="wp-image-26560" srcset="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4417-900x836.jpg 900w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4417-450x418.jpg 450w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4417-768x713.jpg 768w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4417-1536x1427.jpg 1536w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4417-2048x1902.jpg 2048w" sizes="(max-width: 900px) 100vw, 900px" /></figure> <figure class="wp-block-image size-large"><img loading="lazy" decoding="async" width="900" height="675" data-id="26562" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4393-900x675.jpg" alt="" class="wp-image-26562" srcset="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4393-900x675.jpg 900w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4393-450x337.jpg 450w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4393-768x576.jpg 768w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4393-1536x1151.jpg 1536w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4393-2048x1535.jpg 2048w" sizes="(max-width: 900px) 100vw, 900px" /><figcaption class="wp-element-caption">The Stanford Medicine Life Flight crew traveled to the North Pole to bring Santa to Packard Children&#8217;s Hospital. <br>Katja Kane-Foempe, RN, Emily Otto, RN, William Wu, RN, Randy Hough, RN, and Doug Evans, lead pilot</figcaption></figure> </figure> <p>William Wu, RN, a clinical nurse with Stanford Medicine Life Flight, said this mission would be one of the most memorable flights of his career. “Typically, we deal with critical medical situations, but this special flight was about healing the soul. Providing a preflight briefing to Santa Claus was surreal, but the most significant part was spreading joy to the patients, families, and staff at Stanford Medicine. My heart is full from this experience,” William reflected sincerely.</p> <p>The holiday spirit of kindness, joy, and togetherness was alive and well at Lucile Packard Children’s Hospital Stanford, thanks to Santa Claus and the dedicated efforts of Stanford Medicine Life Flight and the hospital staff. This special visit ensured that holiday magic touched every corner of the hospital, bringing smiles and warmth to all.</p>

217. Christian McCaffrey Brightens the Holidays for Young Patients at Packard Children’s Hospital

     Tue, 24 Dec 2024 00:43:04 -0000

     

     Christian McCaffrey, the dynamic running back for the San Francisco 49ers, recently visited Lucile Packard... Read more »

     <div><img width="345" height="291" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4520-scaled-e1735087756331.jpg" class="attachment-768x768 size-768x768 wp-post-image" alt="" style="margin-bottom: 15px;" decoding="async" loading="lazy" /></div> <figure class="wp-block-image size-large"><img decoding="async" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4520-675x900.jpg" alt="" class="wp-image-26581"/></figure> <p>Christian McCaffrey, the dynamic running back for the San Francisco 49ers, recently visited <a href="http://www.stanfordchildrens.org">Lucile Packard Children&#8217;s Hospital Stanford,</a> bringing cheer and smiles to our young patients.</p> <p>With a heart as big as his talent, McCaffrey spent quality time with the young patients, offering not only gifts and hugs, but also creating cherished memories.</p> <p>“The moment he walked through the hospital doors, the atmosphere became electric with excitement and joy,” said Elizabeth Valente, Stanford Medicine Children’s Health spokesperson.&nbsp; “McCaffrey&#8217;s presence illuminated the faces of these brave young fighters, allowing them to momentarily escape the struggles of their medical challenges and experience the magic of the holidays.”</p> <p>Through the Christian McCaffery Foundation and the Logan Project, McCaffrey provides gaming kiosks to children undergoing medical treatment as a way restore a sense of normalcy during their stay in the hospital.</p> <p>“I created the Logan Project so that kids who are in the hospital would still have an opportunity to engage with others and do the things they love to do,” McCaffrey, said. “My Foundation has been so happy to partner with Stanford Medicine Children’s Health and put some of our systems here at Lucile Packard Children’s Hospital for the patients.”</p> <figure class="wp-block-gallery has-nested-images columns-default is-cropped wp-block-gallery-3 is-layout-flex wp-block-gallery-is-layout-flex"> <figure class="wp-block-image size-large"><img loading="lazy" decoding="async" width="675" height="900" data-id="26585" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4508-675x900.jpg" alt="" class="wp-image-26585" srcset="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4508-675x900.jpg 675w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4508-338x450.jpg 338w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4508-768x1024.jpg 768w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4508-1152x1536.jpg 1152w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4508-1536x2048.jpg 1536w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4508-scaled.jpg 1920w" sizes="(max-width: 675px) 100vw, 675px" /></figure> <figure class="wp-block-image size-large"><img loading="lazy" decoding="async" width="675" height="900" data-id="26587" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4513-675x900.jpg" alt="" class="wp-image-26587" srcset="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4513-675x900.jpg 675w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4513-338x450.jpg 338w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4513-768x1024.jpg 768w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4513-1152x1536.jpg 1152w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4513-1536x2048.jpg 1536w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4513-scaled.jpg 1920w" sizes="(max-width: 675px) 100vw, 675px" /></figure> <figure class="wp-block-image size-large"><img loading="lazy" decoding="async" width="675" height="900" data-id="26583" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4493-675x900.jpg" alt="" class="wp-image-26583" srcset="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4493-675x900.jpg 675w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4493-338x450.jpg 338w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4493-768x1024.jpg 768w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4493-1152x1536.jpg 1152w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4493-1536x2048.jpg 1536w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/IMG_4493-scaled.jpg 1920w" sizes="(max-width: 675px) 100vw, 675px" /></figure> </figure> <p>In addition to handing out thoughtfully chosen gifts, McCaffrey took the time to engage in personal conversations, ensuring each child felt special. He posed for photos, ensuring that these special moments will be remembered and shared for years to come.</p> <p><a href="https://www.instagram.com/reel/DD-LJ5SydCL/?utm_source=ig_web_copy_link&amp;igsh=MzRlODBiNWFlZA==">Click here</a> to hear a message of gratitude from Christian McCaffrey.</p>

218. A Goal of Doing More in Honor of Her Donor

     Fri, 20 Dec 2024 16:00:00 -0000

     

     After receiving the gift of a new heart and lungs, Roza Saad strives to live a life that reflects the generosity of her donor.

     <div><img width="768" height="433" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/roza-rose-parade-1200x675-1.jpg" class="attachment-768x768 size-768x768 wp-post-image" alt="Teenager holding a flower to her face" style="margin-bottom: 15px;" decoding="async" loading="lazy" srcset="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/roza-rose-parade-1200x675-1.jpg 1200w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/roza-rose-parade-1200x675-1-450x254.jpg 450w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/roza-rose-parade-1200x675-1-900x507.jpg 900w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/roza-rose-parade-1200x675-1-768x433.jpg 768w" sizes="(max-width: 768px) 100vw, 768px" /></div> <p><em>After receiving the gift of a new heart and lungs, 17-year-old Roza Saad strives to live a life that reflects the generosity of her donor.</em></p> <div class="wp-block-image"> <figure class="alignright size-large is-resized"><img loading="lazy" decoding="async" width="900" height="600" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/051471_Transplant-Rose-Parade-Send-Off-Event-038_12-06-2024-900x600.jpg" alt="" class="wp-image-26523" style="width:407px;height:auto" srcset="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/051471_Transplant-Rose-Parade-Send-Off-Event-038_12-06-2024-900x600.jpg 900w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/051471_Transplant-Rose-Parade-Send-Off-Event-038_12-06-2024-450x300.jpg 450w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/051471_Transplant-Rose-Parade-Send-Off-Event-038_12-06-2024-768x512.jpg 768w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/051471_Transplant-Rose-Parade-Send-Off-Event-038_12-06-2024-1536x1024.jpg 1536w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/051471_Transplant-Rose-Parade-Send-Off-Event-038_12-06-2024-2048x1365.jpg 2048w" sizes="(max-width: 900px) 100vw, 900px" /></figure></div> <p>Roza Saad is a driven young lady. She skipped the 12th grade to attend college earlier. Now, she is studying computer science as a freshman in college. Her long list of goals continues to grow.</p> <p>“I’m currently organizing a blood drive and volunteering at a hospital gift shop,” she said. “After I graduate from college, I plan to open up my own company.”</p> <p>The newest item on her list is to ride on the OneLegacy Donate Life float at the 136th Rose Parade in Pasadena, California, to promote the importance of organ donation. On Jan. 1, 2025, she will fulfill that goal in honor of her donor.</p> <p><strong>A double transplant for a new start</strong></p> <p><a href="https://healthier.stanfordchildrens.org/en/up-and-running-again-with-heart/">Back in early 2019</a>, Roza’s mom, Baydaa, felt something fundamental was wrong because her daughter was continually out of breath and tired. After a battery of tests, Roza was diagnosed with pulmonary arterial hypertension, which meant that the blood pressure in her lungs was much higher than in the rest of her body. It is a condition that, if left untreated, could have dramatically shortened Roza’s life.&nbsp;</p> <p>In 2020, her situation worsened. Roza went into heart and lung failure, and it was necessary to put her on an extracorporeal membrane oxygenation (ECMO) machine, an external artificial heart and lung bypass machine, to save her. ECMO kept her alive by circulating artificially oxygenated blood around her body. Roza had to be mechanically ventilated, so she was also intubated and heavily sedated.</p> <p>Her only hope was a rare <a href="https://www.stanfordchildrens.org/en/services/lung-transplant">heart-lung transplant</a>. Within a few days of being listed for organs, Roza got an offer for a heart and lungs from a compatible donor—something her family and Stanford Medicine Children’s Health medical team called a miracle.</p> <p>“We were all aware that a transplant was the only thing that could save Roza. Suddenly we could offer it,” said <a href="https://www.stanfordchildrens.org/en/doctor/michael-raosen-ma.html">Michael Ma, MD</a>, division chief of Pediatric Cardiac Surgery. “It was thrilling to tell Roza’s family, ‘We can do this now.’”</p> <p>Roza was only 13 years old at the time when she received her double transplant. She fought through unexpected complications and months of a difficult recovery. Today, as a flourishing college student, she said she looks back on those days and thinks, “I wish I knew there was a new life waiting for me.”</p> <figure class="wp-block-image"><img loading="lazy" decoding="async" width="900" height="600" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/051471_Transplant-Rose-Parade-Send-Off-Event-155_12-06-2024-900x600.jpg" alt="" class="wp-image-26527" srcset="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/051471_Transplant-Rose-Parade-Send-Off-Event-155_12-06-2024-900x600.jpg 900w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/051471_Transplant-Rose-Parade-Send-Off-Event-155_12-06-2024-450x300.jpg 450w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/051471_Transplant-Rose-Parade-Send-Off-Event-155_12-06-2024-768x512.jpg 768w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/051471_Transplant-Rose-Parade-Send-Off-Event-155_12-06-2024-1536x1024.jpg 1536w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/051471_Transplant-Rose-Parade-Send-Off-Event-155_12-06-2024-2048x1365.jpg 2048w" sizes="(max-width: 900px) 100vw, 900px" /><figcaption class="wp-element-caption">Roza Saad stands next to her Stanford Children&#8217;s pediatric transplant care team.</figcaption></figure> <p><strong>‘Let Your Life Soar’</strong></p> <p>Roza’s second chance at life has been shaped by the gift of the heart and lungs she received.</p> <p>“She is always trying to do more because she got a heart and two lungs, so she wants to do something special, something different,” Baydaa said.&nbsp;</p> <p>Recently, Roza reunited with her care team at <a href="https://www.stanfordchildrens.org/en/lucile-packard-childrens-hospital.html#toppick">Lucile Packard Children’s Hospital Stanford</a> as they celebrated her for being one of the honorees on this year’s Donate Life float. The float’s theme is “Let Your Life Soar,” something Roza’s care team feels she exemplifies.</p> <div class="wp-block-image"> <figure class="alignleft size-large is-resized"><img loading="lazy" decoding="async" width="900" height="600" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/051471_Transplant-Rose-Parade-Send-Off-Event-169_12-06-2024-900x600.jpg" alt="" class="wp-image-26525" style="width:407px;height:auto" srcset="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/051471_Transplant-Rose-Parade-Send-Off-Event-169_12-06-2024-900x600.jpg 900w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/051471_Transplant-Rose-Parade-Send-Off-Event-169_12-06-2024-450x300.jpg 450w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/051471_Transplant-Rose-Parade-Send-Off-Event-169_12-06-2024-768x512.jpg 768w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/051471_Transplant-Rose-Parade-Send-Off-Event-169_12-06-2024-1536x1024.jpg 1536w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/051471_Transplant-Rose-Parade-Send-Off-Event-169_12-06-2024-2048x1365.jpg 2048w" sizes="(max-width: 900px) 100vw, 900px" /></figure></div> <p>“To see her blossom into this really self-assured, composed, independent young lady has been so great,” said <a href="https://www.stanfordchildrens.org/en/doctor/xin-si.html">Cissy Xin Si, MD</a>, medical director of Pediatric Lung and Heart-Lung Transplant. “Our whole team is so proud of her for coming such a long way since her transplants. Organs are rare. Not everyone is able to get a transplant, so for her to take this gift her donor gave her and really want to do something with it is really wonderful.”</p> <p>Roza’s heart is filled with gratitude as she embraces this opportunity to provide hope to other patients waiting in hospitals across the country for their second chance at life.</p> <p>“I want them to know there is a light at the end of the tunnel,” Roza said. “They are not alone in their journey. There are many people supporting them and thinking of them. Stay strong, keep fighting, and when you receive your transplant, live life to the fullest, and cherish every moment.”</p>

219. Remission Achieved Quickly for Girl With Complex Crohn’s Disease

     Fri, 20 Dec 2024 16:00:00 -0000

     

     Stanford Medicine Children’s Health provides the latest expert, research-driven care to children with bowel disease.

     <div><img width="768" height="432" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/Abby-family-photo-1200x675-1.jpg" class="attachment-768x768 size-768x768 wp-post-image" alt="Abby&#039;s family" style="margin-bottom: 15px;" decoding="async" loading="lazy" srcset="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/Abby-family-photo-1200x675-1.jpg 1200w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/Abby-family-photo-1200x675-1-450x253.jpg 450w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/Abby-family-photo-1200x675-1-900x506.jpg 900w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/Abby-family-photo-1200x675-1-768x432.jpg 768w" sizes="(max-width: 768px) 100vw, 768px" /></div> <p><em>Stanford Medicine Children’s Health provides the latest expert, research-driven care to children with bowel disease</em></p> <figure class="wp-block-image size-large"><img loading="lazy" decoding="async" width="900" height="506" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/Abby-family-photo-1200x675-1-900x506.jpg" alt="Abby's family" class="wp-image-26499" srcset="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/Abby-family-photo-1200x675-1-900x506.jpg 900w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/Abby-family-photo-1200x675-1-450x253.jpg 450w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/Abby-family-photo-1200x675-1-768x432.jpg 768w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/Abby-family-photo-1200x675-1.jpg 1200w" sizes="(max-width: 900px) 100vw, 900px" /></figure> <p>Abigail (Abby) is a high-energy 8-year-old from Visalia, California, who loves to bake sweets, create art, dance around the living room, and do gymnastics in the yard. Yet, she wasn’t always this carefree. She lived with undiagnosed inflammatory bowel disease (IBD) for close to two years.</p> <p>The first sign that something was wrong with Abby was her severe constipation when she was 4 years old. Her parents, Brittani and Aaron, sought help from a local children’s hospital, which performed a colonoscopy. &nbsp;</p> <p>“It came back normal, but it wasn’t,” says Brittani.</p> <p>Abby’s IBD continued to brew, with worsening inflammation in her gut. She developed a perianal fistula, a small tunnel that formed near her bottom, making it painful for her to sit. Her hometown doctors believed the fistula was an external abscess and treated it with surgery.</p> <p>“She couldn’t sit on the carpet or plastic chairs in kindergarten, and she had to receive wound care from the nurse at school and from me at home. It was painful and she was embarrassed,” Brittani says.</p> <p>Several months went by with the family treating the fistula as a wound, and as expected, it didn’t heal.</p> <p>“I am a pediatric nurse practitioner, and I knew there was nothing else I could do to help it heal. I begged the doctors to do exploratory surgery, and that’s when they discovered it was a perianal fistula,” Brittani says.&nbsp;</p> <p>Upon a closer look at Abby’s original colonoscopy, the underlying pathology showed signs of very early-onset IBD, particularly <a href="https://www.stanfordchildrens.org/en/services/inflammatory-bowel-disease/crohns-disease.html">Crohn’s disease</a>. Crohn’s disease causes redness, swelling, and sores along the digestive tract. It is a chronic (long-term) condition.</p> <p>According to a National Institutes of Health study, pediatric IBD is rare. It occurs in 2 out of 1,000 children in Western countries. Its rarity adds to the risk of its being misdiagnosed.</p> <p>Symptoms of Crohn’s disease can include abdominal pain, diarrhea, rectal bleeding, weight loss, fever, joint pain, and rashes. Abby’s constipation is not a classic symptom of Crohn’s, but it does occur.</p> <p><strong>Coming to Stanford Children’s for IBD care</strong></p> <p>Brittani and Aaron were desperate to find the right care for Abby. “Going down a road that we thought would bring relief and finding out we were going in the wrong direction was really disheartening and frustrating for us as parents,” says Aaron.</p> <p>Brittani learned from a former colleague that Stanford Medicine Children’s Health had a robust IBD center. “That was a wonderful godsend,” she says.&nbsp;</p> <p>The couple was excited to hear the news that an advanced center was nearby, but they were even more thrilled to learn that the director of the <a href="https://www.stanfordchildrens.org/en/services/ibd-celiac-center.html">Center for IBD and Celiac Disease</a> at Stanford Children’s, <a href="https://www.stanfordchildrens.org/en/doctor/michael-j-rosen.html">Michael J. Rosen, MD</a>, was a national expert in treating IBD in children. More important, they learned that he cares for a large number of children with rare forms of IBD, including early-onset Crohn’s disease.</p> <p>“We went from feeling very low to having hope again. We thought if anyone could help Abby, Stanford and Dr. Rosen could,” Aaron says.</p> <p>The family made the three-hour drive to Stanford Children’s. Dr. Rosen created a comprehensive treatment plan for Abby, who was soon turning 6. It started with <a href="https://www.stanfordchildrens.org/en/services/genetics.html">genetic testing</a> to rule out a genetic cause for her Crohn’s disease, as well as tests to exclude an immune deficiency. &nbsp;&nbsp;</p> <div class="wp-block-image"> <figure class="alignright size-full is-resized"><img loading="lazy" decoding="async" width="350" height="525" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/abby-infusions.jpg" alt="Abby receiving an infusion" class="wp-image-26504" style="width:307px;height:auto" srcset="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/abby-infusions.jpg 350w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/abby-infusions-300x450.jpg 300w" sizes="(max-width: 350px) 100vw, 350px" /></figure></div> <p>From there, Dr. Rosen recommended an infusion of a biologic medicine to bring down inflammation in Abby’s gut and to heal the fistula. By tailoring her medicine and getting it just right—something that isn’t a simple task—Dr. Rosen helped Abby begin to heal quickly.</p> <p>“He moved fast with <a href="https://www.stanfordchildrens.org/en/services/inflammatory-bowel-disease/services.html">treatment</a>, and in a short time we saw her inflammatory biomarkers improving and trending in the right direction, so our hopes were starting to be realized,” Aaron says. Within a few months, the fistula healed.</p> <p>Dr. Rosen partnered with an infusion center near the family’s home in Visalia to make it easier for Abby to get infusions every four to seven weeks, something that will continue throughout her life to keep her Crohn’s under control. The family appreciates the convenience of meeting with Dr. Rosen via <a href="https://www.stanfordchildrens.org/en/telehealth.html">telehealth</a> and how Stanford Children’s groups procedures in one appointment to save on stress for Abby.&nbsp;</p> <p><strong>Getting all their needs met in one place</strong></p> <p><a>The </a><a href="https://www.stanfordchildrens.org/en/services/inflammatory-bowel-disease.html">Pediatric Inflammatory Bowel Disease</a> program at Stanford Children’s doesn’t just treat the disease, they treat the whole child. “We make sure Abby and her family are supported socially and emotionally so they have the tools they need to cope with her chronic illness and treatments,” Dr. Rosen says. &nbsp;</p> <div class="wp-block-image"> <figure class="alignright size-full"><img loading="lazy" decoding="async" width="350" height="609" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/abby-family-photo.jpg" alt="Abby's family" class="wp-image-26506" srcset="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/abby-family-photo.jpg 350w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/abby-family-photo-259x450.jpg 259w" sizes="(max-width: 350px) 100vw, 350px" /></figure></div> <p>Abby’s holistic care included meeting with <a href="https://www.stanfordchildrens.org/en/services/inflammatory-bowel-disease/services/ibd-nutritional-therapy.html">IBD Nutritional Therapies</a> early on to find a diet that would work well with her medicines, as well as receiving support from an IBD-specialized <a href="https://www.stanfordchildrens.org/en/services/inflammatory-bowel-disease/services/psychosocial-services.html">social worker</a>. He was able to help the family set up a 504 plan at Abby’s school, which established accommodations for her disease, including unfettered bathroom access and time off for medical care. The family was also invited to attend a parent support group through <a href="https://www.stanfordchildrens.org/en/services/inflammatory-bowel-disease/services/psychosocial-services.html">IBD Psychosocial Services</a>.</p> <p>“Since starting treatments, she has picked back up on her growth. Her height growth really slowed and had proportionally dropped during the years prior to her diagnosis. She is now growing well and looks healthy again,” Brittani says. “I feel really blessed that we have access to such a great academic health care system.”</p> <p>Stanford Children’s specializes in treating rare and complicated IBD, like Abby’s, with outstanding outcomes. The center achieves 85% remission for its IBD patients. &nbsp;</p> <p>“With the right medicine, Abby is having regular bowel habits that allow her to go to school and do activities. Her disease doesn’t interfere with her ability to live her life,” Dr. Rosen says. “Abby has done amazing so far, so I am very hopeful she will continue to maintain remission.”</p> <p>Dr. Rosen will manage Abby’s care and tailor her treatments as she grows. As much as he dislikes the fact that children get Crohn’s, he values the chance to care for Abby.</p> <p>“Abby is always so positive and excited to tell me about her life, like how she loves gymnastics. Her parents care for her deeply and prioritize her health,” he says. “Our relationship is an outstanding example of a genuine and trusting partnership between a family and a physician.”</p> <p>Brittani and Aaron are proud of how strong and resilient Abby has been, and they’re extremely relieved to put their rough start behind them.</p> <p>“We now have confidence and hope in her care journey,” Aaron concludes.</p> <p><a href="https://www.stanfordchildrens.org/en/services/ibd-celiac-center.html"><strong>Learn more about the IBD Center at Stanford Medicine Children’s Health ></strong></a></p>

220. Teen Comes Through Near-Fatal Accident

     Thu, 19 Dec 2024 15:59:25 -0000

     

     Neurosurgery, trauma, and neurocritical care teams perform Christmas miracle by saving boy’s life after severe... Read more »

     <div><img width="768" height="432" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/051930_brain-trauma-feature.jpg" class="attachment-768x768 size-768x768 wp-post-image" alt="group photo at hospital" style="margin-bottom: 15px;" decoding="async" loading="lazy" srcset="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/051930_brain-trauma-feature.jpg 1200w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/051930_brain-trauma-feature-450x253.jpg 450w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/051930_brain-trauma-feature-900x506.jpg 900w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/051930_brain-trauma-feature-768x432.jpg 768w" sizes="(max-width: 768px) 100vw, 768px" /></div> <p><em>Neurosurgery, trauma, and neurocritical care teams perform Christmas miracle by saving boy’s life after severe accident</em></p> <p>It is exactly a year since the day Taneesh’s life changed forever. A tragic accident left the Bay Area teen fighting for his life, but it also brought him remarkable clarity about what matters most.</p> <div class="wp-block-image"> <figure class="alignleft size-full is-resized"><img loading="lazy" decoding="async" width="426" height="600" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/051930_brain-trauma-01.jpg" alt="Taneesh, before the accident." class="wp-image-26488" style="width:254px;height:auto" srcset="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/051930_brain-trauma-01.jpg 426w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/051930_brain-trauma-01-320x450.jpg 320w" sizes="(max-width: 426px) 100vw, 426px" /></figure></div> <p>Before the accident, Taneesh was a busy, active high school junior who had a job, excelled in soccer, and got top grades at school. He was preparing to attend college to pursue a mechanical engineering degree.</p> <p>Then, on a fateful rainy day on December 19, 2023, during finals and right before holiday break, everything changed. His friend picked him up from school to get lunch. Taneesh got in the front passenger seat. On the way, his friend lost control of the car. They hit a tree and the roof of the car was crushed, fracturing Taneesh’s skull.</p> <p>“It was such a bizarre accident. The driver and his girlfriend, who was in the back, walked away uninjured, but Taneesh had life-threatening injuries,” says Hema, Taneesh’s mom. &nbsp;&nbsp;</p> <p>Based on his critical injuries, emergency responders took Taneesh to the closest <a href="https://www.stanfordchildrens.org/en/services/trauma.html">Level I Pediatric Trauma Center</a>, which was <a href="https://www.stanfordchildrens.org/en.html">Lucile Packard Children’s Hospital Stanford</a>.</p> <p>“I was very lucky that the team brought me to Packard Children’s, one of the best hospitals in the world,” Taneesh says.</p> <p><strong>Getting advanced neuro-trauma care at Stanford Children’s</strong></p> <p><a href="https://www.stanfordchildrens.org/en/doctor/kelly-b-mahaney.html">Kelly Mahaney, MD</a>, pediatric neurosurgeon, remembers the trauma alert on that Tuesday before Christmas. After she and the team examined Taneesh and worked to stabilize his brain injury, she recalls, they had to tell his family that the medical team was not sure Taneesh would make it.</p> <p>“It was a tough night in intensive care, and we tried to optimize his care medically but he was really deteriorating. We were not confident he would survive,” says Dr. Mahaney.</p> <p>A large care team of 30+ neurological and trauma specialists came together to care for Taneesh, including Dr. Mahaney; <a href="https://www.stanfordchildrens.org/en/doctor/laura-m-prolo.html">Laura Prolo, MD, PhD</a>, pediatric neurosurgeon; <a href="https://www.stanfordchildrens.org/en/doctor/stephanie-d-chao.html">Stephanie Chao, MD</a>, pediatric surgeon; and, very important, the highly specialized <a href="https://www.stanfordchildrens.org/en/services/neuro-picu.html">Pediatric Neurocritical Care</a> team—one of the first in the nation and one of only a few in California, a vital addition for an ideal neurological outcome. Experts from <a href="https://www.stanfordchildrens.org/en/services/plastic-surgery.html">Pediatric Plastic Surgery</a> were also present, since Taneesh had complicated face fractures as well.</p> <p>One of the biggest threats against Taneesh’s life was increasing brain pressure from his severe head trauma. “If brain pressures get too high, normal blood flow to the brain becomes compromised, putting a patient at risk for secondary brain injury, stroke, or herniation—leading to death,” Dr. Mahaney says.</p> <p>She was prepared to do an emergency decompressive craniectomy—a <a href="https://www.stanfordchildrens.org/en/services/neurosurgery.html">neurosurgery</a> to remove bone to open the skull and expose the brain, allowing it to swell into the open space, which would reduce pressure. But Taneesh needed to be more stable for surgery.</p> <p>“We put him on an intracranial pressure monitoring device to keep track of pressures in his brain, and we placed an external ventricular drain to release cerebrospinal fluid to relieve pressure,” says <a href="https://www.stanfordchildrens.org/en/provider/may-casazza.html">May Casazza, c-ACPNP</a> with the neurocritical team. “We pretty much used every type of <a href="https://www.stanfordchildrens.org/en/services/neuro-picu/services.html">specialized neurological equipment</a> we had.”</p> <p>“Our Level I Pediatric Trauma Center is multidisciplinary and one of only five in California,” adds <a href="https://www.stanfordchildrens.org/en/doctor/stephanie-d-chao.html">Dr. Stephanie D Chao,</a> director of the <a href="https://www.stanfordchildrens.org/en/services/trauma.html">Pediatric Trauma Center</a>.&nbsp;&nbsp; &nbsp;</p> <p><strong>Going from no brain function to a twitch of a thumb</strong></p> <p>On the morning after his accident, Taneesh was not showing signs of brain function. Dr. Mahaney talked with his parents about their options. They voiced their desire for the team to do everything they could to save Taneesh, even if that might mean he survived in a comatose state.</p> <p>“As a trauma team we prioritize having honest conversations with families about how seriously injured their child is in those early hours while we do all we can. We always want families to make informed decisions about their child’s care,” says Katherine Alvarez, PA-C.</p> <p>“Taneesh’s family was so thoughtful about care decisions, even while in shock,” Dr. Mahaney says.</p> <p>With the parents’ wishes made clear, the team decided to turn off Taneesh’s sedation to get a better neurological assessment. If he showed signs of even brainstem function, their plan was to go ahead with the craniectomy. Everyone held their breath for the next several hours.</p> <p>“I checked on him every 20 minutes, and hours later I saw him flick his right thumb. That was enough for us to say there was a chance,” Casazza says. She also checked for pupil reaction and saw some activity. “I spoke with the doctors and we said, ‘Let’s go!’”</p> <p>Dr. Mahaney brought Taneesh into surgery for the craniectomy. She was joined by <a href="https://www.stanfordchildrens.org/en/doctor/rohit-k-khosla.html">Rohit Khosla, MD, FACS</a>, pediatric plastic surgeon, who requested she perform the craniectomy with a bicoronal incision—farther toward the back of Taneesh’s skull to preserve his forehead and face for future plastic surgery. He then marked out where he would make future incisions on Taneesh’s scalp.</p> <p>“Even though we were unsure whether or not Taneesh would survive, we wanted to ensure we were set up for a later operation to fix his complex facial fractures and frontal sinus fractures all in one shot,” says Dr. Khosla.</p> <p>All of this happened in the first 24 hours of care.</p> <p><strong>Uncovering an unexpected challenge—brain aneurysm</strong></p> <p>On the way to surgery for his craniectomy, Taneesh received a computed tomography angiography (CTA), where dye is used with a CT scan to create an image of blood vessels and tissues in the brain.</p> <p>“That’s where we detected a traumatic <a href="https://www.stanfordchildrens.org/en/topic/default?id=cerebral-aneurysm-85-P08772">cerebral aneurysm</a> (a bulged brain artery) that had ruptured,” Dr. Mahaney says. “After surgery, I called neuro-interventional radiology to ask them to secure the aneurysm. They took him that night, and because of that, he is still alive.”&nbsp;</p> <p><a href="https://www.stanfordchildrens.org/en/doctor/robert-l-dodd.html">Robert Dodd, MD, PhD</a>, cerebrovascular neurosurgeon and neuro-interventional radiologist, performed the procedure. His team was able to stop the bleeding by deploying a tiny platinum coil into the aneurysm. <a href="https://www.stanfordchildrens.org/en/services/interventional-radiology.html">Neuro-interventional radiology</a> at Stanford Children’s offers the latest in minimally invasive tools and procedures, with doctors who specialize in treating vascular neurological conditions via endovascular approach.</p> <p>“Many community hospitals, even many leading children’s hospitals, do not have access to neuro-interventional radiologists, so the fact that we offer this specialty care and our teams collaborate closely means that we were able to get Taneesh care in a timely fashion, which was critical,” Dr. Mahaney says.</p> <p>The aneurysm was caused at the time of the accident. A part of Taneesh’s skull bone lifted up and lacerated an artery. It’s why his trauma case was extraordinarily complex and partly why he needed so many procedures.</p> <p>“It’s pretty unusual. We see it in wartime injuries, but it isn’t something we see often in traumatic accidents,” Dr. Mahaney says.</p> <p>Before receiving the coil procedure, Taneesh had important visitors—his two best friends, including the driver of the car during the accident. In an astounding show of grace, Taneesh’s parents, Hema and Manju, invited them in. Even though he couldn’t respond, the driver was able to say, ‘I’m sorry, Taneesh.’</p> <p>“That was quite a moment for me to witness. His parents, trying to get their son through the night, telling his friends it’s OK, we’ll get through this, and showing such forgiveness,” Casazza says.</p> <p><strong>One more hurdle on the road to improvement</strong></p> <div class="wp-block-image"> <figure class="alignright size-full is-resized"><img loading="lazy" decoding="async" width="670" height="691" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/051930_brain-trauma-03.jpg" alt="Group photo with Taneesh and care team." class="wp-image-26492" style="width:363px;height:auto" srcset="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/051930_brain-trauma-03.jpg 670w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/051930_brain-trauma-03-436x450.jpg 436w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/051930_brain-trauma-03-24x24.jpg 24w" sizes="(max-width: 670px) 100vw, 670px" /></figure></div> <p>Despite his surgery and the coiling of the aneurysm, Taneesh’s brain pressure stayed unexpectedly high the next day, and he was also having vasospasms. Dr. Dodd expressed concern about a blood clot caused by his ruptured aneurysm. He advocated that the neurosurgery team surgically remove it.</p> <p>Dr. Mahaney took Taneesh back to surgery that day to perform an endoscopic procedure to evacuate the clot, which helped put him on the road to improvement after a rough start. “It’s remarkable the progress he made. Over Christmas I asked my family to pray for him, and when I came back and heard about his improvement, it felt like a Christmas miracle,” she says.&nbsp;</p> <p><strong>Follow-up surgery to repair his facial fractures</strong></p> <p>Over the month at Stanford Children’s, Taneesh continued to heal. His brain pressures came down, and he woke up more each day. He was stable enough for another critical surgery—a combined neurosurgery to close his skull flap from the craniectomy and plastic surgery to repair his facial fractures.</p> <p>“He had extensive fractures. His forehead, midface, around his eye sockets, and his nose were fractured in several pieces, and they were disconnected from his skull. Luckily, it spared his jaw,” Dr. Khosla says.</p> <p>The <a href="https://www.stanfordchildrens.org/en/services/plastic-surgery.html">Pediatric Plastic Surgery</a> team at Stanford Children’s are experts in facial surgery, offering highly advanced techniques including facial trauma microsurgeries (transferring tissue) and 3-D computer-guided surgical planning, among others.&nbsp;</p> <p>“We have a lot of experience with facial injuries, and we know how to put faces back together,” Dr. Khosla says. “In surgery, our team lined up his bones and held them together using titanium plates and screws. We were able to achieve close to normal facial projection and symmetry.”</p> <p>Thanks to Dr. Khosla’s exceptional skills and his planning two steps ahead during those unpredictable early days, no one would ever know Taneesh had had a facial injury.</p> <p>“What’s special about Stanford Children’s is that we are always accessible to one another and we don’t think twice about collaborating or planning together across disciplines, and that worked seamlessly when caring for Taneesh,” Dr. Khosla adds.</p> <div class="wp-block-image"> <figure class="alignright size-full is-resized"><img loading="lazy" decoding="async" width="600" height="337" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/051930_brain-trauma-02.jpg" alt="Taneesh and care team provider." class="wp-image-26494" style="width:424px;height:auto" srcset="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/051930_brain-trauma-02.jpg 600w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/051930_brain-trauma-02-450x253.jpg 450w" sizes="(max-width: 600px) 100vw, 600px" /></figure></div> <p>After recovering at Stanford Children’s, Taneesh was moved to a hospital closer to home for extensive rehabilitation therapies, where he spent another month. Later, he continued therapy at home and at other nearby facilities. &nbsp;</p> <p><strong>A new lease on life and not wasting one second &nbsp;</strong></p> <p>“I wake up every day and tell my dad, ‘Today is the best day of my life!’ I am getting better every day, and even if it is just a little bit, it is more than it was the day before,” Taneesh says. “When you hit rock bottom, everything is upwards and every day is a best day.”&nbsp;</p> <p>Taneesh was a determined, kind teenager before the accident, but now those traits are supercharged and with a clarity that is nearly unheard of in a 17-year-old boy. “The accident made me realize how lucky I am and helped me understand what’s important in life—close family and friends.” He also has immense gratitude for dedicated medical professionals who tirelessly guided him through tough times.</p> <p>He was extremely touched by how his family from near and far rallied to see him through. They came to Stanford Children’s and filled the entire waiting room on his floor. He was also heartened by frequent visits from his school community, including the principal, the school president, teachers, and coaches. “They came throughout winter break and even when they had a school to run. Someone from school was there every day,” Taneesh says.</p> <p>After months of rehabilitation, Taneesh is back to school for his senior year and even more focused on realizing his dream of becoming a mechanical engineer and entrepreneur with hopes of helping people with disabilities. He’s once again considering college, and with his resilience and tenacity, he has made up for the lost semester and expects to graduate on time. His positive outlook is uncompromising, and his steady smile is infectious.</p> <div class="wp-block-image"> <figure class="aligncenter size-large is-resized"><img loading="lazy" decoding="async" width="900" height="506" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/051930_brain-trauma-feature-2-900x506.jpg" alt="Group photo with Taneesh and care team." class="wp-image-26496" style="width:843px;height:auto" srcset="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/051930_brain-trauma-feature-2-900x506.jpg 900w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/051930_brain-trauma-feature-2-450x253.jpg 450w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/051930_brain-trauma-feature-2-768x432.jpg 768w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/051930_brain-trauma-feature-2.jpg 1200w" sizes="(max-width: 900px) 100vw, 900px" /></figure></div> <p>“I’m back, and I want to be better in every aspect—mentally, emotionally, and physically—than I was before the accident,” he says.</p> <p>Taneesh and his family endured incredible pain and suffering, but he doesn’t even mention it. He is finding new ways to enjoy his beloved sport, soccer, by mentoring and training his younger brother and his team. &nbsp;&nbsp;</p> <p>“Taneesh physically suffered, but the outcome is that he is a better person. His sense of gratitude and his sense of purpose and clarity are profound,” Manju says.</p> <p>To mark the first year of what he calls his rebirth after the accident, and to say thank you to Stanford Children’s, Taneesh started a holiday fundraiser called Helping Hands! through Stanford Students for Philanthropy for young patients. “I want to raise awareness and share empathy for those who need intensive care, and I invite people to <a href="https://my.supportlpch.org/fundraiser/5929798">join me</a>,” he says.</p> <p>A highlight for the family and the team at Stanford Children’s was the family’s visit to the ICU to say thank you. “It was touching to see the staff so overwhelmed, some even in tears, at seeing Taneesh on his feet,” Hema says. She recalls running into Dr. Mahaney, whom Taneesh calls his superhero.</p> <p>“Dr. Mahaney is extremely focused and composed, but on that day she showed her emotions when she saw us,” Hema says. “She said, ‘You made my day, getting to see you!’ and I broke down and said, ‘You made our lives, doctor.’”</p> <p><a href="https://www.stanfordchildrens.org/en/services/neurosurgery.html">Learn more about Neurosurgery at Stanford Children’s ></a></p> <p><a href="https://www.stanfordchildrens.org/en/services/trauma.html">Learn more about Trauma Care at Stanford Children’s ></a></p> <p><a href="https://my.supportlpch.org/fundraiser/5929798">Learn more about Taneesh’s fundraiser &gt;</a></p>

221. Tips for Helping Your Picky Eater

     Mon, 16 Dec 2024 16:40:12 -0000

     

     Pediatrician Tara Tanaka, MD, weighs in to help you understand more about picky eating and what you can do about it.

     <div><img width="768" height="432" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/blog-picky-eater.jpg" class="attachment-768x768 size-768x768 wp-post-image" alt="Young child with plate of food." style="margin-bottom: 15px;" decoding="async" loading="lazy" srcset="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/blog-picky-eater.jpg 1200w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/blog-picky-eater-450x253.jpg 450w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/blog-picky-eater-900x506.jpg 900w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/blog-picky-eater-768x432.jpg 768w" sizes="(max-width: 768px) 100vw, 768px" /></div> <p><strong>No Peas, Please: Tips for Helping Your Picky Eater</strong></p> <figure class="wp-block-image size-large"><img loading="lazy" decoding="async" width="900" height="506" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/blog-picky-eater-900x506.jpg" alt="Young child with plate of food." class="wp-image-26460" srcset="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/blog-picky-eater-900x506.jpg 900w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/blog-picky-eater-450x253.jpg 450w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/blog-picky-eater-768x432.jpg 768w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/blog-picky-eater.jpg 1200w" sizes="(max-width: 900px) 100vw, 900px" /></figure> <p>From preschoolers refusing to eat anything green to older kids who only want chicken nuggets and chips, navigating mealtime can be challenging. <a href="https://www.stanfordchildrens.org/en/doctor/tara-linh-tanaka.html">Tara Tanaka, MD</a>, a pediatrician at <a href="https://www.stanfordchildrens.org/en/location/peninsula-pediatric-medical-group-burlingame.html">Peninsula Pediatric Medical Group – Burlingame</a>, part of <a href="https://www.stanfordchildrens.org/en.html">Stanford Medicine Children’s Health</a>, weighs in to help you understand more about picky eating and what you can do about it.</p> <p><strong>What is picky eating?</strong></p> <p>While it can be frustrating, mild pickiness is often manageable and part of normal development, Dr. Tanaka explained. A significant percentage of children will show strong food preferences at some point. &nbsp;</p> <p>“Having food preferences is normal, and there are developmentally appropriate times when kids will go from eating everything that you put in front of them to around 14 months, when they decide that they’re not going to eat everything,” she said. “Picky eating comes in when a kid has definite like and dislikes: refusing to eat certain foods, or a parent feels like they often need to prepare special meals for their child separate from the family.”</p> <p><strong>Preventing picky eating</strong></p> <p>Building an openness to different foods starts in infancy. Breastfeeding, when possible, can expose infants to a range of tastes based on the mother’s diet.</p> <p>“Babies who are breastfed may have a higher acceptance of new foods when they start complementary eating. And that’s also associated with better chewing function in some studies,” Dr. Tanaka said. “Also, if moms are able to breastfeed, maternal intake of fruits and veggies during lactation may be one predictor of the acceptance of fruits and veggies when kids start eating too.”</p> <p>When your baby starts eating on their own, think beyond the state one pureed meals. Incorporating different textures can help expand a baby’s future palate.</p> <p>“Another strategy to prevent picky eating is introducing lumpy foods early, between 6 and 9 months of age,” Dr. Tanaka said. “Delaying lumpy foods has been associated with eating less of different food groups and is more associated with rare eating problems in some studies as opposed to delayed introduction.”</p> <p><strong>Model healthy eating at home</strong></p> <p>Modeling healthy eating is crucial: If family members eat vegetables, fruits, and other nutritious options together, children learn that these foods are a normal part of daily meals. “Kids are natural mimickers, and they will definitely try to imitate what’s around them. So, modeling healthy eating as a parent is another way to manage picky eating. When they observe their parents enjoying a range of foods, they are more likely to be open to trying these foods themselves.”</p> <p><strong>Encourage self-choice and participation</strong></p> <p>Dr. Tanaka recommends giving children choices and involving them in food preparation. This can improve their willingness to try new foods.</p> <p>“Anytime a child can have a say or make a choice around what they’re going to eat, it’s definitely going to help them to accept it,” she said. “So shopping, gardening, cooking: These are all great strategies for incentivizing a child to actually eat the food that they’ve chosen or cooked or grown.”</p> <p><strong>Repeated exposure to new foods</strong></p> <p>Accepting new foods often requires repeated exposure. Dr. Tanaka explained that children may need to try a new food8 to 10 times before accepting it. “Many parents stop after less than five times. And it makes a lot of sense because after a couple of times, it seems like the kid doesn’t like it. So we tend to stop,” she said. “But really they should try introducing foods many times and not just repeated exposures but repeated varied exposures within meals.”</p> <p>Dr. Tanaka suggested offering different types of fruits and vegetables in a variety of preparations and combinations. For example, serving carrots in different forms—raw, shredded, or roasted—and combining them with other foods in different ways can gradually increase a child’s comfort with the food.</p> <p><strong>Avoid food-based rewards</strong></p> <p>Offering desserts or treats as rewards for eating vegetables can backfire, making healthy foods seem like obstacles. Instead, Dr. Tanaka recommends non-food rewards, such as stickers or praise, to positively reinforce good eating behaviors. By avoiding the “eat broccoli, get a cookie” approach, parents can prevent their child from viewing nutritious foods as the “enemy” to be tolerated rather than enjoyed.</p> <p><strong>Adopt the Division of Responsibility</strong></p> <p>One of Dr. Tanaka’s preferred approaches is Ellyn Satter’s “Division of Responsibility,” a model that encourages a healthy balance in feeding. In this approach, parents decide what foods to serve, as well as when and where meals occur, while children decide which foods to eat from what is offered and how much to eat. By setting structured yet flexible boundaries, parents allow children to explore foods in a supportive environment.</p> <p>“We want to be understanding that kids have natural likes and dislikes and try to respect that within these healthy boundaries,” she explained. “I try to reassure parents that it’s OK as long as the kids are growing OK.”</p> <p><strong>Use sneaky nutrition sparingly</strong></p> <p>Mixing vegetables into other foods, like adding kale to pasta sauce, can ensure that children get essential nutrients. While it’s a useful strategy for incorporating foods that a child may not eat, Dr. Tanaka emphasizes that this technique does not actually help to resolve a child’s picky eating. “In addition, I still think it’s important for kids to learn to enjoy food whole,” she said.</p> <p><strong>When to seek help</strong></p> <p>If picky eating leads to nutritional deficiencies, growth issues, or significant stress in the household, or your child is physically having trouble eating, it may be time to consult a pediatrician.</p> <p>“If a kid relies on supplements, like PediaSure, to get enough to eat, if kids are excluding entire food groups, or their picky eating is causing ridiculously high amounts of stress for caregivers, the parent should touch base with their pediatrician,” Dr. Tanaka said. “There are also feeding disorders, like if they can’t chew well, if they’re having trouble swallowing or choking; those are red flags and need medical intervention.</p> <p>Picky eating is a normal part of child development, but with patience and the right strategies, parents can foster healthy eating habits that last a lifetime. “Food is medicine,” Dr. Tanaka said. “We’re trying to shape our children’s choices so that they can have healthy eating preferences as kids and adults.”</p>

222. Doctor Raises Awareness for Hypermobility Spectrum Disorder

     Mon, 16 Dec 2024 16:00:00 -0000

     

     Mekhla Varma, MD, discusses Hypermobility Spectrum Disorder (HSD), a little-known condition affecting connective tissue throughout the body.

     <div><img width="768" height="432" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/hypermobility-disorder.jpg" class="attachment-768x768 size-768x768 wp-post-image" alt="Pediatrician examining boy." style="margin-bottom: 15px;" decoding="async" loading="lazy" srcset="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/hypermobility-disorder.jpg 1200w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/hypermobility-disorder-450x253.jpg 450w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/hypermobility-disorder-900x506.jpg 900w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/hypermobility-disorder-768x432.jpg 768w" sizes="(max-width: 768px) 100vw, 768px" /></div> <figure class="wp-block-image size-large"><img loading="lazy" decoding="async" width="900" height="506" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/hypermobility-disorder-900x506.jpg" alt="Pediatrician examining boy." class="wp-image-26447" srcset="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/hypermobility-disorder-900x506.jpg 900w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/hypermobility-disorder-450x253.jpg 450w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/hypermobility-disorder-768x432.jpg 768w, https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/hypermobility-disorder.jpg 1200w" sizes="(max-width: 900px) 100vw, 900px" /></figure> <p>Children may often appear double-jointed. Their flexibility, until the age of 5, can make it seem like they are made of rubber. They make rebounding from a fall, tumbling, and moving their bodies in unique ways look easy.<a></a></p> <p>While they usually outgrow this resiliency by age 18 as joints mature and stabilize, for some children, joint hypermobility can be a lifelong problem. Joint hypermobility means that some or all of a person’s joints have an unusually large range of movement, and they are able to move their limbs into positions others find impossible.</p> <p>Some people also refer to this as having loose joints or being double-jointed. Because children have high levels of joint hypermobility, it can be difficult to distinguish those with a normal physical trait from those with an underlying disorder.</p> <p><a href="https://www.stanfordchildrens.org/en/doctor/mekhla-varma.html">Mekhla Varma, MD</a>, a <a href="https://www.stanfordchildrens.org/en.html">Stanford Medicine Children’s Health</a> pediatrician at <a href="https://www.stanfordchildrens.org/en/location/south-bascom-pediatrics.html">South Bascom Pediatrics</a> and <a href="https://www.stanfordchildrens.org/en/location/pediatrics-los-gatos">Stanford Medicine Children’s Health Pediatrics – Los Gatos</a> locations, explained that hypermobility disorders were once identified mostly with Ehlers-Danlos syndromes (EDS) and Marfan syndrome, rare but serious connective tissue diseases that are inherited. Hypermobility spectrum disorder (HSD) is now classified as a separate syndrome, with a spectrum of symptoms and severity from asymptomatic to severe.</p> <p>These heritable connective tissue disorders are caused by genetic changes that affect connective tissue. Some features are seen across all types of EDS, including joint hypermobility, skin hyperextensibility, and tissue fragility. The most common type of EDS is hypermobile EDS (hEDS).</p> <p>“In 2017, stricter criteria were developed to diagnose hEDS, after the <a href="https://www.ehlers-danlos.com/international-consortium/" target="_blank" rel="noreferrer noopener">International Consortium on Ehlers-Danlos Syndromes (EDS) and Hypermobility Spectrum Disorders</a> established new guidelines for the condition,” Dr. Varma explained.</p> <p>“It was recognized that joint hypermobility is a continuum, and while not everyone meets criteria for hEDS, joint hypermobility can have severe impact on lives, whether it’s because of direct joint issues or because of other issues associated with joint hypermobility,” she said. “Hence, hypermobility spectrum disorder became a new diagnosis. The essential difference between HSD and hEDS lies in the stricter criteria for hEDS compared to the HSD.”</p> <p>Connective tissue laxity not only affects joints but, more important, can cause other organs and body systems to not work properly, creating many problems. Since connective tissue is found throughout the body, it supports, protects, and gives structure to organs and systems, Dr. Varma said.</p> <p>The core comorbid conditions that children present with are chronic pain, functional GI disorders, chronic fatigue, functional bladder disorders, dysautonomia, and anxiety, she added.</p> <p>“HSD is fluid and keeps evolving, especially as children age, making it difficult to label kids in the different stages of evolution,” she said.</p> <p>Dr. Varma has been advancing her knowledge of HSD for more than a decade and is raising awareness for HSD, as the combined prevalence of HSD and hEDS is between 1 in 600 and 1 in 900—and likely underdiagnosed.</p> <p>“While working at a pediatric rheumatology clinic more than a decade ago, I had many patients who presented with nonspecific joint pain, and after autoimmune arthritis was ruled out, they were all classified in one big category of benign joint hypermobility syndrome. That’s when I started digging deeper into connective tissue disorders. We understand so much more now and continue to learn more.”</p> <p>While joint instability may be obvious, some of the ways the condition affects the body are not readily noticeable, Dr. Varma noted. HSD can be associated with the following:</p> <ul class="wp-block-list"> <li>Stomach and digestive problems (reflux and slow stomach emptying)</li> <li>Poor proprioception (the body’s ability to sense its position and movements in space)</li> <li>Bladder and bowel problems</li> <li>Autonomic dysfunction, including dizziness, fainting, light-headedness, difficulty regulating temperature</li> <li>Easy bruising</li> <li>Poor wound healing</li> <li>Long-term (persistent) pain</li> <li>Stretchy or soft skin</li> <li>Chronic fatigue</li> <li>Mast cell activation</li> <li>Anxiety</li> </ul> <p>It helps to have a team of doctors collaborating on a child’s HSD care, she said, and Stanford Medicine Children’s Health has an extensive network of specialists. “We treat the individual issues that arise related to HSD. As a generalist, I diagnose the condition, understand, and manage the issues, and refer to a specialist as needed.”</p> <p>If parents suspect that their child might be hypermobile, Dr. Varma recommends talking to their pediatrician. “Some kids are hypermobile with no other issues and there is nothing that needs to be done,” she said, “but awareness is key.”</p> <p>Dr. Varma is confident that as she and others continue to study hypermobility disorders, more information will be available. She discusses hypermobility spectrum disorder in a HealthTalks podcast.</p> <center><table style="border: 1px solid #dfdfdf;padding:10px"><tbody><tr><td><center><img loading="lazy" decoding="async" width="300" height="169" style="margin-bottom:0px;" src="https://healthier.stanfordchildrens.org/wp-content/uploads/2024/12/mekhla-varma-md-healthtalks.jpg" alt="Mekhla Varma, MD, Healthtalks." class="wp-image-26453"><br><iframe loading="lazy" src="https://radiomd.com/audio-player/playerwidget/item/65555?clientcode=stanfordchildrens" seamless="" scrolling="no" border="0" frameborder="0" width="302" height="49"></iframe></center></td></tr></tbody></table><p></p></center> <p>For more information, visit <a href="https://www.ehlers-danlos.com/" target="_blank" rel="noreferrer noopener">The Ehlers-Danlos Society</a> and <a href="https://www.hypermobility.org/what-is-hypermobility" target="_blank" rel="noreferrer noopener">Hypermobility Syndromes Association</a>.</p>